Structural analysis and evolution of specificity of the SUMO UFD E1-E2 interactions.

abstract：:Many established inflammation- and nutrition-related factors have been investigated as potential independent prognostic factors in various cancers, including the C-reactive protein/albumin ratio (CAR), lymphocyte/monocyte ratio (LMR), modified Glasgow prognostic score (mGPS), body mass index (BMI), and prognostic nutr...

journal_title：Scientific reports

authors： Zhang W,Ye B,Liang W,Ren Y

更新日期：2017-08-25 00:00:00

abstract：:Cardiac fibroblasts are present throughout the myocardium and are enriched in the microenvironment surrounding the ventricular conduction system (VCS). Several forms of arrhythmias are linked to VCS abnormalities, but it is still unclear whether VCS malformations are cardiomyocyte autonomous or could be linked to cros...

journal_title：Scientific reports

authors： Ribeiro da Silva A,Neri EA,Turaça LT,Dariolli R,Fonseca-Alaniz MH,Santos-Miranda A,Roman-Campos D,Venturini G,Krieger JE

更新日期：2020-09-30 00:00:00

abstract：:At the species level, plants can respond to climate changes by changing their leaf traits; however, there is scant information regarding the responses of morphological, physiological and anatomical traits of plant functional types (PFTs) to aridity. Herein, the leaf traits of five PFTs representing 17 plant species in...

journal_title：Scientific reports

authors： Guo C,Ma L,Yuan S,Wang R

更新日期：2017-01-20 00:00:00

abstract：:RAS genotyping is mandatory to predict anti-EGFR monoclonal antibodies (mAbs) therapy resistance and BRAF genotyping is a relevant prognosis marker in patients with metastatic colorectal cancer. Although the role of hotspot mutations is well defined, the impact of uncommon mutations is still unknown. In this study, we...

journal_title：Scientific reports

authors： Franczak C,Kandathil SM,Gilson P,Husson M,Rouyer M,Demange J,Leroux A,Merlin JL,Harlé A

更新日期：2019-05-08 00:00:00

abstract：:Our study aimed to compare the ability of anthropometric obesity indices to predict MetS and to determine the sex-specific optimal cut-off values for MetS among Malaysian vegetarians. Body weight, height, waist circumference (WC), blood pressure (BP), fasting venous blood sample were collected from 273 vegetarians in ...

journal_title：Scientific reports

authors： Ching YK,Chin YS,Appukutty M,Gan WY,Chan YM

更新日期：2020-11-30 00:00:00

abstract：:This study proposes a new method of visualizing the ambient dose rate distribution using artificial neural networks (ANNs) from airborne radiation monitoring results. The method was applied to the results of the airborne radiation monitoring which was conducted around the Fukushima Daiichi Nuclear Power Plant by an un...

journal_title：Scientific reports

authors： Sasaki M,Sanada Y,Katengeza EW,Yamamoto A

更新日期：2021-01-20 00:00:00

abstract：:Signaling by members of the transforming growth factor-β (TGF-β) superfamily, such as TGF-β3 and BMP7, and oxygen tension play a pivotal role in chondrocyte biology. The objective of this research was to investigate the endogenous BMP7 expression in human osteoarthritis (OA) cartilage and the effect of oxygen tension ...

journal_title：Scientific reports

authors： Huang X,Zhong L,Post JN,Karperien M

更新日期：2018-07-06 00:00:00

abstract：:This paper reports the application of anthracite particles of different sizes and coated with nine kinds of layered double hydroxides (LDHs) varying in M(II)-M(III) cations, as alternative substrates in the simulated vertical-flow constructed wetland columns. Effects of LDHs-coating and particle size of modified anthr...

journal_title：Scientific reports

authors： Zhang X,Guo L,Wang Y,Ruan C

更新日期：2015-10-12 00:00:00

abstract：:This retrospective cohort study examined the relationship between a cholecystectomy and the subsequent risk of peptic ulcers using a population-based database. Data for this study were retrieved from the Taiwan Longitudinal Health Insurance Database 2005. This study included 5209 patients who had undergone a cholecyst...

journal_title：Scientific reports

authors： Tsai MC,Huang CC,Kao LT,Lin HC,Lee CZ

更新日期：2016-07-29 00:00:00

abstract：:Neurotransmitter release is mediated by the SNARE complex, but the role of its phosphorylation has scarcely been elucidated. Although PKC activators are known to facilitate synaptic transmission, there has been a heated debate on whether PKC mediates facilitation of neurotransmitter release through phosphorylation. On...

journal_title：Scientific reports

authors： Katayama N,Yamamori S,Fukaya M,Kobayashi S,Watanabe M,Takahashi M,Manabe T

更新日期：2017-08-11 00:00:00

abstract：:Dissecting the complex molecular interplay between the host plant and invading virus improves our understanding of the mechanisms underlying viral pathogenesis. In this study, immunoprecipitation together with the mass spectrometry analysis revealed that the heat shock protein 70 (Hsp70) family homolog, Hsc70-2, was c...

journal_title：Scientific reports

authors： Wang X,Cao X,Liu M,Zhang R,Zhang X,Gao Z,Zhao X,Xu K,Li D,Zhang Y

更新日期：2018-03-14 00:00:00

abstract：:The mode of action for oncolytic viruses (OVs) in cancer treatment is thought to depend on a direct initial cytotoxic effect against infected tumor cells and subsequent activation of immune cell responses directed against the neoplasm. To study both of these effects in a mouse model of glioblastoma (GBM), we employed ...

journal_title：Scientific reports

authors： Alayo QA,Ito H,Passaro C,Zdioruk M,Mahmoud AB,Grauwet K,Zhang X,Lawler SE,Reardon DA,Goins WF,Fernandez S,Chiocca EA,Nakashima H

更新日期：2020-03-20 00:00:00

abstract：:Natural killer (NK) cells play a major role in anti-viral immunity as first line defense during hepatitis B infection, particularly in untreated patients whose T cells functions are profoundly impaired. Cytokine interferon (IFN)-γ and tumor necrosis factor (TNF)-α produced by NK cells are important anti-viral factors....

journal_title：Scientific reports

authors： Li X,Gu Y,Guo X,Gu L,Zhou L,Wu X,Wang X,Stamataki Z,Huang Y

更新日期：2017-07-19 00:00:00

abstract：:Axonal injury is a common feature of central nervous system insults that culminates with the death of the affected neurons, and an irreversible loss of function. Inflammation is an important component of the neurodegenerative process, where the microglia plays an important role by releasing proinflammatory factors as ...

journal_title：Scientific reports

authors： Nadal-Nicolás FM,Galindo-Romero C,Valiente-Soriano FJ,Barberà-Cremades M,deTorre-Minguela C,Salinas-Navarro M,Pelegrín P,Agudo-Barriuso M

更新日期：2016-12-08 00:00:00

abstract：:The shape of fragments generated by the breakup of solids is central to a wide variety of problems ranging from the geomorphic evolution of boulders to the accumulation of space debris orbiting Earth. Although the statistics of the mass of fragments has been found to show a universal scaling behavior, the comprehensiv...

journal_title：Scientific reports

authors： Domokos G,Kun F,Sipos AÁ,Szabó T

更新日期：2015-03-16 00:00:00

abstract：:Quantifying how close two datasets are to each other is a common and necessary undertaking in scientific research. The Pearson product-moment correlation coefficient r is a widely used measure of the degree of linear dependence between two data series, but it gives no indication of how similar the values of these seri...

journal_title：Scientific reports

authors： Duveiller G,Fasbender D,Meroni M

更新日期：2016-01-14 00:00:00

abstract：:During viral infections, some viruses subvert the host proteins to promote the translation or RNA replication with their protease-mediated cleavage. Poly (A)-binding protein (PABP) is a target for several RNA viruses; however, the impact of duck hepatitis A virus (DHAV) on PABP remains unknown. In this study, we demon...

journal_title：Scientific reports

authors： Sun D,Wang M,Wen X,Cheng A,Jia R,Sun K,Yang Q,Wu Y,Zhu D,Chen S,Liu M,Zhao X,Chen X

更新日期：2017-11-24 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Ayaz G,Razizadeh N,Yaşar P,Kars G,Kahraman DC,Saatci Ö,Şahin Ö,Çetin-Atalay R,Muyan M

更新日期：2020-06-16 00:00:00

abstract：:Membrane proteins are distinguished from soluble proteins by their insertion into biological membranes. This insertion is achieved via a noticeable arrangement of hydrophobic amino acids that are exposed at the surface of the protein, and renders the interaction with the aliphatic tails of lipids more energetically fa...

journal_title：Scientific reports

authors： Robert X,Kassis-Sahyoun J,Ceres N,Martin J,Sawaya MR,Read RJ,Gouet P,Falson P,Chaptal V

更新日期：2017-12-05 00:00:00

abstract：:The aim of this study was to estimate substitution rate and imprints of natural selection on parvovirus B19 genotype 1. Studied datasets included 137 near complete coding B19 genomes (positions 665 to 4851) for phylogenetic and substitution rate analysis and 146 and 214 partial genomes for selection analyses in open r...

journal_title：Scientific reports

authors： Stamenković GG,Ćirković VS,Šiljić MM,Blagojević JV,Knežević AM,Joksić ID,Stanojević MP

更新日期：2016-10-24 00:00:00

abstract：:While researches have focused on drag reduction of various coated surfaces such as superhydrophobic structures and polymer brushes, the insights tso understand the fundamental physics of the laminar skin friction coefficient and the related drag reduction due to the formation of finite velocity at porous surfaces is s...

journal_title：Scientific reports

authors： Mirbod P,Wu Z,Ahmadi G

更新日期：2017-12-08 00:00:00

abstract：:Melanoma is the most lethal cutaneous cancer. New drugs have recently appeared; however, not all patients obtain a benefit of these new drugs. For this reason, it is still necessary to characterize melanoma at molecular level. The aim of this study was to explore the molecular differences between melanoma tumor subtyp...

journal_title：Scientific reports

authors： Trilla-Fuertes L,Gámez-Pozo A,Prado-Vázquez G,Zapater-Moros A,Díaz-Almirón M,Fortes C,Ferrer-Gómez M,López-Vacas R,Parra Blanco V,Márquez-Rodas I,Soria A,Fresno Vara JÁ,Espinosa E

更新日期：2019-05-10 00:00:00

abstract：:The effect of different contact configurations (semi-infinite extended-channel, normal metal and ferromagnetic metal) on quantum transport through thin Bi2Se3 three-dimensional (3D) topological insulator (TI) slab (channel) has been investigated through Non-Equilibrium Green Function. The issue of contact dependent cu...

journal_title：Scientific reports

authors： Gupta G,Jalil MB,Liang G

更新日期：2015-03-30 00:00:00

abstract：:Beaver have been referred to as ecosystem engineers because of the large impacts their dam building activities have on the landscape; however, the benefits they may provide to fluvial fish species has been debated. We conducted a watershed-scale experiment to test how increasing beaver dam and colony persistence in a ...

journal_title：Scientific reports

authors： Bouwes N,Weber N,Jordan CE,Saunders WC,Tattam IA,Volk C,Wheaton JM,Pollock MM

更新日期：2016-07-04 00:00:00

abstract：:Knowing which geodynamic regimes characterised the early Earth is a fundamental question. This implies to determine when and how modern plate tectonics began. Today, the tectonic regime is dominated by mobile-lid tectonics including deep and cold subduction. However, in the early Earth (4.5 to 2 Ga) stagnant-lid tecto...

journal_title：Scientific reports

authors： François C,Debaille V,Paquette JL,Baudet D,Javaux EJ

更新日期：2018-10-18 00:00:00

abstract：:The structures, stabilities, and electronic properties of monolayer black phosphorus (M-BP) with different kinds of defects are investigated within the frame of density-functional theory. All the possible configurations of defects in M-BP are explored, and the calculated results suggest that the stabilities of the con...

journal_title：Scientific reports

authors： Li XB,Guo P,Cao TF,Liu H,Lau WM,Liu LM

更新日期：2015-06-02 00:00:00

abstract：:There is currently a lack of effective drugs to cure recurrent aphthous stomatitis. This study aimed to evaluate the efficacy of probiotics alone or as an adjunct in recurrent aphthous stomatitis (RAS) patients. Seven randomized controlled trials (RCTs) were included, of which three were included in quantitative analy...

journal_title：Scientific reports

authors： Cheng B,Zeng X,Liu S,Zou J,Wang Y

更新日期：2020-12-03 00:00:00

abstract：:Terminally misfolded proteins are selectively recognized and cleared by the endoplasmic reticulum-associated degradation (ERAD) pathway. SEL1L, a component of the ERAD machinery, plays an important role in selecting and transporting ERAD substrates for degradation. We have determined the crystal structure of the mouse...

journal_title：Scientific reports

authors： Jeong H,Sim HJ,Song EK,Lee H,Ha SC,Jun Y,Park TJ,Lee C

更新日期：2016-02-09 00:00:00

abstract：:We present a new class of TiBw/Ti6Al4V composites with a network reinforcement architecture that exhibits a significant creep resistance compared to monolithic Ti6Al4V alloys. Creep tests performed at temperatures between 773 K and 923 K and stress range of 100 MPa-300 MPa indicate both a significant improvement of th...

journal_title：Scientific reports

authors： Wang S,Huang LJ,Geng L,Scarpa F,Jiao Y,Peng HX

更新日期：2017-01-17 00:00:00

abstract：:Working with a large temporal dataset spanning several decades often represents a challenging task, especially when the record is heterogeneous and incomplete. The use of statistical laws could potentially overcome these problems. Here we apply Benford's Law (also called the "First-Digit Law") to the traveled distance...

journal_title：Scientific reports

authors： Joannes-Boyau R,Bodin T,Scheffers A,Sambridge M,May SM

更新日期：2015-07-09 00:00:00