Integrated mRNA and microRNA transcriptome analysis reveals miRNA regulation in response to PVA in potato.

abstract：:Alzheimer disease and other dementias have become the 7th cause of death worldwide. Still lacking a cure, an early detection of the disease in order to provide the best intervention is crucial. To develop an assessment system for the general public, speech analysis is the optimal solution since it reflects the speaker...

journal_title：Scientific reports

authors： Chien YW,Hong SY,Cheah WT,Yao LH,Chang YL,Fu LC

更新日期：2019-12-20 00:00:00

abstract：:Nanomaterials are being extensively produced and applied in society. Human and environmental exposures are, therefore, inevitable and so increased attention is being given to nanotoxicity. While silica nanoparticles (NP) are one of the top five nanomaterials found in consumer and biomedical products, their toxicity pr...

journal_title：Scientific reports

authors： Pham DH,De Roo B,Nguyen XB,Vervaele M,Kecskés A,Ny A,Copmans D,Vriens H,Locquet JP,Hoet P,de Witte PA

更新日期：2016-11-22 00:00:00

abstract：:The natural ligand 17β-estradiol (E2) is so far believed to induce a unique agonist-bound active conformation in the ligand binding domain (LBD) of the estrogen receptors (ERs). Both subtypes, ERα and ERβ, are transcriptionally activated in the presence of E2 with ERβ being somewhat less active than ERα under similar ...

journal_title：Scientific reports

authors： Souza PCT,Textor LC,Melo DC,Nascimento AS,Skaf MS,Polikarpov I

更新日期：2017-06-14 00:00:00

abstract：:Recent whooping cough (pertussis) outbreaks in many countries highlight the crucial need for a better understanding of the pathogenesis of Bordetella pertussis infection of the respiratory tract. The baboon is a recently described preclinical model for the study of B. pertussis infection and may be ideal for the evalu...

journal_title：Scientific reports

authors： Naninck T,Coutte L,Mayet C,Contreras V,Locht C,Le Grand R,Chapon C

更新日期：2018-08-16 00:00:00

abstract：:In honeybees fast and efficient exploitation of nectar and pollen sources is achieved by persistent endothermy throughout the foraging cycle, which means extremely high energy costs. The need for food promotes maximisation of the intake rate, and the high costs call for energetic optimisation. Experiments on how honey...

journal_title：Scientific reports

authors： Stabentheiner A,Kovac H

更新日期：2016-06-20 00:00:00

abstract：:Novel pain killers without adverse effects are urgently needed. Opioids induce central and intestinal side effects such as respiratory depression, sedation, addiction, and constipation. We have recently shown that a newly designed agonist with a reduced acid dissociation constant (pKa) abolished pain by selectively ac...

journal_title：Scientific reports

authors： Spahn V,Del Vecchio G,Rodriguez-Gaztelumendi A,Temp J,Labuz D,Kloner M,Reidelbach M,Machelska H,Weber M,Stein C

更新日期：2018-06-12 00:00:00

abstract：:Breast cancer is the most common cancer among women, and its incidence is on a constant rise. Previous studies suggest that higher levels of plasma prolactin are associated with escalated risk of breast cancer, however, these results are contradictory and inconclusive. PubMed and Medline were used to search and identi...

journal_title：Scientific reports

authors： Wang M,Wu X,Chai F,Zhang Y,Jiang J

更新日期：2016-05-17 00:00:00

abstract：:Terahertz (THz) electromagnetic wave has been widely used as a spectroscopic probe to detect the collective vibrational mode in vast molecular systems and investigate dielectric properties of various materials. Recent technological advances in generating intense THz radiation and the emergence of THz plasmonics operat...

journal_title：Scientific reports

authors： Seo M,Kang JH,Kim HS,Hyong Cho J,Choi J,Min Jhon Y,Lee S,Hun Kim J,Lee T,Park QH,Kim C

更新日期：2015-05-22 00:00:00

abstract：:Non-forest ecosystems (predominant in semi-arid and arid regions) contribute significantly to the increasing trend and interannual variation of land carbon uptake over the last three decades, yet the mechanisms are poorly understood. By analysing the flux measurements from 23 ecosystems in Australia, we found the the ...

journal_title：Scientific reports

authors： Li L,Wang YP,Beringer J,Shi H,Cleverly J,Cheng L,Eamus D,Huete A,Hutley L,Lu X,Piao S,Zhang L,Zhang Y,Yu Q

更新日期：2017-09-15 00:00:00

abstract：:In this study, a noninvasive quantitative measure was used to identify short and long term post-concussion syndrome (PCS) both from each other and from healthy control populations. We used Electrovestibulography (EVestG) for detecting neurophysiological PCS consequent to a mild traumatic brain injury (mTBI) in both sh...

journal_title：Scientific reports

authors： Suleiman A,Lithgow B,Dastgheib Z,Mansouri B,Moussavi Z

更新日期：2017-11-27 00:00:00

abstract：:The phosphatases of regenerating liver (PRLs) are involved in tumorigenesis and metastatic cancer yet their cellular function remains unclear. Recent reports have shown PRL phosphatases bind tightly to the CNNM family of membrane proteins to regulate magnesium efflux. Here, we characterize the interactions between the...

journal_title：Scientific reports

authors： Zhang H,Kozlov G,Li X,Wu H,Gulerez I,Gehring K

更新日期：2017-03-03 00:00:00

abstract：:To understand the role of commensal gut bacteria on the progression of cognitive decline in Alzheimer's disease via the microbiota-gut-brain axis, we isolated anti-inflammatory Bifidobacterium longum (NK46) from human gut microbiota, which potently inhibited gut microbiota endotoxin production and suppressed NF-κB act...

journal_title：Scientific reports

authors： Lee HJ,Lee KE,Kim JK,Kim DH

更新日期：2019-08-14 00:00:00

abstract：:C. canimorsus and C. cynodegmi are dog and cat commensals which can be transmitted to humans via bites or scratches and can cause sepsis, meningitis, endocarditis, and eye- or wound infections. Recently an additional Capnocytophaga species was identified as part of the oral flora of healthy dogs and was given the name...

journal_title：Scientific reports

authors： Zangenah S,Abbasi N,Andersson AF,Bergman P

更新日期：2016-03-07 00:00:00

abstract：:Life-history theory predicts that current behaviour affects future reproduction, implying that animals should optimise their escape strategies to reflect fitness costs and benefits of premature escape. Both costs and benefits of escape may change temporally with important consequences for the evolution of escape strat...

journal_title：Scientific reports

authors： Mikula P,Díaz M,Albrecht T,Jokimäki J,Kaisanlahti-Jokimäki ML,Kroitero G,Møller AP,Tryjanowski P,Yosef R,Hromada M

更新日期：2018-09-18 00:00:00

abstract：:Primary Sjögren's syndrome (pSS) is a complex autoimmune disease characterized by dysfunction of secretory epithelia with only palliative therapy. Patients present with a constellation of symptoms, and the diversity of symptomatic presentation has made it difficult to understand the underlying disease mechanisms. In t...

journal_title：Scientific reports

authors： Tanaka T,Warner BM,Odani T,Ji Y,Mo YQ,Nakamura H,Jang SI,Yin H,Michael DG,Hirata N,Suizu F,Ishigaki S,Oliveira FR,Motta ACF,Ribeiro-Silva A,Rocha EM,Atsumi T,Noguchi M,Chiorini JA

更新日期：2020-09-16 00:00:00

abstract：:Target-guided synthesis is an approach to drug discovery that allows the target to self-assemble its own binding agents. So far, target-guided synthesis and especially in situ click chemistry have attracted extensive attention and have led to the identification of highly potent inhibitors for proteins. In this study, ...

journal_title：Scientific reports

authors： Hu MH,Chen X,Chen SB,Ou TM,Yao M,Gu LQ,Huang ZS,Tan JH

更新日期：2015-11-25 00:00:00

abstract：:We aimed to evaluate the association of plasma biomarkers linked to inflammation (bacterial translocation, inflammatory response, and endothelial dysfunction), coagulopathy, and angiogenesis with the severity of liver cirrhosis (assessed by the Child-Pugh-Turcotte score, CTP) and Child-Pugh B cirrhosis (CTP 7-9) in pa...

journal_title：Scientific reports

authors： Salgüero S,Medrano LM,González-García J,Berenguer J,Montes ML,Diéz C,Garcia-Broncano P,Llop-Herrera E,Pérez-Latorre L,Bellóno JM,Jiménez-Sousa MÁ,Resino S

更新日期：2020-06-25 00:00:00

abstract：:Single nucleotide variations (SNVs) can result in loss or gain of protein functional sites. We analyzed the effects of SNVs on enzyme active sites, ligand binding sites, and various types of post translational modification (PTM) sites. We found that, for most types of protein functional sites, the SNV pattern differs ...

journal_title：Scientific reports

authors： Pan Y,Yan C,Hu Y,Fan Y,Pan Q,Wan Q,Torcivia-Rodriguez J,Mazumder R

更新日期：2017-02-08 00:00:00

abstract：:The brain is a paradigmatic example of a complex system: its functionality emerges as a global property of local mesoscopic and microscopic interactions. Complex network theory allows to elicit the functional architecture of the brain in terms of links (correlations) between nodes (grey matter regions) and to extract ...

journal_title：Scientific reports

authors： Mastrandrea R,Gabrielli A,Piras F,Spalletta G,Caldarelli G,Gili T

更新日期：2017-07-07 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Nikkonen S,Afara IO,Leppänen T,Töyräs J

更新日期：2020-03-13 00:00:00

abstract：:Parametric analysis of Cerebellar Ataxia (CA) could be of immense value compared to its subjective clinical assessments. This study focuses on a comprehensive scheme for objective assessment of CA through the instrumented versions of 9 commonly used neurological tests in 5 domains- speech, upper limb, lower limb, gait...

journal_title：Scientific reports

authors： Kashyap B,Phan D,Pathirana PN,Horne M,Power L,Szmulewicz D

更新日期：2020-06-11 00:00:00

abstract：:Modern society characterized by a 24/7 lifestyle leads to misalignment between environmental cycles and endogenous circadian rhythms. Persisting circadian misalignment leads to deleterious effects on health and healthspan. However, the underlying mechanism remains not fully understood. Here, we subjected adult, wild-t...

journal_title：Scientific reports

authors： Inokawa H,Umemura Y,Shimba A,Kawakami E,Koike N,Tsuchiya Y,Ohashi M,Minami Y,Cui G,Asahi T,Ono R,Sasawaki Y,Konishi E,Yoo SH,Chen Z,Teramukai S,Ikuta K,Yagita K

更新日期：2020-02-13 00:00:00

abstract：:Porcine epidemic diarrhea virus (PEDV) is a devastating cause of diarrhea in pigs worldwide. Most of studies have focused on molecular and pathogenic characterization of PEDV, whereas there were limited studies in understanding the role of gut microbiota (GM) in viral-associated diarrhea. Here, using the Illumina MiSe...

journal_title：Scientific reports

authors： Song D,Peng Q,Chen Y,Zhou X,Zhang F,Li A,Huang D,Wu Q,Ye Y,He H,Wang L,Tang Y

更新日期：2017-12-12 00:00:00

abstract：:Bacterial outer membrane lipopolysaccharide (LPS) potently stimulates the mammalian innate immune system, and can lead to sepsis, the primary cause of death from infections. LPS is sensed by Toll-like receptor 4 (TLR4) in complex with its lipid-binding coreceptor MD-2, but subtle structural variations in LPS can profo...

journal_title：Scientific reports

authors： Paramo T,Tomasio SM,Irvine KL,Bryant CE,Bond PJ

更新日期：2015-12-09 00:00:00

abstract：:In humans, stress can be contagiously transmitted via chemosignals on a subconscious level. This study investigates how pregnancy affects neural responses to anxiety chemosignals. Using cotton pads, 28 men donated axillary sweat immediately before an academic examination (anxiety sweat) and during ergometer training (...

journal_title：Scientific reports

authors： Lübke KT,Busch A,Hoenen M,Schaal B,Pause BM

更新日期：2017-08-23 00:00:00

abstract：:Renal fibrosis is one of the important pathways involved in end-stage renal failure. Investigating the metabolic changes in the progression of disease may enhance the understanding of its pathogenesis and therapeutic information. In this study, (1)H-nuclear magnetic resonance (NMR)-based metabonomics was firstly used ...

journal_title：Scientific reports

authors： Zhao L,Dong M,Liao S,Du Y,Zhou Q,Zheng H,Chen M,Ji J,Gao H

更新日期：2016-06-03 00:00:00

abstract：:Epidemiological investigation have suggested that there is a significantly inverse association between circulating 25-hydroxyvitamin D (25(OH)D) and the risk for developing colorectal cancer (CRC) in humans. However, little is known about the role of vitamin D binding protein (VDBP) in colorectal carcinogenesis. Blood...

journal_title：Scientific reports

authors： Ying HQ,Sun HL,He BS,Pan YQ,Wang F,Deng QW,Chen J,Liu X,Wang SK

更新日期：2015-01-22 00:00:00

abstract：:Metastasis is generally considered a characteristic of malignant tumors. Herein, we describe a patient with more than one hundred discrete Spitz nevi scattered all over her skin. Molecular analysis from three of the lesions identified a ROS1 fusion oncogene with identical genomic breakpoints, indicating that the nevi ...

journal_title：Scientific reports

authors： Raghavan SS,Kapler ES,Dinges MM,Bastian BC,Yeh I

更新日期：2020-10-01 00:00:00

abstract：:Despite the frequent use of ionising radiation (IR) in therapy and diagnostics and the unavoidable exposure to external radiation sources, our knowledge regarding the radiosensitivity of human blood cell populations is limited and published data, obtained under different experimental conditions, are heterogeneous. To ...

journal_title：Scientific reports

authors： Heylmann D,Ponath V,Kindler T,Kaina B

更新日期：2021-01-28 00:00:00

abstract：:Aberrant restoration of AR activity is linked with prostate tumor growth, therapeutic failures and development of castrate-resistant prostate cancer. Understanding the processes leading to AR-reactivation should provide the foundation for novel avenues of drug discovery. A differential gene expression study was conduc...

journal_title：Scientific reports

authors： Bhowal A,Majumder S,Ghosh S,Basu S,Sen D,Roychowdhury S,Sengupta S,Chatterji U

更新日期：2017-08-29 00:00:00