Identification of key metabolic changes in renal interstitial fibrosis rats using metabonomics and pharmacology.

abstract：:The decomposition of methane (CH4) is a catalytically important reaction in the production of syngas that is used to make a wide spectrum of hydrocarbons and alcohols, and a principal carbon deposition pathway in methane reforming. Literatures suggest that stepped Ni surface is uniquely selective toward methane decomp...

journal_title：Scientific reports

authors： Arevalo RL,Aspera SM,Escaño MCS,Nakanishi H,Kasai H

更新日期：2017-10-25 00:00:00

abstract：:Foaming negatively affects anaerobic digestion of food waste (FW). To identify the causes of foaming, reactor performance and microbial community dynamics were investigated in three mesophilic digesters treating FW. The digesters were operated under different modes, and foaming was induced with several methods. Prolif...

journal_title：Scientific reports

authors： He Q,Li L,Zhao X,Qu L,Wu D,Peng X

更新日期：2017-10-20 00:00:00

abstract：:We aimed to investigate the efficacy and safety of primary retropupillary iris claw intraocular lens (R-IOL) implantation in patients with complete intraocular lens (IOL) dislocation. In this single-center retrospective case series, we reviewed the medical records of patients who underwent R-IOL implantation surgery w...

journal_title：Scientific reports

authors： Choi EY,Lee CH,Kang HG,Han JY,Byeon SH,Kim SS,Koh HJ,Kim M

更新日期：2021-01-12 00:00:00

abstract：:The Cancer/Testes (CT) Antigen HORMAD1 is germ cell-restricted and plays developmental roles in generation and processing of meiotic DNA Double Strand Breaks (DSB). Many tumors aberrantly overexpress HORMAD1 yet the potential impact of this CT antigen on cancer biology is unclear. We tested a potential role of HORMAD1...

journal_title：Scientific reports

authors： Gao Y,Kardos J,Yang Y,Tamir TY,Mutter-Rottmayer E,Weissman B,Major MB,Kim WY,Vaziri C

更新日期：2018-10-17 00:00:00

abstract：:InPBi was predicted to be the most robust infrared optoelectronic material but also the most difficult to synthesize within In-VBi (V = P, As and Sb) 25 years ago. We report the first successful growth of InPBi single crystals with Bi concentration far beyond the doping level by gas source molecular beam epitaxy. The ...

journal_title：Scientific reports

authors： Wang K,Gu Y,Zhou HF,Zhang LY,Kang CZ,Wu MJ,Pan WW,Lu PF,Gong Q,Wang SM

更新日期：2014-06-26 00:00:00

abstract：:The place conditioning paradigm is an efficient, widely-used method to study mechanisms that underlie appetitive or aversive learning and memory processes. However, pharmacological agents used to induce conditioned place preference (CPP) or aversion (CPA) can per se interfere with learning and memory processing, hence...

journal_title：Scientific reports

authors： Goltseker K,Barak S

更新日期：2018-05-08 00:00:00

abstract：:How chromosomes fold into 3D structures and how genome functions are affected or even controlled by their spatial organization remain challenging questions. Hi-C experiment has provided important structural insights for chromosome, and Hi-C data are used here to construct the 3D chromatin structure which are character...

journal_title：Scientific reports

authors： Xie WJ,Meng L,Liu S,Zhang L,Cai X,Gao YQ

更新日期：2017-06-06 00:00:00

abstract：:Tumor progression, limited efficacy of current standard treatments, and the rise in patient mortality are associated with gene expression caused by the synergistic action of intratumoral hypoxia and HIF-1α activation. For this reason, recent investigations have focused on HIF-targeting therapeutic agents, with encoura...

journal_title：Scientific reports

authors： Mangraviti A,Raghavan T,Volpin F,Skuli N,Gullotti D,Zhou J,Asnaghi L,Sankey E,Liu A,Wang Y,Lee DH,Gorelick N,Serra R,Peters M,Schriefer D,Delaspre F,Rodriguez FJ,Eberhart CG,Brem H,Olivi A,Tyler B

更新日期：2017-11-02 00:00:00

abstract：:A large amount of energy, perhaps twice the total amount of all other hydrocarbon reserves combined, is trapped within gas hydrate deposits. Despite emerging as a potential energy source for the world over the next several hundred years and one of the key factors in causing future climate change, gas hydrate is poorly...

journal_title：Scientific reports

authors： Palodkar AV,Jana AK

更新日期：2017-07-25 00:00:00

abstract：:We present two transmission-mode dielectric Fresnel-Zone Plate Lens (FZPL) antennas for use within the V-band spectrum. The proposed FZPs are realized via pure plastic material using two different additive manufacturing processes. The proposed FZP lenses are designed with half (λ/2) and quarter (λ/4) phase correction ...

journal_title：Scientific reports

authors： Pourahmadazar J,Denidni TA

更新日期：2018-03-28 00:00:00

abstract：:The prevalence of a macrophage phenotype in atherosclerotic plaque may drive its progression and/or instability. Macrophages from coronary plaques are not available, and monocyte-derived macrophages (MDMs) are usually considered as a surrogate. We compared the MDM profile obtained from coronary artery disease (CAD) pa...

journal_title：Scientific reports

authors： Eligini S,Cosentino N,Fiorelli S,Fabbiocchi F,Niccoli G,Refaat H,Camera M,Calligaris G,De Martini S,Bonomi A,Veglia F,Fracassi F,Crea F,Marenzi G,Tremoli E

更新日期：2019-06-18 00:00:00

abstract：:Sesamin is a furofuran-type lignan that is found abundantly in seeds of Sesamum indicum (sesame) and has been widely accepted as a dietary supplement with positive effects on human health. The biological activity of sesamin in human cells and organs has been analysed extensively, although comparatively few studies sho...

journal_title：Scientific reports

authors： Tera M,Koyama T,Murata J,Furukawa A,Mori S,Azuma T,Watanabe T,Hori K,Okazawa A,Kabe Y,Suematsu M,Satake H,Ono E,Horikawa M

更新日期：2019-06-14 00:00:00

abstract：:Superior cervical ganglion neurons (SCGN) are often used to investigate neurotransmitter release mechanisms. In this study, we optimized the dissociation and culture conditions of rat SCGN cultures for dual patch clamp recordings. Two weeks in vitro are sufficient to achieve a significant CNTF-induced cholinergic swit...

journal_title：Scientific reports

authors： Amendola J,Boumedine N,Sangiardi M,El Far O

更新日期：2015-09-24 00:00:00

abstract：:Enterohemorrhagic Escherichia coli (EHEC) are major food-borne pathogens whose survival and virulence in the human digestive tract remain unclear owing to paucity of relevant models. EHEC interact with the follicle-associated epithelium of Peyer's patches of the distal ileum and translocate across the intestinal epith...

journal_title：Scientific reports

authors： Cordonnier C,Etienne-Mesmin L,Thévenot J,Rougeron A,Rénier S,Chassaing B,Darfeuille-Michaud A,Barnich N,Blanquet-Diot S,Livrelli V

更新日期：2017-03-20 00:00:00

abstract：:Aluminium nitride (AlN) is a promising semiconductor material for use as a substrate in high-power, high-frequency electronic and deep-ultraviolet optoelectronic devices. We study the feasibility of a novel AlN fabrication technique by using the Al/GaN substitution reaction method. The substitution method we propose h...

journal_title：Scientific reports

authors： Noorprajuda M,Ohtsuka M,Adachi M,Fukuyama H

更新日期：2020-08-03 00:00:00

abstract：:There is no treatment for the myelin loss in multiple sclerosis, ultimately resulting in the axonal degeneration that leads to the progressive phase of the disease. We established a multi-tiered platform for the sequential screening of drugs that could be repurposed as remyelinating agents. We screened a library of 2,...

journal_title：Scientific reports

authors： Eleuteri C,Olla S,Veroni C,Umeton R,Mechelli R,Romano S,Buscarinu MC,Ferrari F,Calò G,Ristori G,Salvetti M,Agresti C

更新日期：2017-04-07 00:00:00

abstract：:Pseudomonas aeruginosa is a highly invasive human pathogen in spite of the absence of classical host specific virulence factors. Virulence factors regulated by quorum sensing (QS) in P. aeruginosa cause acute infections to shift to chronic diseases. Several small regulatory RNAs (sRNAs) mediate fine-tuning of bacteria...

journal_title：Scientific reports

authors： Malgaonkar A,Nair M

更新日期：2019-01-23 00:00:00

abstract：:The analysis of cell type-specific activity patterns during behaviors is important for better understanding of how neural circuits generate cognition, but has not been well explored from in vivo neurophysiological datasets. Here, we describe a computational approach to uncover distinct cell subpopulations from in vivo...

journal_title：Scientific reports

authors： Li M,Zhao F,Lee J,Wang D,Kuang H,Tsien JZ

更新日期：2015-07-27 00:00:00

abstract：:The prediction of infarction volume after stroke onset depends on the shape of the growth dynamics of the infarction. To understand growth patterns that predict lesion volume changes, we studied currently available models described in literature and compared the models with Adaptive Neuro-Fuzzy Inference System [ANFIS...

journal_title：Scientific reports

authors： Kamran S,Akhtar N,Alboudi A,Kamran K,Ahmad A,Inshasi J,Salam A,Shuaib A,Qidwai U

更新日期：2017-08-08 00:00:00

abstract：:Primary human hepatocytes are necessary to evaluate cytotoxicity, drug metabolism, and drug-drug interactions for candidate compounds in early-phase drug discovery and development. However, these analyses are often hampered by limited resources and functional or genetic variation among lots. HepaRG human hepatocellula...

journal_title：Scientific reports

authors： Ueyama T,Tsuji S,Sugiyama T,Tada M

更新日期：2017-06-06 00:00:00

abstract：:The renin-angiotensin system (RAS) plays a key role in the control of vasoconstriction as well as sodium and fluid retention mediated mainly by angiotensin (Ang) II acting at the AT1 receptor (AT1R). Ang-(1-7) is another RAS peptide, identified as the endogenous ligand of the Mas receptor and known to counterbalance m...

journal_title：Scientific reports

authors： Teixeira LB,Parreiras-E-Silva LT,Bruder-Nascimento T,Duarte DA,Simões SC,Costa RM,Rodríguez DY,Ferreira PAB,Silva CAA,Abrao EP,Oliveira EB,Bouvier M,Tostes RC,Costa-Neto CM

更新日期：2017-09-19 00:00:00

abstract：:Late endothelial progenitor cells (LEPCs) are derived from mononuclear cells (MNCs) and are thought to directly incorporate into blood vessels and differentiate into mature endothelial cells (ECs). Using transcriptome and proteome analysis, we identified distinctive LEPC profiles and found that Hedgehog-interacting pr...

journal_title：Scientific reports

authors： Lee BNR,Son YS,Lee D,Choi YJ,Kwon SM,Chang HK,Kim PH,Cho JY

更新日期：2017-09-29 00:00:00

abstract：:This study aims to identify promising biomarkers for the early detection of lung cancer and evaluate the prognosis of lung cancer patients. Genome-wide mRNA expression data obtained from the Gene Expression Omnibus (GSE19188, GSE18842 and GSE40791), including 231 primary tumor samples and 210 normal samples, were used...

journal_title：Scientific reports

authors： Shi YX,Yin JY,Shen Y,Zhang W,Zhou HH,Liu ZQ

更新日期：2017-08-14 00:00:00

abstract：:Peripheral blood indices of systemic inflammation such as the neutrophil-lymphocyte ratio (NLR) have been shown to be prognostic in various cancers. We aim to investigate the clinical significance of these indices in patients with soft tissue sarcoma (STS). Seven hundred and twelve patients with available blood counts...

journal_title：Scientific reports

authors： Chan JY,Zhang Z,Chew W,Tan GF,Lim CL,Zhou L,Goh WL,Poon E,Somasundaram N,Selvarajan S,Sittampalam K,Chin F,Teh J,Tan MH,Soo KC,Teo M,Farid M,Quek R

更新日期：2018-08-10 00:00:00

abstract：:Neurokinin B (NKB) is a hypothalamic neuropeptide binding preferentially to the neurokinin 3 receptor. Expression of the gene encoding NKB is elevated in postmenopausal women. Furthermore, rodent studies suggest that NKB signalling may mediate menopausal hot flushes. However, the effects of NKB administration on hot f...

journal_title：Scientific reports

authors： Jayasena CN,Comninos AN,Stefanopoulou E,Buckley A,Narayanaswamy S,Izzi-Engbeaya C,Abbara A,Ratnasabapathy R,Mogford J,Ng N,Sarang Z,Ghatei MA,Bloom SR,Hunter MS,Dhillo WS

更新日期：2015-02-16 00:00:00

abstract：:The arbitrary control of the polarization states of light has attracted the interest of the scientific community because of the wide range of modern optical applications that such control can afford. However, conventional polarization control setups are bulky and very often operate only within a narrow wavelength rang...

journal_title：Scientific reports

authors： Li Z,Liu W,Cheng H,Chen S,Tian J

更新日期：2015-12-15 00:00:00

abstract：:The development and maturation of cortical circuits relies on the coordinated actions of long and short range axonal guidance cues. In this regard, the class 3 semaphorins and their receptors have been seen to be involved in the development and maturation of the hippocampal connections. However, although the role of m...

journal_title：Scientific reports

authors： Mata A,Gil V,Pérez-Clausell J,Dasilva M,González-Calixto MC,Soriano E,García-Verdugo JM,Sanchez-Vives MV,Del Río JA

更新日期：2018-01-22 00:00:00

abstract：:Spin-orbit coupling (SOC) plays an essential role in many exotic and interesting phenomena in condensed matter physics. In neutral-atom-based quantum simulations, synthetic SOC constitutes a key enabling element. The strength of SOC realized so far is limited by various reasons or constraints. This work reports tunabl...

journal_title：Scientific reports

authors： Wu LN,Luo XY,Xu ZF,Ueda M,Wang R,You L

更新日期：2017-04-27 00:00:00

abstract：:In this study, dye-sensitized solar cells (DSSCs) has been assembled with poly(1-vinylpyrrolidone-co-vinyl acetate) (P(VP-co-VAc)) gel polymer electrolytes (GPEs) which have been incorporated with binary salt and an ionic liquid. The potential of this combination was studied and reported. The binary salt system GPEs w...

journal_title：Scientific reports

authors： Ming NH,Ramesh S,Ramesh K

更新日期：2016-06-08 00:00:00

abstract：:Nano-suspensions (NS) exhibit unusual thermophysical behaviors once interparticle aggregations and the shear flows are imposed, which occur ubiquitously in applications but remain poorly understood, because existing theories have not paid these attentions but focused mainly on stationary NS. Here we report the critica...

journal_title：Scientific reports

authors： Sui J,Zhao P,Bin-Mohsin B,Zheng L,Zhang X,Cheng Z,Chen Y,Chen G

更新日期：2016-12-20 00:00:00