A staged screening of registered drugs highlights remyelinating drug candidates for clinical trials.

abstract：:Key calcifying reef taxa are currently threatened by thermal stress associated with elevated sea surface temperatures (SST) and reduced calcification linked to ocean acidification (OA). Here we undertook an 8 week experimental exposure to near-future climate change conditions and explored the microbiome response of th...

journal_title：Scientific reports

authors： Webster NS,Negri AP,Botté ES,Laffy PW,Flores F,Noonan S,Schmidt C,Uthicke S

更新日期：2016-01-13 00:00:00

abstract：:Concurrent chemoradiation therapy (CCRT) is the treatment of choice for locally advanced non-small cell lung cancer (LA-NSCLC). Several clinical trials that combine programmed cell death 1 (PD-1) axis inhibitors with radiotherapy are in development for patients with LA-NSCLC. However, the effect of CCRT on programmed ...

journal_title：Scientific reports

authors： Fujimoto D,Uehara K,Sato Y,Sakanoue I,Ito M,Teraoka S,Nagata K,Nakagawa A,Kosaka Y,Otsuka K,Imai Y,Hamakawa H,Takahashi Y,Kokubo M,Tomii K

更新日期：2017-09-12 00:00:00

abstract：:Desertification due to climate change and increasing drought periods is a worldwide problem for both ecology and economy. Our ability to understand how vegetation manages to survive and propagate through arid and semiarid ecosystems may be useful in the development of future strategies to prevent desertification, pres...

journal_title：Scientific reports

authors： Bordeu I,Clerc MG,Couteron P,Lefever R,Tlidi M

更新日期：2016-09-21 00:00:00

abstract：:The analysis of questionnaires often involves representing the high-dimensional responses in a low-dimensional space (e.g., PCA, MCA, or t-SNE). However questionnaire data often contains categorical variables and common statistical model assumptions rarely hold. Here we present a non-parametric approach based on Fishe...

journal_title：Scientific reports

authors： Har-Shemesh O,Quax R,Lansing JS,Sloot PMA

更新日期：2020-05-25 00:00:00

abstract：:We propose efficient schemes of direct concurrence measurement for two-qubit spin and photon-polarization entangled states via the interaction between single-photon pulses and nitrogen-vacancy (NV) centers in diamond embedded in optical microcavities. For different entangled-state types, diversified quantum devices an...

journal_title：Scientific reports

authors： Cheng LY,Yang GH,Guo Q,Wang HF,Zhang S

更新日期：2016-01-18 00:00:00

abstract：:Sporadic outbreaks caused by coxsackievirus A4 (CV-A4) have been reported worldwide. To further elucidate the detailed genetic characteristics and evolutionary recombination events of CV-A4, virus samples from nationwide hand, foot and mouth disease (HFMD) surveillance, encompassing 27 out of the 31 provinces in China...

journal_title：Scientific reports

authors： Ji T,Guo Y,Lv L,Wang J,Shi Y,Yu Q,Zhang F,Tong W,Ma J,Zeng H,Zhao H,Zhang Y,Han T,Song Y,Yan D,Yang Q,Zhu S,Zhang Y,Xu W

更新日期：2019-09-20 00:00:00

abstract：:This study was to evaluate the effectiveness of oral hygiene care in improving oral health- and health-related quality of life (OHRQoL and HRQoL) among patients receiving outpatient stroke rehabilitation. Subjects were randomized to: (1) a conventional oral hygiene care programme (COHCP) comprising a manual toothbrush...

journal_title：Scientific reports

authors： Dai R,Lam OLT,Lo ECM,Li LSW,McGrath C

更新日期：2017-08-09 00:00:00

abstract：:Soluble starch synthase I (SSI) is a key enzyme in the biosynthesis of plant amylopectin. In this study, the gene named IbSSI, was cloned from sweet potato, an important starch crop. A high expression level of IbSSI was detected in the leaves and storage roots of the sweet potato. Its overexpression significantly incr...

journal_title：Scientific reports

authors： Wang Y,Li Y,Zhang H,Zhai H,Liu Q,He S

更新日期：2017-05-24 00:00:00

abstract：:Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are desirable for diabetes, especially in patients with overweight/obesity. We aimed to determine whether GLP-1RAs exhibit different glucose-lowering efficacies between Asian type 2 diabetes (T2D) patients with and without overweight/obesity. Randomized controlled t...

journal_title：Scientific reports

authors： Zhang F,Tang L,Zhang Y,Lü Q,Tong N

更新日期：2017-11-22 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Radeck J,Meyer D,Lautenschläger N,Mascher T

更新日期：2018-03-06 00:00:00

abstract：:Propofol sedation has been applied during esophagogastroduodenoscopy procedures, but whether topical pharyngeal anesthesia should be administered at the same time has rarely been reported. Our study examined the role of topical pharyngeal anesthesia in sedated endoscopies in a randomized controlled double-blinded clin...

journal_title：Scientific reports

authors： Sun X,Xu Y,Zhang X,Li A,Zhang H,Yang T,Liu Y

更新日期：2018-04-27 00:00:00

abstract：:High-quality, 25 nm octahedral-shaped Fe3O4 magnetite nanocrystals are epitaxially grown on 9 nm Au seed nanoparticles using a modified wet-chemical synthesis. These Fe3O4-Au Janus nanoparticles exhibit bulk-like magnetic properties. Due to their high magnetization and octahedral shape, the hybrids show superior in vi...

journal_title：Scientific reports

authors： Efremova MV,Naumenko VA,Spasova M,Garanina AS,Abakumov MA,Blokhina AD,Melnikov PA,Prelovskaya AO,Heidelmann M,Li ZA,Ma Z,Shchetinin IV,Golovin YI,Kireev II,Savchenko AG,Chekhonin VP,Klyachko NL,Farle M,Majouga AG,Wi

更新日期：2018-07-26 00:00:00

abstract：:Leaching of nitrate from fertilisers diminishes nitrogen use efficiency (the portion of nitrogen used by a plant) and is a major source of agricultural pollution. To improve nitrogen capture, grasses such as brachiaria are increasingly used, especially in South America and Africa, as a cover crop, either via intercrop...

journal_title：Scientific reports

authors： Galdos MV,Brown E,Rosolem CA,Pires LF,Hallett PD,Mooney SJ

更新日期：2020-03-19 00:00:00

abstract：:Three major white matter pathways connect the posterior temporal region and the adjacent inferior parietal lobule with the lateral frontal cortex: the arcuate fasciculus (AF), and the second and third branches of the superior longitudinal fasciculus (SLF II and SLF III). These pathways are found also in nonhuman prima...

journal_title：Scientific reports

authors： Barbeau EB,Descoteaux M,Petrides M

更新日期：2020-05-18 00:00:00

abstract：:Circadian disruption resulting from exposure to irregular light-dark patterns and sleep deprivation has been associated with beta amyloid peptide (Aβ) aggregation, which is a major event in Alzheimer's disease (AD) pathology. We exposed 5XFAD mice and littermate controls to dim-light vs. bright-light photophases to in...

journal_title：Scientific reports

authors： Nagare R,Possidente B,Lagalwar S,Figueiro MG

更新日期：2020-07-10 00:00:00

abstract：:The bioactive lipid sphingosine 1-phosphate (S1P) is a degradation product of sphingolipids that are particularly abundant in neurons. We have shown previously that neuronal S1P accumulation is toxic leading to ER-stress and an increase in intracellular calcium. To clarify the neuronal function of S1P, we generated br...

journal_title：Scientific reports

authors： Mitroi DN,Deutschmann AU,Raucamp M,Karunakaran I,Glebov K,Hans M,Walter J,Saba J,Gräler M,Ehninger D,Sopova E,Shupliakov O,Swandulla D,van Echten-Deckert G

更新日期：2016-11-24 00:00:00

abstract：:Mast cells act as sensors in innate immunity and as effector cells in adaptive immune reactions. Here we demonstrate that SLC10A4, also referred to as the vesicular aminergic-associated transporter, VAAT, modifies mast cell degranulation. Strikingly, Slc10a4 -/- bone marrow-derived mast cells (BMMCs) had a significant...

journal_title：Scientific reports

authors： Pettersson H,Zarnegar B,Westin A,Persson V,Peuckert C,Jonsson J,Hallgren J,Kullander K

更新日期：2017-04-24 00:00:00

abstract：:Benign prostatic hyperplasia (BPH) results in a significant public health burden due to the morbidity caused by the disease and many of the available remedies. As much as 70% of men over 70 will develop BPH. Few studies have been conducted to discover the genetic determinants of BPH risk. Understanding the biological ...

journal_title：Scientific reports

authors： Hellwege JN,Stallings S,Torstenson ES,Carroll R,Borthwick KM,Brilliant MH,Crosslin D,Gordon A,Hripcsak G,Jarvik GP,Linneman JG,Devi P,Peissig PL,Sleiman PAM,Hakonarson H,Ritchie MD,Verma SS,Shang N,Denny JC,Roden DM

更新日期：2019-04-15 00:00:00

abstract：:Parkinson's Disease can be understood as a disorder of motor habits. A prediction of this theory is that early stage Parkinson's patients will display fewer errors caused by interference from previously over-learned behaviours. We test this prediction in the domain of skilled typing, where actions are easy to record a...

journal_title：Scientific reports

authors： Bannard C,Leriche M,Bandmann O,Brown CH,Ferracane E,Sánchez-Ferro Á,Obeso J,Redgrave P,Stafford T

更新日期：2019-03-04 00:00:00

abstract：:The behavior of diatomic molecular solids under pressure have attracted great interest and been extensively studied. Under ambient pressure, the structure of bromine is known to be a molecular phase (phase I). With increasing pressure, it transforms into an incommensurate phase (phase V) before eventually to a monoato...

journal_title：Scientific reports

authors： Wu M,Tse JS,Pan Y

更新日期：2016-05-09 00:00:00

abstract：:The interaction of a mechanical oscillator with the operation actions and environment fields will give rise to the splitting of normal modes. In this study, we investigate the normal mode splitting behaviour of a moving-particles-pumped single-span clamped-hinged elastic homogeneous beam based on the proposed multi-oc...

journal_title：Scientific reports

authors： Sun Z

更新日期：2018-06-28 00:00:00

abstract：:Interaction between polycyclic aromatic hydrocarbon (PAH) molecule and energetic ion is a subject of interest in different areas of modern physics. Here, we present measurements of energy and angular distributions of absolute double differential electron emission cross section for coronene (C24H12) and fluorene (C13H1...

journal_title：Scientific reports

authors： Biswas S,Champion C,Weck PF,Tribedi LC

更新日期：2017-07-17 00:00:00

abstract：:Salmonella spp. and thermotolerant Campylobacter spp. are the most important causes of human bacterial diarrheal infections worldwide. These bacterial species are influenced by several factors like behaviour of the host, shedding, environment incl. directly or indirectly through ambient temperature, and the infections...

journal_title：Scientific reports

authors： Yun J,Greiner M,Höller C,Messelhäusser U,Rampp A,Klein G

更新日期：2016-06-21 00:00:00

abstract：:Pelvic recurrence of colorectal cancer is a crucial problem because radical surgery can lead to excessive invasion. Novel therapeutic strategies are required instead of surgery. However, there are few suitable models because of the difficulty in transplanting and observing tumors in the pelvis. We have established an ...

journal_title：Scientific reports

authors： Yamamoto M,Taniguchi K,Masubuchi S,Tominaga T,Inomata Y,Miyamoto A,Ishizuka TA,Murakami T,Osumi W,Hamamoto H,Tanaka K,Okuda J,Uchiyama K

更新日期：2019-12-23 00:00:00

abstract：:Individuals in the state of psychological suboptimal health keep increasing, only scales and questionnaires were used to diagnose in clinic under current conditions, and symptoms of high reliability and accuracy are destitute. Therefore, the noninvasive and precise laboratory diagnostic methods are needed. This study ...

journal_title：Scientific reports

authors： Tian JS,Xia XT,Wu YF,Zhao L,Xiang H,Du GH,Zhang X,Qin XM

更新日期：2016-09-21 00:00:00

abstract：:We compared the prognostic value of nutritional or volumetric parameters measured by body composition in hospitalized patients on maintenance hemodialysis. We conducted a cohort study to assess the association of different parameters of body composition with all-cause mortality in inpatients admitted to our nephrology...

journal_title：Scientific reports

authors： Wu B,Yan C,Zhang S,Ge Y,Xu X,Wang Y,Xu L,Zhang C,Huang Z,Ren H,Wu J,Xing C,Mao H

更新日期：2020-06-23 00:00:00

abstract：:A wide network of interconnected areas was previously found in neuroimaging studies involving normal as well as pathological subjects; however literature seems to suffer from a lack of investigation in glucose metabolism behaviour under olfactory condition. Thus, the present work describe for the first time a pure olf...

journal_title：Scientific reports

authors： Alessandrini M,Micarelli A,Chiaravalloti A,Candidi M,Bruno E,Di Pietro B,Schillaci O,Pagani M

更新日期：2014-06-03 00:00:00

abstract：:The widespread use of electric light and electronic devices has resulted in an excessive exposure to light during the late-evening and at night. This late light exposure acutely suppresses melatonin and sleepiness and delays the circadian clock. Here we investigate whether the acute effects of late-evening light expos...

journal_title：Scientific reports

authors： Te Kulve M,Schlangen LJM,van Marken Lichtenbelt WD

更新日期：2019-11-05 00:00:00

abstract：:Individuals differ in their level of general anxiety as well as in their level of anxiety towards specific activities, such as mathematics and spatial tasks. Both specific anxieties correlate moderately with general anxiety, but the aetiology of their association remains unexplored. Moreover, the factor structure of s...

journal_title：Scientific reports

authors： Malanchini M,Rimfeld K,Shakeshaft NG,Rodic M,Schofield K,Selzam S,Dale PS,Petrill SA,Kovas Y

更新日期：2017-02-21 00:00:00

abstract：:Two-photon (2P) microscopy is a powerful tool for imaging and exploring label-free biological tissues at high resolution. Although this type of microscopy has been demonstrated in ex vivo ocular tissues of both humans and animal models, imaging the human eye in vivo has always been challenging. This work presents a no...

journal_title：Scientific reports

authors： Ávila FJ,Gambín A,Artal P,Bueno JM

更新日期：2019-07-12 00:00:00