Abstract：
:Individuals in the state of psychological suboptimal health keep increasing, only scales and questionnaires were used to diagnose in clinic under current conditions, and symptoms of high reliability and accuracy are destitute. Therefore, the noninvasive and precise laboratory diagnostic methods are needed. This study aimed to develop an objective method through screen potential biomarkers or a biomarker panel to facilitate the diagnosis in clinic using plasma metabolomics. Profiles were based on H-nuclear magnetic resonance ((1)H-NMR) metabolomics techniques combing with multivariate statistical analysis. Furthermore, methods of correlation analysis with Metaboanalyst 3.0 for selecting a biomarker panel, traditional Chinese medicine (TCM) drug intervention for validating the close relations between the biomarker panel and the state and the receiver operating characteristic curves (ROC curves) analysis for evaluation of clinical diagnosis ability were carried out. 9 endogenous metabolites containing trimethylamine oxide (TMAO), glutamine, N-acetyl-glycoproteins, citrate, tyrosine, phenylalanine, isoleucine, valine and glucose were identified and considered as potential biomarkers. Then a biomarker panel consisting of phenylalanine, glutamine, tyrosine, citrate, N-acetyl-glycoproteins and TMAO was selected, which exhibited the highest area under the curve (AUC = 0.971). This study provided critical insight into the pathological mechanism of psychological suboptimal health and would supply a novel and valuable diagnostic method.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Tian JS,Xia XT,Wu YF,Zhao L,Xiang H,Du GH,Zhang X,Qin XMdoi
10.1038/srep33820subject
Has Abstractpub_date
2016-09-21 00:00:00pages
33820issn
2045-2322pii
srep33820journal_volume
6pub_type
临床试验,杂志文章abstract：:The role of the smoothelin-like 1 (SMTNL1) protein in mediating vascular smooth muscle contractile responses to intraluminal pressure was examined in resistance vessels. Mesenteric arterioles from wild type (WT) and SMTNL1 global knock-out (KO) mice were examined with pressure myography. SMTNL1 deletion was associated...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36564-0
更新日期：2019-01-24 00:00:00
abstract：:Scleroderma is a refractory autoimmune skin fibrotic disorder. Alterations of microRNAs in lesional skin could be a new approach to treating the disease. Here, we found that expression of miR-155 was up regulated in lesional skin tissue from patients with either systemic or localized scleroderma, and correlated with f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20314
更新日期：2016-02-01 00:00:00
abstract：:Spectra-structure interrelationship is still the weakness of NIR spectral assignment. In this paper, a comprehensive investigation from chemical structural property to natural chemical compounds was carried out for NIR spectral assignment. Surprisingly, we discovered that NIR absorption frequency of the skeleton struc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45945-y
更新日期：2019-07-01 00:00:00
abstract：:Magnolia sirindhorniae Noot. & Chalermglin is an endangered species with high ornamental and commercial value that needs to be urgently protected and judiciously commercialized. In this study, a protocol for efficient regeneration of this species is standardized. The lateral buds of the M. sirindhorniae plant were use...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46050-w
更新日期：2019-07-03 00:00:00
abstract：:Currently, the arguments have existed in the strengthening mechanism and microstructural model of the nanocomposite film due to lack of the convincible experimental evidences. In this investigation, the quarternary TiSiCN nanocomposite films with the different C and Si contents are synthesized by the reactive-magnetro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02186-1
更新日期：2017-05-18 00:00:00
abstract：:Phase distribution of emerging organic contaminants is highly influential in their presence, fate and transport in surface water. Therefore, it is crucial to determine their state, partitioning behaviour and tendencies in water environments. In this study, Bisphenol A was investigated in both colloidal and soluble pha...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77454-8
更新日期：2020-11-23 00:00:00
abstract：:As a typical organic solid waste, sludge plays an important role in contributing to greenhouse gas (GHG) emissions resulted by its treatment and disposal. As a temporary and emergent treatment measurement, sludge lime stabilization is regionally adopted in most sludge generated units in China. In present case, sludge ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35052-9
更新日期：2018-11-08 00:00:00
abstract：:To evaluate and improve datasets of anthropogenic land cover change used in local and global climate models, great efforts were made to reconstruct historical land use, including the LandCover 6k project which dedicated to reconstructing human land use over the past 10,000 years. In this study, we utilized historical ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31807-6
更新日期：2018-09-10 00:00:00
abstract：:Amblyopia is a common visual disorder that is treatable in childhood. However, therapies have limited efficacy in adult patients with amblyopia. Fluoxetine can reinstate early-life critical period-like neuronal plasticity and has been used to recover functional vision in adult rats with amblyopia. We conducted a Phase...
journal_title：Scientific reports
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/s41598-018-31169-z
更新日期：2018-08-27 00:00:00
abstract：:In this study, real-time and in-situ permittivity measurements under intense microwave electromagnetic fields are proposed as a powerful technique for the study of microwave-enhanced thermal processes in materials. In order to draw reliable conclusions about the temperatures at which transformations occur, we address ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47296-0
更新日期：2019-07-25 00:00:00
abstract：:In general, the poultry industry uses 0.5-1 ppm chlorine solution in the meat sanitization process. However, chlorine can react with organic material and produce halogenated organic compounds, notably chloroform, which causes bladder and rectal cancer in humans. For this reason, many industries try to avoid chlorine. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58199-w
更新日期：2020-01-31 00:00:00
abstract：:Alterations in the composition of commensal bacterial populations, a phenomenon known as dysbiosis, are linked to multiple gastrointestinal disorders, such as inflammatory bowel disease and irritable bowel syndrome, or to infections by diverse enteric pathogens. Blastocystis is one of the most common single-celled euk...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25255
更新日期：2016-05-05 00:00:00
abstract：:In this paper we present a contactless transient carrier spectroscopy and imaging technique for traps in silicon. At each pixel, we fit the transient decay of the trap emission which allows us to obtain both the trap time constant and trap concentration. Here we show that this technique allows for high-resolution imag...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49804-8
更新日期：2019-10-03 00:00:00
abstract：:Internet technologies have demonstrated their value for the early detection and prediction of epidemics. In diverse cases, electronic surveillance systems can be created by obtaining and analyzing on-line data, complementing other existing monitoring resources. This paper reports the feasibility of building such a sys...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61686-9
更新日期：2020-03-16 00:00:00
abstract：:Genetically encoded calcium indicators and optogenetic actuators can report and manipulate the activity of specific neuronal populations. However, applying imaging and optogenetics simultaneously has been difficult to establish in the mammalian brain, even though combining the techniques would provide a powerful appro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40041
更新日期：2017-01-05 00:00:00
abstract：:Silicon nanocrystals offer huge advantages compared to other semi-conductor quantum dots as they are made from an abundant, non-toxic material and are compatible with silicon devices. Besides, among a wealth of extraordinary properties ranging from catalysis to nanomedicine, metal nanoparticles are known to increase t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02672
更新日期：2013-01-01 00:00:00
abstract：:The Internet of Things is driving extensive efforts to develop intelligent everyday objects. This requires seamless integration of relatively simple electronics, for example through 'stick-on' electronics labels. We believe the future evolution of this technology will be governed by Wright's Law, which was first propo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07398
更新日期：2014-12-10 00:00:00
abstract：:Hormones and placental factors are thought to underlie the maternal immunological changes during pregnancy. However, as several intestinal microbiota are linked to immune modulations, we hypothesized that the intestinal microbiota are altered during pregnancy in favor of species associated with pregnancy associated im...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28292-2
更新日期：2018-07-03 00:00:00
abstract：:Oxygen tolerance of selenium-containing [NiFeSe] hydrogenases (Hases) is attributable to the high reducing power of the selenocysteine residue, which sustains the bimetallic Ni-Fe catalytic center in the large subunit. Genes encoding [NiFeSe] Hases are inherited by few sulphate-reducing δ-proteobacteria globally distr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19742
更新日期：2016-01-28 00:00:00
abstract：:Antimicrobial resistance seriously threatened human health. Combination therapy is generally an effective strategy to fight resistance, while some data on its effects are conflicting. To explore the reasons, the fractional inhibitory concentration indexes (FICIs) of three designed combinations against methicillin-resi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25714-z
更新日期：2018-05-08 00:00:00
abstract：:Term preeclampsia (tPE), ≥37 weeks, is the most common form of PE and the most difficult to predict. Little is known about its pathogenesis. This study aims to elucidate the pathogenesis and assess early prediction of tPE using serial integrated metabolomic and proteomic systems biology approaches. Serial first- (11-1...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15882-9
更新日期：2017-11-23 00:00:00
abstract：:Thermo-elasticity couples the deformation of an elastic (solid) body to its temperature and vice-versa. It is a solid-like property. Highlighting such property in liquids is a paradigm shift: it requires long-range collective interactions that are not considered in current liquid descriptions. The present microthermal...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69404-1
更新日期：2020-08-07 00:00:00
abstract：:Correlating data from different microscopy techniques holds the potential to discover new facets of signaling events in cellular biology. Here we report for the first time a hardware set-up capable of achieving simultaneous co-localized imaging of spatially correlated far-field super-resolution fluorescence microscopy...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57885-z
更新日期：2020-01-24 00:00:00
abstract：:Photodynamic therapy (PDT) is a technique developed to treat the ever-increasing global incidence of cancer. This technique utilises singlet oxygen ((1)O2) generation via a laser excited photosensitiser (PS) to kill cancer cells. However, prolonged sensitivity to intensive light (6-8 weeks for lung cancer), relatively...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03484
更新日期：2013-12-12 00:00:00
abstract：:Mucus is responsible for controlling transport and barrier function in biological systems, and its properties can be significantly affected by compositional and environmental changes. In this study, the impacts of pH and CaCl2 were examined on the solution-to-gel transition of mucin, the primary structural component o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65392-4
更新日期：2020-05-29 00:00:00
abstract：:Pompe disease (PD) is a metabolic myopathy due to acid alpha-glucosidase deficiency and characterized by extensive glycogen storage and impaired autophagy. We previously showed that modulation of autophagy and lysosomal exocytosis by overexpression of the transcription factor EB (TFEB) gene was effective in improving ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15352-2
更新日期：2017-11-08 00:00:00
abstract：:The root-knot nematodes of the genus Meloidogyne are highly adapted, obligate plant parasites, consisting of nearly one hundred valid species, and are considered the most economically important group of plant-parasitic nematodes. Six Meloidogyne species: M. arenaria, M. hapla, M. incognita, M. microtyla, M. naasi and ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48195-0
更新日期：2019-08-13 00:00:00
abstract：:The Fabry-Pérot interferometer is used in a variety of high-precision optical interferometry applications, such as gravitational wave detection. It is also used in various types of laser resonators to act as a narrow band filter. In addition, ultra-compact Fabry-Pérot interferometers are used in the optical resonators...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33665-8
更新日期：2018-10-12 00:00:00
abstract：:Critically endangered sturgeons, having undergone three whole genome duplication events, represent an exceptional example of ploidy plasticity in vertebrates. Three extant ploidy groups, combined with autopolyploidization, interspecific hybridization and the fertility of hybrids are important issues in sturgeon conser...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76680-4
更新日期：2020-11-12 00:00:00
abstract：:During capillary transit, red blood cells (RBCs) must exchange large quantities of CO2 and O2 in typically less than one second, but the degree to which this is rate-limited by diffusion through cytoplasm is not known. Gas diffusivity is intuitively assumed to be fast and this would imply that the intracellular path-l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36018
更新日期：2016-10-25 00:00:00
