Artificial whole genome duplication in paleopolyploid sturgeons yields highest documented chromosome number in vertebrates.

Abstract:

:Critically endangered sturgeons, having undergone three whole genome duplication events, represent an exceptional example of ploidy plasticity in vertebrates. Three extant ploidy groups, combined with autopolyploidization, interspecific hybridization and the fertility of hybrids are important issues in sturgeon conservation and aquaculture. Here we demonstrate that the sturgeon genome can undergo numerous alterations of ploidy without severe physiological consequences, producing progeny with a range of ploidy levels and extremely high chromosome numbers. Artificial suppression of the first mitotic division alone, or in combination with suppression of the second meiotic division of functionally tetraploid zygotes (4n, C-value = 4.15) of Siberian sturgeon Acipenser baerii and Russian sturgeon A. gueldenstaedtii resulted in progeny of various ploidy levels-diploid/hexaploid (2n/6n) mosaics, hexaploid, octoploid juveniles (8n), and dodecaploid (12n) larvae. Counts between 477 to 520 chromosomes in octoploid juveniles of both sturgeons confirmed the modal chromosome numbers of parental species had been doubled. This exceeds the highest previously documented chromosome count among vertebrates 2n ~ 446 in the cyprinid fish Ptychobarbus dipogon.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Lebeda I,Ráb P,Majtánová Z,Flajšhans M

doi

10.1038/s41598-020-76680-4

subject

Has Abstract

pub_date

2020-11-12 00:00:00

pages

19705

issue

1

issn

2045-2322

pii

10.1038/s41598-020-76680-4

journal_volume

10

pub_type

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