Cortico-subcortical metabolic correlates of olfactory processing in healthy resting subjects.

Abstract:

:A wide network of interconnected areas was previously found in neuroimaging studies involving normal as well as pathological subjects; however literature seems to suffer from a lack of investigation in glucose metabolism behaviour under olfactory condition. Thus, the present work describe for the first time a pure olfactory related brain response of metabolism by using (18)F-fluorodeoxyglucose-Positron Emission Tomography/Computer Tomography in eleven resting subjects undergoing a neutral and a pure olfactory condition. By contrasting these experimental phases, it was possible to depict a re-organization pattern of default mode network structures in a relatively ecological environment. Moreover, by correlating such pattern with a battery of validated olfactory and neuropsychological tests, our work allowed in showing peculiar correlation data that could cluster the subjects sample in a certain range of normality. We believe the present study could integrate the current knowledge in olfactory research and could be a start-up for future contributions.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Alessandrini M,Micarelli A,Chiaravalloti A,Candidi M,Bruno E,Di Pietro B,Schillaci O,Pagani M

doi

10.1038/srep05146

subject

Has Abstract

pub_date

2014-06-03 00:00:00

pages

5146

issn

2045-2322

pii

srep05146

journal_volume

4

pub_type

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