Abstract：
:Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are desirable for diabetes, especially in patients with overweight/obesity. We aimed to determine whether GLP-1RAs exhibit different glucose-lowering efficacies between Asian type 2 diabetes (T2D) patients with and without overweight/obesity. Randomized controlled trials were searched in EMBASE, MEDLINE, CENTRAL, and ClinicalTrials.gov. Studies published in English with treatment duration ≥12 weeks and information on HbA1c changes were included. The studies were divided into normal body mass index (BMI) and overweight/obese groups according to baseline BMI. Among 3190 searched studies, 20 trials were included in the meta-analysis. The standardized mean differences in HbA1c change, fasting glucose change, and postprandial glucose change were equivalent between normal BMI and overweight/obese studies (p > 0.05). The relative risk of HbA1c < 6.5% target achievement in normal BMI trials (7.93; 95% confidence interval: 3.27, 19.20) was superior to that in overweight/obesity trials (2.23; 1.67, 2.97), with a significant difference (p = 0.020). Body weight loss (p = 0.572) and hypoglycemic risk(p = 0.920) were similar in the two groups. The glucose-lowering effects of GLP-1RAs were equivalent among Asian T2D patients. With their advantages for weight-loss or weight-maintenance, GLP-1RAs are optimal medicines for Asian T2D patients with and without overweight/obesity.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Zhang F,Tang L,Zhang Y,Lü Q,Tong Ndoi
10.1038/s41598-017-16018-9subject
Has Abstractpub_date
2017-11-22 00:00:00pages
15997issue
1issn
2045-2322pii
10.1038/s41598-017-16018-9journal_volume
7pub_type
杂志文章,meta分析abstract：:Previous studies reported that boreal winter precipitation in southeastern China (SEC) tends to increase during El Niño. In this study, however, we find that most weak El Niño events are accompanied by below-normal precipitation in SEC, although strong El Niño events are accompanied by above-normal precipitation in SE...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53496-5
更新日期：2019-11-22 00:00:00
abstract：:L-R (left and right) symmetry breaking during embryogenesis and the establishment of asymmetric body plan are key issues in developmental biology, but the onset including the handedness-determining gene locus still remains unknown. Using pure dextral (DD) and sinistral (dd) strains of the pond snail Lymnaea stagnalis ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34809
更新日期：2016-10-06 00:00:00
abstract：:The indiscriminate use of antibiotics has led to the emergence of drug-resistant bacteria which has become one of the biggest challenges of the twenty-first century for the researchers to combat and in turn search for novel targets which could lead to the development of effective and sustainable therapies. Inhibition ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43016-w
更新日期：2019-04-24 00:00:00
abstract：:Mitigating climate change effects involves strategic decisions by individuals that may choose to limit their emissions at a cost. Everyone shares the ensuing benefits and thereby individuals can free ride on the effort of others, which may lead to the tragedy of the commons. For this reason, climate action can be conv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52524-8
更新日期：2019-11-07 00:00:00
abstract：:Obstructive heart defects (OHDs) are a major health concern worldwide. The platelet-derived growth factor (PDGF) genes are known to have regulatory functions that are essential for proper heart development. In a zebrafish model, Pdgfra was further demonstrated to interact with ethanol during craniofacial development. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29160-9
更新日期：2018-07-23 00:00:00
abstract：:Neurotransmitter release is mediated by the SNARE complex, but the role of its phosphorylation has scarcely been elucidated. Although PKC activators are known to facilitate synaptic transmission, there has been a heated debate on whether PKC mediates facilitation of neurotransmitter release through phosphorylation. On...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08237-x
更新日期：2017-08-11 00:00:00
abstract：:We introduce multi-gradients including Laplace pressure gradient, wettable gradient and wettable different gradient on a high adhesion surface via special wedge-pattern and improved anodic oxidation method. As a result of the cooperative effect mentioned above, controlled directional motion of a droplet on a high adhe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45687
更新日期：2017-04-03 00:00:00
abstract：:Accumulating evidence suggests that neuroinflammatory processes are implicated in the initiation and progression of amyotrophic lateral sclerosis (ALS). Previous reports have demonstrated an increase in microgliosis and astrogliosis in the lumbar spinal cord of SOD1G93A transgenic mice before the onset of symptoms, a ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53982-w
更新日期：2019-11-27 00:00:00
abstract：:The endosymbiotic bacterium Wolbachia spreads rapidly through populations of Aedes aegypti mosquitoes, and strongly inhibits infection with key human pathogens including the dengue and Zika viruses. Mosquito control programs aimed at limiting transmission of these viruses are ongoing in multiple countries, yet there i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16045-6
更新日期：2017-11-16 00:00:00
abstract：:Using starch as the carbon precursor and different-sized ZnO naoparticles as the hard template, a series of porous carbon materials for electrochemical sensing were prepared. Experiments of scanning electron microscopy, transmission electron microscopy and Nitrogen adsorption-desorption isotherms reveal that the parti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22309
更新日期：2016-02-29 00:00:00
abstract：:Adipose stromal cells (ASC) secrete various trophic factors that assist in the protection of neurons in a variety of neuronal death models. In this study, we tested the effects of human ASC conditional medium (ASC-CM) in human amyotrophic lateral sclerosis (ALS) transgenic mouse model expressing mutant superoxide dism...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16953
更新日期：2015-11-20 00:00:00
abstract：:Utilization of computational approach in the study of social behaviour of animals is increasing and we attempted such an approach in our study of tree-dwelling bats. These bats live in highly dynamic fission-fusion societies that share multiple roosts in a common home range. The key behavioural component associated wi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72999-0
更新日期：2020-10-08 00:00:00
abstract：:Coastal ecosystems play significant ecological and economic roles but are threatened and facing decline. Microbes drive various biogeochemical processes in coastal ecosystems. Tidal flats are critical components of coastal ecosystems; however, the structure and function of microbial communities in tidal flats are poor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36550
更新日期：2016-11-08 00:00:00
abstract：:Marine Fungi are potent secondary metabolite producers. However, limited genetic information are available their biosynthetic gene clusters (BGCs) and their biotechnological applications. To overcome this lack of information, herein, we used next-generation sequencing methods for genome sequencing of two marine fungi,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28473-z
更新日期：2018-07-05 00:00:00
abstract：:A high specificity aptamer-ligand biorecognition and binding system to monitor of dexamethasone (DXN) was developed. The detection principle was based on a label-free electrochemical aptasensor. The selection of the aptamer was successfully performed by the systematic evolution of ligands through exponential enrichmen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42671-3
更新日期：2019-04-29 00:00:00
abstract：:It is well known that tumour-associated macrophages (TAMs) play an important role in tumour development by modulating the tumour microenvironment, and targeting of protumour activation or the M2 polarization of TAMs is expected to be an effective therapy for cancer patients. We previously demonstrated that onionin A (...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29588
更新日期：2016-07-12 00:00:00
abstract：:Excessive tillage and soil compaction threaten the sustainable farmlands in the Huang-Huai-Hai Plains of China. Our study explores tillage practices to improve soil and root ecology and promote productivity in the winter wheat fields. We tested the impact of plowing, rotary, strip rotary tillage and strip rotary tilla...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48159-4
更新日期：2019-08-12 00:00:00
abstract：:Chemotherapy (CTx)-induced premature ovarian failure (POF) in woman remains clinically irreversible. Amniotic fluid stem cells (AFSCs) have shown the potential to treat CTx-induced POF; however, the underlying mechanism is unclear. Here we demonstrate that AFSC-derived exosomes recapitulate the anti-apoptotic effect o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23120
更新日期：2016-03-16 00:00:00
abstract：:The pace of two-dimensional materials (2DM) research has been greatly accelerated by the ability to identify exfoliated thicknesses down to a monolayer from their optical contrast. Since this process requires time-consuming and error-prone manual assignment to avoid false-positives from image features with similar con...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23922-1
更新日期：2018-04-23 00:00:00
abstract：:The intermittent electromagnetic fields with a large [Formula: see text] can enhance the properties of ferromagnetic materials and significantly affect paramagnetic materials. In this study, the effect of a pulsed electromagnetic field on the crystal orientation of the primary phase and microstructure evolution of an ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67352-4
更新日期：2020-06-30 00:00:00
abstract：:Sixty norovirus outbreaks that occurred in Pudong District, Shanghai in 2017 and affected 959 people were summarised. Of the outbreaks, 29 (48.3%), 27 (45.0%), and 4 (6.7%) occurred in kindergartens, primary schools, and middle schools, respectively. Although the total number of outbreaks peaked in March (13/60, 21.7%...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33724-0
更新日期：2018-10-15 00:00:00
abstract：:We present an optimized non-thermal atmospheric plasma (NTAP)-based reaction-discharge system that was applied for a continuous-flow treatment of apple juice (AJ). To optimize this system for a high-throughput production of AJ with ameliorated properties, the effect of several parameters was studied using design of ex...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78131-6
更新日期：2020-12-03 00:00:00
abstract：:Looking for single molecule electronic devices, we have investigated the charge transport properties of individual tetra-phenylporphyrin molecules on different substrates by ultrahigh-vacuum scanning tunneling microscopy and spectroscopy and by first-principles calculations. The tetra-phenylporphyrins with a Co atom (...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08350
更新日期：2015-02-10 00:00:00
abstract：:We present the design and performance characterization of a Faraday laser directly lasing on the Rb 1529 nm transition (Rb, 5P 3/2 - 4D 5/2) with high stability, narrow spectral linewidth and low cost. This system does not need an additional frequency-stabilized pump laser as a prerequisite to preparing Rb atom from 5...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09501-w
更新日期：2017-08-21 00:00:00
abstract：:Urbanization is associated with dramatic increases in noise and light pollution, which affect animal behaviour, physiology and fitness. However, few studies have examined these stressors simultaneously. Moreover, effects of urbanization during early-life may be detrimental but are largely unknown. In developing great ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02940-5
更新日期：2017-06-05 00:00:00
abstract：:Mueller microscopes enable imaging of the optical anisotropic properties of biological or non-biological samples, in phase and amplitude, at sub-micrometre scale. However, the development of Mueller microscopes poses an instrumental challenge: the production of polarimetric parameters must be sufficiently quick to ens...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40467-z
更新日期：2019-03-08 00:00:00
abstract：:Nowadays, intense electromagnetic (EM) radiation in the far-infrared (FIR) spectral range is an advanced tool for scientific research in biology, chemistry, and material science because many materials leave signatures in the radiation spectrum. Narrow-band spectral lines enable researchers to investigate the matter re...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76996-1
更新日期：2020-12-01 00:00:00
abstract：:Diabetic Retinopathy, the main cause of visual loss and blindness among working population, is a complication of Diabetes mellitus (DM), which has been described as a major public health challenge, so it is important to identify biomarkers to predict and to stratify patient´s possibility for developing DR. MicroRNAs (...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56172-w
更新日期：2019-12-23 00:00:00
abstract：:Fungal pathogens represent a significant threat to immunocompromised patients or individuals with traumatic injury. Strategies to efficiently remove fungal spores from hospital surfaces and, ideally, patient skin thus offer the prospect of dramatically reducing infections in at-risk patients. Photodynamic inactivation...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05000-0
更新日期：2017-07-04 00:00:00
abstract：:Urinary biomarkers augment the diagnosis of acute kidney injury (AKI), with AKI after cardiovascular surgeries being a prototype of prognosis scenario. Glutathione S-transferases (GST) were evaluated as biomarkers of AKI. Urine samples were collected in 141 cardiovascular surgical patients and analyzed for urinary alp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26335
更新日期：2016-08-16 00:00:00
