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Ang-(1-7) is an endogenous β-arrestin-biased agonist of the AT1 receptor with protective action in cardiac hypertrophy.

Abstract：

:The renin-angiotensin system (RAS) plays a key role in the control of vasoconstriction as well as sodium and fluid retention mediated mainly by angiotensin (Ang) II acting at the AT1 receptor (AT1R). Ang-(1-7) is another RAS peptide, identified as the endogenous ligand of the Mas receptor and known to counterbalance many of the deleterious effects of AngII. AT1R signaling triggered by β-arrestin-biased agonists has been associated to cardioprotection. Because position 8 in AngII is important for G protein activation, we hypothesized that Ang-(1-7) could be an endogenous β-arrestin-biased agonist of the AT1R. Here we show that Ang-(1-7) binds to the AT1R without activating Gq, but triggering β-arrestins 1 and 2 recruitment and activation. Using an in vivo model of cardiac hypertrophy, we show that Ang-(1-7) significantly attenuates heart hypertrophy by reducing both heart weight and ventricular wall thickness and the increased end-diastolic pressure. Whereas neither the single blockade of AT1 or Mas receptors with their respective antagonists prevented the cardioprotective action of Ang1-7, combination of the two antagonists partially impaired the effect of Ang-(1-7). Taken together, these data indicate that Ang-(1-7) mediates at least part of its cardioprotective effects by acting as an endogenous β-arrestin-biased agonist at the AT1R.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Teixeira LB,Parreiras-E-Silva LT,Bruder-Nascimento T,Duarte DA,Simões SC,Costa RM,Rodríguez DY,Ferreira PAB,Silva CAA,Abrao EP,Oliveira EB,Bouvier M,Tostes RC,Costa-Neto CM

doi

10.1038/s41598-017-12074-3

subject

Has Abstract

pub_date

2017-09-19 00:00:00

pages

11903

issue

1

issn

2045-2322

pii

10.1038/s41598-017-12074-3

journal_volume

7

pub_type

杂志文章

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