Abstract：
:Metastasis is generally considered a characteristic of malignant tumors. Herein, we describe a patient with more than one hundred discrete Spitz nevi scattered all over her skin. Molecular analysis from three of the lesions identified a ROS1 fusion oncogene with identical genomic breakpoints, indicating that the nevi arose from a single transformed melanocyte and then disseminated throughout the integument. The demonstration of widespread distribution of a benign tumor with limited proliferative capability indicates that metastatic dissemination is not contingent on full malignant transformation. Thus, eruptive Spitz nevus is a striking example of benign metastasis, demonstrating that metastasis can occur before malignant transformation.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Raghavan SS,Kapler ES,Dinges MM,Bastian BC,Yeh Idoi
10.1038/s41598-020-73264-0subject
Has Abstractpub_date
2020-10-01 00:00:00pages
16216issue
1issn
2045-2322pii
10.1038/s41598-020-73264-0journal_volume
10pub_type
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