Abstract：
:Regular overconsumption of sugar is associated with obesity and type-2 diabetes, but how genetic factors contribute to variable sugar preferences and intake levels remains mostly unclear. Here we provide evidence for the usefulness of a Drosophila larva model to investigate genetic influence on vulnerability to sugar overconsumption. Using genetic and RNA interference approaches, we show that the activity of the Oamb gene, which encodes a receptor for octopamine (OA, the invertebrate homologue of norepinephrine), plays a major role in controlled sugar consumption. Furthermore, Oamb appears to suppress sugar food intake in fed larvae in an acute manner, and neurons expressing this Oamb receptor do not overlap with neurons expressing Octβ3R, another OA receptor previously implicated in hunger-driven exuberant sugar intake. Together, these results suggest that two separate sub-circuits, defined by Oamb and Octβ3R respectively, co-regulate sugar consumption according to changes in energy needs. We propose that the noradrenergic-like system defines an ancient regulatory mechanism for prevention of sugar overload.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Branch A,Zhang Y,Shen Pdoi
10.1038/s41598-017-17760-wsubject
Has Abstractpub_date
2017-12-15 00:00:00pages
17642issue
1issn
2045-2322pii
10.1038/s41598-017-17760-wjournal_volume
7pub_type
杂志文章abstract：:Obesity and inactivity are major risk factors of feline diabetes mellitus (FDM) and human type II diabetes mellitus (T2DM). In recent years, changes in the gut microbiota have been suggested as a contributing factor to T2DM. Whether the gut microbiota (GM) composition plays a role in FDM remains unknown. The aim of th...
journal_title：Scientific reports
pub_type： 杂志文章,多中心研究
doi：10.1038/s41598-019-41195-0
更新日期：2019-03-18 00:00:00
abstract：:BST-2/tetherin is an interferon-inducible antiviral protein that blocks the release of various enveloped viruses, including HIV-1. Hepatitis B virus (HBV), a major cause of liver disease, belongs to the Hepadnaviridae family of enveloped DNA viruses. Whether BST-2 regulates HBV production is largely unknown. In this r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11736
更新日期：2015-06-29 00:00:00
abstract：:This study sought to compare the image quality and radiation dose of coronary computed tomography angiography (CCTA) from prospectively triggered 128-slice CT (128-MSCT) versus dual-source 64-slice CT (DSCT). The study was approved by the Medical Ethics Committee at Tongji Medical College of Huazhong University of Sci...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34795
更新日期：2016-10-18 00:00:00
abstract：:Circulating miRNAs have attracted attention as serum biomarkers for several diseases. In this study, we aimed to evaluate the diagnostic value of circulating miRNA-21 (miR-21) as a novel biomarker for elderly patients with type 2 cardiorenal syndrome (CRS-2). A total of 157 elderly patients with chronic heart failure ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61836-z
更新日期：2020-03-17 00:00:00
abstract：:The potential of Massively Parallel Sequencing (MPS) technology to vastly expand the capabilities of human identification led to the emergence of different MPS platforms that use forensically relevant genetic markers. Two of the MPS platforms that are currently available are the MiSeq® FGx™ Forensic Genomics System (I...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00510-3
更新日期：2017-03-24 00:00:00
abstract：:In recent years, there has been an impressively fast technological progress in the development of highly efficient lead halide perovskite solar cells. However, the stability of perovskite films and respective solar cells is still an open point of concern and calls for advanced characterization methods. In this work, w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35973
更新日期：2016-10-27 00:00:00
abstract：:Domoic acid (DA, 1), a potent neurotoxin that causes amnesic shellfish poisoning, has been found in diatoms and red algae. While biosynthetic pathway towards DA from geranyl diphosphate and L-glutamate has been previously proposed, its late stage is still unclear. Here, six novel DA related compounds, 7'-methyl-isodom...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18651-w
更新日期：2018-01-10 00:00:00
abstract：:The aim of the study was to investigate the role of endogenous sulfur dioxide (SO2)/ aspartate aminotransferase 1 (AAT1) pathway in stretch-induced excessive collagen expression and its mechanism. The mechanical stretch downregulated SO2/AAT1 pathway and increased collagen I and III protein expression. Importantly, AA...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21112
更新日期：2016-02-16 00:00:00
abstract：:Carabids are considered beneficial arthropods in agroecosystems, where they prey on crop pests or consume weed seeds. Therefore, knowledge of the spatial distribution of carabids in agricultural landscapes is crucial to efficiently manage the ecosystem services that they provide. In the present study, we investigated ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45378-7
更新日期：2019-06-20 00:00:00
abstract：:Inflammatory and metabolic diseases can originate during early-life and have been correlated with shifts in intestinal microbial ecology. Here we demonstrate that minor environmental fluctuations during the early neonatal period had sustained effects on the developing porcine microbiota and host-microbe interface. The...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05689-z
更新日期：2017-07-13 00:00:00
abstract：:The misuse of pharmaceutical opioids is a major public health issue. In Australia, codeine was re-scheduled on 1 February 2018 to restrict access; it is now only available on prescription. The aim of this study was to measure the change in dental opioid prescriptions, one year before and after the codeine re-schedulin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65390-6
更新日期：2020-05-21 00:00:00
abstract：:The article aims to describe the association between midlife body mass index (BMI) and cardiovascular disease (CVD)- and all-cause mortality, and to use early adulthood BMI as an instrumental variable for midlife BMI, in order to obtain an estimate less distorted by midlife confounders and reverse causality. Data from...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29089-z
更新日期：2018-07-31 00:00:00
abstract：:This work presents a new method for assisting in the identification process of missing persons in several contexts, such as enforced disappearances. We apply a Bayesian technique to incorporate non-genetic variables in the construction of prior information. In that way, we can learn from the already-solved cases of a ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59841-3
更新日期：2020-03-19 00:00:00
abstract：:The excessive release and accumulation of glutamate in the brain is known to be associated with excitotoxicity. CE, an extract derived from the plant Coeloglossum viride var. Bracteatum, exerted neuroprotective effects against amyloid toxicity and oxidative stress in cortical neurons. The aims of this study are to exa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08957-0
更新日期：2017-08-23 00:00:00
abstract：:Polyphenol oxidases (PPOs) contain the structurally similar enzymes tyrosinases (TYRs) and catechol oxidases (COs). Two cDNAs encoding pro-PPOs from tomato (Solanum lycopersicum) were cloned and heterologously expressed in Escherichia coli. The two pro-PPOs (SlPPO1-2) differ remarkably in their activity as SlPPO1 reac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39687-0
更新日期：2019-03-11 00:00:00
abstract：:Resistance to adjuvant systemic treatment, including taxanes (docetaxel and paclitaxel) is a major clinical problem for breast cancer patients. lncRNAs (long non-coding RNAs) are non-coding transcripts, which have recently emerged as important players in a variety of biological processes, including cancer development ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36231-4
更新日期：2018-12-19 00:00:00
abstract：:Lactic acid bacteria (LAB) are the common probiotics. Here, we investigated the antiviral protective effects of heat-killed LAB strain Lactobacillus casei DK128 (DK128) on influenza viruses. Intranasal treatment of mice with DK128 conferred protection against different subtypes of influenza viruses by lessening weight...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17487-8
更新日期：2017-12-12 00:00:00
abstract：:We aimed to determine the clinical and microbiological characteristics of Candida bloodstream infections in children and the impact of therapeutic strategies on outcomes. All pediatric patients with candidemia from a medical center in Taiwan over a 13-year period (2003-2015) were included and a total of 262 patients w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01123-6
更新日期：2017-04-24 00:00:00
abstract：:Lipoprotein-associated phospholipase A2 (Lp-PLA2) levels are associated with the development of atherosclerosis. We aimed to assess the genetic determinants of Lp-PLA2 activity and mass by genotyping multiple polymorphisms in PLA2G7, the gene encoding Lp-PLA2, among 1258 participants from the Chinese Multi-provincial ...
journal_title：Scientific reports
pub_type： 杂志文章,多中心研究
doi：10.1038/srep37465
更新日期：2016-12-01 00:00:00
abstract：:Hollow fiber composite NF membranes with improved anti-fouling property and water flux were prepared via interfacial polymerizationand layer-by-layer method using polyethylenimine (PEI), isophthaloyl dichloride (IPC), and β-cyclodextrin (β-CD). The chemical structures and the morphologies of the resultant NF membranes...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48908-5
更新日期：2019-08-27 00:00:00
abstract：:In order to screen out an effective bone loss protectant from natural plant polyphenol and to elucidate the mechanism of the plant polyphenols that alleviate bone loss under simulated microgravity, the proliferation activities of 9 total polyphenol extracts from natural product (TPENP) on osteoblasts were measured. Po...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30992-8
更新日期：2018-08-24 00:00:00
abstract：:Natural infection with measles virus (MV) establishes lifelong immunity. Persistent infection with MV is likely involved in this phenomenon, as non-replicating protein antigens never induce such long-term immunity. Although MV establishes stable persistent infection in vitro and possibly in vivo, the mechanism by whic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37163
更新日期：2016-11-24 00:00:00
abstract：:We report on an angle resolved photoemission (ARPES) study of bulk electron-doped perovskite iridate, (Sr(1-x)La(x))3Ir2O7. Fermi surface pockets are observed with a total electron count in keeping with that expected from La substitution. Depending on the energy and polarization of the incident photons, these pockets ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08533
更新日期：2015-02-23 00:00:00
abstract：:A novel turn-off colorimetric sensor for sequence-specific recognition of single-stranded DNA (ssDNA) was established by combining Y-shaped DNA duplex and G-quadruplex-hemin DNAzyme. A G-rich single-stranded DNA (Oligo-1) displays peroxidase mimicking catalytic activity due to the specific binding with hemin in the pr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30529-z
更新日期：2018-08-13 00:00:00
abstract：:The functions of purinergic P2 receptors (P2Rs) for extracellular adenosine triphosphate (ATP) are poorly understood. Here, for the first time, we show that activation of P2Rs in an important arousal region, the basal forebrain (BF), promotes wakefulness, whereas inhibition of P2Rs promotes sleep. Infusion of a non-hy...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29103-4
更新日期：2018-07-16 00:00:00
abstract：:Lipids play an important role in energy storage, membrane structure stabilization and signaling. Parasitoids are excellent models to study lipidomics because a majority of them do not accumulate during their free-living life-stage. Studies on parasitoids have mostly focused on the changes in the lipids and gene transc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26139-4
更新日期：2018-05-17 00:00:00
abstract：:Plant cis-elements play important roles in global regulation of gene expression. Based on microarray data from rice flag leaves during early senescence, we identified W-box and G-box cis-elements as positive regulators of senescence in the important rice variety Minghui 63. Both cis-elements were bound by leaf senesce...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20881
更新日期：2016-02-11 00:00:00
abstract：:Using classical molecular dynamics with a more reliable reactive LCBOPII potential, we have performed a detailed study on the direct graphite-to-diamond phase transition. Our results reveal a new so-called "wave-like buckling and slipping" mechanism, which controls the transformation from hexagonal graphite to cubic d...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05930
更新日期：2014-08-04 00:00:00
abstract：:X-ray phase-contrast imaging (XPCI) can dramatically improve soft tissue contrast in X-ray medical imaging. Despite worldwide efforts to develop novel XPCI systems, a numerical framework to rigorously predict the performance of a clinical XPCI system at a human scale is not yet available. We have developed such a tool...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12011
更新日期：2015-07-14 00:00:00
abstract：:Empowering an indirect band-gap material like Si with optical functionalities, firstly light emission, represents a huge advancement constantly pursued in the realization of any integrated photonic device. We report the demonstration of giant photoluminescence (PL) emission by a newly synthesized material consisting o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02674
更新日期：2013-01-01 00:00:00
