Abstract：
:The brain is a paradigmatic example of a complex system: its functionality emerges as a global property of local mesoscopic and microscopic interactions. Complex network theory allows to elicit the functional architecture of the brain in terms of links (correlations) between nodes (grey matter regions) and to extract information out of the noise. Here we present the analysis of functional magnetic resonance imaging data from forty healthy humans at rest for the investigation of the basal scaffold of the functional brain network organization. We show how brain regions tend to coordinate by forming a highly hierarchical chain-like structure of homogeneously clustered anatomical areas. A maximum spanning tree approach revealed the centrality of the occipital cortex and the peculiar aggregation of cerebellar regions to form a closed core. We also report the hierarchy of network segregation and the level of clusters integration as a function of the connectivity strength between brain regions.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Mastrandrea R,Gabrielli A,Piras F,Spalletta G,Caldarelli G,Gili Tdoi
10.1038/s41598-017-04716-3subject
Has Abstractpub_date
2017-07-07 00:00:00pages
4888issue
1issn
2045-2322pii
10.1038/s41598-017-04716-3journal_volume
7pub_type
杂志文章abstract：:The GS Junior sequencer provides simplified procedures for library preparation and data processing. Errors in pyrosequencing generate some biases during library construction and emulsion PCR amplification. False-positive mutations are identified by related characteristics described in the manufacturer's manual, and so...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13116-6
更新日期：2017-10-23 00:00:00
abstract：:Unmanned Aerial Systems (UAS) are increasingly being used recreationally, commercially and for wildlife research, but very few studies have quantified terrestrial mammalian reactions to UAS approaches. We used two Vertical Take-off and Landing (VTOL) UAS to approach seven herbivore species in the Moremi Game Reserve, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38610-x
更新日期：2019-02-14 00:00:00
abstract：:The excessive release and accumulation of glutamate in the brain is known to be associated with excitotoxicity. CE, an extract derived from the plant Coeloglossum viride var. Bracteatum, exerted neuroprotective effects against amyloid toxicity and oxidative stress in cortical neurons. The aims of this study are to exa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08957-0
更新日期：2017-08-23 00:00:00
abstract：:Inorganic elements are important components of medicinal herbs, and provide valuable experimental evidence for the quality evaluation and control of traditional Chinese medicine (TCM). In this study, to investigate the relationship between the inorganic elemental fingerprint and geographical origin identification of c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12933-z
更新日期：2017-10-03 00:00:00
abstract：:Electrochemically active bacteria (EAB) are ubiquitous in environment and have important application in the fields of biogeochemistry, environment, microbiology and bioenergy. However, rapid and sensitive methods for EAB identification and evaluation of their extracellular electron transfer ability are still lacking. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01315
更新日期：2013-01-01 00:00:00
abstract：:We study the impact of the direction of magnetic flux on the electron motion in GaAs/InAs core/shell nanowires. At small tilt angles, when the magnetic field is aligned nearly parallel to the nanowire axis, we observe Aharonov-Bohm type h/e flux periodic magnetoconductance oscillations. These are attributed to transpo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24573
更新日期：2016-04-19 00:00:00
abstract：:We used Mendelian randomization to estimate the causal effects of the liver enzymes, alanine aminotransferase (ALT), alkaline phosphatase (ALP) and gamma glutamyltransferase (GGT), on diabetes and cardiovascular disease, using genetic variants predicting these liver enzymes at genome wide significance applied to exten...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38813
更新日期：2016-12-20 00:00:00
abstract：:Extraction of mouse spinal motor neurons from transgenic mouse embryos recapitulating some aspects of neurodegenerative diseases like amyotrophic lateral sclerosis has met with limited success. Furthermore, extraction and long-term culture of adult mouse spinal motor neurons and glia remain also challenging. We presen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16763
更新日期：2015-11-18 00:00:00
abstract：:Although the cognitive impairment in Alzheimer's disease (AD) is believed to be caused by amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs), several postmortem studies have reported cognitive normal subjects with AD brain pathology. As the mechanism underlying these discrepancies has not been clarified, we foc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19442-7
更新日期：2018-01-26 00:00:00
abstract：:Infestation by the biotrophic pathogen Gymnosporangium asiaticum can be devastating for plant of the family Rosaceae. However, the phytopathology of this process has not been thoroughly elucidated. Using a metabolomics approach, we discovered the intrinsic activities that induce disease symptoms after fungal invasion ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37434
更新日期：2016-11-28 00:00:00
abstract：:VCF2CNA is a tool (Linux commandline or web-interface) for copy-number alteration (CNA) analysis and tumor purity estimation of paired tumor-normal VCF variant file formats. It operates on whole genome and whole exome datasets. To benchmark its performance, we applied it to 46 adult glioblastoma and 146 pediatric neur...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45938-x
更新日期：2019-07-17 00:00:00
abstract：:Genetic alterations identified in adjacent normal appearing tissue in bladder cancer patients are indicative of a field disease. Here we assessed normal urothelium transformation and intra-tumour heterogeneity (ITH) in four patients with bladder cancer. Exome sequencing identified private acquired mutations in a lymph...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11291-0
更新日期：2017-09-15 00:00:00
abstract：:With Motor imagery (MI), movements are mentally rehearsed without overt actions; this procedure has been adopted in motor rehabilitation, primarily in brain-damaged patients. Here we rather tested the clinical potentials of MI in purely orthopaedic patients who, by definition, should maximally benefit of mental exerci...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65820-5
更新日期：2020-06-02 00:00:00
abstract：:Following radiation induced DNA damage, several repair pathways are activated to help preserve genome integrity. Double Strand Breaks (DSBs), which are highly toxic, have specified repair pathways to address them. The main repair pathways used to resolve DSBs are Non-Homologous End Joining (NHEJ) and Homologous Recomb...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42901-8
更新日期：2019-04-23 00:00:00
abstract：:Many stroke survivors with aphasia in the acute period experience spontaneous recovery within the first six months after the stroke. However, approximately 30-40% sustain permanent aphasia and the factors determining incomplete recovery are unclear. Suboptimal recovery may be influenced by disruption of areas seemingl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07607-9
更新日期：2017-08-15 00:00:00
abstract：:Biosorption is a cost-effective and simple technique for removing heavy metals and rare earth elements from aqueous solution. Here, metals were recovered from aqueous solutions using phosphorylated dry baker's yeast cells. The cells were phosphorylated using cyclo-triphosphate, Na3P3O9. The total P content of the phos...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36306-2
更新日期：2019-01-18 00:00:00
abstract：:GABAergic and glutamatergic dysfunction in the dorsolateral prefrontal cortex (DLPFC) are thought to be the core pathophysiological mechanisms of schizophrenia. Recently, we have established a method to index these functions from the DLPFC using the paired transcranial magnetic stimulation (TMS) paradigms of short int...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17052-3
更新日期：2017-12-06 00:00:00
abstract：:A fundamental question in biology is how cell populations evolve into different subtypes based on homogeneous processes at the single cell level. Here we show that population bimodality can emerge even when biological processes are homogenous at the cell level and the environment is kept constant. Our model is based o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45882-w
更新日期：2019-06-28 00:00:00
abstract：:Mammalian Eag1 (Kv10.1) potassium (K+) channels are widely expressed in the brain. Several mutations in the gene encoding human Eag1 K+ channel have been associated with congenital neurodevelopmental anomalies. Currently very little is known about the molecules mediating protein synthesis and degradation of Eag1 chann...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40825
更新日期：2017-01-18 00:00:00
abstract：:We aimed to evaluate the association of plasma biomarkers linked to inflammation (bacterial translocation, inflammatory response, and endothelial dysfunction), coagulopathy, and angiogenesis with the severity of liver cirrhosis (assessed by the Child-Pugh-Turcotte score, CTP) and Child-Pugh B cirrhosis (CTP 7-9) in pa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67159-3
更新日期：2020-06-25 00:00:00
abstract：:Besides lifetime risks, we estimated life expectancy (LE), expected years of life lost (EYLL), lifetime costs, and cost-per-LY (life-year) stratified by different stages of esophageal cancer (EC). From the Taiwan Cancer Registry, we collected 14,420 EC to estimate the incidence rates during 2008-2014. They were follow...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60701-3
更新日期：2020-02-28 00:00:00
abstract：:Pesticides are the main tactics for pest control because they reduce the pest population very fast and their efficiency does not depend on abiotic factors. However, the indiscriminate use of these substances can speed up the development of resistant populations and causing environmental contamination. Therefore, alter...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26043-x
更新日期：2018-05-16 00:00:00
abstract：:Beaver have been referred to as ecosystem engineers because of the large impacts their dam building activities have on the landscape; however, the benefits they may provide to fluvial fish species has been debated. We conducted a watershed-scale experiment to test how increasing beaver dam and colony persistence in a ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28581
更新日期：2016-07-04 00:00:00
abstract：:Recently, a new class of nonlinear systems was introduced, in which the self-trapping of fundamental and vortical localized modes in space of dimension D is supported by cubic self-repulsion with a strength growing as a function of the distance from the center, r, at any rate faster that r(D). These systems support ro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09420
更新日期：2015-03-24 00:00:00
abstract：:Air pollution has been classified as a group 1 carcinogen in humans, but the underlying tumourigenic mechanisms remain unclear. In Xuanwei city of Yunnan Province, the lung cancer incidence is among the highest in China, owing to severe air pollution generated by the combustion of smoky coal, providing a unique opport...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14331
更新日期：2015-09-23 00:00:00
abstract：:The novel neuropeptide spexin (SPX) was discovered to activate galanin receptor 2 (GALR2) and 3 (GALR3) but not galanin receptor 1 (GALR1). Although GALR2 is known to display a function, particularly in anxiety, depression, and appetite regulation, the further determination of its function would benefit from a more st...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21453
更新日期：2016-02-24 00:00:00
abstract：:Saliva, as a non-invasive and easily accessible biofluid, has been shown to contain RNA biomarkers for prediction and diagnosis of several diseases. However, systematic analysis done by our group identified two problematic issues not coherently described before: (1) most of the isolated RNA originates from the oral mi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67825-6
更新日期：2020-07-07 00:00:00
abstract：:Characterisation of G protein-coupled receptors (GPCR) relies on the availability of a toolbox of ligands that selectively modulate different functional states of the receptors. To uncover such molecules, we explored a unique strategy for ligand discovery that takes advantage of the evolutionary conservation of the 60...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41002
更新日期：2017-02-01 00:00:00
abstract：:Dielectric Discharge Barrier (DBD) plasma actuators are considered as one of the best active electro-hydrodynamic control devices, and are considered by many contemporary researchers. Here a simple electrostatic model, which is improved by authors, and uses the Maxwell's and the Navier-Stokes equations, is proposed fo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75419-5
更新日期：2020-11-02 00:00:00
abstract：:Arctic river watersheds are important components of the global climate system and show an amplified response to climate change. Here, we characterize origins and transformations of dissolved organic matter (DOM) in five major Arctic rivers (Kolyma, Lena, Yenisei, Ob, Mackenzie) over 3 years with seasonal sampling peri...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12729-1
更新日期：2017-10-19 00:00:00
