Abstract：
:A fundamental question in biology is how cell populations evolve into different subtypes based on homogeneous processes at the single cell level. Here we show that population bimodality can emerge even when biological processes are homogenous at the cell level and the environment is kept constant. Our model is based on the stochastic partitioning of a cell component with an optimal copy number. We show that the existence of unimodal or bimodal distributions depends on the variance of partition errors and the growth rate tolerance around the optimal copy number. In particular, our theory provides a consistent explanation for the maintenance of aneuploid states in a population. The proposed model can also be relevant for other cell components such as mitochondria and plasmids, whose abundances affect the growth rate and are subject to stochastic partition at cell division.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Fernandez-de-Cossio-Diaz J,Mulet R,Vazquez Adoi
10.1038/s41598-019-45882-wsubject
Has Abstractpub_date
2019-06-28 00:00:00pages
9406issue
1issn
2045-2322pii
10.1038/s41598-019-45882-wjournal_volume
9pub_type
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