Colorectal Cancer Screening Programme in Spain: Results of Key Performance Indicators After Five Rounds (2000-2012).

Abstract:

:Effective quality assurance is essential in any screening programme. This article provides a unique insight into key quality indicators of five rounds of the first population-based colorectal cancer screening programme implemented in Spain (2000-2012), providing the results according to the type of screening (prevalent or first screen and incident or subsequent screen) and test (guaiac or immunochemical). The total crude participation rate increased from 17.2% (11,011) in the first round to 35.9% (22,988) in the last one. Rescreening rate was very high (88.6% in the fifth round). Positivity rate was superior with the faecal immunochemical test (6.2%) than with the guaiac-based test (0.7%) (p < 0.0001) and detection rates were also better with the immunochemical test. The most significant rise in detection rate was observed for high risk adenoma in men (45.5 per 1,000 screened). Most cancers were diagnosed at an early stage (61.4%) and there was a statistically significant difference between those detected in first or subsequent screening (52.6% and 70.0% respectively; p = 0.024). The availability of these results substantially improves data comparisons and the exchange of experience between screening programmes.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Binefa G,Garcia M,Milà N,Fernández E,Rodríguez-Moranta F,Gonzalo N,Benito L,Clopés A,Guardiola J,Moreno V

doi

10.1038/srep19532

subject

Has Abstract

pub_date

2016-01-20 00:00:00

pages

19532

issn

2045-2322

pii

srep19532

journal_volume

6

pub_type

杂志文章
  • Depletion of B cell-activating factor attenuates hepatic fat accumulation in a murine model of nonalcoholic fatty liver disease.

    abstract::Obesity-induced adipose-tissue dysfunction is a critical contributor to the pathogenesis of nonalcoholic fatty liver disease (NAFLD). B cell-activating factor (BAFF) is an adipokine related to impaired insulin sensitivity, and the serum BAFF concentration is associated with NAFLD severity. In this study, we aimed to d...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-37403-y

    authors: Nakamura Y,Abe M,Kawasaki K,Miyake T,Watanabe T,Yoshida O,Hirooka M,Matsuura B,Hiasa Y

    更新日期:2019-01-30 00:00:00

  • Dietary n-3 and n-6 polyunsaturated fatty acids, the FADS gene, and the risk of gastric cancer in a Korean population.

    abstract::n-3 polyunsaturated fatty acids (PUFAs) and n-6 PUFAs are reported to have immunomodulatory effects, but few studies have examined these functions. Thus, we examined whether dietary n-3 and n-6 PUFAs are associated with the risk of gastric cancer and further investigated whether fatty acid desaturases 1 and 2 (FADS1 a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-21960-3

    authors: Lee S,Lee J,Choi IJ,Kim YW,Ryu KW,Kim YI,Kim J

    更新日期:2018-02-28 00:00:00

  • Cold tolerance and silencing of three cold-tolerance genes of overwintering Chinese white pine larvae.

    abstract::The values of physiological indices and the enzymes activities involved in the overwintering stage were studied in D. armandi larvae in each month from October 2014 to March 2015. The sorbitol, trehalose and glycerol values initially tended to increase as the ambient temperature decreased, before declining until the e...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep34698

    authors: Wang J,Zhang RR,Gao GQ,Ma MY,Chen H

    更新日期:2016-10-05 00:00:00

  • Quantitative x-ray phase imaging at the nanoscale by multilayer Laue lenses.

    abstract::For scanning x-ray microscopy, many attempts have been made to image the phase contrast based on a concept of the beam being deflected by a specimen, the so-called differential phase contrast imaging (DPC). Despite the successful demonstration in a number of representative cases at moderate spatial resolutions, these ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep01307

    authors: Yan H,Chu YS,Maser J,Nazaretski E,Kim J,Kang HC,Lombardo JJ,Chiu WK

    更新日期:2013-01-01 00:00:00

  • Bile signalling promotes chronic respiratory infections and antibiotic tolerance.

    abstract::Despite aggressive antimicrobial therapy, many respiratory pathogens persist in the lung, underpinning the chronic inflammation and eventual lung decline that are characteristic of respiratory disease. Recently, bile acid aspiration has emerged as a major comorbidity associated with a range of lung diseases, shaping t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep29768

    authors: Reen FJ,Flynn S,Woods DF,Dunphy N,Chróinín MN,Mullane D,Stick S,Adams C,O'Gara F

    更新日期:2016-07-19 00:00:00

  • Cyclin Y inhibits plasticity-induced AMPA receptor exocytosis and LTP.

    abstract::Cyclin Y (CCNY) is a member of the cyclin protein family, known to regulate cell division in proliferating cells. Interestingly, CCNY is expressed in neurons that do not undergo cell division. Here, we report that CCNY negatively regulates long-term potentiation (LTP) of synaptic strength through inhibition of AMPA re...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep12624

    authors: Cho E,Kim DH,Hur YN,Whitcomb DJ,Regan P,Hong JH,Kim H,Ho Suh Y,Cho K,Park M

    更新日期:2015-07-29 00:00:00

  • Spin-helix Larmor mode.

    abstract::A two-dimensional electron gas (2DEG) with equal-strength Rashba and Dresselhaus spin-orbit coupling sustains persistent helical spin-wave states, which have remarkably long lifetimes. In the presence of an in-plane magnetic field, there exist single-particle excitations that have the character of propagating helical ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-21818-8

    authors: Karimi S,Ullrich CA,D'Amico I,Perez F

    更新日期:2018-02-22 00:00:00

  • The screening and identification of DNA barcode sequences for Rehmannia.

    abstract::In this study, ITS, ITS2, matK, rbcL and psbA-trnH in Rehmannia were successfully amplified and sequenced, but some ITS sequences need to be proofread according to ITS2 sequences. Compared with rbcL, matK and psbA-trnH, ITS and ITS2 had higher mutation rate and more information sites, and ITS2 had higher interspecific...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-53752-8

    authors: Duan H,Wang W,Zeng Y,Guo M,Zhou Y

    更新日期:2019-11-21 00:00:00

  • Accumulation and transformation of inorganic and organic arsenic in rice and role of thiol-complexation to restrict their translocation to shoot.

    abstract::Environmental contamination of arsenic (As) and its accumulation in rice (Oryza sativa L.) is of serious human health concern. In planta speciation of As is an important tool to understand As metabolism in plants. In the present study, we investigated root to shoot As translocation and speciation in rice exposed to in...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40522

    authors: Mishra S,Mattusch J,Wennrich R

    更新日期:2017-01-17 00:00:00

  • Copy Number Variations in a Cohort of 420 Individuals with Neurodevelopmental Disorders From the South of Brazil.

    abstract::Chromosomal microarray (CMA) is now recommended as first tier for the evaluation in individuals with unexplained neurodevelopmental disorders (ND). However, in developing countries such as Brazil, classical cytogenetic tests are still the most used in clinical practice, as reflected by the scarcity of publications of ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-54347-z

    authors: Chaves TF,Baretto N,Oliveira LF,Ocampos M,Barbato IT,Anselmi M,De Luca GR,Barbato Filho JH,Pinto LLC,Bernardi P,Maris AF

    更新日期:2019-11-28 00:00:00

  • A framework to identify structured behavioral patterns within rodent spatial trajectories.

    abstract::Animal behavior is highly structured. Yet, structured behavioral patterns-or "statistical ethograms"-are not immediately apparent from the full spatiotemporal data that behavioral scientists usually collect. Here, we introduce a framework to quantitatively characterize rodent behavior during spatial (e.g., maze) navig...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-79744-7

    authors: Donnarumma F,Prevete R,Maisto D,Fuscone S,Irvine EM,van der Meer MAA,Kemere C,Pezzulo G

    更新日期:2021-01-11 00:00:00

  • Coarse-grained molecular dynamics studies of the translocation mechanism of polyarginines across asymmetric membrane under tension.

    abstract::Understanding interactions between cell-penetrating peptides and biomembrane under tension can help improve drug delivery and elucidate mechanisms underlying fundamental cellular events. As far as the effect of membrane tension on translocation, it is generally thought that tension should disorder the membrane structu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep12808

    authors: He X,Lin M,Sha B,Feng S,Shi X,Qu Z,Xu F

    更新日期:2015-08-03 00:00:00

  • C-terminal short arginine/serine repeat sequence-dependent regulation of Y14 (RBM8A) localization.

    abstract::Y14 (RBM8A) is an RNA recognition motif-containing protein that forms heterodimers with MAGOH and serves as a core factor of the RNA surveillance machinery for the exon junction complex (EJC). The role of the Y14 C-terminal serine/arginine (RS) repeat-containing region, which has been reported to undergo modifications...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-18765-1

    authors: Tatsuno T,Ishigaki Y

    更新日期:2018-01-12 00:00:00

  • Viewing Majorana Bound States by Rabi Oscillations.

    abstract::We propose to use Rabi oscillation as a probe to view the fractional Josepshon relation (FJR) associated with Majorana bound states (MBSs) expected in one-dimensional topological superconductors. The system consists of a quantum dot (QD) and an rf-SQUID with MBSs at the Josephson junction. Rabi oscillations between en...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep11686

    authors: Wang Z,Liang QF,Yao DX,Hu X

    更新日期:2015-07-08 00:00:00

  • The characteristic, antioxidative and multiple organ protective of acidic-extractable mycelium polysaccharides by Pleurotus eryngii var. tuoliensis on high-fat emulsion induced-hypertriglyceridemic mice.

    abstract::The antioxidant and multiple organ protection effects of acid- extracted mycelia polysaccharides (Ac-MPS) from Pleurotus eryngii var. tuoliensis on HFE-induced hypertriglyceridemic mice were investigated. The results showed that Ac-MPS have potential ability to relieve the hypertriglyceridemia and preventing oxidative...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-35706-8

    authors: Gao Z,Lai Q,Yang Q,Xu N,Liu W,Zhao F,Liu X,Zhang C,Zhang J,Jia L

    更新日期:2018-11-30 00:00:00

  • Atomic scale verification of oxide-ion vacancy distribution near a single grain boundary in YSZ.

    abstract::This study presents atomic scale characterization of grain boundary defect structure in a functional oxide with implications for a wide range of electrochemical and electronic behavior. Indeed, grain boundary engineering can alter transport and kinetic properties by several orders of magnitude. Here we report experime...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep02680

    authors: An J,Park JS,Koh AL,Lee HB,Jung HJ,Schoonman J,Sinclair R,Gür TM,Prinz FB

    更新日期:2013-01-01 00:00:00

  • Publisher Correction: Bacillus SEVA siblings: A Golden Gate-based toolbox to create personalized integrative vectors for Bacillus subtilis.

    abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-018-22369-8

    authors: Radeck J,Meyer D,Lautenschläger N,Mascher T

    更新日期:2018-03-06 00:00:00

  • Engineering of versatile redox partner fusions that support monooxygenase activity of functionally diverse cytochrome P450s.

    abstract::Most bacterial cytochrome P450 monooxygenases (P450s or CYPs) require two redox partner proteins for activity. To reduce complexity of the redox chain, the Bacillus subtilis flavodoxin YkuN (Y) was fused to the Escherichia coli flavodoxin reductase Fpr (R), and activity was tuned by placing flexible (GGGGS)n or rigid ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-10075-w

    authors: Bakkes PJ,Riehm JL,Sagadin T,Rühlmann A,Schubert P,Biemann S,Girhard M,Hutter MC,Bernhardt R,Urlacher VB

    更新日期:2017-08-29 00:00:00

  • RNA sequencing reveals a transcriptomic portrait of human mesenchymal stem cells from bone marrow, adipose tissue, and palatine tonsils.

    abstract::Human mesenchymal stem cells (MSCs) are adult multipotent cells that have plasticity and inhabit the stroma of diverse tissues. The potential utility of MSCs has been heavily investigated in the fields of regenerative medicine and cell therapy. However, MSCs represent diverse populations that may depend on the tissue ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-16788-2

    authors: Cho KA,Park M,Kim YH,Woo SY,Ryu KH

    更新日期:2017-12-07 00:00:00

  • Temporal changes in the radiocesium distribution in forests over the five years after the Fukushima Daiichi Nuclear Power Plant accident.

    abstract::To elucidate the temporal changes in the radiocesium distribution in forests contaminated by the Fukushima Daiichi Nuclear Power Plant accident, we monitored the 137Cs concentration and inventory within forests from 2011 to 2015 across nine plots containing variable tree species and different contamination levels. The...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-08261-x

    authors: Imamura N,Komatsu M,Ohashi S,Hashimoto S,Kajimoto T,Kaneko S,Takano T

    更新日期:2017-08-15 00:00:00

  • Early weaning increases anxiety via brain-derived neurotrophic factor signaling in the mouse prefrontal cortex.

    abstract::Deprivation of maternal care during early development markedly affects emotional development, but the underlying neuromolecular mechanisms are not fully understood. In a mouse model of disrupted mother-infant relationship, early weaning causes long-term impacts on pups to exhibit increased corticosterone secretion, an...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40530-9

    authors: Kikusui T,Kanbara N,Ozaki M,Hirayama N,Ida K,Tokita M,Tanabe N,Mitsuyama K,Abe H,Yoshida M,Nagasawa M,Mogi K

    更新日期:2019-03-08 00:00:00

  • Occurrence of multiclass endocrine disrupting compounds in a drinking water supply system and associated risks.

    abstract::Contamination by endocrine disrupting compounds (EDCs) concerns the security and sustainability of a drinking water supply system and human exposure via water consumption. This study analyzed the selected EDCs in source (river water, n = 10) and supply (tap water, n = 155) points and the associated risks. A total of 1...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-74061-5

    authors: Wee SY,Aris AZ,Yusoff FM,Praveena SM

    更新日期:2020-10-20 00:00:00

  • Trichoderma harzianum favours the access of arbuscular mycorrhizal fungi to non-host Brassicaceae roots and increases plant productivity.

    abstract::The family Brassicaceae includes plants that are non-host for arbuscular mycorrhizal fungi (AMF) such as the model plant Arabidopsis thaliana (arabidopsis) and the economically important crop plant Brassica napus (rapeseed). It is well known that Trichoderma species have the ability to colonize the rhizosphere of Bras...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-48269-z

    authors: Poveda J,Hermosa R,Monte E,Nicolás C

    更新日期:2019-08-12 00:00:00

  • Comparative studies of alignment, alignment-free and SVM based approaches for predicting the hosts of viruses based on viral sequences.

    abstract::Predicting the hosts of newly discovered viruses is important for pandemic surveillance of infectious diseases. We investigated the use of alignment-based and alignment-free methods and support vector machine using mononucleotide frequency and dinucleotide bias to predict the hosts of viruses, and applied these approa...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-28308-x

    authors: Li H,Sun F

    更新日期:2018-07-03 00:00:00

  • A central role for PI3K-AKT signaling pathway in linking SAMHD1-deficiency to the type I interferon signature.

    abstract::The autoimmune disorder Aicardi-Goutières syndrome (AGS) is characterized by a constitutive type I interferon response. SAMHD1 possesses both dNTPase and RNase activities and mutations in SAMHD1 cause AGS; however, how SAMHD1-deficiency causes the type I interferon response in patients with AGS remains unknown. Here, ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-18308-8

    authors: Oh C,Ryoo J,Park K,Kim B,Daly MB,Cho D,Ahn K

    更新日期:2018-01-08 00:00:00

  • Humans best judge how much to cooperate when facing hard problems in large groups.

    abstract::We report the results of a game-theoretic experiment with human players who solve problems of increasing complexity by cooperating in groups of increasing size. Our experimental environment is set up to make it complicated for players to use rational calculation for making the cooperative decisions. This environment i...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-41773-2

    authors: Guazzini A,Stefanelli F,Imbimbo E,Vilone D,Bagnoli F,Levnajić Z

    更新日期:2019-04-02 00:00:00

  • A new perspective on the 137Cs retention mechanism in surface soils during the early stage after the Fukushima nuclear accident.

    abstract::The Fukushima Daiichi nuclear power plant accident caused serious radiocesium (137Cs) contamination of the soil in multiple terrestrial ecosystems. Soil is a complex system where minerals, organic matter, and microorganisms interact with each other; therefore, an improved understanding of the interactions of 137Cs wit...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-43499-7

    authors: Koarashi J,Nishimura S,Atarashi-Andoh M,Muto K,Matsunaga T

    更新日期:2019-05-07 00:00:00

  • Effect of Substrate Surface Roughening on the Capacitance and Cycling Stability of Ni(OH)2 Nanoarray Films.

    abstract::The effect of substrate surface roughening on the capacitance of Ni(OH)2/NiOOH nanowall array samples produced via chemical bath deposition for 2, 4, 6, 24 and 48 h on an as-received stainless steel substrate and the same substrate after sandblasting has been investigated. Symmetric cells were subjected to 120,000 cha...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-53365-1

    authors: Pimsawat A,Tangtrakarn A,Pimsawat N,Daengsakul S

    更新日期:2019-11-14 00:00:00

  • Temporal tuning in the bat auditory cortex is sharper when studied with natural echolocation sequences.

    abstract::Precise temporal coding is necessary for proper acoustic analysis. However, at cortical level, forward suppression appears to limit the ability of neurons to extract temporal information from natural sound sequences. Here we studied how temporal processing can be maintained in the bats' cortex in the presence of suppr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep29102

    authors: Beetz MJ,Hechavarría JC,Kössl M

    更新日期:2016-06-30 00:00:00

  • Dynamical footprint of cross-reactivity in a human autoimmune T-cell receptor.

    abstract::The present work focuses on the dynamical aspects of cross-reactivity between myelin based protein (MBP) self-peptide and two microbial peptides (UL15, PMM) for Hy.1B11 T-cell receptor (TCR). This same TCR was isolated from a patient suffering from multiple sclerosis (MS). The study aims at highlighting the chemical i...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep42496

    authors: Kumar A,Delogu F

    更新日期:2017-02-14 00:00:00