当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Comprehensive multiregional analysis of molecular heterogeneity in bladder cancer.

Comprehensive multiregional analysis of molecular heterogeneity in bladder cancer.

Abstract：

:Genetic alterations identified in adjacent normal appearing tissue in bladder cancer patients are indicative of a field disease. Here we assessed normal urothelium transformation and intra-tumour heterogeneity (ITH) in four patients with bladder cancer. Exome sequencing identified private acquired mutations in a lymph node metastasis and local recurrences. Deep re-sequencing revealed presence of at least three and four subclones in two patients with multifocal disease, while no demarcation of subclones was identified in the two patients with unifocal disease. Analysis of adjacent normal urothelium showed low frequency mutations in patients with multifocal disease. Expression profiling showed intra-tumour and intra-patient co-existence of basal- and luminal-like tumour regions, and patients with multifocal disease had a greater degree of genomic and transcriptomic ITH, as well as transformation of adjacent normal cells, compared to patients with unifocal disease. Analysis of the adjacent urothelium may pave the way for therapies targeting the field disease.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Thomsen MBH,Nordentoft I,Lamy P,Vang S,Reinert L,Mapendano CK,Høyer S,Ørntoft TF,Jensen JB,Dyrskjøt L

doi

10.1038/s41598-017-11291-0

subject

Has Abstract

pub_date

2017-09-15 00:00:00

pages

11702

issue

1

issn

2045-2322

pii

10.1038/s41598-017-11291-0

journal_volume

7

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • First in situ evidence of wakes in the far field behind offshore wind farms.

    abstract：:More than 12 GW of offshore wind turbines are currently in operation in European waters. To optimise the use of the marine areas, wind farms are typically clustered in units of several hundred turbines. Understanding wakes of wind farms, which is the region of momentum and energy deficit downwind, is important for opt...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-20389-y

    authors： Platis A,Siedersleben SK,Bange J,Lampert A,Bärfuss K,Hankers R,Cañadillas B,Foreman R,Schulz-Stellenfleth J,Djath B,Neumann T,Emeis S

    更新日期：2018-02-01 00:00:00

  • Comparison of phosphorylation and assembly of photosystem complexes and redox homeostasis in two wheat cultivars with different drought resistance.

    abstract：:Reversible phosphorylation of proteins and the assembly of thylakoid complexes are the important protective mechanism against environmental stresses in plants. This research was aimed to investigate the different responses of the antioxidant defense system and photosystem II (PSII) to osmotic stress between drought-re...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-13145-1

    authors： Chen YE,Cui JM,Su YQ,Zhang CM,Ma J,Zhang ZW,Yuan M,Liu WJ,Zhang HY,Yuan S

    更新日期：2017-10-05 00:00:00

  • Acclimation of bacterial cell state for high-throughput enzyme engineering using a DmpR-dependent transcriptional activation system.

    abstract：:Genetic circuit-based biosensors have emerged as an effective analytical tool in synthetic biology; these biosensors can be applied to high-throughput screening of new biocatalysts and metabolic pathways. Sigma 54 (σ54)-dependent transcription factor (TF) can be a valuable component of these biosensors owing to its in...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-62892-1

    authors： Kwon KK,Yeom SJ,Choi SL,Rha E,Lee H,Kim H,Lee DH,Lee SG

    更新日期：2020-04-08 00:00:00

  • Gender Differences in Infant Mortality and Neonatal Morbidity in Mixed-Gender Twins.

    abstract：:In the present study, we aimed to explore gender differences in infant mortality and neonatal morbidity in mixed-gender twin pairs. Data were obtained from the US National Center for Health Statistics Linked Birth-Infant Death Cohort. A total of 108,038 pairs of mixed-gender twins were included in this analysis. Among...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-08951-6

    authors： Zhao D,Zou L,Lei X,Zhang Y

    更新日期：2017-08-18 00:00:00

  • Plasmonically Enhanced Schottky Photovoltaic Devices.

    abstract：:Solar-cells based on Schottky junctions between metals and semiconductors (without or with an intermediate insulator) are among the main possibilities towards economical photovoltaic conversion of the solar energy. This is mainly due to their structural simplicity and hence the ease of their realization. We propose he...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-14528-0

    authors： Farhat M,Kais S,Alharbi FH

    更新日期：2017-10-27 00:00:00

  • Signalling mechanisms mediating Zn2+-induced TRPM2 channel activation and cell death in microglial cells.

    abstract：:Excessive Zn2+ causes brain damage via promoting ROS generation. Here we investigated the role of ROS-sensitive TRPM2 channel in H2O2/Zn2+-induced Ca2+ signalling and cell death in microglial cells. H2O2/Zn2+ induced concentration-dependent increases in cytosolic Ca2+ concentration ([Ca2+]c), which was inhibited by PJ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep45032

    authors： Mortadza SS,Sim JA,Stacey M,Jiang LH

    更新日期：2017-03-21 00:00:00

  • Significantly enhanced creep resistance of low volume fraction in-situ TiBw/Ti6Al4V composites by architectured network reinforcements.

    abstract：:We present a new class of TiBw/Ti6Al4V composites with a network reinforcement architecture that exhibits a significant creep resistance compared to monolithic Ti6Al4V alloys. Creep tests performed at temperatures between 773 K and 923 K and stress range of 100 MPa-300 MPa indicate both a significant improvement of th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep40823

    authors： Wang S,Huang LJ,Geng L,Scarpa F,Jiao Y,Peng HX

    更新日期：2017-01-17 00:00:00

  • A soluble starch synthase I gene, IbSSI, alters the content, composition, granule size and structure of starch in transgenic sweet potato.

    abstract：:Soluble starch synthase I (SSI) is a key enzyme in the biosynthesis of plant amylopectin. In this study, the gene named IbSSI, was cloned from sweet potato, an important starch crop. A high expression level of IbSSI was detected in the leaves and storage roots of the sweet potato. Its overexpression significantly incr...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-02481-x

    authors： Wang Y,Li Y,Zhang H,Zhai H,Liu Q,He S

    更新日期：2017-05-24 00:00:00

  • Antifungal synergy of a topical triazole, PC945, with a systemic triazole against respiratory Aspergillus fumigatus infection.

    abstract：:Invasive pulmonary Aspergillosis is a leading cause of morbidity and mortality in immunosuppressed patients and treatment outcomes using oral antifungal triazoles remain suboptimal. Here we show that combining topical treatment using PC945, a novel inhaled triazole, with systemic treatment using known triazoles demons...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-45890-w

    authors： Colley T,Sehra G,Daly L,Kimura G,Nakaoki T,Nishimoto Y,Kizawa Y,Strong P,Rapeport G,Ito K

    更新日期：2019-07-01 00:00:00

  • Reduction of randomness in seismic noise as a short-term precursor to a volcanic eruption.

    abstract：:Ambient seismic noise is characterized by randomness incurred by the random position and strength of the noise sources as well as the heterogeneous properties of the medium through which it propagates. Here we use ambient noise data recorded prior to the 1996 Gjálp eruption in Iceland in order to show that a reduction...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep37733

    authors： Glynn CC,Konstantinou KI

    更新日期：2016-11-24 00:00:00

  • Fine mapping of a leaf flattening gene Bralcm through BSR-Seq in Chinese cabbage (Brassica rapa L. ssp. pekinensis).

    abstract：:Leaf flattening influences plant photosynthesis, thereby affecting product yield and quality. Here, we obtained a stably inherited leaf crinkled mutant (lcm), derived from the Chinese cabbage doubled haploid (DH) 'FT' line using EMS mutagenesis combined with isolated microspore culture. The crinkled phenotype was cont...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-70975-2

    authors： Zhang M,Huang S,Gao Y,Fu W,Qu G,Zhao Y,Shi F,Liu Z,Feng H

    更新日期：2020-08-18 00:00:00

  • Improved assemblies using a source-agnostic pipeline for MetaGenomic Assembly by Merging (MeGAMerge) of contigs.

    abstract：:Assembly of metagenomic samples is a very complex process, with algorithms designed to address sequencing platform-specific issues, (read length, data volume, and/or community complexity), while also faced with genomes that differ greatly in nucleotide compositional biases and in abundance. To address these issues, we...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep06480

    authors： Scholz M,Lo CC,Chain PS

    更新日期：2014-10-01 00:00:00

  • Achieving sub-wavelength imaging through a flat hyperlens in a modified anodic aluminum oxide template.

    abstract：:Constrained by the diffraction limit, a lens can only resolve features larger than half of the incident wavelength owing to the decaying nature of evanescent waves. Several novel devices have been proposed, for example, superlenses and hyperlenses to break this limit. In this work, we present a flat hyperlens composed...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-62243-0

    authors： Tao CW,Yen TJ,Huang TY

    更新日期：2020-03-24 00:00:00

  • Manganese oxide electrode with excellent electrochemical performance for sodium ion batteries by pre-intercalation of K and Na ions.

    abstract：:Materials with a layered structure have attracted tremendous attention because of their unique properties. The ultrathin nanosheet structure can result in extremely rapid intercalation/de-intercalation of Na ions in the charge-discharge progress. Herein, we report a manganese oxide with pre-intercalated K and Na ions ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-02028-0

    authors： Feng M,Du Q,Su L,Zhang G,Wang G,Ma Z,Gao W,Qin X,Shao G

    更新日期：2017-05-22 00:00:00

  • Time-resolved double-slit interference pattern measurement with entangled photons.

    abstract：:The double-slit experiment strikingly demonstrates the wave-particle duality of quantum objects. In this famous experiment, particles pass one-by-one through a pair of slits and are detected on a distant screen. A distinct wave-like pattern emerges after many discrete particle impacts as if each particle is passing th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep04685

    authors： Kolenderski P,Scarcella C,Johnsen KD,Hamel DR,Holloway C,Shalm LK,Tisa S,Tosi A,Resch KJ,Jennewein T

    更新日期：2014-04-28 00:00:00

  • Rarity of monodominance in hyperdiverse Amazonian forests.

    abstract：:Tropical forests are known for their high diversity. Yet, forest patches do occur in the tropics where a single tree species is dominant. Such "monodominant" forests are known from all of the main tropical regions. For Amazonia, we sampled the occurrence of monodominance in a massive, basin-wide database of forest-inv...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-50323-9

    authors： Ter Steege H,Henkel TW,Helal N,Marimon BS,Marimon-Junior BH,Huth A,Groeneveld J,Sabatier D,Coelho LS,Filho DAL,Salomão RP,Amaral IL,Matos FDA,Castilho CV,Phillips OL,Guevara JE,Carim MJV,Cárdenas López D,Magnusson WE

    更新日期：2019-09-25 00:00:00

  • Temozolomide suppresses MYC via activation of TAp63 to inhibit progression of human glioblastoma.

    abstract：:Glioblastoma multiforme (GBM) is a highly invasive and chemoradioresistant brain malignancy. Temozolomide (TMZ), a DNA-alkylating agent, is effective against GBM and has become the standard first-line drug. However, the mechanism by which TMZ regulates the progression of GBM remains elusive. Here, we demonstrate that ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep01160

    authors： Yamaki T,Suenaga Y,Iuchi T,Alagu J,Takatori A,Itami M,Araki A,Ohira M,Inoue M,Kageyama H,Yokoi S,Saeki N,Nakagawara A

    更新日期：2013-01-01 00:00:00

  • Elevated nitrogen allows the weak invasive plant Galinsoga quadriradiata to become more vigorous with respect to inter-specific competition.

    abstract：:Elevated nitrogen associated with global change is believed to promote the invasion of many vigorous exotic plants. However, it is unclear how a weak exotic plant will respond to elevated nitrogen in the future. In this study, the competitive outcome of a weak invasive plant (Galinsoga quadriradiata) and two non-invas...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-21546-z

    authors： Liu G,Yang YB,Zhu ZH

    更新日期：2018-02-16 00:00:00

  • HIF-1α- Targeting Acriflavine Provides Long Term Survival and Radiological Tumor Response in Brain Cancer Therapy.

    abstract：:Tumor progression, limited efficacy of current standard treatments, and the rise in patient mortality are associated with gene expression caused by the synergistic action of intratumoral hypoxia and HIF-1α activation. For this reason, recent investigations have focused on HIF-targeting therapeutic agents, with encoura...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-14990-w

    authors： Mangraviti A,Raghavan T,Volpin F,Skuli N,Gullotti D,Zhou J,Asnaghi L,Sankey E,Liu A,Wang Y,Lee DH,Gorelick N,Serra R,Peters M,Schriefer D,Delaspre F,Rodriguez FJ,Eberhart CG,Brem H,Olivi A,Tyler B

    更新日期：2017-11-02 00:00:00

  • Effects of a microbial restoration substrate on plant growth and rhizosphere bacterial community in a continuous tomato cropping greenhouse.

    abstract：:Continuous cropping of tomato is increasingly practiced in greenhouse cultivation, leading to several soil-related obstacles. In this study, a type of microbial restoration substrate (MRS) was used to amend soils from the re-cropping of tomato for 8 years under greenhouse-cultivated conditions. Two treatments were est...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-70737-0

    authors： Zheng X,Wang Z,Zhu Y,Wang J,Liu B

    更新日期：2020-08-13 00:00:00

  • Highly Multiplexed RNA Aptamer Selection using a Microplate-based Microcolumn Device.

    abstract：:We describe a multiplexed RNA aptamer selection to 19 different targets simultaneously using a microcolumn-based device, MEDUSA (Microplate-based Enrichment Device Used for the Selection of Aptamers), as well as a modified selection process, that significantly reduce the time and reagents needed for selections. We exp...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep29771

    authors： Reinholt SJ,Ozer A,Lis JT,Craighead HG

    更新日期：2016-07-19 00:00:00

  • A protein with simultaneous capsid scaffolding and dsRNA-binding activities enhances the birnavirus capsid mechanical stability.

    abstract：:Viral capsids are metastable structures that perform many essential processes; they also act as robust cages during the extracellular phase. Viruses can use multifunctional proteins to optimize resources (e.g., VP3 in avian infectious bursal disease virus, IBDV). The IBDV genome is organized as ribonucleoproteins (RNP...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep13486

    authors： Mertens J,Casado S,Mata CP,Hernando-Pérez M,de Pablo PJ,Carrascosa JL,Castón JR

    更新日期：2015-09-04 00:00:00

  • Work stress, anthropometry, lung function, blood pressure, and blood-based biomarkers: a cross-sectional study of 43,593 French men and women.

    abstract：:Work stress is a risk factor for cardio-metabolic diseases, but few large-scale studies have examined the clinical profile of individuals with work stress. To address this limitation, we conducted a cross-sectional study including 43,593 working adults from a French population-based sample aged 18-72 years (the CONSTA...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-07508-x

    authors： Magnusson Hanson LL,Westerlund H,Goldberg M,Zins M,Vahtera J,Hulvej Rod N,Stenholm S,Steptoe A,Kivimäki M

    更新日期：2017-08-24 00:00:00

  • Region-specific mechanisms of corticosteroid-mediated inotropy in rat cardiomyocytes.

    abstract：:Regional differences in ion channel activity in the heart control the sequence of repolarization and may contribute to differences in contraction. Corticosteroids such as aldosterone or corticosterone increase the L-type Ca2+ current (ICaL) in the heart via the mineralocorticoid receptor (MR). Here, we investigate the...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-68308-4

    authors： Wacker C,Dams N,Schauer A,Ritzer A,Volk T,Wagner M

    更新日期：2020-07-14 00:00:00

  • Internal Extractive Electrospray Ionization Mass Spectrometry for Quantitative Determination of Fluoroquinolones Captured by Magnetic Molecularly Imprinted Polymers from Raw Milk.

    abstract：:Antibiotics contamination in food products is of increasing concern due to their potential threat on human health. Herein solid-phase extraction based on magnetic molecularly imprinted polymers coupled with internal extractive electrospray ionization mass spectrometry (MMIPs-SPE-iEESI-MS) was designed for the quantita...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-15202-1

    authors： Zhang H,Kou W,Bibi A,Jia Q,Su R,Chen H,Huang K

    更新日期：2017-11-07 00:00:00

  • Clinical significance of miR-1180-3p in hepatocellular carcinoma: a study based on bioinformatics analysis and RT-qPCR validation.

    abstract：:miRNAs play an indispensable role in human carcinogenesis. Dysregulated miR-1180-3p has been observed in several types of cancer, including hepatocellular carcinoma (HCC). This study intends to correlate the expression level of miR-1180-3p with clinical features and overall survival in HCC patients. The expression and...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-68450-z

    authors： Zhou Z,Zhou X,Jiang Y,Qiu M,Liang X,Lin Q,Guo Q,Nong C,Huo R,Chen Q,Liu H,Liu Y,Zhu S,Wang M,Yu H

    更新日期：2020-07-14 00:00:00

  • Linearly polarized photoluminescence of InGaN quantum disks embedded in GaN nanorods.

    abstract：:We have investigated the emission from InGaN/GaN quantum disks grown on the tip of GaN nanorods. The emission at 3.21 eV from the InGaN quantum disk doesn't show a Stark shift, and it is linearly polarized when excited perpendicular to the growth direction. The degree of linear polarization is about 39.3% due to the a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-26642-8

    authors： Park Y,Chan CCS,Nuttall L,Puchtler TJ,Taylor RA,Kim N,Jo Y,Im H

    更新日期：2018-05-25 00:00:00

  • Controlling the impact of the managed honeybee on wild bees in protected areas.

    abstract：:In recent years, conservation biologists have raised awareness about the risk of ecological interference between massively introduced managed honeybees and the native wild bee fauna in protected natural areas. In this study, we surveyed wild bees and quantified their nectar and pollen foraging success in a rosemary Me...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-27591-y

    authors： Henry M,Rodet G

    更新日期：2018-06-18 00:00:00

  • Reversal of established liver fibrosis by IC-2-engineered mesenchymal stem cell sheets.

    abstract：:Chronic hepatitis viral infection, alcoholic intoxication, and obesity cause liver fibrosis, which progresses to decompensated liver cirrhosis, a disease for which medical demands cannot be met. Since there are currently no approved anti-fibrotic therapies for established liver fibrosis, the development of novel modal...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-43298-0

    authors： Itaba N,Kono Y,Watanabe K,Yokobata T,Oka H,Osaki M,Kakuta H,Morimoto M,Shiota G

    更新日期：2019-05-02 00:00:00

  • Pathophysiological mechanisms underlying phenotypic differences in pulmonary radioresponse.

    abstract：:Differences in the pathogenesis of radiation-induced lung injury among murine strains offer a unique opportunity to elucidate the molecular mechanisms driving the divergence in tissue response from repair and recovery to organ failure. Here, we utilized two well-characterized murine models of radiation pneumonitis/fib...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep36579

    authors： Jackson IL,Zhang Y,Bentzen SM,Hu J,Zhang A,Vujaskovic Z

    更新日期：2016-11-15 00:00:00