Signalling mechanisms mediating Zn2+-induced TRPM2 channel activation and cell death in microglial cells.

abstract：:Acoustic energy transfer is a promising energy harvesting technology candidate for implantable biomedical devices. However, it does not show competitive strength for enabling self-powered implantable biomedical devices due to two issues - large size of bulk piezoelectric ultrasound transducers and output power fluctua...

journal_title：Scientific reports

authors： Shi Q,Wang T,Lee C

更新日期：2016-04-26 00:00:00

abstract：:Organic light-emitting devices and solar cells are devices that create, manipulate, and convert excited states in organic semiconductors. It is crucial to characterize these excited states, or excitons, to optimize device performance in applications like displays and solar energy harvesting. This is complicated if the...

journal_title：Scientific reports

authors： Reineke S,Baldo MA

更新日期：2014-01-21 00:00:00

abstract：:Kashin-Beck disease (KBD) is a chronic osteoarthropathy, which manifests as joint deformities and growth retardation. Only a few genetic studies of growth retardation associated with the KBD have been carried out by now. In this study, we conducted a two-stage bivariate genome-wide association study (BGWAS) of the KBD...

journal_title：Scientific reports

authors： Hao J,Wang W,Wen Y,Xiao X,He A,Guo X,Yang T,Liu X,Shen H,Chen X,Tian Q,Deng HW,Zhang F

更新日期：2016-08-22 00:00:00

abstract：:Previous trial evidence suggested potential risk of serious urinary tract infections (UTIs) and genital infections in type 2 diabetes patients using sodium glucose co-transporter-2 inhibitors (SGLT2) inhibitors. We conducted a systematic review and meta-analysis to assess the effects of SGLT2 inhibitors on UTIs and ge...

journal_title：Scientific reports

authors： Liu J,Li L,Li S,Jia P,Deng K,Chen W,Sun X

更新日期：2017-06-06 00:00:00

abstract：:Coral reefs are vital for the marine ecosystem and their potential disappearance can have unequivocal consequences on our environment. Aside from pollution-related threats (changes in water temperature, plastics, and acidity), corals can be injured by diseases, predators, humans and other invasive species. Diseases pl...

journal_title：Scientific reports

authors： Contardi M,Montano S,Liguori G,Heredia-Guerrero JA,Galli P,Athanassiou A,Bayer IS

更新日期：2020-01-22 00:00:00

abstract：:Drug-induced cholestasis is a leading cause of drug withdrawal. However, the use of primary human hepatocytes (PHHs), the gold standard for predicting cholestasis in vitro, is limited by their high cost and batch-to-batch variability. Mature hepatocyte characteristics have been observed in human induced hepatocytes (h...

journal_title：Scientific reports

authors： Ni X,Gao Y,Wu Z,Ma L,Chen C,Wang L,Lin Y,Hui L,Pan G

更新日期：2016-12-09 00:00:00

abstract：:Genetic mutations of the Methyl-CpG-binding protein-2 (MECP2) gene underlie Rett syndrome (RTT). Developmental processes are often considered to be irrelevant in RTT pathogenesis but neuronal activity at birth has not been recorded. We report that the GABA developmental shift at birth is abolished in CA3 pyramidal neu...

journal_title：Scientific reports

authors： Lozovaya N,Nardou R,Tyzio R,Chiesa M,Pons-Bennaceur A,Eftekhari S,Bui TT,Billon-Grand M,Rasero J,Bonifazi P,Guimond D,Gaiarsa JL,Ferrari DC,Ben-Ari Y

更新日期：2019-06-25 00:00:00

abstract：:Intractable diseases such as cancer are associated with breakdown in multiple individual functions, which conspire to create unhealthy phenotype-combinations. An important challenge is to decipher how these functions are coordinated in health and disease. We approach this by drawing on dynamical systems theory. We pos...

journal_title：Scientific reports

authors： Deritei D,Aird WC,Ercsey-Ravasz M,Regan ER

更新日期：2016-03-16 00:00:00

abstract：:Case-control genetic association studies typically ignore possible later disease onset in currently healthy subjects and assume that subjects with diseases equally contribute to the likelihood for inference, regardless of their onset age. Therefore, we used an event-history with risk-free model to simultaneously chara...

journal_title：Scientific reports

authors： Yang HC,Chen IC,Tsay YC,Li ZR,Chen CH,Hwu HG,Chen CH

更新日期：2017-05-16 00:00:00

abstract：:Nitrification directly contributes to the ammonia removal in sponges, and it plays an indispensable role in sponge-mediated nitrogen cycle. Previous studies have demonstrated genomic evidences of nitrifying lineages in the sponge Theonella swinhoei. However, little is known about the transcriptional activity of nitrif...

journal_title：Scientific reports

authors： Feng G,Sun W,Zhang F,Karthik L,Li Z

更新日期：2016-04-26 00:00:00

abstract：:Heating on the microscale using focused lasers gave rise to recent applications, e.g., in biomedicine, biology and microfluidics, especially using gold nanoparticles as efficient nanoabsorbers of light. However, such an approach naturally leads to nonuniform, Gaussian-like temperature distributions due to the diffusiv...

journal_title：Scientific reports

authors： Durdevic L,Robert HML,Wattellier B,Monneret S,Baffou G

更新日期：2019-03-15 00:00:00

abstract：:Horizontal gene transfer (HGT) drives the evolution of recipient organism particularly if it provides a novel function which enhances the fitness or its adaption to the environment. Virus-host co-evolution is attractive for studying co-evolutionary processes, since viruses strictly replicate inside of the host cells a...

journal_title：Scientific reports

authors： Chen DS,Wu YQ,Zhang W,Jiang SJ,Chen SZ

更新日期：2016-06-07 00:00:00

abstract：:Method for production of alpha emitter 149Tb by irradiation of 151Eu with 70 MeV 3He nuclei is proposed. For the first time, the cross sections for the formation of isotopes 149,150,151,152Tb were measured experimentally using a stack foil technique in the 3He particles energy range 70 → 12 MeV. The thick target yield...

journal_title：Scientific reports

authors： Moiseeva AN,Aliev RA,Unezhev VN,Zagryadskiy VA,Latushkin ST,Aksenov NV,Gustova NS,Voronuk MG,Starodub GY,Ogloblin AA

更新日期：2020-01-16 00:00:00

abstract：:Metabolic syndrome, including obesity and insulin resistance, has been reported to lower lung function in elderly subjects with asthma or chronic obstructive lung disease. This study aimed to find the association between lung function and insulin resistance in Korean young adults. This study used data from the Korean ...

journal_title：Scientific reports

authors： Lee YB,Kim YS,Lee DH,Kim HY,Lee JI,Ahn HS,Sohn TS,Lee TK,Song JY,Yeo CD,Hong M,Han K,Jeong SC,Chae HS

更新日期：2017-09-15 00:00:00

abstract：:The interaction between matter and electromagnetic radiation provides a rich understanding of what the matter is composed of and how it can be quantified using spectrometers. In many cases, however, the calibration of the spectrometer changes as a function of time (such as in electron spectrometers), or the absolute c...

journal_title：Scientific reports

authors： Chatzidakis M,Botton GA

更新日期：2019-02-14 00:00:00

abstract：:Materials and construction methods of nests vary between bird species and at present, very little is known about the relationships between architecture and function in these structures. This study combines computational and experimental techniques to study the structural biology of nests fabricated by the edible nest ...

journal_title：Scientific reports

authors： Jessel HR,Chen S,Osovski S,Efroni S,Rittel D,Bachelet I

更新日期：2019-03-18 00:00:00

abstract：:Labeling nuclear proteins with electron dense probes in living cells has been a major challenge due to their inability to penetrate into nuclei. We developed a lipid-based approach for delivering antibodies coupled to 0.8 nm ultrasmall gold particles into the nucleus to label RNA polymerase II. Focussed Ion Beam slici...

journal_title：Scientific reports

authors： Orlov I,Schertel A,Zuber G,Klaholz B,Drillien R,Weiss E,Schultz P,Spehner D

更新日期：2015-02-09 00:00:00

abstract：:Root-knot nematodes (RKNs) are obligate biotrophic parasites that invade plant roots and engage in prolonged and intimate relationships with their hosts. Nematode secretions, some of which have immunosuppressing activity, play essential roles in successful parasitism; however, their mechanisms of action remain largely...

journal_title：Scientific reports

authors： Niu J,Liu P,Liu Q,Chen C,Guo Q,Yin J,Yang G,Jian H

更新日期：2016-01-22 00:00:00

abstract：:Many scientists are seeking better therapies for treating fibromyalgia (FM) pain. We used a mouse model of FM to determine if ASIC3 and its relevant signaling pathway participated in FM pain. We demonstrated that FM-induced mechanical hyperalgesia was attenuated by electroacupuncture (EA). The decrease in fatigue-indu...

journal_title：Scientific reports

authors： Yen LT,Hsieh CL,Hsu HC,Lin YW

更新日期：2017-04-25 00:00:00

abstract：:RNA is transcribed from DNA, and therefore, there should be no RNA transcript from the deleted DNA region. Our study attempted to analyse whether any RNA cache that maps the deleted regions is present in human cells. Using data from the 1000 genome project, we selected 41 CEPH (CEU) and 38 Yoruba (YRI) samples that in...

journal_title：Scientific reports

authors： Byeon B,Kovalchuk I

更新日期：2016-11-17 00:00:00

abstract：:The DNA methyltransferase DNMT3A R882H mutation is observed in 25% of all AML patients. DNMT3A is active as tetramer and the R882H mutation is located in one of the subunit/subunit interfaces. Previous work has reported that formation of mixed wildtype/R882H complexes leads to a strong loss of catalytic activity obser...

journal_title：Scientific reports

authors： Emperle M,Dukatz M,Kunert S,Holzer K,Rajavelu A,Jurkowska RZ,Jeltsch A

更新日期：2018-09-05 00:00:00

abstract：:The inward rectifier Kir2.1 current (IKir2.1) was reported to be facilitated by fluid flow. However, the mechanism underlying this facilitation remains uncertain. We hypothesized that during K+ influx or efflux, [K+] adjacent to the outer mouth of the Kir2.1 channel might decrease or increase, respectively, compared w...

journal_title：Scientific reports

authors： Kim JG,Park SW,Byun D,Choi WS,Sung DJ,Shin KC,Kim HJ,Leem YE,Kang JS,Cho H,Kim B,Cho SI,Bae YM

更新日期：2016-12-22 00:00:00

abstract：:Anticarsia gemmatalis (velvetbean caterpillar) and Chrysodeixis includens (soybean looper) are two important defoliation pests of soybeans. In the present study, we have investigated the susceptibility and brush border membrane-binding properties of both species to Bacillus thuringiensis Cry1Ea toxin. Bioassays perfor...

journal_title：Scientific reports

authors： Bel Y,Zack M,Narva K,Escriche B

更新日期：2019-12-03 00:00:00

abstract：:Microalgal harvesting and dewatering are the main bottlenecks that need to be overcome to tap the potential of microalgae for production of valuable compounds. Water surface-floating microalgae form robust biofilms, float on the water surface along with gas bubbles entrapped under the biofilms, and have great potentia...

journal_title：Scientific reports

authors： Maeda Y,Nojima D,Sakurai M,Nomaguchi T,Ichikawa M,Ishizuka Y,Tanaka T

更新日期：2019-08-01 00:00:00

abstract：:The concept of milk as a healthy food has opened the way for studies on milk components, from nutrients to microRNAs, molecules with broad regulatory properties present in large quantities in milk. Characterization of these components has been performed in several species, such as humans and bovine, depending on the s...

journal_title：Scientific reports

authors： Le Guillou S,Leduc A,Laubier J,Barbey S,Rossignol MN,Lefebvre R,Marthey S,Laloë D,Le Provost F

更新日期：2019-12-30 00:00:00

abstract：:Blood platelets are instrumental in blood clotting and are thus heavily involved in early wound closure. After adhering to a substrate they spread by forming protrusions like lamellipodia and filopodia. However, the interaction of these protrusions with the physical environment of platelets while spreading is not full...

journal_title：Scientific reports

authors： Sandmann R,Köster S

更新日期：2016-03-03 00:00:00

abstract：:Three-dimensional models of kidney tissue that recapitulate human responses are needed for drug screening, disease modeling, and, ultimately, kidney organ engineering. Here, we report a bioprinting method for creating 3D human renal proximal tubules in vitro that are fully embedded within an extracellular matrix and h...

journal_title：Scientific reports

authors： Homan KA,Kolesky DB,Skylar-Scott MA,Herrmann J,Obuobi H,Moisan A,Lewis JA

更新日期：2016-10-11 00:00:00

abstract：:Slow disintegration and poor solubility are common problems facing the dispersible tablets of Traditional Chinese Medicine (TCM). In an early study, the research group found that co-grinding of extracts and silica could achieve a rapid disintegration effect, though the mechanism of this effect was not thoroughly eluci...

journal_title：Scientific reports

authors： Li P,Feng B,Jiang H,Han X,Wu Z,Wang Y,Lin J,Zhang Y,Yang M,Han L,Zhang D

更新日期：2018-07-09 00:00:00

abstract：:By using silver nanoplatelets with a widely tunable localized surface plasmon resonance (LSPR), and their corresponding local field enhancement, here we show large manipulation of plasmonic enhanced upconversion in NaYF4:Yb(3+)/Er(3+) nanocrystals at the single particle level. In particular, we show that when the plas...

journal_title：Scientific reports

authors： Wang YL,Mohammadi Estakhri N,Johnson A,Li HY,Xu LX,Zhang Z,Alù A,Wang QQ,Shih CK

更新日期：2015-05-15 00:00:00

abstract：:The efficacy of prospective cancer treatments is routinely estimated by in vitro cell-line proliferation screens. However, it is unclear whether tumor aggressiveness and patient survival are influenced more by the proliferative or the migratory properties of cancer cells. To address this question, we experimentally me...

journal_title：Scientific reports

authors： Nair NU,Das A,Rogkoti VM,Fokkelman M,Marcotte R,de Jong CG,Koedoot E,Lee JS,Meilijson I,Hannenhalli S,Neel BG,de Water BV,Le Dévédec SE,Ruppin E

更新日期：2019-07-29 00:00:00