Abstract：
:Intractable diseases such as cancer are associated with breakdown in multiple individual functions, which conspire to create unhealthy phenotype-combinations. An important challenge is to decipher how these functions are coordinated in health and disease. We approach this by drawing on dynamical systems theory. We posit that distinct phenotype-combinations are generated by interactions among robust regulatory switches, each in control of a discrete set of phenotypic outcomes. First, we demonstrate the advantage of characterizing multi-switch regulatory systems in terms of their constituent switches by building a multiswitch cell cycle model which points to novel, testable interactions critical for early G2/M commitment to division. Second, we define quantitative measures of dynamical modularity, namely that global cell states are discrete combinations of switch-level phenotypes. Finally, we formulate three general principles that govern the way coupled switches coordinate their function.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Deritei D,Aird WC,Ercsey-Ravasz M,Regan ERdoi
10.1038/srep21957subject
Has Abstractpub_date
2016-03-16 00:00:00pages
21957issn
2045-2322pii
srep21957journal_volume
6pub_type
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