Utilization of lactic acid in human myotubes and interplay with glucose and fatty acid metabolism.

abstract：:Bacterial vaginosis (BV) causes genital inflammation and increased HIV acquisition risk. The standard-of-care for BV, antibiotic therapy, is associated with high recurrence rates. Probiotics may improve treatment outcomes, although substantial heterogeneity in efficacy has been observed during clinical trials. To eval...

journal_title：Scientific reports

authors： Chetwin E,Manhanzva MT,Abrahams AG,Froissart R,Gamieldien H,Jaspan H,Jaumdally SZ,Barnabas SL,Dabee S,Happel AU,Bowers D,Davids L,Passmore JS,Masson L

更新日期：2019-02-13 00:00:00

abstract：:Topological phase transition is accompanied with a change of topological numbers. According to the bulk-edge correspondence, the gap closing and the breakdown of the adiabaticity are necessary at the phase transition point to make the topological number ill-defined. However, the gap closing is not always needed. In th...

journal_title：Scientific reports

authors： Ezawa M,Tanaka Y,Nagaosa N

更新日期：2013-09-27 00:00:00

abstract：:Leukemia cells are superior to hematopoietic cells with a normal differentiation potential in buffering cellular stresses, but the underlying mechanisms for this leukemic advantage are not fully understood. Using CRISPR/Cas9 deletion of the canonical autophagy-essential gene Atg7, we found that erythroleukemia K562 ce...

journal_title：Scientific reports

authors： Wang J,Fang Y,Yan L,Yuan N,Zhang S,Xu L,Nie M,Zhang X,Wang J

更新日期：2016-04-19 00:00:00

abstract：:Mercury pollution in soil poses serious risks to human health through consumption of contaminated vegetables. We used a meta-analysis to examine the mercury enrichment ability of different vegetables and the main factors affecting mercury uptake. We drew the following conclusions. (1) Plants with a lower bioconcentrat...

journal_title：Scientific reports

authors： Yu H,Li J,Luan Y

更新日期：2018-01-19 00:00:00

abstract：:Histone methyltransferase EZH2 is upregulated during osteoarthritis (OA), which is the most widespread rheumatic disease worldwide, and a leading cause of disability. This study aimed to assess the impact of EZH2 inhibition on cartilage degradation, inflammation and functional disability. In vitro, gain and loss of EZ...

journal_title：Scientific reports

authors： Allas L,Brochard S,Rochoux Q,Ribet J,Dujarrier C,Veyssiere A,Aury-Landas J,Grard O,Leclercq S,Vivien D,Ea HK,Maubert E,Cohen-Solal M,Boumediene K,Agin V,Baugé C

更新日期：2020-11-11 00:00:00

abstract：:Single-photon emitters with stable and uniform photoluminescence properties are important for quantum technology. However, in many cases, colour centres in diamond exhibit spectral diffusion and photoluminescence intensity fluctuation. It is therefore essential to investigate the dynamics of colour centres at the sing...

journal_title：Scientific reports

authors： Liu Y,Chen G,Rong Y,McGuinness LP,Jelezko F,Tamura S,Tanii T,Teraji T,Onoda S,Ohshima T,Isoya J,Shinada T,Wu E,Zeng H

更新日期：2015-07-23 00:00:00

abstract：:Sigma-1 and sigma-2 receptors are emerging therapeutic targets. We have identified that simple ammonium salts bind to these receptors and are effective in vivo. Radioligand binding assays were used to obtain structure-activity relationships of these salts. MTS assays were performed to determine their effect on growth ...

journal_title：Scientific reports

authors： Brimson JM,Akula KK,Abbas H,Ferry DR,Kulkarni SK,Russell ST,Tisdale MJ,Tencomnao T,Safrany ST

更新日期：2020-06-08 00:00:00

abstract：:G-quadruplexes (G4s) are nucleic acids secondary structures, epigenetic regulators in cells and viruses. In herpes simplex virus 1 (HSV-1)-infected cells, G4s are massively present during viral replication. We here aimed at investigating the possibility to target the HSV-1 G4s by a core extended naphtalene diimide (c-...

journal_title：Scientific reports

authors： Callegaro S,Perrone R,Scalabrin M,Doria F,Palù G,Richter SN

更新日期：2017-05-24 00:00:00

abstract：:Andrographolide is a traditional herb medicine, widely used in Asia for conditions involving inflammation. The andrographlide-lipoic acid conjugate, AL-1, has been found being able to alleviate inflammation in our previous reports. Although the anti-inflammatory activity of AL-1 contributes to its cytoprotective effec...

journal_title：Scientific reports

authors： Yang Y,Yan H,Jing M,Zhang Z,Zhang G,Sun Y,Shan L,Yu P,Wang Y,Xu L

更新日期：2016-07-20 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Alam MK,Zheng L,Liu R,Papagerakis S,Papagerakis P,Geyer CR

更新日期：2020-09-09 00:00:00

abstract：:Autophagy is a crucial and physiological process for cell survival from yeast to mammals, including protozoan parasites. Toxoplasma gondii, an intracellular parasite, typically exploits autophagic machinery of host cell; however host cell upregulates autophagy to combat the infection. Herein we tested the efficacy of ...

journal_title：Scientific reports

authors： Ietta F,Maioli E,Daveri E,Gonzaga Oliveira J,da Silva RJ,Romagnoli R,Cresti L,Maria Avanzati A,Paulesu L,Barbosa BF,Gomes AO,Roberto Mineo J,Ferro EAV

更新日期：2017-04-28 00:00:00

abstract：:Non-traumatic osteonecrosis (ON) of the femoral head is a common disease affecting a young population as the peak age of diagnosis is in the 40 s. The natural history of non-traumatic ON leads to a collapse of the femoral head requiring prosthetic replacement in a 60% of cases. Although trabecular bone involvement in ...

journal_title：Scientific reports

authors： Pascart T,Falgayrac G,Migaud H,Quinchon JF,Norberciak L,Budzik JF,Paccou J,Cotten A,Penel G,Cortet B

更新日期：2017-03-07 00:00:00

abstract：:Volatile organic compounds (VOCs) represent a broad class of chemicals, many of which can be found in indoor air including residential indoor air. VOCs derive from a variety of sources including cleaning products, cooking practices, fragrances and fresheners, hobbies and at-home work behaviors. This study examined res...

journal_title：Scientific reports

authors： Wickliffe JK,Stock TH,Howard JL,Frahm E,Simon-Friedt BR,Montgomery K,Wilson MJ,Lichtveld MY,Harville E

更新日期：2020-12-10 00:00:00

abstract：:Extracellular matrix (ECM) mechanical properties upregulate cancer invasion, cell contractility, and focal adhesion formation. Alteration in energy metabolism is a known characteristic of cancer cells (i.e., Warburg effect) and modulates cell invasion. There is little evidence to show if collagen density can alter can...

journal_title：Scientific reports

authors： Mah EJ,Lefebvre AEYT,McGahey GE,Yee AF,Digman MA

更新日期：2018-11-20 00:00:00

abstract：:Fatigue is a very common and costly symptom associated with various diseases and disorders. Nonetheless, understanding the pathobiology and developing of therapies for fatigue have been difficult, partly because of a lack of consensus on the measures to phenotype this behavior, both in clinical settings and in animal ...

journal_title：Scientific reports

authors： Wolff BS,Raheem SA,Saligan LN

更新日期：2018-09-24 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with diverse clinical presentation and outcome. Bio-clinical prognostic models including oncogene expression and cell-of-origin phenotyping has been developed, however, approximately 30% of all patients still die from their disease, illustrating the need...

journal_title：Scientific reports

authors： Jespersen DS,Schönherz AA,Due H,Bøgsted M,Sondergaard TE,Dybkær K

更新日期：2019-01-23 00:00:00

abstract：:Type IV secretion systems are multiprotein complexes that mediate the translocation of macromolecules across the bacterial cell envelope. In Helicobacter pylori a type IV secretion system encoded by the cag pathogenicity island encodes 27 proteins and most are essential for virulence. We here present the identificatio...

journal_title：Scientific reports

authors： Arya T,Oudouhou F,Casu B,Bessette B,Sygusch J,Baron C

更新日期：2019-04-24 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a highly metastatic cancer that is consistently associated with Epstein-Barr virus (EBV) infection. In this study, we identify for the first time a role for monoamine oxidase A (MAOA) in NPC. MAOA is a mitochondrial enzyme that catalyzes oxidative deamination of neurotransmitters and ...

journal_title：Scientific reports

authors： Lee HM,Sia APE,Li L,Sathasivam HP,Chan MSA,Rajadurai P,Tsang CM,Tsao SW,Murray PG,Tao Q,Paterson IC,Yap LF

更新日期：2020-04-09 00:00:00

abstract：:Dating the start of intensive anthropogenic influence on ecosystems is important for identifying the conditions necessary for ecosystem recovery. However, few studies have focused on determining when anthropogenic influences on wetland began through sedimentary archives. To fill this critical gap in our knowledge, com...

journal_title：Scientific reports

authors： Cong J,Gao C,Zhang Y,Zhang S,He J,Wang G

更新日期：2016-02-24 00:00:00

abstract：:1,3,5-trinitroperhydro-1,3,5-triazine (RDX), octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX), and pentaerythritol tetranitrate (PETN), the major components in plastic explosives, pose a significant threat to public safety. A quick, sensitive, and low-cost detection method for these non-volatile explosives is ea...

journal_title：Scientific reports

authors： Wang C,Huang H,Bunes BR,Wu N,Xu M,Yang X,Yu L,Zang L

更新日期：2016-05-05 00:00:00

abstract：:Our previous study suggested that microtubule network alteration affects the process of glycolysis in cardiomyocytes (CMs) via the regulation of hypoxia-inducible factor (HIF)-1α during the early stages of hypoxia. However, little is known regarding the underlying mechanisms of microtubule network alteration-induced c...

journal_title：Scientific reports

authors： Jiang X,Zhang D,Zhang H,Huang Y,Teng M

更新日期：2015-03-17 00:00:00

abstract：:It has been an old unsolved puzzle to evolutionary theorists on which mechanisms would increase large-scale cooperation in human societies. Thus, how such mechanisms operate in a biological network is still not well understood. This study addresses these questions with empirical evidence from agent-based models design...

journal_title：Scientific reports

authors： Ezeigbo IC

更新日期：2017-12-11 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Motoki K,Sugiura M,Kawashima R

更新日期：2020-01-24 00:00:00

abstract：:Prion-like behaviour is attracting much attention due to the growing evidences that amyloid-like self-assembly may reach beyond neurodegeneration and be a conserved functional mechanism. The best characterized functional prions correspond to a subset of yeast proteins involved in translation or transcription. Their co...

journal_title：Scientific reports

authors： Batlle C,de Groot NS,Iglesias V,Navarro S,Ventura S

更新日期：2017-09-21 00:00:00

abstract：:The regeneration of WPAC through pyrolysis and its adsorption capacity of phosphorus were studied. The optimum conditions for WPAC regeneration were 650 °C and 2 h which resulted in a recovery of BET surface and total pore volume with a value of 1161.4 m2/g and 1.2176 m3/g. WPAC had a maximum PO43--P adsorption capaci...

journal_title：Scientific reports

authors： Li Y,Jin H,Liu W,Su H,Lu Y,Li J

更新日期：2018-01-15 00:00:00

abstract：:Perception can often be described as a statistically optimal inference process whereby noisy and incomplete sensory evidence is combined with prior knowledge about natural scene statistics. Previous evidence has shown that humans tend to underestimate the speed of unreliable moving visual stimuli. This finding has bee...

journal_title：Scientific reports

authors： Senna I,Parise CV,Ernst MO

更新日期：2015-09-15 00:00:00

abstract：:In bacteria, the SecA ATPase provides the driving force for protein secretion via the SecYEG translocon. While the dynamic interplay between SecA and SecYEG in translocation is widely appreciated, it is not clear how SecA associates with the translocon in the crowded cellular environment. We use super-resolution micro...

journal_title：Scientific reports

authors： Seinen AB,Spakman D,van Oijen AM,Driessen AJM

更新日期：2021-01-14 00:00:00

abstract：:Nerve fibers are known to reside within malignant tumors and the greater the neuronal density the worse prognosis for the patient. Recent discoveries using tumor bearing animal models have eluded to the autonomic nervous system having a direct effect on tumor growth and metastasis. We report the first direct and chron...

journal_title：Scientific reports

authors： McCallum GA,Shiralkar J,Suciu D,Covarrubias G,Yu JS,Karathanasis E,Durand DM

更新日期：2020-09-09 00:00:00

abstract：:The objective of this study was to examine whether shorter leukocyte telomere length (LTL) is associated with more rapid pulmonary function decline in a longitudinal study of World Trade Center (WTC) responders. WTC responders (N = 284) participating in a monitoring study underwent blood sampling and were followed pro...

journal_title：Scientific reports

authors： Clouston SAP,Edelman NH,Aviv A,Stewart C,Luft BJ

更新日期：2019-05-31 00:00:00

abstract：:Most pollination in large-scale agriculture is dependent on managed colonies of a single species, the honey bee Apis mellifera. More than 1 million hives are transported to California each year just to pollinate the almonds, and bees are trucked across the country for various cropping systems. Concerns have been raise...

journal_title：Scientific reports

authors： Simone-Finstrom M,Li-Byarlay H,Huang MH,Strand MK,Rueppell O,Tarpy DR

更新日期：2016-08-24 00:00:00