Abstract:
:An amendment to this paper has been published and can be accessed via a link at the top of the paper.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Motoki K,Sugiura M,Kawashima Rdoi
10.1038/s41598-020-58293-zsubject
Has Abstractpub_date
2020-01-24 00:00:00pages
1397issue
1issn
2045-2322pii
10.1038/s41598-020-58293-zjournal_volume
10pub_type
已发布勘误abstract::Sirtuins are NAD(+) dependent lysine deacylases involved in many regulatory processes such as control of metabolic pathways, DNA repair and stress response. Modulators of sirtuin activity are required as tools for uncovering the biological function of these enzymes and as potential therapeutic agents. Systematic disco...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22643
更新日期:2016-03-04 00:00:00
abstract::Transit-time flow measurement (TTFM) is frequently used to evaluate intraoperative quality control during coronary artery bypass grafting (CABG) and has the ability to assess graft failure intraoperatively. However, perioperative factors affecting TTFM during CABG remain poorly understood. Patients who underwent CABG ...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-020-69924-w
更新日期:2020-07-31 00:00:00
abstract::Pericytes regulate vessel stability and pericyte dysfunction contributes to retinopathies, stroke, and cancer. Here we define Notch as a key regulator of pericyte function during angiogenesis. In Notch1(+/-); Notch3(-/-) mice, combined deficiency of Notch1 and Notch3 altered pericyte interaction with the endothelium a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16449
更新日期:2015-11-13 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-44354-5
更新日期:2019-05-23 00:00:00
abstract::Coherent, optically dressed media composed of two-level molecular systems without inversion symmetry are considered as all-optically tunable sources of coherent radiation in the microwave domain. A theoretical model and a numerical toolbox are developed to confirm the main finding: the generation of low-frequency radi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74569-w
更新日期:2020-10-19 00:00:00
abstract::The Arabidopsis Tóxicos en Levadura (ATL) protein family is a class of E3 ubiquitin ligases with a characteristic RING-H2 Zn-finger structure that mediates diverse physiological processes and stress responses in plants. We carried out a genome-wide survey of grapevine (Vitis vinifera L.) ATL genes and retrieved 96 seq...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38260
更新日期:2016-12-02 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-22369-8
更新日期:2018-03-06 00:00:00
abstract::Although recovery following a stroke is limited, undamaged neurons under the right conditions can establish new connections and take on-board lost functions. Sonic hedgehog (Shh) signaling is integral for developmental axon growth, but its role after injury has not been fully examined. To investigate the effects of Sh...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21896
更新日期:2016-02-23 00:00:00
abstract::The mangrove fern genus Acrostichum grows in the extremely unstable marine intertidal zone under harsh conditions, such as high salt concentrations, tidal rhythms and long-term climate changes. To explore the phylogenetic relationships and molecular mechanisms underlying adaptations in this genus, we sequenced the tra...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35634
更新日期:2016-10-26 00:00:00
abstract::Blood platelets are instrumental in blood clotting and are thus heavily involved in early wound closure. After adhering to a substrate they spread by forming protrusions like lamellipodia and filopodia. However, the interaction of these protrusions with the physical environment of platelets while spreading is not full...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22357
更新日期:2016-03-03 00:00:00
abstract::Shigella spp., emerging from multiple origins of Escherichia coli, poses a significant health threat as a causative agent of bacillary dysentery. While multiple serotypes of four different species have evolved via independent lineages, Shigella spp. are designated as a single pathotype, primarily because of their comm...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39810-1
更新日期:2019-03-01 00:00:00
abstract::Emergence and time evolution of micro-structured new-phase domains play a crucial role in determining the macroscopic physical and mechanical behaviors of iron under shock compression. Here, we investigate, through molecular dynamics simulations and theoretical modelings, shock-induced phase transition process of iron...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03628
更新日期:2014-01-10 00:00:00
abstract::Endoplasmic reticulum (ER) stress preconditioning protects cells against methylmercury (MeHg) cytotoxicity by inducing integrated stress responses such as eIF2α phosphorylation, ATF4 accumulation, and nonsense-mediated mRNA decay (NMD) suppression. Here we demonstrated that ER stress preconditioning results in the upr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09435-3
更新日期:2017-09-28 00:00:00
abstract::Climate change and human activity are dooming species at an unprecedented rate via a plethora of direct and indirect, often synergic, mechanisms. Among these, primary extinctions driven by environmental change could be just the tip of an enormous extinction iceberg. As our understanding of the importance of ecological...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35068-1
更新日期:2018-11-13 00:00:00
abstract::The new π-extended redox-active ligand with both TTF and triazole units, 6-(4,5-bis(propylthio)-1,3-dithiol-2-ylidene)-1H-[1,3]dithiolo[4',5':4,5]benzo [1,2-d] [1-3]triazole, has been successfully prepared. Based on the versatile ligand and Cu(tta)2 precursors (tta(-) = 4,4,4-trifluoro-1-(thiophen-2-yl)butane-1,3-dion...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25544
更新日期:2016-05-06 00:00:00
abstract::Online gambling sites offer many different gambling games. In this work we analyse the gambling logs of numerous solely probability-based gambling games and extract the wager and odds distributions. We find that the log-normal distribution describes the wager distribution at the aggregate level. Viewing the gamblers' ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50168-2
更新日期:2019-10-11 00:00:00
abstract::Short chain fatty acids (SCFAs) produced by intestinal microbes mediate anti-inflammatory effects, but whether they impact on antimicrobial host defenses remains largely unknown. This is of particular concern in light of the attractiveness of developing SCFA-mediated therapies and considering that SCFAs work as inhibi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37944
更新日期:2016-11-29 00:00:00
abstract::Sorafenib is a multikinase inhibitor used as a first-line treatment for advanced hepatocellular carcinoma (HCC), but it has shown modest to low response rates. The characteristic tumour hypoxia of advanced HCC maybe a major factor underlying hypoxia-mediated treatment failure. Thus, it is urgent to elucidate the mecha...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30483
更新日期:2016-08-01 00:00:00
abstract::We study ultrafast ionization dynamics using orthogonally polarized two-color (OTC) laser pulses involving the resonant "first plus second" (ω + 2ω) scheme. The scheme is illustrated by numerical simulations of the time-dependent Schrödinger equation and recording the photoelectron momentum distribution. On the basis ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-57125-z
更新日期:2020-01-14 00:00:00
abstract::We study the change in magnetisation with paramagnetic Al addition in the CoFeNi0.5Cr0.5-Alx (x: 0, 0.5, 1, and 1.5) complex concentrated alloy. The compositions were developed utilising the Mulliken electronegativity and d-electron/atom ratio. Spherical FeCr rich nanoprecipitates are observed for X: 1.0 and 1.5 in an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71463-3
更新日期:2020-09-02 00:00:00
abstract::TiO2/graphene (TiO2-x/GR) composites, which are Ti(3+) self-doped TiO2 nanorods decorated on boron doped graphene sheets, were synthesized via a simple one-step hydrothermal method using low-cost NaBH4 as both a reducing agent and a boron dopant on graphene. The resulting TiO2 nanorods were about 200 nm in length with...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05493
更新日期:2014-06-30 00:00:00
abstract::The CRISPR/Cas9 system is widely used to generate gene-edited animals. Here, we developed an efficient system for generating genetically modified mice using maternal Cas9 from Cas9 transgenic mice. Using this system, we achieved lower mosaicism and higher rates of knock-in success, gene-editing, and birth compared to ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57996-7
更新日期:2020-01-23 00:00:00
abstract::Passive immunotherapy with monoclonal antibodies (mAbs) is an efficacious treatment for Ebola virus (EBOV) infections in animal models and humans. Understanding what constitutes a protective response is critical for the development of novel therapeutic strategies. We generated an EBOV-glycoprotein-pseudotyped Human im...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45552
更新日期:2017-03-30 00:00:00
abstract::Chronic kidney disease (CKD) patients have many affected physiological pathways. Variations in the genes regulating these pathways might affect the incidence and predisposition to this disease. A total of 722 Spanish adults, including 548 patients and 174 controls, were genotyped to better understand the effects of ge...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56695-2
更新日期:2020-01-10 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-59779-6
更新日期:2020-03-16 00:00:00
abstract::Studies of locomotor activity in Svalbard reindeer reported the temporary absence of diel rhythms under Arctic photic conditions. However, using Lomb-Scargle periodogram analyses with high statistical power we found diel or circadian rhythmicity throughout the entire year in measures of behaviour, temperature in the r...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32778-4
更新日期:2018-09-27 00:00:00
abstract::We investigated the dynamics of the interaction between spin-polarized photo-created carriers and Mn ions on InGaAs/GaAs: Mn structures. The carriers are confined in an InGaAs quantum well and the Mn ions come from a Mn delta-layer grown at the GaAs barrier close to the well. Even though the carriers and the Mn ions a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24537
更新日期:2016-04-15 00:00:00
abstract::Microalgal harvesting and dewatering are the main bottlenecks that need to be overcome to tap the potential of microalgae for production of valuable compounds. Water surface-floating microalgae form robust biofilms, float on the water surface along with gas bubbles entrapped under the biofilms, and have great potentia...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47612-8
更新日期:2019-08-01 00:00:00
abstract::Tunable metasurfaces have emerged as an efficient approach to manipulate the wave propagation. Different from previous work concentrating on electrically tunable mechanisms, here we demonstrate a magnetically tunable metasurface composed of ferrite rods and metallic foils. By tuning the thickness of ferrite rods, meta...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05625-1
更新日期:2017-07-14 00:00:00
abstract::Enoyl-acyl carrier protein reductase (ENR) catalyzes the last reduction step in the bacterial type II fatty acid biosynthesis cycle. ENRs include FabI, FabL, FabL2, FabK, and FabV. Previously, we reported a unique triclosan (TCL) resistant ENR homolog that was predominant in obligate intracellular pathogenic bacteria ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51895-2
更新日期:2019-10-28 00:00:00