Abstract：
:Sorafenib is a multikinase inhibitor used as a first-line treatment for advanced hepatocellular carcinoma (HCC), but it has shown modest to low response rates. The characteristic tumour hypoxia of advanced HCC maybe a major factor underlying hypoxia-mediated treatment failure. Thus, it is urgent to elucidate the mechanisms of hypoxia-mediated sorafenib resistance in HCC. In this study, we found that hypoxia induced the nuclear translocation of Yes associate-Protein (YAP) and the subsequent transactivation of target genes that promote cell survival and escape apoptosis, thereby leading to sorafenib resistance. Statins, the inhibitors of hydroxymethylglutaryl-CoA reductase, could ameliorate hypoxia-induced nuclear translocation of YAP and suppress mRNA levels of YAP target genes both in vivo and in vitro. Combined treatment of statins with sorafenib greatly rescued the loss of anti-proliferative effects of sorafenib under hypoxia and improved the inhibitory effects on HepG2 xenograft tumour growth, accompanied by enhanced apoptosis as evidenced by the increased sub-G1 population and PARP cleavage. The expression levels of YAP and its target genes were highly correlated with poor prognosis and predicted a high risk of HCC patients. These findings collectively suggest that statins utilization maybe a promising new strategy to counteract hypoxia-mediated resistance to sorafenib in HCC patients.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Zhou TY,Zhuang LH,Hu Y,Zhou YL,Lin WK,Wang DD,Wan ZQ,Chang LL,Chen Y,Ying MD,Chen ZB,Ye S,Lou JS,He QJ,Zhu H,Yang Bdoi
10.1038/srep30483subject
Has Abstractpub_date
2016-08-01 00:00:00pages
30483issn
2045-2322pii
srep30483journal_volume
6pub_type
杂志文章abstract：:Genomic selection (GS) by selecting lines prior to field phenotyping using genotyping data has the potential to enhance the rate of genetic gains. Genotype × environment (G × E) interaction inclusion in GS models can improve prediction accuracy hence aid in selection of lines across target environments. Phenotypic dat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30027-2
更新日期：2018-08-03 00:00:00
abstract：:The connection between structure and stability of ecological networks has been widely studied in the last fifty years. A challenge that scientists continue to face is that in-depth mathematical model analysis is often difficult, unless the considered systems are specifically constrained. This makes it challenging to g...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50373-z
更新日期：2019-10-01 00:00:00
abstract：:We organized a crowdsourcing experiment in the form of a snapshot sampling campaign to assess the spatial distribution of nitrogen solutes, namely, nitrate, ammonium and dissolved organic nitrogen (DON), in German surface waters. In particular, we investigated (i) whether crowdsourcing is a reasonable sampling method ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16503
更新日期：2015-11-12 00:00:00
abstract：:It is well known that the Gobi Desert is the dominant source area of the Badain Jaran Desert (BJD) and the Chinese Loess Plateau (CLP). However, due to the absence of quantitative analyses, there are nearly no exact assessments of its actual contribution. Combinations of field investigations, wind tunnel experiments, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37635-y
更新日期：2019-01-30 00:00:00
abstract：:The sinusoidal endothelial cells present in the liver (LSECs) are tipically characterized by the presence of pores (fenestrae). During some pathological conditions LSECs undergo "capillarization", a process characterized by loss of fenestrations and acquisition of a vascular phenotype. In chronic liver disease capilla...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-019-45114-1
更新日期：2019-06-19 00:00:00
abstract：:Cancer cells can have a broad scope of proliferation rates. Here we aim to identify the molecular mechanisms that allow some cancer cell lines to grow up to 4 times faster than other cell lines. The correlation of gene expression profiles with the growth rate in 60 different cell lines has been analyzed using several ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03041
更新日期：2013-10-24 00:00:00
abstract：:Ice-albedo feedback due to the albedo contrast between water and ice is a major factor in seasonal sea ice retreat, and has received increasing attention with the Arctic Ocean shifting to a seasonal ice cover. However, quantitative evaluation of such feedbacks is still insufficient. Here we provide quantitative eviden...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08467-z
更新日期：2017-08-15 00:00:00
abstract：:Anaerobic ammonium oxidation (anammox) bacteria significantly improve the efficiency and reduce cost of nitrogen removal in wastewater treatment plants. However, their slow growth and vulnerable activity limit the application of anammox technology. In this paper, the enhancement of biotin on the nitrogen removal activ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81738-y
更新日期：2021-01-21 00:00:00
abstract：:Previous studies highlight the winners and losers in fisheries under climate change based on shifts in biomass, species composition and potential catches. Understanding how climate change is likely to alter the fisheries revenues of maritime countries is a crucial next step towards the development of effective socio-e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32607
更新日期：2016-09-07 00:00:00
abstract：:The exopeptidases of family S46 are exceptional, as the closest homologs of these enzymes are the endopeptidases of clan PA. The three-dimensional structure of S46 enzymes is unknown and only one of the catalytic residues, the serine, has been identified. The catalytic histidine and aspartate residues are not experime...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04292
更新日期：2014-03-06 00:00:00
abstract：:Enhancers play a crucial role in gene regulation but the participation of enhancer transcripts (i.e. enhancer RNA, eRNAs) in regulatory systems remains unclear. We provide a computational analysis on eRNAs using genome-wide data across 12 mouse tissues. The expression of genes targeted by transcribing enhancer is posi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12648
更新日期：2015-07-29 00:00:00
abstract：:Functionalization of monoclonal antibodies (mAbs) requires chemical derivatization and/or genetic manipulation. Inherent in these methods are challenges with protein heterogeneity, stability and solubility. Such perturbations could potentially be avoided by using a high affinity, non-covalent intermediate to bridge th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07817
更新日期：2015-01-15 00:00:00
abstract：:We developed a novel integrated technology for diver-operated surveying of shallow marine ecosystems. The HyperDiver system captures rich multifaceted data in each transect: hyperspectral and color imagery, topographic profiles, incident irradiance and water chemistry at a rate of 15-30 m2 per minute. From surveys in ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07337-y
更新日期：2017-08-02 00:00:00
abstract：:Poor CD4+ T-cell recovery after cART has been associated with skewed T-cell maturation, inflammation and immunosenescence; however, T-cell functionality in those individuals has not been fully characterized. In the present study, we assessed T-cell function by assessing cytokine production after polyclonal, CMV and HI...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12013-2
更新日期：2017-09-15 00:00:00
abstract：:The functionalization of graphene remains an important challenge for numerous applications expected by this fascinating material. To keep advantageous properties of graphene after modification or functionalization of its structure, local approaches are a promising road. A novel technique is reported here that allows p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19719
更新日期：2016-01-29 00:00:00
abstract：:The applications of spin dynamos, which could potentially power complex nanoscopic devices, have so far been limited owing to their extremely low energy conversion efficiencies. Here, we present a unique plasmonic diabolo cavity (PDC) that dramatically improves the spin rectification signal (enhancement of more than t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05634-0
更新日期：2017-07-13 00:00:00
abstract：:Haemodynamic disorders are common clinical findings in hypertension and lead to adverse cardiovascular events. However, the haemodynamic conditions in hypertension models are poorly understood. This study aimed to observe the characteristics of haemodynamics in spontaneously hypertensive rats (SHRs) and antihypertensi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01906-x
更新日期：2017-05-17 00:00:00
abstract：:Laser radiation pressure is a basis of numerous applications in science and technology such as atom cooling, particle manipulation, material processing, etc. This light force for the case of scalar beams is proportional to the intensity-weighted wavevector known as optical current. The ability to design the optical cu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35341
更新日期：2016-10-13 00:00:00
abstract：:We aimed to investigate whether the newborns of mothers with maternal depression (MD) had lower vitamin D levels than newborns of non-MD (NMD) mothers and identify the potential mechanism underlying this association. Maternal depressive symptoms in late pregnancy and concentrations of cord blood 25 hydroxyvitamin D (2...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01778-1
更新日期：2017-05-08 00:00:00
abstract：:The International Institute of Tropical Agriculture maintains the world's largest collection of cowpea germplasm of over 15,000 accessions. A sub-set of 298 lines from the loosely composed mini core collection of 370 landraces were genotyped based on genotyping by sequencing (GBS). Ward's minimum variance hierarchical...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34555-9
更新日期：2018-10-30 00:00:00
abstract：:Triple-negative breast cancers (TNBC) are unlikely to respond to hormonal therapies and anti-HER2-targeted therapies. TNBCs overexpress EGFR and exhibit constitutive activation of the PI3K/AKT/mTOR signalling pathway. We hypothesized that simultaneously blocking EGFR and mTOR could be a potential therapeutic strategy ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63310-2
更新日期：2020-04-14 00:00:00
abstract：:Boolean multiplex (multilevel) networks (BMNs) are currently receiving considerable attention as theoretical arguments for modeling of biological systems and system level analysis. Studying control-related problems in BMNs may not only provide new views into the intrinsic control in complex biological systems, but als...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46495
更新日期：2017-04-28 00:00:00
abstract：:Childbearing women with rheumatoid (RA) and psoriatic arthritis (PsA) have significant peripartum issues. A retrospective anonymous RedCAP survey of peripartum period in females with RA/PsA in the RAPPORT registry was performed. Completed analyses included descriptive statistics, Chi-square and Fisher's exact test. 16...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60451-2
更新日期：2020-02-28 00:00:00
abstract：:In unpredictable environments in which reliable cues for predicting environmental variation are lacking, a diversifying bet-hedging strategy for diapause exit is expected to evolve, whereby only a portion of diapausing forms will resume development at the first occurrence of suitable conditions. This study focused on ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77727-2
更新日期：2020-12-07 00:00:00
abstract：:Macro- and micro-environmental factors modulate parasite loads in fish, determining parasitic abundances, diversity, and interaction dynamics. In this study, seasonal variations in larval ectoparasites on fish larvae in the northern Humboldt Current System (HCS) were evaluated using a delta-gamma generalized linear mo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79847-1
更新日期：2021-01-12 00:00:00
abstract：:Conventional spin-singlet Cooper pairs convert into spin-triplet pairs in ferromagnetic Josephson junctions in which the superconductor/ferromagnet interfaces (S/F) are magnetically inhomogeneous. Although much of the theoretical work describing this triplet proximity effect has considered ideal junctions with magneti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00699
更新日期：2012-01-01 00:00:00
abstract：:In this work, we apply homodyne detection to investigate the frequency-resolved photon statistics of a cw light field emitted by a driven-dissipative semiconductor system in real time. We demonstrate that studying the frequency dependence of the photon number noise allows us to distinguish intrinsic noise properties o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79686-0
更新日期：2020-12-29 00:00:00
abstract：:The Next-Generation Sequencing (NGS) platforms provide a major approach to obtaining millions of short reads from samples. NGS has been used in a wide range of analyses, such as for determining genome sequences, analyzing evolutionary processes, identifying gene expression and resolving metagenomic analyses. Usually, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48242-w
更新日期：2019-08-12 00:00:00
abstract：:The live attenuated yellow fever (YF) vaccine is a highly effective human vaccine and induces long-term protective neutralizing antibodies directed against the viral envelope protein E. The generation of such antibodies requires the help of CD4 T cells which recognize peptides derived from proteins in virus particles ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09331-w
更新日期：2017-08-21 00:00:00
abstract：:Analysis of volatile organic compounds (VOCs) is a promising approach for non-invasive, fast and potentially inexpensive diagnostics. Here, we present a new methodology for profiling the body chemistry by using the volatile fraction of molecules in various body fluids. Using mass spectrometry and cross-reactive nanoma...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04611
更新日期：2014-04-09 00:00:00
