Production of genetically engineered mice with higher efficiency, lower mosaicism, and multiplexing capability using maternally expressed Cas9.

abstract：:Intrasynovial tendon injuries are among the most challenging in orthopedics. Despite significant improvements in operative and rehabilitation methods, functional outcomes continue to be limited by adhesions, gap formation, and rupture. Adhesions result from excessive inflammation, whereas tendon gapping and rupture re...

journal_title：Scientific reports

authors： Shen H,Jayaram R,Yoneda S,Linderman SW,Sakiyama-Elbert SE,Xia Y,Gelberman RH,Thomopoulos S

更新日期：2018-07-23 00:00:00

abstract：:MCM7, a subunit of mini-chromosome maintenance proteins (MCM) complex, plays an important role in initiating DNA replication during the G1 phase and extending DNA strands during the S phase. Here, we demonstrated that MCM7 is not only sustained but maintains association with chromatin during M phase. Remarkably, MCM7 ...

journal_title：Scientific reports

authors： Zheng D,Ye S,Wang X,Zhang Y,Yan D,Cai X,Gao W,Shan H,Gao Y,Chen J,Hu Z,Li H,Li J

更新日期：2017-06-06 00:00:00

abstract：:Occlusion of the middle cerebral artery (MCA) by an intraluminal filament is widely used to study focal brain ischemia in male Sprague-Dawley rats. However, permanent occlusion goes along with a high fatality. To overcome this drawback we designed a new filament carrying a bowling pin-shaped tip (BP-tip) and compared ...

journal_title：Scientific reports

authors： Shanbhag NC,Henning RH,Schilling L

更新日期：2016-06-22 00:00:00

abstract：:By moving the alkoxy group on the spacer from position 5 to position 4 to add another protocol for the algorithm for intermolecular and intramolecular hydrogen bonding interactions, highly regioselectivity of noncovalent synthesis of the hydrazide-based cyclic hexamers was achieved: one out of thirteen possible isomer...

journal_title：Scientific reports

authors： Yang Y,Huang F,Chen CF,Xia M,Cai Q,Qian FJ,Xiang J

更新日期：2013-01-01 00:00:00

abstract：:In spite of much work on topological insulators (TIs), systematic experiments for TI/TI heterostructures remain absent. We grow a high quality heterostructure containing single quintuple layer (QL) of Bi2Se3 on 19 QLs of Bi2Te3 and compare its transport properties with 20 QLs Bi2Se3 and 20 QLs Bi2Te3. All three films ...

journal_title：Scientific reports

authors： Zhao Y,Chang CZ,Jiang Y,DaSilva A,Sun Y,Wang H,Xing Y,Wang Y,He K,Ma X,Xue QK,Wang J

更新日期：2013-10-28 00:00:00

abstract：:The correlations between early responses and the variations in physical density and primary tumor volume (TV) according to cone-beam computed tomography (CBCT) during chemoradiotherapy for non-small cell lung cancer (NSCLC) patients were investigated. 54 patients with inoperable and locally advanced NSCLC were include...

journal_title：Scientific reports

authors： Wen Q,Zhu J,Meng X,Ma C,Bai T,Sun X,Yu J

更新日期：2017-11-07 00:00:00

abstract：:Cell therapy using intramuscular injections of autologous bone-marrow mononuclear cells (BM-MNCs) improves clinical symptoms and can prevent limb amputation in atherosclerotic peripheral arterial disease (PAD) patients with critical limb ischemia (CLI). The purpose of this study was to evaluate the effects of the numb...

journal_title：Scientific reports

authors： Yusoff FM,Kajikawa M,Takaeko Y,Kishimoto S,Hashimoto H,Maruhashi T,Nakashima A,Wahid SFSA,Higashi Y

更新日期：2020-11-16 00:00:00

abstract：:Measurement of intracranial aneurysm wall motion may refine the current rupture risk estimation. A golden standard for measuring aneurysm pulsation is lacking. The aim is to evaluate magnitudes of aneurysm pulsation as published in current literature. Embase and PubMed were searched for publications containing quantit...

journal_title：Scientific reports

authors： Stam LB,Aquarius R,de Jong GA,Slump CH,Meijer FJA,Boogaarts HD

更新日期：2021-01-26 00:00:00

abstract：:In optical modulation, the highest available modulation rate is basically limited to the GHz frequency range at best. This is because optical modulation is often performed using electro-optic or acousto-optic effects that require application of an external signal to solid-state nonlinear optical materials. Here we des...

journal_title：Scientific reports

authors： Zaitsu S,Izaki H,Tsuchiya T,Imasaka T

更新日期：2016-02-18 00:00:00

abstract：:We use satellite gravity measurements in the Gravity Recovery and Climate Experiment (GRACE) to estimate terrestrial water storage (TWS) change in the continental United States (US) from 2003 to 2012, and establish a GRACE-based Hydrological Drought Index (GHDI) for drought monitoring. GRACE-inferred TWS exhibits oppo...

journal_title：Scientific reports

authors： Yi H,Wen L

更新日期：2016-01-27 00:00:00

abstract：:The 'brain regionalization genes' Six3/6, Otx, Pax2/5/8, Gbx, and Hox1 are expressed in a similar fashion in the deuterostome, ecdysozoan, and the cephalopod brain, questioning whether this holds also true for the remaining Mollusca. We investigated developmental Gbx-expression in representatives of both molluscan sis...

journal_title：Scientific reports

authors： Wollesen T,Scherholz M,Rodríguez Monje SV,Redl E,Todt C,Wanninger A

更新日期：2017-07-14 00:00:00

abstract：:Antimicrobial peptides (AMP) are highly conserved immune effectors across the tree of life and are employed as combinations. In the beetle Tenebrio molitor, a defensin and a coleoptericin are highly expressed in vivo after inoculation with S. aureus. The defensin displays strong in vitro activity but no survival benef...

journal_title：Scientific reports

authors： Makarova O,Johnston P,Rodriguez-Rojas A,El Shazely B,Morales JM,Rolff J

更新日期：2018-10-18 00:00:00

abstract：:The number of patients with dry eye disease (DED) is increasing, and DED has become an urgent public health problem. A comorbidity of mental disorders has been reported in DED patients. We hypothesized that physical and psychological stressors impair tear secretion. To examine the relationship between stress loading a...

journal_title：Scientific reports

authors： Sano K,Kawashima M,Imada T,Suzuki T,Nakamura S,Mimura M,Tanaka KF,Tsubota K

更新日期：2019-03-04 00:00:00

abstract：:The d-band center model of Hammer and Nørskov is widely used in understanding and predicting catalytic activity on transition metal (TM) surfaces. Here, we demonstrate that this model is inadequate for capturing the complete catalytic activity of the magnetically polarized TM surfaces and propose its generalization. W...

journal_title：Scientific reports

authors： Bhattacharjee S,Waghmare UV,Lee SC

更新日期：2016-11-03 00:00:00

abstract：:Rapid changes observed today in mountain glaciers need to be put into a longer-term context to understand global sea-level contributions, regional climate-glacier systems and local landscape evolution. In this study we determined volume changes for 400 mountain glaciers across the Southern Alps, New Zealand for three ...

journal_title：Scientific reports

authors： Carrivick JL,James WHM,Grimes M,Sutherland JL,Lorrey AM

更新日期：2020-08-07 00:00:00

abstract：:CEST-MRI of the rNOE signal has been demonstrated in vitro to be closely linked to the protein conformational state. As the detectability of denaturation and aggregation processes on a physiologically relevant scale in living organisms has yet to be verified, the aim of this study was to perform heat-shock experiments...

journal_title：Scientific reports

authors： Kleimaier D,Goerke S,Nies C,Zaiss M,Kunz P,Bachert P,Ladd ME,Gottwald E,Schad LR

更新日期：2020-07-06 00:00:00

abstract：:Archaeologically defined Upper Palaeolithic (UP, 45,000-10,000 years ago) "cultures" are often used as proxies to designate fossil populations. While recent genomic studies have partly clarified the complex relationship between European UP "cultures" and past population dynamics, they leave open numerous questions reg...

journal_title：Scientific reports

authors： Mounier A,Heuzé Y,Samsel M,Vasilyev S,Klaric L,Villotte S

更新日期：2020-12-14 00:00:00

abstract：:Tinnitus (phantom auditory perception associated with hearing loss) can seriously affect wellbeing. Its neural substrate is unknown however it has been linked with abnormal activity in auditory pathways. Though no cure currently exists, repetitive transcranial magnetic stimulation (rTMS) has been shown to reduce tinni...

journal_title：Scientific reports

authors： Mulders WH,Vooys V,Makowiecki K,Tang AD,Rodger J

更新日期：2016-12-01 00:00:00

abstract：:Recent data suggest that tumor laterality and mucinous histology may be clinically relevant. We investigated how both variables impact on the prognosis and the response to therapies in a large population-based cohort of cancer patients. Incidence data, clinical and pathological features, and outcome were systematicall...

journal_title：Scientific reports

authors： Negri F,De Giorgi A,Gilli A,Azzoni C,Bottarelli L,Gnetti L,Goldoni M,Manotti L,Sgargi P,Michiara M,Leonardi F,Rindi G,Cascinu S,Silini EM

更新日期：2019-03-06 00:00:00

abstract：:With land privatization and fencing of thousands of hectares of communal grazing areas, East Africa is struggling with one of the most radical cultural and environmental changes in its history. The 668,500-hectare Greater Mara is of crucial importance for the great migrations of large mammals and for Maasai pastoralis...

journal_title：Scientific reports

authors： Løvschal M,Bøcher PK,Pilgaard J,Amoke I,Odingo A,Thuo A,Svenning JC

更新日期：2017-01-25 00:00:00

abstract：:Nowadays, increasing awareness of environment and fossil fuels protection stimulates intensive research on clean and renewable sources of energy. Production of hydrogen from water through solar-driven splitting reactions is one of the most promising approaches in the field of photoelectrochemistry (PEC). In this work ...

journal_title：Scientific reports

authors： Zare M,Solaymani S,Shafiekhani A,Kulesza S,Ţălu Ş,Bramowicz M

更新日期：2018-07-18 00:00:00

abstract：:Prolonged tomato consumption can mitigate ultraviolet (UV) light induced sunburn via unknown mechanisms. Dietary carotenoids distributed to skin are hypothesized to protect skin against UV-induced damage, although other phytochemicals may play a role. We hypothesize that tomato consumption would protect against skin c...

journal_title：Scientific reports

authors： Cooperstone JL,Tober KL,Riedl KM,Teegarden MD,Cichon MJ,Francis DM,Schwartz SJ,Oberyszyn TM

更新日期：2017-07-11 00:00:00

abstract：:An important property of spin-torque nano-oscillators (STNOs) is their ability to produce a frequency modulated (FM) signal, which is very critical for communication applications. We here demonstrate a novel single sideband (SSB) modulation phenomenon using a magnetic tunnel junction (MTJ)-based STNO, which saves tran...

journal_title：Scientific reports

authors： Sharma R,Sisodia N,Iacocca E,Awad AA,Åkerman J,Muduli PK

更新日期：2017-10-18 00:00:00

abstract：:Atropine eye drops and myopic retinal defocus each slow progression of myopia (short-sight). They also cause thickening of the choroid, and it has been suggested that the thickening is a precursor for reduced eye growth and slowed myopia progression. We investigated whether choroidal thickening due to optical defocus ...

journal_title：Scientific reports

authors： Chiang ST,Turnbull PRK,Phillips JR

更新日期：2020-10-27 00:00:00

abstract：:This study provides a pore-scale investigation of two-phase flow dynamics during primary drainage in a realistic heterogeneous rock sample. Using the lattice Boltzmann (LB) method, a series of three-dimensional (3D) immiscible displacement simulations are conducted and three typical flow patterns are identified and ma...

journal_title：Scientific reports

authors： Bakhshian S,Hosseini SA,Shokri N

更新日期：2019-03-04 00:00:00

abstract：:Combining strong magnetic anisotropy with strong exchange interaction is a long standing goal in the design of quantum magnets. The lanthanide complexes, while exhibiting a very strong ionic anisotropy, usually display a weak exchange coupling, amounting to only a few wavenumbers. Recently, an isostructural series of ...

journal_title：Scientific reports

authors： Vieru V,Iwahara N,Ungur L,Chibotaru LF

更新日期：2016-04-18 00:00:00

abstract：:We have studied in-situ cleaved (0001) surfaces of the magnetic Weyl semimetal Mn3Sn by low-temperature scanning tunneling microscopy and spectroscopy (STM/S). It was found that freshly cleaved Mn3Sn surfaces are covered with unknown clusters, and the application of voltage pulses in the tunneling condition was needed...

journal_title：Scientific reports

authors： Yang HH,Lee CC,Yoshida Y,Ikhlas M,Tomita T,Nugroho A,Ozaki T,Nakatsuji S,Hasegawa Y

更新日期：2019-07-04 00:00:00

abstract：:In this study, dye-sensitized solar cells (DSSCs) has been assembled with poly(1-vinylpyrrolidone-co-vinyl acetate) (P(VP-co-VAc)) gel polymer electrolytes (GPEs) which have been incorporated with binary salt and an ionic liquid. The potential of this combination was studied and reported. The binary salt system GPEs w...

journal_title：Scientific reports

authors： Ming NH,Ramesh S,Ramesh K

更新日期：2016-06-08 00:00:00

abstract：:Understanding the human cytotoxic T lymphocyte (CTL) biology is crucial to develop novel strategies aiming at maximizing their lytic capacity against cancer cells. Here we introduce an agent-based model, calibrated on population-scale experimental data that allows quantifying human CTL per capita killing. Our model hi...

journal_title：Scientific reports

authors： Khazen R,Müller S,Lafouresse F,Valitutti S,Cussat-Blanc S

更新日期：2019-08-23 00:00:00

abstract：:Predicting the risk of liver metastasis can have important prognostic and therapeutic implications, given the availability of liver-directed therapy. Uveal melanoma has a striking predisposition for liver metastasis despite the absence of anatomical proximity. Understanding its biology may uncover factors promoting li...

journal_title：Scientific reports

authors： Tsantoulis P,Delorenzi M,Bièche I,Vacher S,Mariani P,Cassoux N,Houy A,Stern MH,Roman-Roman S,Dietrich PY,Roth A,Cacheux W

更新日期：2019-11-20 00:00:00