Abstract：
:Recent data suggest that tumor laterality and mucinous histology may be clinically relevant. We investigated how both variables impact on the prognosis and the response to therapies in a large population-based cohort of cancer patients. Incidence data, clinical and pathological features, and outcome were systematically collected from the Tumor Registry of Parma over the years 2004-2009. Survival data were modeled by multivariable analysis. 1358 patients affected by stage I-IV colon cancer were considered; 661 (49%) had right-sided and 697 (51%) left-sided tumors. 144 (11%) had mucinous (MAC) and 1214 (89%) non-mucinous (NMAC) histology. MACs and NMACs of the right colon showed no difference in stage distribution, whereas left colon MACs were more frequently in an advanced stage (stage IV) (p = 0.008). Stage IV right colon tumors had a poorer overall survival than stage IV left-sided colon cancers (75th percentile 20 vs 34 months, p < 0.001). At relapse, MACs were less responsive to systemic therapy and had worse survival compared with NMACs regardless of tumor side (7.1 vs 13.1 months, p = 0.018). Right-sided colon cancers had poorer survival compared to left-sided tumors; the effect was mainly attributable to NMACs. At relapse, MACs had unfavorable prognosis regardless of the primary tumor-side.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Negri F,De Giorgi A,Gilli A,Azzoni C,Bottarelli L,Gnetti L,Goldoni M,Manotti L,Sgargi P,Michiara M,Leonardi F,Rindi G,Cascinu S,Silini EMdoi
10.1038/s41598-019-40096-6subject
Has Abstractpub_date
2019-03-06 00:00:00pages
3668issue
1issn
2045-2322pii
10.1038/s41598-019-40096-6journal_volume
9pub_type
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