Long-term survival in permanent middle cerebral artery occlusion: a model of malignant stroke in rats.

abstract：:Breast cancer (BC) has a higher incidence in young Lebanese woman as compared to the West. We assessed the microRNA (miRNA) microarray profile of tissues derived from Lebanese patients with early BC and performed mRNA-miRNA integration analysis. 173 miRNAs were significantly dysregulated in 45 BC versus 17 normal adja...

journal_title：Scientific reports

authors： Nassar FJ,Talhouk R,Zgheib NK,Tfayli A,El Sabban M,El Saghir NS,Boulos F,Jabbour MN,Chalala C,Boustany RM,Kadara H,Zhang Z,Zheng Y,Joyce B,Hou L,Bazarbachi A,Calin G,Nasr R

更新日期：2017-12-04 00:00:00

abstract：:The dynamics of cell wall polysaccharides may modulate the cell wall mechanics and thus control the expansion growth of plant cells. The unique composition of type II primary cell wall characteristic of grasses suggests that they employ specific mechanisms for cell enlargement. We characterized the transcriptomes in f...

journal_title：Scientific reports

authors： Kozlova LV,Nazipova AR,Gorshkov OV,Petrova AA,Gorshkova TA

更新日期：2020-07-02 00:00:00

abstract：:Prostate cancer is the most commonly diagnosed cancer in men with African American men disproportionally suffering from the burden of this disease. Biomarkers that could discriminate indolent from aggressive and drug resistance disease are lacking. MicroRNAs are small non-coding RNAs that affect numerous physiological...

journal_title：Scientific reports

authors： Cagle P,Niture S,Srivastava A,Ramalinga M,Aqeel R,Rios-Colon L,Chimeh U,Suy S,Collins SP,Dahiya R,Kumar D

更新日期：2019-07-05 00:00:00

abstract：:Conditional genome engineering in the human malaria pathogen Plasmodium falciparum remains highly challenging. Here we describe a strategy for facile and rapid functional analysis of genes using an approach based on the Cre/lox system and tailored for organisms with short and few introns. Our method allows the conditi...

journal_title：Scientific reports

authors： Jones ML,Das S,Belda H,Collins CR,Blackman MJ,Treeck M

更新日期：2016-02-19 00:00:00

abstract：:Autism spectrum disorder involves persistent difficulties in social communication. Although these difficulties affect both verbal and nonverbal communication, there are no quantitative behavioral studies to date investigating the cross-modal coordination of verbal and nonverbal communication in autism. The objective o...

journal_title：Scientific reports

authors： Sorensen T,Zane E,Feng T,Narayanan S,Grossman R

更新日期：2019-12-04 00:00:00

abstract：:Excessive retention of neutral lipids in cardiac lipid droplets (LDs) is a common observation in cardiomyopathy. Thus, the systematic investigation of the cardiac LD proteome will help to dissect the underlying mechanisms linking cardiac steatosis and myocardial dysfunction. Here, after isolation of LDs from normal an...

journal_title：Scientific reports

authors： Li L,Zhang H,Wang W,Hong Y,Wang J,Zhang S,Xu S,Shu Q,Li J,Yang F,Zheng M,Qian Z,Liu P

更新日期：2016-01-22 00:00:00

abstract：:Tau is a Microtubule-associated protein that induces and stabilizes the formation of the Microtubule cytoskeleton and plays an important role in neurodegenerative diseases. The Microtubules binding region of Tau has been determined for a long time but where and how Tau binds to its partner still remain a topic of deba...

journal_title：Scientific reports

authors： Martinho M,Allegro D,Huvent I,Chabaud C,Etienne E,Kovacic H,Guigliarelli B,Peyrot V,Landrieu I,Belle V,Barbier P

更新日期：2018-09-14 00:00:00

abstract：:An intensified and continuous West Nile virus (WNV) spread across northern Italy has been observed since 2008, which caused more than one hundred reported human infections until 2016. Veneto is one of the Italian regions where WNV is considered endemic, and the greatest intensity of circulation was observed during 201...

journal_title：Scientific reports

authors： Marini G,Rosà R,Pugliese A,Rizzoli A,Rizzo C,Russo F,Montarsi F,Capelli G

更新日期：2018-09-18 00:00:00

abstract：:To explore the pathologies of Kashin-Beck disease (KBD) and KBD accompanied with dental fluorosis (DF), we conducted a comparative analysis of gene expression profiles. 12 subjects were recruited, including 4 KBD patients, 4 patients with KBD and DF and 4 healthy subjects. Genome-wide expression profiles from their pe...

journal_title：Scientific reports

authors： Zhang Q,Ma J,Liu H,He D,Chen L,Wu H,Jiang H,Lu Q,Bai S

更新日期：2018-01-09 00:00:00

abstract：:Atherosclerotic arteries exhibit characteristic constrictions and substantial deviations from cylindrical shape. Therefore, determining the artery's cross-section along the centerline is challenging, although high-resolution isotropic three-dimensional data are available. Herein, we apply high-resolution computed tomo...

journal_title：Scientific reports

authors： Buscema M,Hieber SE,Schulz G,Deyhle H,Hipp A,Beckmann F,Lobrinus JA,Saxer T,Müller B

更新日期：2019-10-04 00:00:00

abstract：:Chemical conjugation is commonly used to enhance the pharmacokinetics, biodistribution, and potency of protein therapeutics, but often leads to non-specific modification or loss of bioactivity. Here, we present a simple, versatile and widely applicable method that allows exquisite N-terminal specific modification of p...

journal_title：Scientific reports

authors： Sur S,Qiao Y,Fries A,O'Meally RN,Cole RN,Kinzler KW,Vogelstein B,Zhou S

更新日期：2015-12-17 00:00:00

abstract：:The importance of microbial natural products has been widely demonstrated in the search for new antibiotics. However, the functional role of microbial metabolites in nature remains to be deciphered. Several natural products are known to mediate microbial interactions through metabolic exchange. One approach to investi...

journal_title：Scientific reports

authors： Caraballo-Rodríguez AM,Dorrestein PC,Pupo MT

更新日期：2017-07-14 00:00:00

abstract：:Cancer vaccines are less effective at old than at young age because of immunosenescence. Besides, in preliminary observations we showed that the immunization with HER-2/neu DNA plasmid in transgenic young mice (standard immunization, SI) delays but not abrogate spontaneous mammary tumours progressively appearing durin...

journal_title：Scientific reports

authors： Provinciali M,Barucca A,Orlando F,Pierpaoli E

更新日期：2017-06-08 00:00:00

abstract：:The dispersion of organic N-benzyl-2-methyl-4-nitroaniline (BNA) in nematic liquid crystals (LCs) is studied. BNA doping decreases the threshold voltage of cell because of the reduced splay elastic constant and increased dielectric anisotropy of the LC mixture. When operated in the high voltage difference condition, t...

journal_title：Scientific reports

authors： Selvaraj P,Subramani K,Srinivasan B,Hsu CJ,Huang CY

更新日期：2020-08-31 00:00:00

abstract：:Periodontal (gum) disease is a highly prevalent infection and inflammation accounting for the majority of tooth loss in adult population worldwide. Porphyromonas gingivalis is a keystone periodontal pathogen and its lipopolysaccharide (PgLPS) acts as a major virulence attribute to the disease. Herein, we deciphered th...

journal_title：Scientific reports

authors： Herath TDK,Darveau RP,Seneviratne CJ,Wang CY,Wang Y,Jin L

更新日期：2016-08-19 00:00:00

abstract：:We have recently reported that repeated systemic treatments of extract from Corydalis yanhusuo alleviate neuropathic pain and levo-tetrahydropalmatine (l-THP) is one of active components from Corydalis. We designed this study to investigate antinociceptive effect of l-THP in acute and chronic pain models and related m...

journal_title：Scientific reports

authors： Kang DW,Moon JY,Choi JG,Kang SY,Ryu Y,Park JB,Lee JH,Kim HW

更新日期：2016-12-02 00:00:00

abstract：:Self-cleaving ribozymes fold into intricate structures, which orient active site groups into catalytically competent conformations. Most ribozyme families have distinct catalytic cores stabilized by tertiary interactions between domains peripheral to those cores. We show that large hepatitis delta virus (HDV)-like rib...

journal_title：Scientific reports

authors： Webb CH,Nguyen D,Myszka M,Lupták A

更新日期：2016-06-15 00:00:00

abstract：:Acetylcholine binding proteins (AChBPs) are unique spatial homologs of the ligand-binding domains of nicotinic acetylcholine receptors (nAChRs), and they reproduce some pharmacological properties of nAChRs. X-ray crystal structures of AСhBP in complex with α-conotoxins provide important insights into the interactions ...

journal_title：Scientific reports

authors： Lin B,Xu M,Zhu X,Wu Y,Liu X,Zhangsun D,Hu Y,Xiang SH,Kasheverov IE,Tsetlin VI,Wang X,Luo S

更新日期：2016-03-01 00:00:00

abstract：:Monoclonal antibodies (mAbs) are attractive therapeutics for treating a wide range of human disorders, and bind to the antigen through their complementarity-determining regions (CDRs). Small stable proteins containing structurally retained CDRs are promising alternatives to mAbs. In this report, we present a method to...

journal_title：Scientific reports

authors： Kadonosono T,Yimchuen W,Ota Y,See K,Furuta T,Shiozawa T,Kitazawa M,Goto Y,Patil A,Kuchimaru T,Kizaka-Kondoh S

更新日期：2020-01-21 00:00:00

abstract：:Storage of solar radiation is currently accomplished by coupling two separate devices, one that captures and converts the energy into an electrical impulse (a photovoltaic cell) and another that stores this electrical output (a battery or a supercapacitor electrochemical cell). This configuration however has several c...

journal_title：Scientific reports

authors： Arora Y,Battu S,Haram S,Khushalani D

更新日期：2018-08-24 00:00:00

abstract：:In the present work, the mechanisms involved in the recently reported antiviral activity of zebrafish C-reactive protein-like protein (CRP1-7) against the spring viraemia of carp rhabdovirus (SVCV) in fish are explored. The results neither indicate blocking of the attachment or the binding step of the viral replicatio...

journal_title：Scientific reports

authors： Bello-Perez M,Pereiro P,Coll J,Novoa B,Perez L,Falco A

更新日期：2020-01-17 00:00:00

abstract：:The anti-diabetic biguanide drugs metformin (METF) and phenformin (PHEN) may have anti-cancer effects. Biguanides suppress plasma growth factors, but nonetheless, the view that these mitochondrial inhibitors accumulate in tumor tissue to an extent that leads to severe energetic stress or alleviation of hypoxia-induced...

journal_title：Scientific reports

authors： Iversen AB,Horsman MR,Jakobsen S,Jensen JB,Garm C,Jessen N,Breining P,Frøkiær J,Busk M

更新日期：2017-08-25 00:00:00

abstract：:Therapies that target the signal transduction and metabolic pathways of cancer stem cells (CSCs) are innovative strategies to effectively reduce the recurrence and significantly improve the outcome of glioblastoma multiforme (GBM). CSCs exhibit an increased rate of glycolysis, thus rendering them intrinsically more se...

journal_title：Scientific reports

authors： Daniele S,Giacomelli C,Zappelli E,Granchi C,Trincavelli ML,Minutolo F,Martini C

更新日期：2015-10-23 00:00:00

abstract：:By applying a slow curing process, we show that biomolecules can be incorporated via a simple process as liquid stable phases inside a polydimethylsiloxane (PDMS) matrix. The process is carried out under mild conditions with regards to temperature, pH and relative humidity, and is thus suitable for application to biol...

journal_title：Scientific reports

authors： Faccio G,Cont A,Mailand E,Zare-Eelanjegh E,Innocenti Malini R,Maniura-Weber K,Rossi RM,Spano F

更新日期：2019-11-26 00:00:00

abstract：:Flexible energy storage devices are highly demanded for various applications. Carbon cloth (CC) woven by carbon fibers (CFs) is typically used as electrode or current collector for flexible devices. The low surface area of CC and the presence of big gaps (ca. micro-size) between individual CFs lead to poor performance...

journal_title：Scientific reports

authors： Zou Y,Wang S

更新日期：2015-07-07 00:00:00

abstract：:Hexagonal Fe(3)Sn has many of the desirable properties for a new permanent magnet phase with a Curie temperature of 725 K, a saturation moment of 1.18 MA/m. and anisotropy energy, K1 of 1.8 MJ/m(3). However, contrary to earlier experimental reports, we found both experimentally and theoretically that the easy magnetic...

journal_title：Scientific reports

authors： Sales BC,Saparov B,McGuire MA,Singh DJ,Parker DS

更新日期：2014-11-12 00:00:00

abstract：:It has been contended that any observed difference of the corpus callosum (CC) size between men and women is not sex-related but brain-size-related. A recent report, however, showed that the midsagittal CC area was significantly larger in women in 37 brain-size-matched pairs of normal young adults. Since this constitu...

journal_title：Scientific reports

authors： Shiino A,Chen YW,Tanigaki K,Yamada A,Vigers P,Watanabe T,Tooyama I,Akiguchi I

更新日期：2017-01-03 00:00:00

abstract：:This corrects the article DOI: 10.1038/srep44797. ...

journal_title：Scientific reports

authors： Paci P,Colombo T,Fiscon G,Gurtner A,Pavesi G,Farina L

更新日期：2017-06-16 00:00:00

abstract：:We report the phonon and magnetic properties of various well-stabilized Co3O4 nanoparticles. The net valence in cobalt (II)/(III) cation can be obtained by subtracting the Co2+ ions in tetrahedral interstices and Co3+ ions in the octahedral interstices, respectively, which will possess spatial inhomogeneity of its mag...

journal_title：Scientific reports

authors： Gawali SR,Gandhi AC,Gaikwad SS,Pant J,Chan TS,Cheng CL,Ma YR,Wu SY

更新日期：2018-01-10 00:00:00

abstract：:Shoulder problems are common in patients with a cervical herniated intervertebral disc (HIVD). This study aimed to explore the incidence and risk of shoulder capsulitis/tendonitis following cervical HIVD surgery. We used data from the Taiwan "Longitudinal Health Insurance Database". We identified all patients who were...

journal_title：Scientific reports

authors： Kang JH,Lin HC,Tsai MC,Chung SD

更新日期：2016-05-27 00:00:00