Abstract:
:By applying a slow curing process, we show that biomolecules can be incorporated via a simple process as liquid stable phases inside a polydimethylsiloxane (PDMS) matrix. The process is carried out under mild conditions with regards to temperature, pH and relative humidity, and is thus suitable for application to biological entities. Fluorescence and enzymatic activity measurements show that the biochemical properties of the proteins and enzyme tested are preserved, without loss due to adsorption at the liquid-polymer interface. Protected from external stimuli by the PDMS matrix, these soft liquid composite materials are new tools of interest for robotics, microfluidics, diagnostics and chemical microreactors.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Faccio G,Cont A,Mailand E,Zare-Eelanjegh E,Innocenti Malini R,Maniura-Weber K,Rossi RM,Spano Fdoi
10.1038/s41598-019-54155-5subject
Has Abstractpub_date
2019-11-26 00:00:00pages
17575issue
1issn
2045-2322pii
10.1038/s41598-019-54155-5journal_volume
9pub_type
杂志文章abstract::We determined the prevalence of hyposalivation and xerostomia in older Mexicans (≥60 years), and its relationship with diverse factors. A cross-sectional study was realized in elderly subjects from Pachuca, Mexico. Chewing-stimulated saliva was collected under standardized conditions and salivary flow was measured; su...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40686
更新日期:2017-01-17 00:00:00
abstract::We report a three dimensional (3D) quantitative visualization of a mammalian mitochondrion by coherent x-ray diffractive imaging (CXDI) using synchrotron radiation. The internal structures of a mitochondrion from a mouse embryonic fibroblast cell line (NIH3T3) were visualized by tomographic imaging at approximately 60...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01833-x
更新日期:2017-05-12 00:00:00
abstract::Long daylength artificial light exposure associates with disorders, and a potential physiological mechanism has been proposed. However, previous studies have examined no more than three artificial light treatments and limited metabolic parameters, which have been insufficient to demonstrate mechanical responses. Here,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24808
更新日期:2016-04-21 00:00:00
abstract::The observation and analysis of dendritic spines morphological changes poses a major challenge in neuroscience studies. The alterations of their density and/or morphology are indicators of the cellular processes involved in neural plasticity underlying learning and memory, and are symptomatic in neuropsychiatric disor...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21753-8
更新日期:2018-02-23 00:00:00
abstract::The study of factors influencing animal intake can provide a better understanding of the dynamics of the pasture ecosystem and serve as a basis for managing livestock in a more efficient way. We measured different sward surface heights of tall fescue in the process of short-term intake rate of sheep. There was a signi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68827-0
更新日期:2020-07-16 00:00:00
abstract::Angiogenesis is one of the hallmarks of cancer and, as such, one of the alternative general targets for anticancer therapy. Since angiogenesis is a complex process involving a high number of interconnected components, a network approach would be a convenient systemic way to analyse responses to directed drug attacks. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00061
更新日期:2011-01-01 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-42749-y
更新日期:2019-04-19 00:00:00
abstract::Interleukin-10 (IL-10) plays a central role in regulation of intestinal mucosal homeostasis and prevention of inflammatory bowel disease (IBD). We previously reported that CD11b(hi) regulatory dendritic cells (DCs) can produce more IL-10, and CD11b can negatively regulate Toll-like receptors (TLRs)-induced inflammator...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26252
更新日期:2016-05-18 00:00:00
abstract::Previous research has shown that exposure to volatile anesthetics can induce acute neuroinflammation and neuroapoptopsis in neonatal rodents and that these events can lead to cognitive dysfunction at later stages. Isoflurane and sevoflurane are two of the most popular anesthetics used in the field of pediatrics. Howev...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76147-6
更新日期:2020-11-09 00:00:00
abstract::IncX4 plasmids are associated with the dissemination of the mcr-1 genes in Enterobacteriaceae. We screened IncX4 plasmids among 2,470 isolates of Enterobacteriaceae and determined the mcr-1 positive isolates. Forty-three isolates were observed to carry IncX4 type plasmid, among which 13 were identified to carry mcr-1 ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00095-x
更新日期:2017-03-24 00:00:00
abstract::We developed an optimized Dipheylthiocarbazone or Dithizone (DTZ) with improved physical and chemical properties to characterize human islets and insulin-producing cells differentiated from embryonic stem cells. Application of the newly formulated iDTZ (i stands for islet) over a range of temperatures, time intervals ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45678-y
更新日期:2019-06-26 00:00:00
abstract::Some studies have reported that upper limb tightness is a risk factor for shoulder/elbow pain in high school baseball pitchers; but there has been insufficient research on the relationship between lower limb tightness and shoulder and elbow pain in pitchers. This study aimed to clarify the correlation among pre-season...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76894-6
更新日期:2020-11-17 00:00:00
abstract::Maize is rapidly replacing traditionally cultivated dual purpose crops of South Asia, primarily due to the better economic remuneration. This has created an impetus for improving maize for both grain productivity and stover traits. Molecular techniques can largely assist breeders in determining approaches for effectiv...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80118-2
更新日期:2021-01-12 00:00:00
abstract::Negative hemodynamic response has been widely reported in blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging studies, however its origin is still controversial. Optical intrinsic signal (OIS) imaging can be used to study brain activity by simultaneously recording hemodynamic signals at diff...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21627
更新日期:2016-02-10 00:00:00
abstract::We design a soft infrared metamaterial absorber based on gold nanorods dispersed in liquid crystal (LC) placed on a gold film and theoretically investigate its total absorption character. Because the nanorods align with the LC molecule, the gold nanorods/LC hybrid exhibits different permittivity as a function of tilt ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16698
更新日期:2015-11-18 00:00:00
abstract::An investigation was carried out to assess the effect of the P content on the microstructure and mechanical properties of ZCuPb20Sn5 alloy. Alloys of various compositions, (0.05, 0.1, 0.2, 0.3, 0.5% wt.% P) were melted in a melting furnace under 1200 °C and cast into metal mould, the hardness, strength and elongation ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49441-1
更新日期:2019-09-16 00:00:00
abstract::Solar thermal energy conversion has attracted substantial renewed interest due to its applications in industrial heating, air conditioning, and electricity generation. Achieving stagnation temperatures exceeding 200 °C, pertinent to these technologies, with unconcentrated sunlight requires spectrally selective absorbe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05235-x
更新日期:2017-07-13 00:00:00
abstract::Optical measurement of membrane potentials enables fast, direct and simultaneous detection of membrane potentials from a population of neurons, providing a desirable approach for functional analysis of neuronal circuits. Here, we applied recently developed genetically encoded voltage indicators, ASAP1 (Accelerated Sen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23906-1
更新日期:2018-04-16 00:00:00
abstract::Bovine milk is vital for infant nutrition and is a major component of the human diet. Bovine mastitis is a common inflammatory disease of mammary gland in cattle. It alters the immune profile of the animal and lowers the quality and yield of milk causing huge economic losses to dairy industry. The incidence of sub-cli...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66211-6
更新日期:2020-06-09 00:00:00
abstract::Exotic pattern formation as a result of drying of an aqueous solution containing DNA and silica nanoparticles is reported. The pattern due to segregation was found to critically depend on the relative ratio of nanoparticles and DNA, as revealed by polarization microscopy, scanning electron microscopy, and fluorescence...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03660
更新日期:2014-01-13 00:00:00
abstract::Angulin-2/ILDR1 is a member of the angulin protein family, which is exclusively expressed at tricellular tight junctions in epithelia. Tricellular tight junctions are found where three cells meet and where three bicellular tight junction strands converge. Tricellular tight junctions are thought to be important for par...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67319-5
更新日期:2020-06-25 00:00:00
abstract::The fundamental mechanism how heterogeneous hepatic macrophage (Mφ) subsets fulfill diverse functions in health and disease has not been elucidated. We recently reported that CCR9+ inflammatory Mφs play a critical role in the course of acute liver injury. To clarify the origin and differentiation of CCR9+Mφs, we used ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35146
更新日期:2016-10-11 00:00:00
abstract::An intractable challenge in glaucoma treatment has been to identify druggable targets within the conventional aqueous humor outflow pathway, which is thought to be regulated/dysregulated by elusive mechanosensitive protein(s). Here, biochemical and functional analyses localized the putative mechanosensitive cation cha...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30583
更新日期:2016-08-11 00:00:00
abstract::Muscle wasting and atrophy are regulated by multiple molecular processes, including mRNA processing. Reduced levels of the polyadenylation binding protein nucleus 1 (PABPN1), a multifactorial regulator of mRNA processing, cause muscle atrophy. A proteomic study in muscles with reduced PABPN1 levels suggested dysregula...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74676-8
更新日期:2020-10-19 00:00:00
abstract::Significant technical and optical advances are required for intraoperative optical coherence tomography (OCT) to be utilized during otological surgeries. Integrating OCT with surgical microscopy makes it possible to evaluate soft tissue in real-time and at a high resolution. Herein, we describe an augmented-reality, i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35563-5
更新日期:2018-11-27 00:00:00
abstract::Memristive systems have gained considerable attention in the field of neuromorphic engineering, because they allow the emulation of synaptic functionality in solid state nano-physical systems. In this study, we show that memristive behavior provides a broad working framework for the phenomenological modelling of cellu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27616-6
更新日期:2018-06-19 00:00:00
abstract::Elymus nutans is an herbaceous plant that can be used to restore degraded alpine and subalpine ecosystems. Here, we evaluated how sowing density affects soil reinforcement and slope stabilization properties of vegetation-concrete structures. To investigate the optimal sowing density of E. nutans in vegetation-concrete...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77407-1
更新日期:2020-11-24 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-60514-4
更新日期:2020-02-19 00:00:00
abstract::A growing body of research suggests that impaired bladder Cajal-like interstitial cells (ICCs) are a important component in the pathogenesis of diabetes-induced bladder dysfunction, although the molecular mechanisms have not been illustrated completely. The purpose of this study was to examine whether the hyperpolariz...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24844
更新日期:2016-04-28 00:00:00
abstract::Rheumatoid Arthritis (RA) is a chronic inflammatory disorder where incidence and severity of myocardial infarction are increased. Data on the incidence and outcome of stroke are conflicting. Thus, we investigated outcome after Ischemia/Reperfusion (I/R) brain injury in a mouse model of RA and assessed for the role of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-38670-z
更新日期:2019-02-18 00:00:00