Complete inclusion of bioactive molecules and particles in polydimethylsiloxane: a straightforward process under mild conditions.

Abstract:

:By applying a slow curing process, we show that biomolecules can be incorporated via a simple process as liquid stable phases inside a polydimethylsiloxane (PDMS) matrix. The process is carried out under mild conditions with regards to temperature, pH and relative humidity, and is thus suitable for application to biological entities. Fluorescence and enzymatic activity measurements show that the biochemical properties of the proteins and enzyme tested are preserved, without loss due to adsorption at the liquid-polymer interface. Protected from external stimuli by the PDMS matrix, these soft liquid composite materials are new tools of interest for robotics, microfluidics, diagnostics and chemical microreactors.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Faccio G,Cont A,Mailand E,Zare-Eelanjegh E,Innocenti Malini R,Maniura-Weber K,Rossi RM,Spano F

doi

10.1038/s41598-019-54155-5

subject

Has Abstract

pub_date

2019-11-26 00:00:00

pages

17575

issue

1

issn

2045-2322

pii

10.1038/s41598-019-54155-5

journal_volume

9

pub_type

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