Abstract:
:Therapies that target the signal transduction and metabolic pathways of cancer stem cells (CSCs) are innovative strategies to effectively reduce the recurrence and significantly improve the outcome of glioblastoma multiforme (GBM). CSCs exhibit an increased rate of glycolysis, thus rendering them intrinsically more sensitive to prospective therapeutic strategies based on the inhibition of the glycolytic pathway. The enzyme lactate dehydrogenase-A (LDH-A), which catalyses the interconversion of pyruvate and lactate, is up-regulated in human cancers, including GBM. Although several papers have explored the benefits of targeting cancer metabolism in GBM, the effects of direct LDH-A inhibition in glial tumours have not yet been investigated, particularly in the stem cell subpopulation. Here, two representative LDH-A inhibitors (NHI-1 and NHI-2) were studied in GBM-derived CSCs and compared to differentiated tumour cells. LDH-A inhibition was particularly effective in CSCs isolated from different GBM cell lines, where the two compounds blocked CSC formation and elicited long-lasting effects by triggering both apoptosis and cellular differentiation. These data demonstrate that GBM, particularly the stem cell subpopulation, is sensitive to glycolytic inhibition and shed light on the therapeutic potential of LDH-A inhibitors in this tumour type.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Daniele S,Giacomelli C,Zappelli E,Granchi C,Trincavelli ML,Minutolo F,Martini Cdoi
10.1038/srep15556subject
Has Abstractpub_date
2015-10-23 00:00:00pages
15556issn
2045-2322pii
srep15556journal_volume
5pub_type
杂志文章abstract::Accurate placement of a coordinate system on the radius is important to quantitatively report 3D surgical planning parameters or joint kinematics using 4D imaging techniques. In clinical practice, the scanned length of the radial shaft varies among scanning protocols and scientific studies. The error in positioning a ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65060-7
更新日期:2020-05-15 00:00:00
abstract::Traditionally, dynamic atomic force microscopy (AFM) techniques are based on the analysis of the quasi-steady state response of the cantilever deflection in terms of Fourier analysis. Here we describe a technique that instead exploits the often disregarded transient response of the cantilever through a relatively mode...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49104-1
更新日期:2019-09-03 00:00:00
abstract::This study aimed to identify single nucleotide polymorphisms (SNPs) associated with milk cholesterol (CHL) content via a genome wide association study (GWAS). Milk CHL content was determined by gas chromatography and expressed as mg of CHL in 100 g of fat (CHL_fat) or in 100 mg of milk (CHL_milk). GWAS was performed w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31427-0
更新日期:2018-09-05 00:00:00
abstract::ZnO/SiC heterojunctions show great potential for various optoelectronic applications (e.g., ultraviolet light emitting diodes, photodetectors, and solar cells). However, the lack of a detailed understanding of the ZnO/SiC interface prevents an efficient and rapid optimization of these devices. Here, intrinsic (but inh...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23106
更新日期:2016-03-15 00:00:00
abstract::The live attenuated yellow fever (YF) vaccine is a highly effective human vaccine and induces long-term protective neutralizing antibodies directed against the viral envelope protein E. The generation of such antibodies requires the help of CD4 T cells which recognize peptides derived from proteins in virus particles ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09331-w
更新日期:2017-08-21 00:00:00
abstract::Keloid is the abnormal wound healing puzzled by the aggressive growth and high recurrence rate due to its unrevealed key pathogenic mechanism. MicroRNAs contribute to a series of biological processes including epithelial-mesenchymal transition (EMT) and cells stemness involved in fibrotic disease. Here, using microRNA...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28281
更新日期:2016-09-06 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-46782-9
更新日期:2019-07-24 00:00:00
abstract::Due to the potentially detrimental consequences of low performance in basic functional tasks, individuals are expected to improve performance with age and show the most marked changes during early stages of life. Soaring-gliding birds use rising-air columns (thermals) to reduce energy expenditure allocated to flight. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27865
更新日期:2016-06-13 00:00:00
abstract::Chitin is a valuable peat substrate amendment by increasing lettuce growth and reducing the survival of the zoonotic pathogen Salmonella enterica on lettuce leaves. The production of chitin-catabolic enzymes (chitinases) play a crucial role and are mediated through the microbial community. A higher abundance of plant-...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46106-x
更新日期:2019-07-09 00:00:00
abstract::Mesenchymal stem cells (MSC) are osteoblasts progenitors and a variety of studies suggest that they may play an important role for the health in the field of bone regeneration. Magnesium supplementation is gaining importance as adjuvant treatment to improve osteogenesis, although the mechanisms involving this process ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08379-y
更新日期:2017-08-10 00:00:00
abstract::The determinants of Xpert MTB/RIF sensitivity, a widely used PCR test for the diagnosis of tuberculosis (TB) are poorly understood. We compared culture time-to-positivity (TTP; a surrogate of bacterial load), MTB/RIF TB-specific and internal positive control (IPC)-specific C(T) values, and clinical characteristics in ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05658
更新日期:2014-07-11 00:00:00
abstract::In the last few years, significant changes in climate have had a disparate effect on biodiversity. The influences of these changes are random and unpredictable. The resurgence of insect pests, especially of medical and veterinary importance, often corresponds with climate changes. The Old World screwworm, Chrysomya be...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61962-8
更新日期:2020-03-18 00:00:00
abstract::Silicon, the workhorse of semiconductor industry, is being exploited for various functional applications in numerous fields of nanotechnology. In this paper, we report the fabrication of depth controllable amorphous silicon (a-Si) layers under 80 keV Ar+ ion sputtering at off-normal ion incidences of 30°, 40° and 50° ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68873-8
更新日期:2020-07-17 00:00:00
abstract::Oral submucous fibrosis (OSF), regarded as a precancerous condition, is characterized by juxta-epithelial inflammatory reaction followed by fibro-elastic change in the lamina properia and epithelial atrophy. The pathologic mechanisms of OSF still need to be further clarified. In the study, we investigated the function...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37004
更新日期:2016-11-15 00:00:00
abstract::Danggui Buxue Tang (DBT) is a classic Chinese herbal formula which consists of Astragali mongholici Radix and Angelica sinensis Radix (ASR). For chemical ingredients, HPLC were performed. Results showed compared with single herbs, DBT decoction could promote the dissolution of ingredients such as ferulic acid and caly...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45111
更新日期:2017-03-22 00:00:00
abstract::We developed a spongy-like porous polymer (spongy monolith) consisting of poly(ethylene-co-glycidyl methacrylate) with continuous macropores that allowed efficient in situ reaction between the epoxy groups and proteins of interest. Immobilization of protein A on the spongy monolith enabled high-yield collection of imm...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00264-y
更新日期:2017-03-14 00:00:00
abstract::Micro- and nanoscale surface textures, when optimally designed, present a unique approach to improve surface functionalities. Coupling surface texture with shape memory polymers may generate reversibly tuneable surface properties. A shape memory polyetherurethane is used to prepare various surface textures including 2...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23686
更新日期:2016-03-30 00:00:00
abstract::Finding overlapping communities of complex networks remains a challenge in network science. To address this challenge, one of the widely used approaches is finding the communities of links by optimizing the objective function, partition density. In this study, we show that partition density suffers from inverse resolu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12432-1
更新日期:2017-09-29 00:00:00
abstract::ATP depletion and succinate accumulation during ischemia lead to oxidative damage to mammalian organs upon reperfusion. In contrast, freshwater turtles survive weeks of anoxia at low temperatures without suffering from oxidative damage upon reoxygenation, but the mechanisms are unclear. To determine how turtles surviv...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39836-5
更新日期:2019-02-26 00:00:00
abstract::P130CAS/BCAR1 belongs to the CAS family of adaptor proteins, with important regulatory roles in cell migration, cell cycle control, and apoptosis. Previously, we and others showed that P130CAS mediates VEGF-A and PDGF signalling in vitro, but its cardiovascular function in vivo remains relatively unexplored. We charac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71753-w
更新日期:2020-09-24 00:00:00
abstract::Myodural bridges have been described in various species as connective tissue structures "bridging" small cranio-cervical muscles to the dura. Myodural bridges are thought to stabilize the dural sac during head and neck movements and promote cerebrospinal fluid motion; however, their role in neurological diseases has n...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46444-w
更新日期:2019-07-10 00:00:00
abstract::Bacterial artificial chromosomes (BACs) offer a means of manipulating gene expression and tagging gene products in the mammalian genome without the need to alter endogenous gene structure and risk deleterious phenotypic consequences. However, for a BAC clone to be useful for such purposes it must be shown to contain a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35458-5
更新日期:2018-11-23 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-42948-7
更新日期:2019-05-02 00:00:00
abstract::Ecosystem functions are regulated by compositional and functional traits of bacterial communities, shaped by stochastic and deterministic processes. Biogeographical studies have revealed microbial community taxonomy in a given ecosystem to change alongside varying environmental characteristics. Considering that stable...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40315-0
更新日期:2019-03-06 00:00:00
abstract::Metal nitrides have been proposed to replace noble metals in plasmonics for some specific applications. In particular, while titanium nitride (TiN) and zirconium nitride (ZrN) possess localized plasmon resonances very similar to gold in magnitude and wavelength, they benefit from a much higher sustainability to temper...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38647
更新日期:2016-12-09 00:00:00
abstract::Infection of humans with Chlamydia trachomatis, a bacterial pathogen with a unique intracellular replication cycle, may cause a variety of clinical manifestations. These are linked to various serovars of the pathogen; trachoma to serovars A-C, oculogenital infections to serovars D-K, and lymphogranuloma venereum to se...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54886-5
更新日期:2019-12-04 00:00:00
abstract::An orb web's prey capture thread relies on its glue droplets to retain insects until a spider can subdue them. Each droplet's viscoelastic glycoprotein adhesive core extends to dissipate the forces of prey struggle as it transfers force to stiffer, support line flagelliform fibers. In large orb webs, switchback captur...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56707-1
更新日期:2019-12-30 00:00:00
abstract::Numerous studies have investigated the association between eosinophilia and clinical outcome of patients with chronic obstructive pulmonary disease (COPD) but the evidence is conflicting. We conducted a pooled analysis of outcome measures comparing eosinophilic and non-eosinophilic COPD patients. We searched articles ...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-017-13745-x
更新日期:2017-10-18 00:00:00
abstract::Tyrosinase efficiently catalyzes the ortho-hydroxylation of monophenols and the oxidation of diphenols without any additional cofactors. Although it is of significant interest for the biosynthesis of catechol derivatives, the rapid catechol oxidase activity and inactivation of tyrosinase have hampered its practical ut...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17635-0
更新日期:2017-12-08 00:00:00
abstract::Currently, the arguments have existed in the strengthening mechanism and microstructural model of the nanocomposite film due to lack of the convincible experimental evidences. In this investigation, the quarternary TiSiCN nanocomposite films with the different C and Si contents are synthesized by the reactive-magnetro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02186-1
更新日期:2017-05-18 00:00:00