Genome wide association study identifies novel potential candidate genes for bovine milk cholesterol content.

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Weckmann K,Diefenthäler P,Baeken MW,Yusifli K,Turck CW,Asara JM,Behl C,Hajieva P

更新日期：2018-08-10 00:00:00

abstract：:There is a growing interest in developing microphysiological systems that can be used to model both normal and pathological human organs in vitro. This "organs-on-chips" approach aims to capture key structural and physiological characteristics of the target tissue. Here we describe in vitro vascularized microtumors (V...

journal_title：Scientific reports

authors： Sobrino A,Phan DT,Datta R,Wang X,Hachey SJ,Romero-López M,Gratton E,Lee AP,George SC,Hughes CC

更新日期：2016-08-23 00:00:00

abstract：:The human brain has evolved specialised mechanisms to enable the rapid detection of threat cues, including emotional face expressions (e.g., fear and anger). However, contextual cues - such as gaze direction - influence the ability to recognise emotional expressions. For instance, anger paired with direct gaze, and fe...

journal_title：Scientific reports

authors： Caruana N,Inkley C,Zein ME,Seymour K

更新日期：2019-11-07 00:00:00

abstract：:Gram-positive bacteria homeostasis and antibiotic resistance mechanisms are dependent on the intricate architecture of the cell wall, where amidated peptidoglycan plays an important role. The amidation reaction is carried out by the bi-enzymatic complex MurT-GatD, for which biochemical and structural information is ve...

journal_title：Scientific reports

authors： Leisico F,V Vieira D,Figueiredo TA,Silva M,Cabrita EJ,Sobral RG,Ludovice AM,Trincão J,Romão MJ,de Lencastre H,Santos-Silva T

更新日期：2018-03-28 00:00:00

abstract：:Bisphenol A (BPA) is widely used in the manufacture of plastics and epoxy resins and is prevalent in the aquatic environment. BPA disrupts endocrine pathways in fish, but the long-term developmental implications are unknown. We demonstrate that BPA deposition in the eggs of rainbow trout (Oncorhynchus mykiss), an ecol...

journal_title：Scientific reports

authors： Sadoul B,Birceanu O,Aluru N,Thomas JK,Vijayan MM

更新日期：2017-10-26 00:00:00

abstract：:The use of O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) as a positron emission tomography (PET) tracer for brain tumor imaging might have some limitations because of the relatively low affinity for the L-type amino acid transporter 1 (LAT1). To assess the stereospecificity and evaluate the influence of aromatic ring m...

journal_title：Scientific reports

authors： Verhoeven J,Hulpia F,Kersemans K,Bolcaen J,De Lombaerde S,Goeman J,Descamps B,Hallaert G,Van den Broecke C,Deblaere K,Vanhove C,Van der Eycken J,Van Calenbergh S,Goethals I,De Vos F

更新日期：2019-02-27 00:00:00

abstract：:Dietary exposure of insects to a feeding deterrent substance for hours to days can induce habituation and concomitant desensitization of the response of peripheral gustatory neurons to such a substance. In the present study, larvae of the herbivore Helicoverpa armigera were fed on diets containing either a high, mediu...

journal_title：Scientific reports

authors： Ma Y,Li J,Tang Q,Zhang X,Zhao X,Yan F,van Loon JJ

更新日期：2016-12-14 00:00:00

abstract：:The use of fire played an important role in the social and technological development of the genus Homo. Most archaeologists agree that this was a multi-stage process, beginning with the exploitation of natural fires and ending with the ability to create fire from scratch. Some have argued that in the Middle Palaeolith...

journal_title：Scientific reports

authors： Brittingham A,Hren MT,Hartman G,Wilkinson KN,Mallol C,Gasparyan B,Adler DS

更新日期：2019-10-25 00:00:00

abstract：:We investigate whether the collapse of the quantum state of a single photon split between two space-like separated places takes a nonvanishing time. We realize this by using a source of heralded single photons, then splitting the resulting single photon state and letting it propagate over distances much larger than th...

journal_title：Scientific reports

authors： Garrisi F,Massara MP,Zambianchi A,Galli M,Bajoni D,Rimini A,Nicrosini O

更新日期：2019-08-15 00:00:00

abstract：:The Dirac materials, such as graphene and three-dimensional topological insulators, have attracted much attention because they exhibit novel quantum phenomena with their low energy electrons governed by the relativistic Dirac equations. One particular interest is to generate Dirac cone anisotropy so that the electrons...

journal_title：Scientific reports

authors： Feng Y,Wang Z,Chen C,Shi Y,Xie Z,Yi H,Liang A,He S,He J,Peng Y,Liu X,Liu Y,Zhao L,Liu G,Dong X,Zhang J,Chen C,Xu Z,Dai X,Fang Z,Zhou XJ

更新日期：2014-06-20 00:00:00

abstract：:Primordial germ cells (PGCs), the embryonic precursors of the sperm and egg, are used for the introduction of genetic modifications into avian genome. Introduction of small defined sequences using genome editing has not been demonstrated in bird species. Here, we compared oligonucleotide-mediated HDR using wild type S...

journal_title：Scientific reports

authors： Idoko-Akoh A,Taylor L,Sang HM,McGrew MJ

更新日期：2018-10-11 00:00:00

abstract：:This is the first study to demonstrate that colour transformations in the volume of a photochromic material (PM) are induced at the intersections of two control light channels, one controlling PM colouration and the other controlling decolouration. Thus, PM colouration is induced by position selectivity, and therefore...

journal_title：Scientific reports

authors： Hirayama R,Shiraki A,Naruse M,Nakamura S,Nakayama H,Kakue T,Shimobaba T,Ito T

更新日期：2016-08-16 00:00:00

abstract：:The trace addition of rare earth (RE) elements in Mg alloys can modify the extrusion texture, leading to the formation of RE texture and thus improved formability. The interrupted extrusion experiment as well as electron back-scatter diffraction (EBSD) characterization was conducted in Mg-1.5Zn-0.5Gd (wt.%) alloy to u...

journal_title：Scientific reports

authors： Jiang MG,Xu C,Yan H,Lu SH,Nakata T,Lao CS,Chen RS,Kamado S,Han EH

更新日期：2018-11-14 00:00:00

abstract：:Due to chromatic aberration, blue images are defocused when the eye is focused to the middle of the visible spectrum, yet we normally are not aware of chromatic blur. The eye suffers from monochromatic aberrations which degrade the optical quality of all images projected on the retina. The combination of monochromatic...

journal_title：Scientific reports

authors： Benedi-Garcia C,Vinas M,Dorronsoro C,Burns SA,Peli E,Marcos S

更新日期：2021-01-11 00:00:00

abstract：:Magnetic refrigeration is of great interest due to its high energy efficiency, environmental friendliness and low cost. However, undesired hysteresis losses, concentrated working temperature interval (WTI) and poor mechanical stability are vital drawbacks that hinder its practical application. Off-stoichiometric Ni-Mn...

journal_title：Scientific reports

authors： Qian M,Zhang X,Wei L,Martin P,Sun J,Geng L,Scott TB,Peng HX

更新日期：2018-11-08 00:00:00

abstract：:We summarized published data on the associations of apolipoprotein E (APOE) gene ε2/ε3/ε4 polymorphism with both cancer risk and circulating lipid profiles, aiming to examine the causal relevance between lipids and cancer risk. Article identification and data abstraction were conducted in duplicate and independently b...

journal_title：Scientific reports

authors： Yang C,Tian G,Mi J,Wei X,Li X,Li X,Wang W,Wang B

更新日期：2015-03-30 00:00:00

abstract：:The control of structural and chemical transitions in bimetallic nanoalloys at finite temperatures is one of the challenges for their use in advanced applications. Comparing Nested Sampling and Molecular Dynamics simulations, we investigate the phase changes of CuPt nanoalloys with the aim to elucidate the role of kin...

journal_title：Scientific reports

authors： Rossi K,Pártay LB,Csányi G,Baletto F

更新日期：2018-06-14 00:00:00

abstract：:Photoluminescence (PL) was used to estimate the concentration of carbon in GaN grown by hydride vapor phase epitaxy (HVPE). The PL data were compared with profiles of the impurities obtained from secondary ion mass spectrometry (SIMS) measurements. Comparison of PL and SIMS data has revealed that apparently high conce...

journal_title：Scientific reports

authors： Reshchikov MA,Vorobiov M,Andrieiev O,Ding K,Izyumskaya N,Avrutin V,Usikov A,Helava H,Makarov Y

更新日期：2020-02-10 00:00:00

abstract：:Currently, a comprehensive assessment between mitochondrial DNA (mtDNA) content and cancer risk is lacking. We designed this meta-analysis to test the hypothesis that altered mtDNA copy number might influence genetic susceptibility to some specific types of cancer. The processes of literature search, eligibility appra...

journal_title：Scientific reports

authors： Mi J,Tian G,Liu S,Li X,Ni T,Zhang L,Wang B

更新日期：2015-05-08 00:00:00

abstract：:The upper airway is a complex tissue structure that is prone to collapse. Current methods for studying airway obstruction are inadequate in safety, cost, or availability, such as CT or MRI, or only provide localized qualitative information such as flexible endoscopy. Long range optical coherence tomography (OCT) has b...

journal_title：Scientific reports

authors： Jing JC,Chou L,Su E,Wong BJF,Chen Z

更新日期：2016-12-19 00:00:00

abstract：:We demonstrate a novel route to achieving highly efficient and strongly confined spoof surface plasmon polaritons (SPPs) waveguides at subwavelength scale enabled by planar staggered plasmonic waveguides (PSPWs). The structure of these new waveguides consists of an ultrathin metallic strip with periodic subwavelength ...

journal_title：Scientific reports

authors： Ye L,Xiao Y,Liu Y,Zhang L,Cai G,Liu QH

更新日期：2016-12-05 00:00:00

abstract：:The identification of the most influential individuals in structured populations is an important research question, with many applications across the social and natural sciences. Here, we study this problem in evolutionary populations on static networks, where invading cheaters can lead to the collapse of cooperation....

journal_title：Scientific reports

authors： Yang G,Cavaliere M,Zhu C,Perc M

更新日期：2020-02-10 00:00:00

abstract：:To explore the pathologies of Kashin-Beck disease (KBD) and KBD accompanied with dental fluorosis (DF), we conducted a comparative analysis of gene expression profiles. 12 subjects were recruited, including 4 KBD patients, 4 patients with KBD and DF and 4 healthy subjects. Genome-wide expression profiles from their pe...

journal_title：Scientific reports

authors： Zhang Q,Ma J,Liu H,He D,Chen L,Wu H,Jiang H,Lu Q,Bai S

更新日期：2018-01-09 00:00:00

abstract：:Keloid is the abnormal wound healing puzzled by the aggressive growth and high recurrence rate due to its unrevealed key pathogenic mechanism. MicroRNAs contribute to a series of biological processes including epithelial-mesenchymal transition (EMT) and cells stemness involved in fibrotic disease. Here, using microRNA...

journal_title：Scientific reports

authors： Yan L,Cao R,Liu Y,Wang L,Pan B,Lv X,Jiao H,Zhuang Q,Sun X,Xiao R

更新日期：2016-09-06 00:00:00

abstract：:Novel glasses in a Ga2S3-Sb2S3-AgI system were prepared with a melt-quenching method, and their glass-forming region was identified. The maximum dissolvable AgI in glasses was 65 mol%. The thermal, optical, and structural properties of glasses were investigated as a function of AgI and Ga2S3 contents. The Ga2S3-Sb2S3-...

journal_title：Scientific reports

authors： Huang X,Jiao Q,Lin C,Ma H,Zhang X,Zhu E,Liu X,Dai S,Xu T

更新日期：2018-01-26 00:00:00

abstract：:The liver has a variety of functions for maintaining homeostasis, and hepatocytes play a major role. In contrast with the high regenerative capacity of mature hepatocytes (MHs) in vivo, they have not been successfully expanded ex vivo. Here we demonstrate that CD44-positive cells sorted from small hepatocyte (SH) colo...

journal_title：Scientific reports

authors： Ishii M,Kino J,Ichinohe N,Tanimizu N,Ninomiya T,Suzuki H,Mizuguchi T,Hirata K,Mitaka T

更新日期：2017-04-11 00:00:00

abstract：:Evidence showed preventive impacts of the highly active antiretroviral therapy (HAART) on the Human Immunodeficiency Virus (HIV) transmission amomg heterosexual population, however, that is of deficit among men who have sex with men (MSM). The aim was to systematically examine the efficacy of HAART on HIV transmission...

journal_title：Scientific reports

authors： Jiang Y,Su S,Borné Y

更新日期：2020-01-23 00:00:00

abstract：:Extracellular adenosine, generated via the concerted action of CD39 and CD73, contributes to T-cell differentiation and function. Adenosine concentrations are furthermore influenced by adenosine deaminase binding protein CD26. Because aberrant T-cell phenotypes had been reported in anti-neutrophil cytoplasmic auto-ant...

journal_title：Scientific reports

authors： Kling L,Benck U,Breedijk A,Leikeim L,Heitzmann M,Porubsky S,Krämer BK,Yard BA,Kälsch AI

更新日期：2017-09-15 00:00:00

abstract：:Adolescent idiopathic scoliosis (AIS) patients have been reported to be taller and more slender than normal controls, suggesting less mechanical stiffness of their trunk and spine. For assessment of mechanical stiffness, to our best knowledge this is the first to study height-width-depth relations at the level of the ...

journal_title：Scientific reports

authors： Chen H,Schlösser TPC,Brink RC,Colo D,van Stralen M,Shi L,Chu WCW,Heng PA,Castelein RM,Cheng JCY

更新日期：2017-04-18 00:00:00

abstract：:Flavonoids, theanine and caffeine are the main secondary metabolites of the tea plant (Camellia sinensis), which account for the tea's unique flavor quality and health benefits. The biosynthesis pathways of these metabolites have been extensively studied at the transcriptional level, but the regulatory mechanisms are ...

journal_title：Scientific reports

authors： Qiao D,Yang C,Chen J,Guo Y,Li Y,Niu S,Cao K,Chen Z

更新日期：2019-02-25 00:00:00