Abstract：
:The upper airway is a complex tissue structure that is prone to collapse. Current methods for studying airway obstruction are inadequate in safety, cost, or availability, such as CT or MRI, or only provide localized qualitative information such as flexible endoscopy. Long range optical coherence tomography (OCT) has been used to visualize the human airway in vivo, however the limited imaging range has prevented full delineation of the various shapes and sizes of the lumen. We present a new long range OCT system that integrates high speed imaging with a real-time position tracker to allow for the acquisition of an accurate 3D anatomical structure in vivo. The new system can achieve an imaging range of 30 mm at a frame rate of 200 Hz. The system is capable of generating a rapid and complete visualization and quantification of the airway, which can then be used in computational simulations to determine obstruction sites.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Jing JC,Chou L,Su E,Wong BJF,Chen Zdoi
10.1038/srep39443subject
Has Abstractpub_date
2016-12-19 00:00:00pages
39443issn
2045-2322pii
srep39443journal_volume
6pub_type
杂志文章abstract：:RT-qPCR offers high sensitivity, for accurate interpretations of qPCR results however, normalisation using suitable reference genes is fundamental. Androgens can regulate transcriptional expression including reference gene expression in prostate cancer. In this study, we evaluated ten mRNA and six non-protein coding R...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19458-z
更新日期：2018-01-31 00:00:00
abstract：:Changes in climate and atmospheric CO2 and nitrogen (N) over the last several decades have induced significant effects on forest carbon (C) cycling. However, contributions of individual factors are largely unknown because of the lack of long observational data and the undifferentiating between intrinsic factors and ex...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04461
更新日期：2014-03-25 00:00:00
abstract：:The prevalence of patients on automated peritoneal dialysis (APD) is increasing worldwide and may be guided by clinical characteristics, financial issues and patient option. Whether socioeconomic factors at the patient level may influence the decision for the initial peritoneal dialysis (PD) modality is unknown. This ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05544-1
更新日期：2017-07-12 00:00:00
abstract：:Autophagy is a lysosomal degradation pathway that plays an essential role in neuronal homeostasis and is perturbed in many neurological diseases. Transcriptional downregulation of fat was previously observed in a Drosophila model of the polyglutamine disease Dentatorubral-pallidoluysian atrophy (DRPLA) and this was sh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52684-7
更新日期：2019-11-06 00:00:00
abstract：:Graphene grown by high temperature molecular beam epitaxy on hexagonal boron nitride (hBN) forms continuous domains with dimensions of order 20 μm, and exhibits moiré patterns with large periodicities, up to ~30 nm, indicating that the layers are highly strained. Topological defects in the moiré patterns are observed ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22440
更新日期：2016-03-01 00:00:00
abstract：:Protein phosphorylation is an important type of post-translational modification that is involved in a variety of biological activities. Most phosphorylation events occur on serine, threonine and tyrosine residues in eukaryotes. In recent years, many phosphorylation sites have been identified as a result of advances in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24735
更新日期：2016-04-19 00:00:00
abstract：:We utilized size-tunable gold nanoparticles (Au NPs) to investigate the toxicogenomic responses of the model organism Caenorhabditis elegans. We demonstrated that the nematode C. elegans can uptake Au NPs coated with or without 11-mercaptoundecanoic acid (MUA), and Au NPs are detectable in worm intestines using X-ray ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33585-7
更新日期：2018-10-15 00:00:00
abstract：:The cancer stem cell (CSC) hypothesis proposes a hierarchical organization of tumors, in which stem-like cells sustain tumors and drive metastasis. The molecular mechanisms underlying the acquisition of CSCs and metastatic traits are not well understood. SOX9 is a transcription factor linked to stem cell maintenance a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32350
更新日期：2016-08-30 00:00:00
abstract：:One-carbon metabolism is essential for multiple cellular processes and can be assessed by the concentration of folate metabolites in the blood. One-carbon metabolites serve as methyl donors that are required for epigenetic regulation. Deficiencies in these metabolites are associated with a variety of poor health outco...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35111-1
更新日期：2018-11-15 00:00:00
abstract：:Endovascular sealing is a new technique for the repair of abdominal aortic aneurysms. Commercially available in Europe since 2013, it takes a revolutionary approach to aneurysm repair through minimally invasive techniques. Although aneurysm sealing may be thought as more stable than conventional endovascular stent gra...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17759-3
更新日期：2017-12-18 00:00:00
abstract：:Drug repositioning strategies have improved substantially in recent years. At present, two advances are poised to facilitate new strategies. First, the LINCS project can provide rich transcriptome data that reflect the responses of cells upon exposure to various drugs. Second, machine learning algorithms have been app...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07705-8
更新日期：2017-08-02 00:00:00
abstract：:The micro-mechanisms of brittle failure affect the bulk mechanical behaviour and permeability of crustal rocks. In low-porosity crystalline rocks, these mechanisms are related to mineralogy and fabric anisotropy, while confining pressure, temperature and strain rates regulate the transition from brittle to ductile beh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15523-1
更新日期：2017-11-10 00:00:00
abstract：:Social projection is the tendency to project one's own characteristics onto others. This phenomenon can potentially explain cooperation in prisoner's dilemma experiments and other social dilemmas. The social projection hypothesis has recently been formalized for symmetric games as co-action equilibrium and for general...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-19085-0
更新日期：2018-01-15 00:00:00
abstract：:Widespread economic growth in China has led to increasing episodes of severe air pollution, especially in major urban areas. Thermal power plants represent a particularly important class of emissions. Here we present an evaluation of the predicted effectiveness of a series of recently proposed thermal power plant emis...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19481-0
更新日期：2018-01-17 00:00:00
abstract：:As a noninvasive and "task-free" technique, resting-state functional magnetic resonance imaging (rs-fMRI) has been gradually applied to pre-surgical functional mapping. Independent component analysis (ICA)-based mapping has shown advantage, as no a priori information is required. We developed an automated method for i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14248-5
更新日期：2017-10-23 00:00:00
abstract：:Cancer cells accumulate somatic mutations as result of DNA damage, inaccurate repair and other mechanisms. Different genetic instability processes result in characteristic non-random patterns of DNA mutations, also known as mutational signatures. We developed mutSignatures, an integrated R-based computational framewor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75062-0
更新日期：2020-10-26 00:00:00
abstract：:We report on a highly efficient magneto-actuated cancer cell apoptosis method using a biaxial pulsed magnetic field configuration, which maximizes the induced magnetic torque. The light transmissivity dynamics show that the biaxial magnetic field configuration can actuate the magnetic nanoparticles with higher respons...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11279-w
更新日期：2017-09-07 00:00:00
abstract：:Mountain ecosystems serve as sentinels of change, and those in the Canadian Rocky Mountains have undergone a pronounced shift over the past century. We present quantitative analyses of 81 high-resolution image pairs of systematic historic surveys and repeat photographs of Canadian Rocky Mountain habitats, measuring tr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66277-2
更新日期：2020-06-16 00:00:00
abstract：:Online financial markets can be represented as complex systems where trading dynamics can be captured and characterized at different resolutions and time scales. In this work, we develop a methodology based on non-negative tensor factorization (NTF) aimed at extracting and revealing the multi-timescale trading dynamic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29537-w
更新日期：2018-07-25 00:00:00
abstract：:Although various function of chemerin have been suggested, its physiological role remains to be elucidated. Here we show that chemerin-deficient mice are glucose intolerant irrespective of exhibiting reduced macrophage accumulation in adipose tissue. The glucose intolerance was mainly due to increased hepatic glucose ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00123
更新日期：2011-01-01 00:00:00
abstract：:The understanding of the relationship between topology and behaviour in interconnected networks would allow to charac- terise and predict behaviour in many real complex networks since both are usually not simultaneously known. Most previous studies have focused on the relationship between topology and synchronisation....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22617
更新日期：2016-03-04 00:00:00
abstract：:Siglec-2 undergoes constitutive endocytosis and is a drug target for autoimmune diseases and B cell-derived malignancies, including hairy cell leukaemia, marginal zone lymphoma, chronic lymphocytic leukaemia and non-Hodgkin's lymphoma (NHL). An alternative to current antibody-based therapies is the use of liposomal na...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36012
更新日期：2016-11-03 00:00:00
abstract：:Among the range of complex interactions, especially at the interfaces of epitaxial oxide systems, contributing to the occurrence of intriguing effects, a predominant role is played by the local structural parameters. In this study, oxide molecular beam epitaxy grown lanthanum cuprate-based bilayers (consisting of a me...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00539-4
更新日期：2017-03-28 00:00:00
abstract：:HIV-1 Tat plays an important role in HIV-associated neurocognitive disorders (HAND) by disrupting neurotransmission including dopamine uptake by human dopamine transporter (hDAT). Previous studies have demonstrated that HIV-1 Tat directly binds to hDAT and some amino-acid mutations that attenuate the hDAT-Tat binding ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27314
更新日期：2016-06-02 00:00:00
abstract：:We propose and demonstrate a type of a broadband half-wave plate that operates in the reflective mode. It consists of a metal grating embedded in a dielectric slab and placed on top of a grounded metal surface. We theoretically show that owing to the optical feedback effect which originates from the wave reflections a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09561-y
更新日期：2017-08-22 00:00:00
abstract：:The nanoscale molecular assembly of mammalian viruses during their infectious life cycle remains poorly understood. Their small dimensions, generally bellow the 300nm diffraction limit of light microscopes, has limited most imaging studies to electron microscopy. The recent development of super-resolution (SR) light m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29132
更新日期：2016-07-04 00:00:00
abstract：:Melanoma is the most lethal cutaneous cancer. New drugs have recently appeared; however, not all patients obtain a benefit of these new drugs. For this reason, it is still necessary to characterize melanoma at molecular level. The aim of this study was to explore the molecular differences between melanoma tumor subtyp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43512-z
更新日期：2019-05-10 00:00:00
abstract：:Selective removal of lignin and other recalcitrant compounds, collectively registered as acid-unhyrolyzable residue (AUR), results in bleaching of leaf litter, but the importance of bleaching in decomposition processes on forest soil has not been fully evaluated. The aims of this study were to elucidate the occurrence...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81206-7
更新日期：2021-01-19 00:00:00
abstract：:Through a geomorphological study relying on statistically assessed classes of hilltop elevations, we reconstruct a suite of paleo-surfaces along the Tiber River Valley north of Rome that we identify as fluvial terraces formed by interplay between global sea-level fluctuations and regional upift. Using biostratigraphic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02437-1
更新日期：2017-05-31 00:00:00
abstract：:As a class, 'BET' inhibitors disrupt binding of bromodomain and extra-terminal motif (BET) proteins, BRD2, BRD3, BRD4 and BRDT, to acetylated histones preventing recruitment of RNA polymerase 2 to enhancers and promoters, especially super-enhancers, to inhibit gene transcription. As such, BET inhibitors may be useful ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46516-x
更新日期：2019-07-16 00:00:00
