Abstract:
:Extracellular adenosine, generated via the concerted action of CD39 and CD73, contributes to T-cell differentiation and function. Adenosine concentrations are furthermore influenced by adenosine deaminase binding protein CD26. Because aberrant T-cell phenotypes had been reported in anti-neutrophil cytoplasmic auto-antibody (ANCA)-associated vasculitis (AAV) patients, an impaired expression of these molecules on T-cells of AAV patients was hypothesized in the present study. While in AAV patients (n = 29) CD26 was increased on CD4+ lymphocytes, CD39 and CD73 were generally reduced on patients' T-cells. In CD4+ cells significant differences in CD73 expression were confined to memory CD45RA- cells, while in CD4- lymphocytes differences were significant in both naïve CD45RA+ and memory CD45RA- cells. The percentage of CD4-CD73+ cells correlated with micro-RNA (miR)-31 expression, a putative regulator of factor inhibiting hypoxia-inducible factor 1 alpha (FIH-1), inversely with serum C-reactive protein (CRP) and positively with estimated glomerular filtration rate (eGFR). No correlation with disease activity, duration, and ANCA profile was found. It remains to be assessed if a decreased CD73 and CD39 expression underlies functional impairment of lymphocytes in AAV patients. Likewise, the relations between frequencies of CD4-CD73+ cells and serum CRP or eGFR require further functional elucidation.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kling L,Benck U,Breedijk A,Leikeim L,Heitzmann M,Porubsky S,Krämer BK,Yard BA,Kälsch AIdoi
10.1038/s41598-017-12011-4subject
Has Abstractpub_date
2017-09-15 00:00:00pages
11683issue
1issn
2045-2322pii
10.1038/s41598-017-12011-4journal_volume
7pub_type
杂志文章abstract::Genotyping-by-sequencing (GBS) or restriction-site associated DNA marker sequencing (RAD-seq) is a practical and cost-effective method for analysing large genomes from high diversity species. This method of sequencing, coupled with methylation-sensitive enzymes (often referred to as methylation-sensitive restriction e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19655-w
更新日期:2018-02-01 00:00:00
abstract::High quality wafer-scale free-standing WS2 grown by van der Waals rheotaxy (vdWR) using Ni as a texture promoting layer is reported. The microstructure of vdWR grown WS2 was significantly modified from mixture of crystallites with their c-axes both parallel to (type I) and perpendicular to (type II) the substrate to l...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37833
更新日期:2016-11-29 00:00:00
abstract::The use of lithium (Li) metal anodes has been reconsidered because of the necessity for a higher energy density in secondary batteries. However, Li metal anodes suffer from 'dead' Li formation and surface deactivation which consequently form a porous layer of redundant Li aggregates. In this work, a fibrous metal felt...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30830
更新日期:2016-08-03 00:00:00
abstract::There remain parts of our planet that are seldom visited by humans, let alone scientists. In such locations, crowd-sourced or citizen scientist data can be critical in describing biodiversity and detecting change. Rangitāhua, the Kermadec Islands, are 750 km from the nearest human-habitation. Although our knowledge of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60136-w
更新日期:2020-02-21 00:00:00
abstract::Habitat loss is jeopardizing marine biodiversity. In the Mediterranean Sea, the algal forests of Cystoseira spp. form one of the most complex, productive and vulnerable shallow-water habitats. These forests are rapidly regressing with negative impact on the associated biodiversity, and potential consequences in terms ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76817-5
更新日期:2020-11-17 00:00:00
abstract::There is a global concern about the effects of climate change driven shifts in species phenology on crop pests. Using geographically and temporally extensive data set of moth trap catches and temperatures across the cotton growing states of India, we predicted the phenology of cotton pink bollworm Pectinophora gossypi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80184-6
更新日期:2021-01-11 00:00:00
abstract::The airways of individuals with cystic fibrosis (CF) are abundantly colonised by Staphylococcus aureus and Pseudomonas aeruginosa. Co-infecting hypoxic regions of static mucus within CF airways, together with decreases in pulmonary function, mucus plugging and oxygen consumption by host neutrophils gives rise to regio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42952-x
更新日期:2019-05-01 00:00:00
abstract::The linkage between oxidative stress and idiopathic chronic fatigue (ICF) has not been explored in detail. This study thoroughly compared the serum levels of biomarkers for oxidative stress and antioxidants from 103 subjects with ICF (20 men and 83 women) to those of 82 healthy volunteers (27 men and 55 women). Oxidat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31270-3
更新日期:2018-08-27 00:00:00
abstract::Luteinizing hormone (LH) is one of the main pituitary hormones that regulate ovulation, however its role has not been studied in giant panda. In this study, we developed an ELISA method for the detection of panda urinary LH. We analyzed urinary hormones of 24 female pandas during 36 breeding periods, we found females ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40749
更新日期:2017-01-16 00:00:00
abstract::By means of extensive ab initio calculations, a new two-dimensional (2D) atomic material tin selenide monolayer (coined as tinselenidene) is predicted to be a semiconductor with an indirect gap (~1.45 eV) and a high hole mobility (of order 10000 cm(2)V(-1)S(-1)), and will bear an indirect-direct gap transition under a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19830
更新日期:2016-02-01 00:00:00
abstract::The tricarboxylic acid cycle produces NADH for oxidative phosphorylation and fumarase [EC 4.2.1.2] is a critical enzyme in this cycle, catalysing the reversible conversion of fumarate and L-malate. Fumarase is applied to industrial L-malate production as a biocatalyst. L-malate is used in a wide range of industries su...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47025-7
更新日期:2019-07-23 00:00:00
abstract::To investigate the potential role of vitamin D (1,25(OH)2D3) in preventing the development of nasal polyps, we examined the effect of vitamin D on myofibroblast differentiation and extracellular matrix (ECM) production in TGF-β1-induced nasal polyp-derived fibroblasts (NPDFs) and elucidated the mechanisms underlying i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07561-6
更新日期:2017-08-04 00:00:00
abstract::Fibrin glue has been used clinically for decades in a wide variety of surgical specialties and is now being investigated as a medium for local, prolonged drug delivery. Effective local delivery of antibacterial substances is important perioperatively in patients with implanted medical devices or postoperatively for de...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38318-4
更新日期:2019-02-14 00:00:00
abstract::Metasurfaces, owing to their attractive features, provide a wide range of potential applications. Electromagnetic absorbers based on metasurfaces have significantly improved responses compared to the earlier absorbers made from composite materials. Active metasurfaces, in contrast to the passive designs, can exhibit m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28574-9
更新日期:2018-07-05 00:00:00
abstract::We developed a virus-like particle (VLP)-based therapeutic vaccine against angiotensin II receptor type 1, ATR-AP205-001, which could significantly reduce the blood pressure and protect target organs of hypertensive animals. In this study, we focused on the immunological effect and safety of the VLP-based vaccine. By ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12996-y
更新日期:2017-10-03 00:00:00
abstract::Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and fatal lung disease. This disease is characterized by an excessive accumulation of extracellular matrix deposition that modify normal lung physiology. Up to date, there are not efficient therapeutic tools to fight IPF. Glucagon-like peptide-1 receptor (...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74912-1
更新日期:2020-10-22 00:00:00
abstract::Cassava is one of the most important root crops as a reliable source of food and carbohydrates. Carbohydrate metabolism and starch accumulation in cassava storage root is a cascade process that includes large amounts of proteins and cofactors. Here, comparative proteomics were conducted in cassava root at nine develop...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19643
更新日期:2016-01-21 00:00:00
abstract::Amyloids are cross-β-sheet fibrillar aggregates, associated with various human diseases and native functions such as protein/peptide hormone storage inside secretory granules of neuroendocrine cells. In the current study, using amyloid detecting agents, we show that growth hormone (GH) could be stored as amyloid in th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23370
更新日期:2016-03-23 00:00:00
abstract::Breast tissue heterogeneity is related to risk factors that lead to more aggressive tumour growth and worse prognosis, yet such heterogeneity has not been well characterized. The aim of this study is to reveal the heterogeneous signal patterns of the apparent diffusion coefficient (ADC) of a tumour and its surrounding...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03122-z
更新日期:2017-06-06 00:00:00
abstract::Amyloid formation is associated with multiple amyloidosis diseases. Human calcitonin (hCT) is a typical amyloidogenic peptide, its aggregation is associated with medullary carcinoma of the thyroid (MTC), and also limits its clinical application. Magnolia officinalis is a traditional Chinese herbal medicine; its two ma...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13556
更新日期:2015-09-01 00:00:00
abstract::Every day we are exposed to different ideas, or memes, competing with each other for our attention. Previous research explained popularity and persistence heterogeneity of memes by assuming them in competition for limited attention resources, distributed in a heterogeneous social network. Little has been said about wh...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06477
更新日期:2014-09-26 00:00:00
abstract::Leaching of nitrate from fertilisers diminishes nitrogen use efficiency (the portion of nitrogen used by a plant) and is a major source of agricultural pollution. To improve nitrogen capture, grasses such as brachiaria are increasingly used, especially in South America and Africa, as a cover crop, either via intercrop...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61986-0
更新日期:2020-03-19 00:00:00
abstract::Reliable quantification of miRNA expression by qRT-PCR crucially depends on validated housekeepers for data normalization. Here we present thoroughly tested miRNAs eligible as references in immunological studies utilizing endothelial cells and macrophages, respectively. Endothelial cells (cell line: TIME) and macropha...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49241-7
更新日期:2019-09-04 00:00:00
abstract::A silica gel coated microsphere resonator is proposed and experimentally demonstrated for measurements of ammonia (NH3) concentration in air with ultra-high sensitivity. The optical properties of the porous silica gel layer change when it is exposed to low (parts per million (ppm)) and even ultra-low (parts per billio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20025-9
更新日期:2018-01-26 00:00:00
abstract::Thermal rectifiers whose forward heat fluxes are greater than reverse counterparts have been extensively studied. Here we have discovered, idealized, and derived the ultimate limit of such rectification ratios, which are partially validated by numerical simulations, experiments, and micro-scale Hamiltonian-oscillator ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12677
更新日期:2015-08-04 00:00:00
abstract::The Vacuole Membrane Protein 1 -VMP1- is a pancreatitis-associated transmembrane protein whose expression triggers autophagy in several human diseases. In the current study, we unveil the mechanism through which this protein induces autophagosome formation in mammalian cells. We show that VMP1 autophagy-related functi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01055
更新日期:2013-01-01 00:00:00
abstract::Particles manipulation with optical forces is known as optical tweezing. While tweezing in free space with laser beams was established in the 1980s, integrating the optical tweezers on a chip is a challenging task. Recent experiments with plasmonic nanoantennas, microring resonators, and photonic crystal nanocavities ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02290
更新日期:2013-01-01 00:00:00
abstract::The complexity of the frictional dynamics at the microscopic scale makes difficult to identify all of its controlling parameters. Indeed, experiments on sheared elastic bodies have shown that the static friction coefficient depends on loading conditions, the real area of contact along the interfaces and the confining ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06772
更新日期:2014-10-27 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-64342-4
更新日期:2020-05-08 00:00:00
abstract::Chloroquine (CQ) and hydroxychloroquine, are promising anti-inflammatory drugs for the treatment of Diabetes mellitus (DM) to prevent associated complications. Therefore, this study evaluated the anti-inflammatory effects of CQ-free and CQ-incorporated polylactic acid nanoparticles (NPs) in the peripheral blood mononu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69001-2
更新日期:2020-07-21 00:00:00