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Bisphenol A in eggs causes development-specific liver molecular reprogramming in two generations of rainbow trout.

Abstract：

:Bisphenol A (BPA) is widely used in the manufacture of plastics and epoxy resins and is prevalent in the aquatic environment. BPA disrupts endocrine pathways in fish, but the long-term developmental implications are unknown. We demonstrate that BPA deposition in the eggs of rainbow trout (Oncorhynchus mykiss), an ecologically and economically important species of fish, reprograms liver metabolism in the offspring and alters the developmental growth trajectory in two generations. Specifically, BPA reduces growth during early development, followed by a catch-up growth post-juveniles. More importantly, we observed a developmental shift in the liver transcriptome, including an increased propensity for protein breakdown during early life stages to lipid and cholesterol synthesis post- juveniles. The liver molecular responses corresponded with the transient growth phenotypes observed in the F1 generation, and this was also evident in the F2 generation. Altogether, maternal and/or ancestral embryonic exposure to BPA affects liver metabolism leading to development-distinct effects on growth, underscoring the need for novel risk assessment strategies for this chemical in the aquatic environment. This is particularly applicable to migratory species, such as salmon, where distinct temporal changes in growth and physiology during development are critical for their spawning success.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Sadoul B,Birceanu O,Aluru N,Thomas JK,Vijayan MM

doi

10.1038/s41598-017-13301-7

subject

Has Abstract

pub_date

2017-10-26 00:00:00

pages

14131

issue

1

issn

2045-2322

pii

10.1038/s41598-017-13301-7

journal_volume

7

pub_type

杂志文章

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