Abstract:
:Mesenchymal stem cells (MSC) are osteoblasts progenitors and a variety of studies suggest that they may play an important role for the health in the field of bone regeneration. Magnesium supplementation is gaining importance as adjuvant treatment to improve osteogenesis, although the mechanisms involving this process are not well understood. The objective of this study was to investigate the effects of magnesium on MSC differentiation. Here we show that in rat bone marrow MSC, magnesium chloride increases MSC proliferation in a dose-dependent manner promoting osteogenic differentiation and mineralization. These effects are reduced by 2-APB administration, an inhibitor of magnesium channel TRPM7. Of note, magnesium supplementation did not increase the canonical Wnt/β-catenin pathway, although it promoted the activation of Notch1 signaling, which was also decreased by addition of 2-APB. Electron microscopy showed higher proliferation, organization and maturation of osteoblasts in bone decellularized scaffolds after magnesium addition. In summary, our results demonstrate that magnesium chloride enhances MSC proliferation by Notch1 signaling activation and induces osteogenic differentiation, shedding light on the understanding of the role of magnesium during bone regeneration.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Díaz-Tocados JM,Herencia C,Martínez-Moreno JM,Montes de Oca A,Rodríguez-Ortiz ME,Vergara N,Blanco A,Steppan S,Almadén Y,Rodríguez M,Muñoz-Castañeda JRdoi
10.1038/s41598-017-08379-ysubject
Has Abstractpub_date
2017-08-10 00:00:00pages
7839issue
1issn
2045-2322pii
10.1038/s41598-017-08379-yjournal_volume
7pub_type
杂志文章abstract::Endosymbioses are driving forces underlying cell evolution. The endosymbiosis exhibited by Paramecium bursaria is an excellent model with which to study symbiosis. A single-cell microscopic analysis of P. bursaria reveals that endosymbiont numbers double when the host is in the division phase. Consequently, endosymbio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31638
更新日期:2016-08-17 00:00:00
abstract::There is emerging evidence that microRNAs (miRNAs) dysregulation is involved in the genesis and the progression of Prostate Cancer (PCa), thus potentially increasing their use in urological clinical practice. This is the first pilot study which utilizes Illumina Deep Sequencing to examine the entire miRNAs spectrum ex...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24236-y
更新日期:2018-05-08 00:00:00
abstract::Hydrogels are being extensively used for three-dimensional immobilization and culture of cells in fundamental biological studies, biochemical processes, and clinical treatments. However, it is still a challenge to support viability and regulate phenotypic activities of cells in a structurally stable gel, because the g...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08948
更新日期:2015-03-10 00:00:00
abstract::Graphene derivatives (GD) are currently being evaluated for technological and biomedical applications owing to their unique physico-chemical properties over other carbon allotrope such as carbon nanotubes (CNTs). But, the possible association of their properties with underlying in vitro effects have not fully examined...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39548
更新日期:2016-12-21 00:00:00
abstract::Hollow silica spheres (HSS) with special interior spaces, high specific surface area and excellent adsorption and permeability performance were synthesized via micelle-template method using cetyl trimethyl ammonium bromide (CTAB) micelles as soft template and tetraethoxysilane (TEOS) as silica precursor. SEM, TEM, FT-...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46638
更新日期:2017-04-21 00:00:00
abstract::Targeting embryonic stem cells (ESCs) is important for ESC labeling, drug delivery and cell fate control. In this study, we identified twenty-two phage clones that bind specifically to the hESC cell line X-01, which was derived from human blastocysts of Chinese origin. One phage (H178), which displays the sequence VGG...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03134
更新日期:2013-11-05 00:00:00
abstract::Stable electroluminescence from micro-pixelated light-emitting diode (μLED) occurs when electrons and holes are continuously injected from external electrodes. Different from the general recognition, in this work, μLED works in an operation mode, namely, non-electrical contact and non-carrier injection mode, and can b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65092-z
更新日期:2020-05-15 00:00:00
abstract::Tissue culture is very important for identifying the gene function of Camellia sinensis (L.) and exploiting novel germplasm through transgenic technology. Regeneration system of tea plant has been explored but not been well established since the molecular mechanism of tea plant regeneration is not clear yet. In this s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39264-5
更新日期:2019-02-27 00:00:00
abstract::Roots have important roles for plants to withstand adverse environmental conditions, including salt stress. Biostimulant application was shown to enhance plant resilience towards abiotic stresses. Here, we studied the effect of a tannin-based biostimulant on tomato (Solanum lycopersicum L.) grown under salt stress con...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79770-5
更新日期:2021-01-11 00:00:00
abstract::Sodium glucose cotransporter 2 (SGLT2) inhibitors, an antidiabetic drug, promotes urinary excretion of glucose by blocking its reabsorption in the renal proximal tubules. It is unclear whether SGLT2 inhibition could attenuate nonalcoholic steatohepatitis (NASH) and NASH-associated hepatocellular carcinoma. We examined...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19658-7
更新日期:2018-02-05 00:00:00
abstract::To resolve the pore-associated bottleneck problem observed in the electrode materials used for ultracapacitors, which inhibits the transport of the electrolyte ions, we designed hierarchically structured activated carbon (HAC) by synthesizing a mesoporous silica template/carbon composite and chemically activating it t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21182
更新日期:2016-02-16 00:00:00
abstract::In the era of precision medicine the treatment options for cancer patients and subsequent outcomes are expected to improve. We present a review of patients enrolled in first-in-human Phase1 trials at University of Alabama at Birmingham. Between 1/2015-6/2017, 162 cancer patients (whole cohort, WC) were enrolled on pha...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析,评审
doi:10.1038/s41598-020-64906-4
更新日期:2020-05-13 00:00:00
abstract::The taxonomic composition of egg-associated microbial communities can play a crucial role in the development of fish embryos. In response, hosts increasingly influence the composition of their associated microbial communities during embryogenesis, as concluded from recent field studies and laboratory experiments. Howe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17084
更新日期:2015-11-27 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) is one of the most common inflammatory diseases resulting from habitual smoking. Impaired clearance of apoptotic cell by airway macrophages contributes to lung inflammation. Milk fat globule-EGF factor 8 (MFG-E8), as a link between apoptotic cells and phagocytes, facilitate...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42642
更新日期:2017-02-14 00:00:00
abstract::Allelic differential expression (ADE) is common in diploid organisms, and is often the key reason for specific phenotype variations. Thus, ADE detection is important for identification of major genes and causal mutations. To date, sensitive and simple methods to detect ADE are still lacking. In this study, we have dev...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42815-5
更新日期:2019-04-19 00:00:00
abstract::Light's polarisation contains information about its source and interactions, from distant stars to biological samples. Polarimeters can recover this information, but reliance on birefringent or rotating optical elements limits their wavelength range and stability. Here we present a static, single-shot polarimeter base...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39118-0
更新日期:2019-02-25 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-24031-9
更新日期:2018-04-11 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-62994-w
更新日期:2020-04-24 00:00:00
abstract::The potency of cellular immune responses strongly depends on T cell avidity to antigen. Yet, functional avidity measurements are rarely performed in patients, mainly due to the technical challenges of characterizing heterogeneous T cells. The mean functional T cell avidity can be determined by the IFN-γ Elispot assay,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44320
更新日期:2017-03-13 00:00:00
abstract::Ocimum is one of the most revered medicinally useful plants which have various species. Each of the species is distinct in terms of metabolite composition as well as the medicinal property. Some basil types are used more often as an aromatic and flavoring ingredient. It would be informative to know relatedness among t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61957-5
更新日期:2020-03-23 00:00:00
abstract::Skin burns due to accidental exposure to hot steam have often been reported to be more severe than the ones occurring from dry heat. While skin burns due to flames or radiant heat have been thoroughly characterized, the mechanisms leading to steam burns are not well understood and a conundrum still exists: can second ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24647-x
更新日期:2018-05-02 00:00:00
abstract::Transition metal oxides potentially present higher specific capacities than the current anodes based on carbon, providing an increasing energy density as compared to commercial Li-ion batteries. However, many parameters could influence the performance of the batteries, which depend on the processing of the electrode m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62505-x
更新日期:2020-03-26 00:00:00
abstract::We present a highly ordered surface modification layer for polymers based on ambient solution-processed triptycene (Trip) derivatives for high-mobility organic thin-film transistors (OTFTs). The nested packing of Trip molecules results in the formation of 2D hexagonal arrays, which stack one-dimensionally on the surfa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45559-4
更新日期:2019-06-24 00:00:00
abstract::Features of sleep were shown to reflect aging, typical sex differences and cognitive abilities of humans. However, these measures are characterized by redundancy and arbitrariness. Our present approach relies on the assumptions that the spontaneous human brain activity as reflected by the scalp-derived electroencephal...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81230-7
更新日期:2021-01-21 00:00:00
abstract::We investigated how the organization of functional brain networks was related to cognitive reserve (CR) during a memory task in healthy aging. We obtained the magnetoencephalographic functional networks of 20 elders with a high or low CR level to analyse the differences at network features. We reported a negative corr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28747-6
更新日期:2018-07-12 00:00:00
abstract::The pace of two-dimensional materials (2DM) research has been greatly accelerated by the ability to identify exfoliated thicknesses down to a monolayer from their optical contrast. Since this process requires time-consuming and error-prone manual assignment to avoid false-positives from image features with similar con...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23922-1
更新日期:2018-04-23 00:00:00
abstract::The identification of genome-wide selection signatures can provide insights on the mechanisms of natural and/or artificial selection and uncover genes related to biological functions and/or phenotypes. Tibetan sheep are an important livestock in Tibet, providing meat and wool for Tibetans who are renown for breeding l...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81932-y
更新日期:2021-01-28 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-24189-2
更新日期:2018-04-12 00:00:00
abstract::The neuropathology of Parkinson's disease (PD) involves the frontal-subcortical circuit, an area responsible for processing affective theory of mind (ToM). Patients with PD are expected to experience deficits in the affective ToM. This study aims to investigate whether the ability to infer emotion in others is affecte...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33988-6
更新日期:2018-10-30 00:00:00
abstract::The aim of this study was to analyse postoperative haemorrhage (POH) after a total thyroidectomy and explore the possible risk factors. Records of patients receiving a total thyroidectomy were reviewed and analysed for risk factors of POH. From the 2,678 patients in this study, a total of 39 patients had POH, represen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07334-1
更新日期:2017-08-01 00:00:00