Abstract：
:We have recently reported that repeated systemic treatments of extract from Corydalis yanhusuo alleviate neuropathic pain and levo-tetrahydropalmatine (l-THP) is one of active components from Corydalis. We designed this study to investigate antinociceptive effect of l-THP in acute and chronic pain models and related mechanism within the spinal cord. We found that intraperitoneal pretreatment with l-THP significantly inhibited the second phase of formalin-induced pain behavior. In addition, intrathecal as well as intraperitoneal pretreatment with l-THP reduced the mechanical allodynia (MA) induced by direct activation of sigma-1 receptor (Sig-1). In chronic constriction injury mice, these treatments remarkably suppressed the increase in MA and spinal phosphorylation of the NMDA receptor NR1 subunit expression on day 7 after surgery. Intrathecal treatment with l-THP combined with the Sig-1R antagonist, BD1047 synergistically blocked MA suggesting that l-THP modulates spinal Sig-1R activation. CatWalk gait analysis also supported that antinociceptive effect of l-THP as demonstrated by restoration of percentages of print area and single stance. Meanwhile, intrathecal pretreatment with naloxone, non-selective opioid receptor antagonist, did not affect the effect of l-THP. In conclusion, these results demonstrate that l-THP possesses antinociceptive effects through spinal Sig-1R mechanism and may be a useful analgesic in the management of neuropathic pain.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kang DW,Moon JY,Choi JG,Kang SY,Ryu Y,Park JB,Lee JH,Kim HWdoi
10.1038/srep37850subject
Has Abstractpub_date
2016-12-02 00:00:00pages
37850issn
2045-2322pii
srep37850journal_volume
6pub_type
杂志文章abstract：:Two-photon (2P) microscopy is a powerful tool for imaging and exploring label-free biological tissues at high resolution. Although this type of microscopy has been demonstrated in ex vivo ocular tissues of both humans and animal models, imaging the human eye in vivo has always been challenging. This work presents a no...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46568-z
更新日期：2019-07-12 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-21980-z
更新日期：2018-03-13 00:00:00
abstract：:Ultrafast betatron x-ray emission from electron oscillations in laser wakefield acceleration (LWFA) has been widely investigated as a promising source. Betatron x-rays are usually produced via self-injected electron beams, which are not controllable and are not optimized for x-ray yields. Here, we present a new method...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27633
更新日期：2016-06-08 00:00:00
abstract：:The protection of tropical forests is one of the most urgent issues in conservation biology because of the rapid deforestation that has occurred over the last 50 years. Even in protected forests, the anthropogenic effects from newly expanding villages such as harvesting of medicinal plants, pasturing cattle and forest...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14689
更新日期：2015-10-05 00:00:00
abstract：:Proper regulation of endothelial cell-cell contacts is essential for physiological functioning of the endothelium. Interendothelial junctions are actively involved in the control of vascular leakage, leukocyte diapedesis, and the initiation and progression of angiogenesis. We found that the RNA-binding protein quaking...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21643
更新日期：2016-02-24 00:00:00
abstract：:Published data have shown inconsistent results about the pharmacogenetics of XRCC1 gene on clinical outcomes of advanced lung cancer patients treated with platinum-based chemotherapy. This meta-analysis aimed to summarize published findings and provide more reliable association. A total of 53 eligible studies includin...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep16482
更新日期：2015-11-20 00:00:00
abstract：:Global change is predicted to cause shifts in species distributions and biodiversity in arctic tundra. We applied factorial warming and nutrient manipulation to a nutrient and species poor alpine/arctic heath community for seven years. Vascular plant abundance in control plots increased by 31%. There were also notable...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10197
更新日期：2015-05-07 00:00:00
abstract：:Adulterant herbal materials are a threat to consumer safety. In this study, we used DNA barcoding to investigate the proportions and varieties of adulterant species in traditional Chinese medicine (TCM) markets. We used a DNA barcode database of TCM (TCMD) that was established by our group to investigate 1436 samples ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18723
更新日期：2016-01-07 00:00:00
abstract：:β-Lactamases are a major threat to the clinical use of carbapenems, which are often antibiotics of last resort. Despite this, the reaction outcomes and mechanisms by which β-lactamases degrade carbapenems are still not fully understood. The carbapenem bicyclic core consists of a β-lactam ring fused to a pyrroline ring...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49264-0
更新日期：2019-09-20 00:00:00
abstract：:This work reports a facile method for preparing the new photoactive In(2)O(3) films as well as their implementation in photoelectrochemical (PEC) application. We firstly investigated the relationship between oxygen vacancies (V(O)) and PEC performance and revealed a rule between them. We found that the optimized In(2)...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01021
更新日期：2013-01-01 00:00:00
abstract：:The impact of reperfusion therapies on cognition has been poorly explored and little knowledge exists. We explored the influence of endovascular treatment (EVT) on cognitive outcome in patients with anterior circulation ischemic stroke. Patients presenting with ischemic stroke due to anterior large vessel occlusion wh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75609-1
更新日期：2020-10-28 00:00:00
abstract：:The brain is possibly the most complex system known to mankind, and its complexity has been called upon to explain the emergence of consciousness. However, complexity has been defined in many ways by multiple different fields: here, we investigate measures of algorithmic and process complexity in both the temporal and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57695-3
更新日期：2020-01-23 00:00:00
abstract：:An inexpensive and compact frequency multi-mode diode laser enables a compact two-photon polarization entanglement source via the continuous wave broadband pumped spontaneous parametric down-conversion (SPDC) process. Entanglement degradation caused by polarization mode dispersion (PMD) is one of the critical issues i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25846
更新日期：2016-05-13 00:00:00
abstract：:Type-III secreted effectors (T3Es) play critical roles during bacterial pathogenesis in plants. Plant recognition of certain T3Es can trigger defence, often accompanied by macroscopic cell death, termed the hypersensitive response (HR). Economically important species of kiwifruit are susceptible to Pseudomonas syringa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03704-x
更新日期：2017-06-15 00:00:00
abstract：:This study aimed to assess the validity and functional relevance of a standardized procedure to assess lower limb muscle power by means of the 30-s sit-to-stand (STS) test when compared to leg extension power (LEP), traditional STS performance and handgrip strength. A total of 628 community-dwelling older subjects (60...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73395-4
更新日期：2020-10-01 00:00:00
abstract：:Ultrafast ultrasound imaging is used to capture driven spinal vibrations as a new method for non-invasive spinal testing in living subjects. Previously, it has been shown that accelerometer-based vibration testing in cadaveric models can reveal the presence, location and magnitude of spinal pathology. However, this pr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27816-0
更新日期：2018-06-25 00:00:00
abstract：:Escherichia coli and Salmonella Enteritidis are foodborne pathogens forming challenging biofilms that contribute to their virulence, antimicrobial resistance, and survival on surfaces. Interspecies interactions occur between species in mixed biofilms promoting different outcomes to each species. Here we describe the i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54847-y
更新日期：2019-12-03 00:00:00
abstract：:We report the use of 2H-NbS2 film as a novel counter electrode in perovskite solar cells fabricated with a cold isostatic pressing method. The 2H-NbS2 film, which was prepared through an exfoliation method followed by restacking from LixNbS2 powder, shows high electrical conductivity of 8.7 × 103 S cm-1 and work funct...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25449-x
更新日期：2018-05-04 00:00:00
abstract：:Recognition of the potential for vegetated coastal ecosystems to store and sequester carbon has led to their increasing inclusion into global carbon budgets and carbon offset schemes. However, kelp forests have been overlooked in evaluations of this 'blue carbon', which have been limited to tidal marshes, mangrove for...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69258-7
更新日期：2020-07-23 00:00:00
abstract：:Many tissues exhibit subatmospheric interstitial pressures under normal physiologic conditions. The mechanisms by which the lymphatic system extracts fluid from these tissues against the overall pressure gradient are unknown. We address this important physiologic issue by combining experimental measurements of contrac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11599-x
更新日期：2017-09-21 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-29056-8
更新日期：2018-07-18 00:00:00
abstract：:The aim of the present study was to evaluate the predictive value of 25-hydroxyvitamin D, calcium and parathormone level, co-existence of thyroid nodule, thyroidectomy history and adenoma volume on the success of neck ultrasound (US) and technetium-99m sestamibi (MIBI) scan in primary hyperparathyroidism (PHP) patient...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48536-z
更新日期：2019-08-19 00:00:00
abstract：:Pain is a highly unpleasant sensory and emotional experience, and no objective diagnosis test exists to assess it. In clinical practice there are two main methods for the estimation of pain, a patient's self-report and clinical judgement. However, these methods are highly subjective and the need of biomarkers to measu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42098-w
更新日期：2019-04-04 00:00:00
abstract：:Transient ischemia produces postischemic tingling sensation. Ischemia also produces nerve conduction block that may modulate spinal neural circuits. In the present study, reduced mechanical thresholds for hindpaw-withdrawal reflex were found in mice after transient hindpaw ischemia, which was produced by a high pressu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11191
更新日期：2015-07-13 00:00:00
abstract：:Osteolineage cells represent one of the critical bone marrow niche components that support maintenance of hematopoietic stem and progenitor cells (HSPCs). Recent studies demonstrate that extracellular vesicles (EVs) regulate stem cell development via horizontal transfer of bioactive cargo, including microRNAs (miRNAs)...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32034
更新日期：2016-09-02 00:00:00
abstract：:Ziziphus is a genus of spiny shrubs and small trees in the Rhamnaceae family. This group has a controversial taxonomy, with more than 200 species described, including Chinese jujube (Ziziphus jujuba Mill. var. jujuba) and Indian jujube (Z. mauritiana), as well as several other important cultivated fruit crops. Using 2...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31503
更新日期：2016-08-17 00:00:00
abstract：:Sex hormones may have a role in the pathophysiology of substance use disorders, as demonstrated by the association between testosterone and addictive behaviour in opioid dependence. Although opioid use has been found to suppress testosterone levels in men and women, the extent of this effect and how it relates to meth...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06189
更新日期：2014-08-26 00:00:00
abstract：:The palette of laser technology has significantly been enriched by the innovations in ultrafast optical pulse generation. Our knowledge of the complex pulse dynamics, which is often highly nonlinear and stochastic in nature, is however limited by the scarcity of technologies that can measure fast variation/fluctuation...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27937
更新日期：2016-06-13 00:00:00
abstract：:Human papillomavirus (HPV) is the most common sexually transmitted infection in the world and the main cause of cervical cancer. Nowadays, the virus-like particles (VLPs) based on L1 proteins have been considered as the best candidate for vaccine development against HPV infections. Two commercial HPV (Gardasil and Cer...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51679-8
更新日期：2019-10-23 00:00:00
abstract：:The strange three-dimensional flight behaviour of slowly spinning soccer balls is one of the most interesting and unknown phenomenon associated with the trajectories of sports balls. Many spectators have experienced numerous exciting and emotional instances while observing the curious flight behaviour of these balls. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01871
更新日期：2013-01-01 00:00:00
