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Consciousness & Brain Functional Complexity in Propofol Anaesthesia.

Abstract：

:The brain is possibly the most complex system known to mankind, and its complexity has been called upon to explain the emergence of consciousness. However, complexity has been defined in many ways by multiple different fields: here, we investigate measures of algorithmic and process complexity in both the temporal and topological domains, testing them on functional MRI BOLD signal data obtained from individuals undergoing various levels of sedation with the anaesthetic agent propofol, replicating our results in two separate datasets. We demonstrate that the various measures are differently able to discriminate between levels of sedation, with temporal measures showing higher sensitivity. Further, we show that all measures are strongly related to a single underlying construct explaining most of the variance, as assessed by Principal Component Analysis, which we interpret as a measure of "overall complexity" of our data. This overall complexity was also able to discriminate between levels of sedation and serum concentrations of propofol, supporting the hypothesis that consciousness is related to complexity - independent of how the latter is measured.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Varley TF,Luppi AI,Pappas I,Naci L,Adapa R,Owen AM,Menon DK,Stamatakis EA

doi

10.1038/s41598-020-57695-3

subject

Has Abstract

pub_date

2020-01-23 00:00:00

pages

1018

issue

1

issn

2045-2322

pii

10.1038/s41598-020-57695-3

journal_volume

10

pub_type

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