The RNA-binding protein quaking maintains endothelial barrier function and affects VE-cadherin and β-catenin protein expression.

abstract：:microRNAs (miRNAs) are small double stranded RNA molecules consisting of two complementary strands called the 5p and 3p arms. Following imprecise processing and/or addition of nucleotides at the ends, miRNA biogenesis can give rise to variants called isomiRs. Exosomes are small vesicles released by cells. They have at...

journal_title：Scientific reports

authors： Karlsen TA,Aae TF,Brinchmann JE

更新日期：2019-12-27 00:00:00

abstract：:Published data have shown inconsistent results about the pharmacogenetics of XRCC1 gene on clinical outcomes of advanced lung cancer patients treated with platinum-based chemotherapy. This meta-analysis aimed to summarize published findings and provide more reliable association. A total of 53 eligible studies includin...

journal_title：Scientific reports

authors： Yuan Z,Li J,Hu R,Jiao Y,Han Y,Weng Q

更新日期：2015-11-20 00:00:00

abstract：:The Mont-Blanc massif, being iconic with its large glaciers and peaks of over 4,000 m, will experience a sharp increase in summer temperatures during the twenty-first century. By 2100, the impact of climate change on the cryosphere and hydrosphere in the Alps is expected to lead to a decrease in annual river discharge...

journal_title：Scientific reports

authors： Laurent L,Buoncristiani JF,Pohl B,Zekollari H,Farinotti D,Huss M,Mugnier JL,Pergaud J

更新日期：2020-06-26 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Liu J,Huang W,Ren C,Wen Q,Liu W,Yang X,Wang L,Zhu B,Zeng L,Feng X,Zhang C,Chen H,Jia W,Zhang L,Xia X,Chen Y

更新日期：2020-04-20 00:00:00

abstract：:Cisplatin is a highly effective anti-cancer chemotherapeutic agent; however, its clinical use is severely limited by serious side effects, of which nephrotoxicity is the most important. In this study, we investigated whether Qiong-Yu-Gao (QYG), a popular traditional Chinese medicinal formula described 840 years ago, e...

journal_title：Scientific reports

authors： Teng ZY,Cheng XL,Cai XT,Yang Y,Sun XY,Xu JD,Lu WG,Chen J,Hu CP,Zhou Q,Wang XN,Li SL,Cao P

更新日期：2015-10-29 00:00:00

abstract：:Centenarians exhibit extreme longevity and a remarkable compression of morbidity. They have a unique capacity to maintain homeostatic mechanisms. Since small non-coding RNAs (including microRNAs) are implicated in the regulation of gene expression, we hypothesised that longevity of centenarians may reflect alterations...

journal_title：Scientific reports

authors： Serna E,Gambini J,Borras C,Abdelaziz KM,Belenguer A,Sanchis P,Avellana JA,Rodriguez-Mañas L,Viña J

更新日期：2012-01-01 00:00:00

abstract：:Virus pseudotyping is a useful and safe technique for studying entry of emerging strains of influenza virus. However, few studies have compared different reassortant combinations in pseudoparticle systems, or compared entry kinetics of native viruses and their pseudotyped analogs. Here, vesicular stomatitis virus (VSV...

journal_title：Scientific reports

authors： Hsu HL,Millet JK,Costello DA,Whittaker GR,Daniel S

更新日期：2016-10-18 00:00:00

abstract：:Genotyping-by-sequencing (GBS) or restriction-site associated DNA marker sequencing (RAD-seq) is a practical and cost-effective method for analysing large genomes from high diversity species. This method of sequencing, coupled with methylation-sensitive enzymes (often referred to as methylation-sensitive restriction e...

journal_title：Scientific reports

authors： Mayne BT,Leemaqz SY,Buckberry S,Rodriguez Lopez CM,Roberts CT,Bianco-Miotto T,Breen J

更新日期：2018-02-01 00:00:00

abstract：:Rare individuals remain cognitively intact despite the presence of neuropathology usually associated with fully symptomatic Alzheimer's disease (AD), which we refer to as Non-Demented with Alzheimer's disease Neuropathology (NDAN). Understanding the involved mechanism(s) of their cognitive resistance may reveal novel ...

journal_title：Scientific reports

authors： Briley D,Ghirardi V,Woltjer R,Renck A,Zolochevska O,Taglialatela G,Micci MA

更新日期：2016-06-14 00:00:00

abstract：:CD96 is a promising candidate for immunotherapy. However, its role and importance in glioma remains unknown. We thus aimed to genetically and clinically characterize CD96 expression in gliomas. For this, we extracted RNA-seq data of 699 glioma samples from the TCGA dataset and validated these findings using the CGGA d...

journal_title：Scientific reports

authors： Liu F,Huang J,He F,Ma X,Fan F,Meng M,Zhuo Y,Zhang L

更新日期：2020-07-01 00:00:00

abstract：:Galvanic vestibular stimulation (GVS) can be applied to induce the feeling of directional virtual head motion by stimulating the vestibular organs electrically. Conventional studies used a two-pole GVS, in which electrodes are placed behind each ear, or a three-pole GVS, in which an additional electrode is placed on t...

journal_title：Scientific reports

authors： Aoyama K,Iizuka H,Ando H,Maeda T

更新日期：2015-05-11 00:00:00

abstract：:Intravitreal anti-vascular endothelial growth factor (VEGF) agents can treat macular edema (ME) in branch retinal vein occlusion (BRVO). However, refractory ME, the mechanism of which is not well elucidated, occurs frequently. Sixty-six eyes with ME secondary to BRVO were enrolled in this retrospective observational c...

journal_title：Scientific reports

authors： Tomiyasu T,Hirano Y,Yoshida M,Suzuki N,Nishiyama T,Uemura A,Yasukawa T,Ogura Y

更新日期：2016-07-08 00:00:00

abstract：:We studied scattering and extinction of individual silver nanorods coupled to the J-aggregate form of the cyanine dye TDBC as a function of plasmon--exciton detuning. The measured single particle spectra exhibited a strongly suppressed scattering and extinction rate at wavelengths corresponding to the J-aggregate abso...

journal_title：Scientific reports

authors： Zengin G,Johansson G,Johansson P,Antosiewicz TJ,Käll M,Shegai T

更新日期：2013-10-29 00:00:00

abstract：:Root-knot nematodes (RKNs) are obligate biotrophic parasites that invade plant roots and engage in prolonged and intimate relationships with their hosts. Nematode secretions, some of which have immunosuppressing activity, play essential roles in successful parasitism; however, their mechanisms of action remain largely...

journal_title：Scientific reports

authors： Niu J,Liu P,Liu Q,Chen C,Guo Q,Yin J,Yang G,Jian H

更新日期：2016-01-22 00:00:00

abstract：:The objective of this study was to investigate associations between education in early life and cognitive impairment in later life in Colombia. Participants were community-dwelling adults aged 60 years or older from the National Study of Health, Wellbeing and Ageing. Trained interviewers administered a shorter version...

journal_title：Scientific reports

authors： O'Donovan G,Hamer M,Sarmiento OL,Hessel P

更新日期：2020-10-19 00:00:00

abstract：:State of the art clinical hand prostheses are controlled in a simple and limited way that allows the activation of one function at a time. More advanced laboratory approaches, based on machine learning, offer a significant increase in functionality, but their clinical impact is limited, mainly due to lack of reliabili...

journal_title：Scientific reports

authors： Hahne JM,Markovic M,Farina D

更新日期：2017-06-30 00:00:00

abstract：:Mind wandering (MW) refers to the disengagement of attention from the external environment and the generation of thoughts unrelated to the task at hand. It is a ubiquitous cognitive process resulting in lapses of attention. MW imposes a negative impact on attention-based task performance, but also has been associated ...

journal_title：Scientific reports

authors： Leszczynski M,Chaieb L,Reber TP,Derner M,Axmacher N,Fell J

更新日期：2017-08-31 00:00:00

abstract：:The Morris Water Maze is a widely used task in studies of spatial learning with rodents. Classical performance measures of animals in the Morris Water Maze include the escape latency, and the cumulative distance to the platform. Other methods focus on classifying trajectory patterns to stereotypical classes representi...

journal_title：Scientific reports

authors： Gehring TV,Luksys G,Sandi C,Vasilaki E

更新日期：2015-10-01 00:00:00

abstract：:In this paper, we analyze the synchronization problem of master-slave probabilistic Boolean networks (PBNs). The master Boolean network (BN) is a deterministic BN, while the slave BN is determined by a series of possible logical functions with certain probability at each discrete time point. In this paper, we firstly ...

journal_title：Scientific reports

authors： Lu J,Zhong J,Li L,Ho DW,Cao J

更新日期：2015-08-28 00:00:00

abstract：:Hedgehog interacting protein (Hhip) is essential for islet formation and beta-cell proliferation during pancreatic development; abnormally elevated Hhip expression has been linked to human pancreatitis. Here, we investigate the role of Hhip in modulating insulin secretion in adult Hhip mice (Hhip +/- vs. Hhip+/+) fed ...

journal_title：Scientific reports

authors： Nchienzia H,Liao MC,Zhao XP,Chang SY,Lo CS,Chenier I,Ingelfinger JR,Chan JSD,Zhang SL

更新日期：2019-08-01 00:00:00

abstract：:It has been demonstrated that development of three-dimensional printing technology has supported the researchers and surgeons to apply the bone tissue engineering to the oromandibular reconstruction. In this study, poly caprolactone/beta tricalcium phosphate (PCL/β-TCP) scaffolds were fabricated by multi-head depositi...

journal_title：Scientific reports

authors： Lee S,Choi D,Shim JH,Nam W

更新日期：2020-03-18 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with diverse clinical presentation and outcome. Bio-clinical prognostic models including oncogene expression and cell-of-origin phenotyping has been developed, however, approximately 30% of all patients still die from their disease, illustrating the need...

journal_title：Scientific reports

authors： Jespersen DS,Schönherz AA,Due H,Bøgsted M,Sondergaard TE,Dybkær K

更新日期：2019-01-23 00:00:00

abstract：:People with ataxia-telangiectasia (A-T) display phenotypic variability with regard to progression of immunodeficiency, sino-pulmonary disease, and neurologic decline. To determine the association between differential gene expression, epigenetic state, and phenotypic variation among people with A-T, we performed transc...

journal_title：Scientific reports

authors： McGrath-Morrow SA,Ndeh R,Helmin KA,Khuder B,Rothblum-Oviatt C,Collaco JM,Wright J,Reyfman PA,Lederman HM,Singer BD

更新日期：2020-05-04 00:00:00

abstract：:Reduced near-infrared reflectance observed in September 1973 in Skylab images of the western flank of Mt. Etna has been interpreted as an eruption precursor of the January 1974 eruption. Until now, it has been unclear when this signal started, whether it was sustained and which process(es) could have caused it. By ana...

journal_title：Scientific reports

authors： Seiler R,Houlié N,Cherubini P

更新日期：2017-03-07 00:00:00

abstract：:A high throughput method for species identification and classification through chemometric processing of direct analysis in real time (DART) mass spectrometry-derived fingerprint signatures has been developed. The method entails introduction of samples to the open air space between the DART ion source and the mass spe...

journal_title：Scientific reports

authors： Musah RA,Espinoza EO,Cody RB,Lesiak AD,Christensen ED,Moore HE,Maleknia S,Drijfhout FP

更新日期：2015-07-09 00:00:00

abstract：:Cancer cells accumulate somatic mutations as result of DNA damage, inaccurate repair and other mechanisms. Different genetic instability processes result in characteristic non-random patterns of DNA mutations, also known as mutational signatures. We developed mutSignatures, an integrated R-based computational framewor...

journal_title：Scientific reports

authors： Fantini D,Vidimar V,Yu Y,Condello S,Meeks JJ

更新日期：2020-10-26 00:00:00

abstract：:To comprehensively assess whether p75ECD in urine could be a candidate biomarker for ALS evaluation. Urine samples were collected from 101 ALS patients, 108 patients with other neurological disease (OND) and 97 healthy controls. 61 ALS patients were followed up with clinical data including ALSFRS-r every 6 to 12 month...

journal_title：Scientific reports

authors： Jia R,Shepheard S,Jin J,Hu F,Zhao X,Xue L,Xiang L,Qi H,Qu Q,Guo F,Rogers ML,Dang J

更新日期：2017-07-11 00:00:00

abstract：:We demonstrate numerically and experimentally the enhancement of Surface Plasmon Resonance (SPR) sensing via dispersion engineering of the plasmonic response using plasmonic nanograting. Following their design and optimization, the plasmonic nanograting structures are fabricated using e-beam lithography and lift-off p...

journal_title：Scientific reports

authors： Arora P,Talker E,Mazurski N,Levy U

更新日期：2018-06-13 00:00:00

abstract：:Daily life stress is an omnipresent phenomenon in modern society. Research has linked prolonged activation of the hypothalamic-pituitary-adrenal axis to psychiatric and somatic diseases. Everyday stressors substantially contribute to these health risks. Despite the notion that the physiological stress response is high...

journal_title：Scientific reports

authors： Linz R,Singer T,Engert V

更新日期：2018-10-18 00:00:00

abstract：:Proteins that act as global transcriptional regulators play key roles in bacterial adaptation to new niches. These proteins recognize multiple DNA sites across the bacterial genome by different mechanisms. Enterococcus faecalis is able to survive in various niches of the human host, either as a commensal or as a leadi...

journal_title：Scientific reports

authors： Ruiz-Cruz S,Moreno-Blanco A,Espinosa M,Bravo A

更新日期：2019-04-16 00:00:00