Centenarians, but not octogenarians, up-regulate the expression of microRNAs.

abstract：:This research aimed to assess the associations of 7 parkin RBR E3 ubiquitin protein ligase (PRKN) and 4 parkin coregulated gene (PACRG) single-nucleotide polymorphisms (SNPs), their haplotypes, gene-gene (G × G) and gene-environment (G × E) interactions with hyperlipidaemia in the Chinese Maonan minority. The genotype...

journal_title：Scientific reports

authors： Zheng PF,Yin RX,Wei BL,Liu CX,Deng GX,Guan YZ

更新日期：2020-08-03 00:00:00

abstract：:In the central nervous system of vertebrates, cell bodies of neurons are often assembled as nuclei or cellular layers that play specific roles as functional units. The purpose of this work was to selectively highlight such cell assemblies by magnetic resonance imaging using signals from water protons that are associat...

journal_title：Scientific reports

authors： Watanabe T,Wang X,Tan Z,Frahm J

更新日期：2019-03-25 00:00:00

abstract：:Zika virus is a teratogenic mosquito-transmitted flavivirus that is associated with birth defects in newborns and Guillain-Barré syndrome in adults. The virus can also be sexually transmitted, but currently, very little is known about the cell types supporting virus replication and persistence in human testes. Using p...

journal_title：Scientific reports

authors： Kumar A,Jovel J,Lopez-Orozco J,Limonta D,Airo AM,Hou S,Stryapunina I,Fibke C,Moore RB,Hobman TC

更新日期：2018-04-03 00:00:00

abstract：:This work aimed to prepare solvent-free or green Bi2O2CO3 for quantum dot nanostructures (QDNSs) based on cellulose as a stabilizer and green capping agent to sorafenib delivery for liver targeting. Because the walnut tree is one of the most abundant trees in Iran, it was tried to synthesize Bi2O2CO3 QDNSs using a wal...

journal_title：Scientific reports

authors： Samarehfekri H,Rahimi HR,Ranjbar M

更新日期：2020-12-04 00:00:00

abstract：:Tyrosylprotein sulfotransferases (TPSTs) are enzymes that catalyze post-translational tyrosine sulfation of proteins. In humans, there are only two TPST isoforms, designated TPST1 and TPST2. In a previous study, we reported the crystal structure of TPST2, which revealed the catalytic mechanism of the tyrosine sulfatio...

journal_title：Scientific reports

authors： Tanaka S,Nishiyori T,Kojo H,Otsubo R,Tsuruta M,Kurogi K,Liu MC,Suiko M,Sakakibara Y,Kakuta Y

更新日期：2017-08-18 00:00:00

abstract：:The biggest challenge in colorectal cancer therapy is to avoid intestinal drug absorption before reaching the colon, while focusing on tumor specific delivery with high local concentration and minimal toxicity. In our work, thymoquinone (TQ)-loaded polymeric nanocapsules were prepared using the nanoprecipitation techn...

journal_title：Scientific reports

authors： Ramzy L,Metwally AA,Nasr M,Awad GAS

更新日期：2020-07-03 00:00:00

abstract：:How diverse adult stem and progenitor populations regenerate tissue following damage to the brain is poorly understood. In highly regenerative vertebrates, such as zebrafish, radial-glia (RG) and neuro-epithelial-like (NE) stem/progenitor cells contribute to neuronal repair after injury. However, not all RG act as neu...

journal_title：Scientific reports

authors： Lindsey BW,Aitken GE,Tang JK,Khabooshan M,Douek AM,Vandestadt C,Kaslin J

更新日期：2019-03-14 00:00:00

abstract：:This work presents the first comprehensive investigation of phonon-electron interactions in bulk acoustic standing wave (BAW) resonators made from piezoelectric semiconductor (PS) materials. We show that these interactions constitute a significant energy loss mechanism and can set practical loss limits lower than anha...

journal_title：Scientific reports

authors： Gokhale VJ,Rais-Zadeh M

更新日期：2014-07-08 00:00:00

abstract：:Adropin is a peptide hormone encoded by the Energy Homeostasis Associated (ENHO) gene whose physiological role in humans remains incompletely defined. Here we investigated the impact of dietary interventions that affect systemic glucose and lipid metabolism on plasma adropin concentrations in humans. Consumption of gl...

journal_title：Scientific reports

authors： Butler AA,St-Onge MP,Siebert EA,Medici V,Stanhope KL,Havel PJ

更新日期：2015-10-05 00:00:00

abstract：:One of the factors that has increased the incidence and worse prognosis of breast cancer is obesity. In this condition, high amounts of leptin are secreted, which have proliferative, mitogenic, antiapoptotic, and proinflammatory activity that may be antagonistic to treatment with tamoxifen, considered the first choice...

journal_title：Scientific reports

authors： Linares RL,Benítez JGS,Reynoso MO,Romero CG,Sandoval-Cabrera A

更新日期：2019-12-16 00:00:00

abstract：:Obesity is a major cause of type 2 diabetes mellitus (T2DM) in mammals. We have previously established a zebrafish model of diet-induced obesity (DIO zebrafish) by overfeeding Artemia. Here we created DIO zebrafish using a different method to induce T2DM. Zebrafish were overfed a commercially available fish food using...

journal_title：Scientific reports

authors： Zang L,Shimada Y,Nishimura N

更新日期：2017-05-03 00:00:00

abstract：:Magnetic vortex is one of the simplest topologically non-trivial textures in condensed matter physics. It is the ground state of submicron magnetic elements (dots) of different shapes: cylindrical, square etc. So far, the vast majority of the vortex dynamics studies were focused on thin dots with thickness 5-50 nm and...

journal_title：Scientific reports

authors： Guslienko KY,Kakazei GN,Ding J,Liu XM,Adeyeye AO

更新日期：2015-09-10 00:00:00

abstract：:The growing prevalence of resistance to antibiotics motivates the search for new antibacterial agents. Antimicrobial peptides are a diverse class of well-studied membrane-active peptides which function as part of the innate host defence system, and form a promising avenue in antibiotic drug research. Some antimicrobia...

journal_title：Scientific reports

authors： Timmons PB,Hewage CM

更新日期：2020-07-02 00:00:00

abstract：:Toxins are believed to play a crucial role in Burkholderia pseudomallei pathogenicity, however to date, only a few have been identified. The discovery of additional toxic molecules is limited by the lack of a sensitive indicator of B. pseudomallei toxicity. Previously, from a whole genome transcriptome analysis of B. ...

journal_title：Scientific reports

authors： Wong RR,Kong C,Lee SH,Nathan S

更新日期：2016-06-07 00:00:00

abstract：:Bacterial artificial chromosomes (BACs) offer a means of manipulating gene expression and tagging gene products in the mammalian genome without the need to alter endogenous gene structure and risk deleterious phenotypic consequences. However, for a BAC clone to be useful for such purposes it must be shown to contain a...

journal_title：Scientific reports

authors： Warr N,May J,Teboul L,Suzuki T,Asami M,Perry ACF,Wells S,Greenfield A

更新日期：2018-11-23 00:00:00

abstract：:Spin-wave dynamics in full-Heusler Co2FeAl0.5Si0.5 films are studied using all-optical pump-probe magneto-optical polar Kerr spectroscopy. Backward volume magnetostatic spin-wave (BVMSW) mode is observed in films with thickness ranging from 20 to 100 nm besides perpendicular standing spin-wave (PSSW) mode, and found t...

journal_title：Scientific reports

authors： Chen Z,Yan Y,Li S,Xu X,Jiang Y,Lai T

更新日期：2017-02-14 00:00:00

abstract：:Whole-room indirect calorimeters (WRICs) have traditionally been used for real-time resting metabolic rate (RMR) measurements, while metabolic rate (MR) during short-interval exercises has commonly been measured by metabolic carts (MCs). This study aims to investigate the feasibility of incorporating short-interval ex...

journal_title：Scientific reports

authors： Chen S,Scott C,Pearce JV,Farrar JS,Evans RK,Celi FS

更新日期：2020-08-31 00:00:00

abstract：:An efficient [4 + 1] annulation between α-bromooximes and sulfur ylides via in situ generation of nitrosoalkenes under mild basic reaction conditions has been developed, providing an expeditious and scalable approach to synthesize biologically interesting isoxazoline derivatives with good to excellent yields. ...

journal_title：Scientific reports

authors： Hua TB,Liu CX,Hu WM,Wang L,Yang QQ

更新日期：2021-01-22 00:00:00

abstract：:An inexpensive and compact frequency multi-mode diode laser enables a compact two-photon polarization entanglement source via the continuous wave broadband pumped spontaneous parametric down-conversion (SPDC) process. Entanglement degradation caused by polarization mode dispersion (PMD) is one of the critical issues i...

journal_title：Scientific reports

authors： Lim HT,Hong KH,Kim YH

更新日期：2016-05-13 00:00:00

abstract：:Membranes with selective superwettability for oil/water separation have received significant attention during the past decades. Hierarchical structures and surface roughness are believed to improve the oil repellency and the stability of Cassie-Baxter state. Diatoms, unicellular photosynthetic algae, possess sophistic...

journal_title：Scientific reports

authors： Lo YH,Yang CY,Chang HK,Hung WC,Chen PY

更新日期：2017-05-03 00:00:00

abstract：:Grapevine is an important and extensively grown fruit crop, which is severely hampered by drought worldwide. So, comprehending the impact of drought on grapevine genetic resources is necessary. In the present study, RNA-sequencing was executed using cDNA libraries constructed from both drought-stress and control plant...

journal_title：Scientific reports

authors： Haider MS,Zhang C,Kurjogi MM,Pervaiz T,Zheng T,Zhang C,Lide C,Shangguan L,Fang J

更新日期：2017-10-13 00:00:00

abstract：:Cooperation in one-shot anonymous interactions is a widely documented aspect of human behaviour. Here we shed light on the motivations behind this behaviour by experimentally exploring cooperation in a one-shot continuous-strategy Prisoner's Dilemma (i.e. one-shot two-player Public Goods Game). We examine the distribu...

journal_title：Scientific reports

authors： Capraro V,Jordan JJ,Rand DG

更新日期：2014-10-28 00:00:00

abstract：:The aim of this study was to assess the systemic and analgesic effects of epidural dexmedetomidine in thoracic epidural anaesthesia (TEA) combined with total intravenous anaesthesia during thoracic surgery. Seventy-one patients undergoing open thoracotomy were included in this study and randomly divided into three gro...

journal_title：Scientific reports

authors： Zeng X,Jiang J,Yang L,Ding W

更新日期：2017-06-21 00:00:00

abstract：:Reconstructed annual streamflows using tree-ring chronologies provide useful information on moisture availability during the pre-historic period, but they have limitations in estimating high flows due to the upper bound on soil water holding capacity and trees' metabolic growth limits. We propose a hybrid approach tha...

journal_title：Scientific reports

authors： Mukhopadhyay S,Patskoski JM,Sankarasubramanian A

更新日期：2018-03-21 00:00:00

abstract：:Marek's disease virus (MDV) is a highly cell-associated alphaherpesvirus that causes deadly lymphomas in chickens. While vaccination protects against clinical symptoms, MDV field strains can still circulate in vaccinated flocks and continuously evolve towards greater virulence. MDV vaccines do not provide sterilizing ...

journal_title：Scientific reports

authors： Hagag IT,Wight DJ,Bartsch D,Sid H,Jordan I,Bertzbach LD,Schusser B,Kaufer BB

更新日期：2020-07-02 00:00:00

abstract：:The western North-Atlantic coast experienced major coastal floods in recent years. Coastal floods are primarily composed of tides and storm surges due to tropical (TCs) and extra-tropical cyclones (ETCs). We present a reanalysis from 1988 to 2015 of extreme sea levels that explicitly include TCs for the western North-...

journal_title：Scientific reports

authors： Muis S,Lin N,Verlaan M,Winsemius HC,Ward PJ,Aerts JCJH

更新日期：2019-03-04 00:00:00

abstract：:Honey bees (Apis mellifera) are important pollinators and their health is threatened worldwide by persistent exposure to a wide range of factors including pesticides, poor nutrition, and pathogens. Nosema ceranae is a ubiquitous microsporidian associated with high colony mortality. We used lab micro-colonies of honey ...

journal_title：Scientific reports

authors： Lecocq A,Jensen AB,Kryger P,Nieh JC

更新日期：2016-02-25 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： García-Fernández C,Font-Porterias N,Kučinskas V,Sukarova-Stefanovska E,Pamjav H,Makukh H,Dobon B,Bertranpetit J,Netea MG,Calafell F,Comas D

更新日期：2020-10-20 00:00:00

abstract：:Accurately establishing the state of large-scale quantum systems is an important tool in quantum information science; however, the large number of unknown parameters hinders the rapid characterisation of such states, and reconstruction procedures can become prohibitively time-consuming. Compressive sensing, a procedur...

journal_title：Scientific reports

authors： Tonolini F,Chan S,Agnew M,Lindsay A,Leach J

更新日期：2014-10-13 00:00:00

abstract：:Notarchirico (Southern Italy) has yielded the earliest evidence of Acheulean settlement in Italy and four older occupation levels have recently been unearthed, including one with bifaces, extending the roots of the Acheulean in Italy even further back in time. New 40Ar/39Ar on tephras and ESR dates on bleached quartz ...

journal_title：Scientific reports

authors： Moncel MH,Santagata C,Pereira A,Nomade S,Voinchet P,Bahain JJ,Daujeard C,Curci A,Lemorini C,Hardy B,Eramo G,Berto C,Raynal JP,Arzarello M,Mecozzi B,Iannucci A,Sardella R,Allegretta I,Delluniversità E,Terzano R,Dug

更新日期：2020-08-14 00:00:00