Abstract:
:An efficient [4 + 1] annulation between α-bromooximes and sulfur ylides via in situ generation of nitrosoalkenes under mild basic reaction conditions has been developed, providing an expeditious and scalable approach to synthesize biologically interesting isoxazoline derivatives with good to excellent yields.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Hua TB,Liu CX,Hu WM,Wang L,Yang QQdoi
10.1038/s41598-021-81370-wsubject
Has Abstractpub_date
2021-01-22 00:00:00pages
2078issue
1issn
2045-2322pii
10.1038/s41598-021-81370-wjournal_volume
11pub_type
杂志文章abstract::Patterns of temperature fluctuations in nature affect numerous biological processes, yet, empirical studies often utilize constant temperature treatments. This can limit our understanding of how thermally sensitive species respond to ecologically relevant temperatures. Research on turtles with temperature-dependent se...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17708-0
更新日期:2018-01-08 00:00:00
abstract::In order to limit the smoking tobacco sector crisis, a new non-GMO Nicotiana tabacum L. cv. Solaris was proposed as oil seed crop. Residues of oil extraction were successfully used in swine nutrition. The aim of this study was to explore the full potential of this innovative tobacco cultivar as multitasking feedstock ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53237-8
更新日期:2019-11-14 00:00:00
abstract::Can humans produce well-timed blink responses to a neutral stimulus voluntarily, without receiving any blink-eliciting, unconditional, stimulus? And if they can, to what degree does classical eyeblink conditioning depend on volition? Here we show that voluntary blink responses learned in two paradigms that did not inv...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03343-2
更新日期:2017-06-13 00:00:00
abstract::The influence of catechol-o-methyltransferase (COMT) Val(158)Met on brain activation and functional connectivity has been widely reported. However, voxel-wise effects of this genotype on resting-state brain networks remain unclear. Here, we used resting-state fMRI and eigenvector centrality to examine the effects of C...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10105
更新日期:2015-06-09 00:00:00
abstract::This study aims to identify promising biomarkers for the early detection of lung cancer and evaluate the prognosis of lung cancer patients. Genome-wide mRNA expression data obtained from the Gene Expression Omnibus (GSE19188, GSE18842 and GSE40791), including 231 primary tumor samples and 210 normal samples, were used...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08615-5
更新日期:2017-08-14 00:00:00
abstract::Green microalgae contain many active pigments such as carotenoids having antioxidant and protective activity on human cells. Here we investigate the biological activity of an ethanol/water extract of the marine green microalga Tetraselmis suecica containing high levels of carotenoids such as the xanthophylls lutein, v...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41215
更新日期:2017-01-24 00:00:00
abstract::The new era of spintronics promises the development of nanodevices, where the electron spin will be used to store information and charge currents will be replaced by spin currents. For this, ferromagnetic semiconductors at room temperature are needed. We report on significant room-temperature spin polarization of EuS ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01333
更新日期:2013-01-01 00:00:00
abstract::Mammalian innate and acquired immune responses involve a coordinated, sequential, and self limiting sequence of events controlled by positive and negative regulatory mechanism. MicroRNAs have been implicated as a negative regulator for diverse biological events including immune responses. However, the involvement of m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12226
更新日期:2015-07-31 00:00:00
abstract::Outbreaks of arbovirus infections vectored by invasive Aedes albopictus have already occurred and are predicted to become increasingly frequent in Southern Europe. We present a probabilistic model to assess risk of arbovirus outbreaks based on incident cases worldwide, on the probability of arrival of infected travele...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34664-5
更新日期:2018-11-06 00:00:00
abstract::To study the influence of the position of the double bond and ring size on the stability of hydrogen bonded complexes, the 1:1 complexes formed between 2,2,2-trifluoroethanol (TFE) and three heterocyclic compounds including 2,3-dihydrofuran (2,3-DHF), 2,5-dihydrofuran (2,5-DHF) and 3,4-dihydropyran (3,4-DHP) were inve...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11921-7
更新日期:2017-09-12 00:00:00
abstract::The South American Monsoon System (SAMS) is generally considered to be highly sensitive to Northern Hemisphere (NH) temperature variations on multi-centennial timescales. The direct influence of solar forcing on moisture convergence in global monsoon systems on the other hand, while well explored in modeling studies, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24762
更新日期:2016-04-21 00:00:00
abstract::Autism spectrum disorder involves persistent difficulties in social communication. Although these difficulties affect both verbal and nonverbal communication, there are no quantitative behavioral studies to date investigating the cross-modal coordination of verbal and nonverbal communication in autism. The objective o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54587-z
更新日期:2019-12-04 00:00:00
abstract::After its recent rediscovery, the Hula painted frog (Latonia nigriventer) has remained one of the world's rarest and least understood amphibian species. Together with its apparently low dispersal capability and highly disturbed niche, the low abundance of this living fossil calls for urgent conservation measures. We u...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23587-w
更新日期:2018-04-03 00:00:00
abstract::In this study, we describe a web-based resource, developed for assisting the scientific community in designing an effective therapeutics against the Ebola virus. Firstly, we predicted and identified experimentally validated epitopes in each of the antigens/proteins of the five known ebolaviruses. Secondly, we generate...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24782
更新日期:2016-04-26 00:00:00
abstract::Microbial life below the seafloor has changed over geological time, but these changes are often not obvious, as they are not recorded in the sediment. Sulphur (S) isotope values in pyrite extracted from a Plio- to Holocene sequence of the Peru Margin (Ocean Drilling Program, ODP, Site 1229) show a down-core pattern th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36943-7
更新日期:2019-01-24 00:00:00
abstract::A central challenge in designing and administering effective anticoagulants is achieving the proper therapeutic window and dosage for each patient. The Hill coefficient, nH, which measures the steepness of a dose-response relationship, may be a useful gauge of this therapeutic window. We sought to measure the Hill coe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29387
更新日期:2016-07-21 00:00:00
abstract::The Xanthomonadaceae family consists of species of non-pathogenic and pathogenic γ-proteobacteria that infect different hosts, including humans and plants. In this study, we performed a comparative analysis using 69 fully sequenced genomes belonging to this family, with a focus on identifying proteins enriched in phyt...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16325-1
更新日期:2017-11-23 00:00:00
abstract::Uropathogenic strains of Escherichia coli establish urinary tract infections by attaching to host epithelial cells using adhesive organelles called fimbriae. Fimbriae are helix-like structures with a remarkable adaptability, offering safeguarding for bacteria exposed to changing fluid forces in the urinary tract. We c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03393
更新日期:2013-12-02 00:00:00
abstract::Separation of enantiomers by flows is a promising chiral resolution method using cost-effective microfluidics. Notwithstanding a number of experimental and numerical studies, a fundamental understanding still remains elusive, and an important question as to whether it is possible to specify common physical properties ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35144
更新日期:2016-10-14 00:00:00
abstract::The efficacy and safety of misoprostol alone for missed abortion varied with different regimens. To evaluate existing evidence for the medical management of missed abortion using misoprostol, we undertook a comprehensive review and meta-analysis. The electronic literature search was conducted using PubMed, the Cochran...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-017-01892-0
更新日期:2017-05-10 00:00:00
abstract::Mitochondria-generated reactive oxygen species (mROS) are frequently associated with DNA damage and cell cycle arrest, but physiological increases in mROS serve to regulate specific cell functions. T3 is a major regulator of mROS, including hydrogen peroxide (H2O2). Here we show that exogenous thyroid hormone (T3) adm...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53705-1
更新日期:2019-11-27 00:00:00
abstract::The ability for magnetite to act as a recyclable electron donor and acceptor for Fe-metabolizing bacteria has recently been shown. However, it remains poorly understood whether microbe-mineral interfacial electron transfer processes are limited by the redox capacity of the magnetite surface or that of whole particles....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30969
更新日期:2016-08-05 00:00:00
abstract::Nitrogen-doped hierarchical porous carbons were synthesized successfully by a controllable one-pot method using glucose and dicyandiamide as carbon source and nitrogen source via hydrothermal carbonization process. The nitrogen-doped materials, possessing high nitrogen content (up to 7 wt%), large surface area (>320 m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21365
更新日期:2016-02-25 00:00:00
abstract::We study the entanglement structure and the topological edge states of the ground state of the spin-1/2 XXZ model with bond alternation. We employ parity-density matrix renormalization group with periodic boundary conditions. The finite-size scaling of Rényi entropies S2 and S∞ are used to construct the phase diagram ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26453
更新日期:2016-05-24 00:00:00
abstract::Magnetic carboxyl functional nanoporous polymer (MCFNP) was chemically fabricated by incorporation of magnetic Fe3O4 precursor into the carboxyl functional nanoporous polymer (CFNP). The as-synthesized MCFNP was characterized and used as an adsorbent for rapid adsorption removal of methylene blue (MB) from wastewater....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24873-3
更新日期:2018-04-25 00:00:00
abstract::Rolling circle amplification (RCA) for generation of distinct fluorescent signals in situ relies upon the self-collapsing properties of single-stranded DNA in commonly used RCA-based methods. By introducing a cross-hybridizing DNA oligonucleotide during rolling circle amplification, we demonstrate that the fluorophore...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12317
更新日期:2015-07-23 00:00:00
abstract::The biological functions of nitric oxide (NO) depend on its concentration, and excessive levels of NO induce various harmful situations known as nitrosative stress. Therefore, organisms possess many kinds of strategies to regulate the intracellular NO concentration and/or to detoxify excess NO. Here, we used genetic s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62890-3
更新日期:2020-04-07 00:00:00
abstract::The non-enzymatic browning, namely Maillard reaction is commonly invoked to account for abiotic chemical transformations of organic matter. Here we report a new reaction pathway via the Maillard reaction to systematically synthesize a series of nitrogen-doped carbon dots (C-dots) with superhigh quantum yield (QY) and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03564
更新日期:2014-01-06 00:00:00
abstract::The controlled interaction of two high intensity beams opens new degrees of freedom for manipulating electromagnetic waves in air. The growing number of applications for laser filaments requires fine control of their formation and propagation. We demonstrate, experimentally and theoretically, that the attraction and f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10565-x
更新日期:2017-08-31 00:00:00
abstract::This retrospective study was designed to compare prognostic relevance of magnetic resonance imaging (MRI) findings before and after neoadjuvant chemoradiotherapy (CRT). From 2002 to 2010, 399 patients who underwent surgery after CRT for rectal cancer (≥T3) and had adequate pre-CRT (mr) and post-CRT (ymr) MRI findings ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46499-9
更新日期:2019-07-11 00:00:00