Mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides.

Abstract:

:An efficient [4 + 1] annulation between α-bromooximes and sulfur ylides via in situ generation of nitrosoalkenes under mild basic reaction conditions has been developed, providing an expeditious and scalable approach to synthesize biologically interesting isoxazoline derivatives with good to excellent yields.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Hua TB,Liu CX,Hu WM,Wang L,Yang QQ

doi

10.1038/s41598-021-81370-w

subject

Has Abstract

pub_date

2021-01-22 00:00:00

pages

2078

issue

1

issn

2045-2322

pii

10.1038/s41598-021-81370-w

journal_volume

11

pub_type

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