Abstract：
:The growing prevalence of resistance to antibiotics motivates the search for new antibacterial agents. Antimicrobial peptides are a diverse class of well-studied membrane-active peptides which function as part of the innate host defence system, and form a promising avenue in antibiotic drug research. Some antimicrobial peptides exhibit toxicity against eukaryotic membranes, typically characterised by hemolytic activity assays, but currently, the understanding of what differentiates hemolytic and non-hemolytic peptides is limited. This study leverages advances in machine learning research to produce a novel artificial neural network classifier for the prediction of hemolytic activity from a peptide's primary sequence. The classifier achieves best-in-class performance, with cross-validated accuracy of [Formula: see text] and Matthews correlation coefficient of 0.71. This innovative classifier is available as a web server at https://research.timmons.eu/happenn , allowing the research community to utilise it for in silico screening of peptide drug candidates for high therapeutic efficacies.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Timmons PB,Hewage CMdoi
10.1038/s41598-020-67701-3subject
Has Abstractpub_date
2020-07-02 00:00:00pages
10869issue
1issn
2045-2322pii
10.1038/s41598-020-67701-3journal_volume
10pub_type
杂志文章abstract：:Embryonic Stem Cells (ESCs) are expected to show a stable euploid karyotype, but in the last decade (sub)chromosomal aberrations have been systematically described in these cell lines when maintained in vitro. Culture conditions and long-term culture have been traditionally proposed as possible factors involved in the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05324
更新日期：2014-06-17 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37039-y
更新日期：2019-01-30 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-02-07 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Scientific reports
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-04-16 00:00:00
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pub_type： 杂志文章
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更新日期：2017-01-16 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章,已发布勘误
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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