The allergic response mediated by fire ant venom proteins.

Abstract:

:Fire ants are widely studied, invasive and venomous arthropod pests. There is significant biomedical interest in immunotherapy against fire ant stings. However, mainly due to practical reasons, the physiological effects of envenomation has remained poorly characterized. The present study takes advantage of a recently-described venom protein extract to delineate the immunological pathways underlying the allergic reaction to fire ant venom toxins. Mice were injected with controlled doses of venom protein extract. Following sensitization and a second exposure, a marked footpad swelling was observed. Based on eosinophil recruitment and production of Th2 cytokines, we hereby establish that fire ant proteins per se can lead to an allergic response, which casts a new light into the mechanism of action of these toxins.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Zamith-Miranda D,Fox EGP,Monteiro AP,Gama D,Poublan LE,de Araujo AF,Araujo MFC,Atella GC,Machado EA,Diaz BL

doi

10.1038/s41598-018-32327-z

subject

Has Abstract

pub_date

2018-09-26 00:00:00

pages

14427

issue

1

issn

2045-2322

pii

10.1038/s41598-018-32327-z

journal_volume

8

pub_type

杂志文章
  • Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans.

    abstract::How microgravitational space environments affect aging is not well understood. We observed that, in Caenorhabditis elegans, spaceflight suppressed the formation of transgenically expressed polyglutamine aggregates, which normally accumulate with increasing age. Moreover, the inactivation of each of seven genes that we...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep00487

    authors: Honda Y,Higashibata A,Matsunaga Y,Yonezawa Y,Kawano T,Higashitani A,Kuriyama K,Shimazu T,Tanaka M,Szewczyk NJ,Ishioka N,Honda S

    更新日期:2012-01-01 00:00:00

  • Biotic soil-plant interaction processes explain most of hysteric soil CO2 efflux response to temperature in cross-factorial mesocosm experiment.

    abstract::Ecosystem carbon flux partitioning is strongly influenced by poorly constrained soil CO2 efflux (Fsoil). Simple model applications (Arrhenius and Q10) do not account for observed diel hysteresis between Fsoil and soil temperature. How this hysteresis emerges and how it will respond to variation in vegetation or soil m...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-55390-6

    authors: Dusza Y,Sanchez-Cañete EP,Galliard JL,Ferrière R,Chollet S,Massol F,Hansart A,Juarez S,Dontsova K,Haren JV,Troch P,Pavao-Zuckerman MA,Hamerlynck E,Barron-Gafford GA

    更新日期:2020-01-22 00:00:00

  • Endothelial Cell-derived Extracellular Vesicles Size-dependently Exert Procoagulant Activity Detected by Thromboelastometry.

    abstract::Endothelial cells (ECs) are major modulators of hemostasis by expressing and releasing pro- and anticoagulant mediators into the circulation. Previous studies showed that cultured ECs release procoagulant mediators into cell culture supernatants as evidenced by the reduction of viscoelastic clotting time. This effect ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-03159-0

    authors: Holnthoner W,Bonstingl C,Hromada C,Muehleder S,Zipperle J,Stojkovic S,Redl H,Wojta J,Schöchl H,Grillari J,Weilner S,Schlimp CJ

    更新日期:2017-06-16 00:00:00

  • Enhanced thermoelectric performance of a chalcopyrite compound CuIn3Se5-xTex (x = 0~0.5) through crystal structure engineering.

    abstract::In this work the chalcopyrite CuIn3Se5-xTex (x = 0~0.5) with space group through isoelectronic substitution of Te for Se have been prepared, and the crystal structure dilation has been observed with increasing Te content. This substitution allows the anion position displacement ∆u = 0.25-u to be zero at x ≈ 0.15. Howe...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40224

    authors: Lu Y,Chen S,Wu W,Du Z,Chao Y,Cui J

    更新日期:2017-01-06 00:00:00

  • First fossil frog from Antarctica: implications for Eocene high latitude climate conditions and Gondwanan cosmopolitanism of Australobatrachia.

    abstract::Cenozoic ectothermic continental tetrapods (amphibians and reptiles) have not been documented previously from Antarctica, in contrast to all other continents. Here we report a fossil ilium and an ornamented skull bone that can be attributed to the Recent, South American, anuran family Calyptocephalellidae or helmeted ...

    journal_title:Scientific reports

    pub_type: 历史文章,杂志文章

    doi:10.1038/s41598-020-61973-5

    authors: Mörs T,Reguero M,Vasilyan D

    更新日期:2020-04-23 00:00:00

  • Genome-wide patterns of local adaptation in Western European Drosophila melanogaster natural populations.

    abstract::Signatures of spatially varying selection have been investigated both at the genomic and transcriptomic level in several organisms. In Drosophila melanogaster, the majority of these studies have analyzed North American and Australian populations, leading to the identification of several loci and traits under selection...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-34267-0

    authors: Mateo L,Rech GE,González J

    更新日期:2018-11-01 00:00:00

  • Growth hormone secretagogues hexarelin and JMV2894 protect skeletal muscle from mitochondrial damages in a rat model of cisplatin-induced cachexia.

    abstract::Chemotherapy can cause cachexia, which consists of weight loss associated with muscle atrophy. The exact mechanisms underlying this skeletal muscle toxicity are largely unknown and co-therapies to attenuate chemotherapy-induced side effects are lacking. By using a rat model of cisplatin-induced cachexia, we here chara...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-13504-y

    authors: Sirago G,Conte E,Fracasso F,Cormio A,Fehrentz JA,Martinez J,Musicco C,Camerino GM,Fonzino A,Rizzi L,Torsello A,Lezza AMS,Liantonio A,Cantatore P,Pesce V

    更新日期:2017-10-12 00:00:00

  • In vivo evidence for an endothelium-dependent mechanism in radiation-induced normal tissue injury.

    abstract::The pathophysiological mechanism involved in side effects of radiation therapy, and especially the role of the endothelium remains unclear. Previous results showed that plasminogen activator inhibitor-type 1 (PAI-1) contributes to radiation-induced intestinal injury and suggested that this role could be driven by an e...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep15738

    authors: Rannou E,François A,Toullec A,Guipaud O,Buard V,Tarlet G,Mintet E,Jaillet C,Iruela-Arispe ML,Benderitter M,Sabourin JC,Milliat F

    更新日期:2015-10-29 00:00:00

  • Facet-specific assembly of proteins on SrTiO₃ polyhedral nanocrystals.

    abstract::Precisely controlling the protein-nanomaterial interactions at selective sites is crucial in engineering biomolecule composite architectures with tailored nanostructures and functions for a variety of biomedical applications. This strategy, however, is only beginning to be explored. Here, we demonstrate the facet-spec...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep05084

    authors: Dong L,Luo Q,Cheng K,Shi H,Wang Q,Weng W,Han WQ

    更新日期:2014-05-28 00:00:00

  • Development of a lateral flow test for bed bug detection.

    abstract::Lateral flow strip tests are a cost-effective method for detecting specific proteins in biological samples, which can be performed in the field without specialized expertise. While most recognizable in the pregnancy tests, there are many other applications for lateral flow strip technology. The pest control industry h...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-70200-0

    authors: Ko A,Choe DH

    更新日期:2020-08-07 00:00:00

  • Intranasal Administration of Chitosan Against Influenza A (H7N9) Virus Infection in a Mouse Model.

    abstract::Influenza virus evolves constantly in an unpredictable fashion, making it necessary to vaccinate people annually for effective prevention and control of influenza. In general, however, during the first wave of an influenza outbreak caused by a newly emerging virus strain, influenza morbidity and mortality have been ob...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep28729

    authors: Zheng M,Qu D,Wang H,Sun Z,Liu X,Chen J,Li C,Li X,Chen Z

    更新日期:2016-06-29 00:00:00

  • An integrative approach to discovering cryptic species within the Bemisia tabaci whitefly species complex.

    abstract::Bemisia tabaci is a cryptic whitefly-species complex that includes some of the most damaging pests and plant-virus vectors of a diverse range of food and fibre crops worldwide. We combine experimental evidence of: (i) differences in reproductive compatibility, (ii) hybrid verification using a specific nuclear DNA mark...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-29305-w

    authors: Vyskočilová S,Tay WT,van Brunschot S,Seal S,Colvin J

    更新日期:2018-07-18 00:00:00

  • Long-range propagation of protons in single-crystal VO2 involving structural transformation to HVO2.

    abstract::Vanadium dioxide (VO2) is a strongly correlated electronic material with a metal-insulator transition (MIT) near room temperature. Ion-doping to VO2 dramatically alters its transport properties and the MIT temperature. Recently, insulating hydrogenated VO2 (HVO2) accompanied by a crystal structure transformation from ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-56685-4

    authors: Muraoka K,Kanki T

    更新日期:2019-12-27 00:00:00

  • Assembly of luminescent ordered multilayer thin-films based on oppositely-charged MMT and magnetic NiFe-LDHs nanosheets with ultra-long lifetimes.

    abstract::In this present report, luminescent ordered multilayer thin films (OMFs) based on oppositely-charged inorganic nanosheets and the different oppositely-charged chromophores were fabricated via layer-by-layer assembly method. Exfoliated layered double hydroxides (LDHs) and montmorillonite (MMT) nanosheets with opposite ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep07147

    authors: Liu M,Wang T,Ma H,Fu Y,Hu K,Guan C

    更新日期:2014-11-21 00:00:00

  • 640-Gbit/s fast physical random number generation using a broadband chaotic semiconductor laser.

    abstract::An ultra-fast physical random number generator is demonstrated utilizing a photonic integrated device based broadband chaotic source with a simple post data processing method. The compact chaotic source is implemented by using a monolithic integrated dual-mode amplified feedback laser (AFL) with self-injection, where ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep45900

    authors: Zhang L,Pan B,Chen G,Guo L,Lu D,Zhao L,Wang W

    更新日期:2017-04-04 00:00:00

  • microRNA Expression in Ethnic Specific Early Stage Breast Cancer: an Integration and Comparative Analysis.

    abstract::Breast cancer (BC) has a higher incidence in young Lebanese woman as compared to the West. We assessed the microRNA (miRNA) microarray profile of tissues derived from Lebanese patients with early BC and performed mRNA-miRNA integration analysis. 173 miRNAs were significantly dysregulated in 45 BC versus 17 normal adja...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-16978-y

    authors: Nassar FJ,Talhouk R,Zgheib NK,Tfayli A,El Sabban M,El Saghir NS,Boulos F,Jabbour MN,Chalala C,Boustany RM,Kadara H,Zhang Z,Zheng Y,Joyce B,Hou L,Bazarbachi A,Calin G,Nasr R

    更新日期:2017-12-04 00:00:00

  • Modelling water levels of northwestern India in response to improved irrigation use efficiency.

    abstract::The groundwater crisis in northwestern India is the result of over-exploitation of groundwater resources for irrigation. The Government of India has targeted a 20 percent improvement in irrigation groundwater use efficiency. In this perspective, and using a regional-scale calibrated and validated three-dimensional gro...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-70416-0

    authors: Shekhar S,Kumar S,Densmore AL,van Dijk WM,Sinha R,Kumar M,Joshi SK,Rai SP,Kumar D

    更新日期:2020-08-10 00:00:00

  • Rogdi Defines GABAergic Control of a Wake-promoting Dopaminergic Pathway to Sustain Sleep in Drosophila.

    abstract::Kohlschutter-Tönz syndrome (KTS) is a rare genetic disorder with neurological dysfunctions including seizure and intellectual impairment. Mutations at the Rogdi locus have been linked to development of KTS, yet the underlying mechanisms remain elusive. Here we demonstrate that a Drosophila homolog of Rogdi acts as a n...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-11941-3

    authors: Kim M,Jang D,Yoo E,Oh Y,Sonn JY,Lee J,Ki Y,Son HJ,Hwang O,Lee C,Lim C,Choe J

    更新日期:2017-09-12 00:00:00

  • Investigating glycemic potential of rice by unraveling compositional variations in mature grain and starch mobilization patterns during seed germination.

    abstract::Rice lines with slower starch digestibility provide opportunities in mitigating the global rise in type II diabetes and related non-communicable diseases. However, screening for low glycemic index (GI) in rice breeding programs is not possible due to time and cost constraints. This study evaluated the feasibility of u...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-06026-0

    authors: Guzman MK,Parween S,Butardo VM,Alhambra CM,Anacleto R,Seiler C,Bird AR,Chow CP,Sreenivasulu N

    更新日期:2017-07-19 00:00:00

  • Biomechanical Evaluation of Wasp and Honeybee Stingers.

    abstract::In order to design a painless and mechanically durable micro syringe-needle system for biomedical applications, the study of insect stingers is of interest because of their elegant structures and functionalities. In the present work, the structure, mechanical properties and the mechanical behavior during insertion of ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-33386-y

    authors: Das R,Yadav RN,Sihota P,Uniyal P,Kumar N,Bhushan B

    更新日期:2018-10-08 00:00:00

  • CD36 is expressed in a defined subpopulation of neurons in the olfactory epithelium.

    abstract::The sensory neurons in the olfactory epithelium (OSNs) are equipped with a large repertoire of olfactory receptors and the associated signal transduction machinery. In addition to the canonical OSNs, which express odorant receptors (ORs), the epithelium contains specialized subpopulations of sensory neurons that can d...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep25507

    authors: Xavier AM,Ludwig RG,Nagai MH,de Almeida TJ,Watanabe HM,Hirata MY,Rosenstock TR,Papes F,Malnic B,Glezer I

    更新日期:2016-05-05 00:00:00

  • Multi-pass transmission electron microscopy.

    abstract::Feynman once asked physicists to build better electron microscopes to be able to watch biology at work. While electron microscopes can now provide atomic resolution, electron beam induced specimen damage precludes high resolution imaging of sensitive materials, such as single proteins or polymers. Here, we use simulat...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-01841-x

    authors: Juffmann T,Koppell SA,Klopfer BB,Ophus C,Glaeser RM,Kasevich MA

    更新日期:2017-05-10 00:00:00

  • UbC-StarTrack, a clonal method to target the entire progeny of individual progenitors.

    abstract::Clonal cell analysis defines the potential of single cells and the diversity they can produce. To achieve this, we have developed a novel adaptation of the genetic tracing strategy, UbC-StarTrack, which attributes a specific and unique color-code to single neural precursors, allowing all their progeny to be tracked. W...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep33896

    authors: Figueres-Oñate M,García-Marqués J,López-Mascaraque L

    更新日期:2016-09-22 00:00:00

  • Electron beam-assisted healing of nanopores in magnesium alloys.

    abstract::Nanopore-based sensing has emerged as a promising candidate for affordable and powerful DNA sequencing technologies. Herein, we demonstrate that nanopores can be successfully fabricated in Mg alloys via focused electron beam (e-beam) technology. Employing in situ high-resolution transmission electron microscopy techni...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep01920

    authors: Zheng H,Liu Y,Cao F,Wu S,Jia S,Cao A,Zhao D,Wang J

    更新日期:2013-01-01 00:00:00

  • Dilute-As AlNAs Alloy for Deep-Ultraviolet Emitter.

    abstract::The band structures of dilute-As AlNAs alloys with As composition ranging from 0% up to 12.5% are studied by using First-Principle Density Functional Theory (DFT) calculation. The energy band gap shows remarkable reduction from 6.19 eV to 3.87 eV with small amount of As content in the AlNAs alloy, which covers the dee...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep22215

    authors: Tan CK,Borovac D,Sun W,Tansu N

    更新日期:2016-02-24 00:00:00

  • Silicon-core glass fibres as microwire radial-junction solar cells.

    abstract::Vertically aligned radial-junction solar cell designs offer potential improvements over planar geometries, as carrier generation occurs close to the junction for all absorption depths, but most production methods still require a single crystal substrate. Here, we report on the fabrication of such solar cells from poly...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep06283

    authors: Martinsen FA,Smeltzer BK,Nord M,Hawkins T,Ballato J,Gibson UJ

    更新日期:2014-09-04 00:00:00

  • Instability of 8E5 calibration standard revealed by digital PCR risks inaccurate quantification of HIV DNA in clinical samples by qPCR.

    abstract:ABTRACT:Establishing a cure for HIV is hindered by the persistence of latently infected cells which constitute the viral reservoir. Real-time qPCR, used for quantification of this reservoir by measuring HIV DNA, requires external calibration; a common choice of calibrator is the 8E5 cell line, which is assumed to be st...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-01221-5

    authors: Busby E,Whale AS,Ferns RB,Grant PR,Morley G,Campbell J,Foy CA,Nastouli E,Huggett JF,Garson JA

    更新日期:2017-04-26 00:00:00

  • Gravity modeling finds a large magma body in the deep crust below the Gulf of Naples, Italy.

    abstract::We analyze a wide gravity low in the Campania Active Volcanic Area and interpret it by a large and deep source distribution of partially molten, low-density material from about 8 to 30 km depth. Given the complex spatial-temporal distribution of explosive volcanism in the area, we model the gravity data consistently w...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-26346-z

    authors: Fedi M,Cella F,D'Antonio M,Florio G,Paoletti V,Morra V

    更新日期:2018-05-29 00:00:00

  • Changes in membrane sphingolipid composition modulate dynamics and adhesion of integrin nanoclusters.

    abstract::Sphingolipids are essential constituents of the plasma membrane (PM) and play an important role in signal transduction by modulating clustering and dynamics of membrane receptors. Changes in lipid composition are therefore likely to influence receptor organisation and function, but how this precisely occurs is difficu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep20693

    authors: Eich C,Manzo C,de Keijzer S,Bakker GJ,Reinieren-Beeren I,García-Parajo MF,Cambi A

    更新日期:2016-02-12 00:00:00

  • Integrins outside focal adhesions transmit tensions during stable cell adhesion.

    abstract::Integrins coupled with other proteins form protein complexes named focal adhesions (FA) which are considered as the primary sites for cellular forces transduction during cell stable adhesion. Cell traction forces transmitted by FAs and integrin tensions inside FAs have been extensively studied. However, it remains unk...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep36959

    authors: Wang Y,Wang X

    更新日期:2016-11-15 00:00:00