The allergic response mediated by fire ant venom proteins.

Abstract:

:Fire ants are widely studied, invasive and venomous arthropod pests. There is significant biomedical interest in immunotherapy against fire ant stings. However, mainly due to practical reasons, the physiological effects of envenomation has remained poorly characterized. The present study takes advantage of a recently-described venom protein extract to delineate the immunological pathways underlying the allergic reaction to fire ant venom toxins. Mice were injected with controlled doses of venom protein extract. Following sensitization and a second exposure, a marked footpad swelling was observed. Based on eosinophil recruitment and production of Th2 cytokines, we hereby establish that fire ant proteins per se can lead to an allergic response, which casts a new light into the mechanism of action of these toxins.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Zamith-Miranda D,Fox EGP,Monteiro AP,Gama D,Poublan LE,de Araujo AF,Araujo MFC,Atella GC,Machado EA,Diaz BL

doi

10.1038/s41598-018-32327-z

subject

Has Abstract

pub_date

2018-09-26 00:00:00

pages

14427

issue

1

issn

2045-2322

pii

10.1038/s41598-018-32327-z

journal_volume

8

pub_type

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