Abstract：
:Endothelin-B receptor agonist, IRL-1620, provides significant neuroprotection following cerebral ischemia in rats. Whether this neuroprotection is due to inhibition of apoptosis is unknown. IRL-1620-treated rats following permanent middle cerebral artery occlusion (MCAO) showed significant improvement in neurological and motor functions along with a decrease in infarct volume at 24 h (-81.3%) and day 7 (-73.0%) compared to vehicle group. Cerebral blood flow (CBF) significantly improved in IRL-1620-treated animals compared to vehicle by day 7 post MCAO. IRL-1620-treated rats showed an increase in phospho-Akt and decrease in Bad level 7 h post-occlusion compared to vehicle, while Akt and Bad expression was similar in cerebral hemispheres at 24 h post-MCAO. The phospho-Bad level was lower in vehicle- but not in IRL-1620-treated rats at 24 h. Anti-apoptotic Bcl-2 expression decreased, while pro-apoptotic Bax expression increased in vehicle-treated MCAO rats, these changes were attenuated (P < 0.01) by IRL-1620. Mitochondrial membrane-bound Bax intensity significantly decreased in IRL-1620 compared to vehicle-treated MCAO rats. IRL-1620 treatment reduced (P < 0.001) the number of TUNEL-positive cells compared to vehicle at 24 h and day 7 post MCAO. The results demonstrate that IRL-1620 is neuroprotective and attenuates neural damage following cerebral ischemia in rats by increasing CBF and reducing apoptosis.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Briyal S,Ranjan AK,Hornick MG,Puppala AK,Luu T,Gulati Adoi
10.1038/s41598-019-46203-xsubject
Has Abstractpub_date
2019-07-18 00:00:00pages
10439issue
1issn
2045-2322pii
10.1038/s41598-019-46203-xjournal_volume
9pub_type
杂志文章abstract：:Obesity and inactivity are major risk factors of feline diabetes mellitus (FDM) and human type II diabetes mellitus (T2DM). In recent years, changes in the gut microbiota have been suggested as a contributing factor to T2DM. Whether the gut microbiota (GM) composition plays a role in FDM remains unknown. The aim of th...
journal_title：Scientific reports
pub_type： 杂志文章,多中心研究
doi：10.1038/s41598-019-41195-0
更新日期：2019-03-18 00:00:00
abstract：:Sodium butyrate (NaBu), a form of short-chain fatty acid (SCFA), acts classically as a potent anti-angiogenic agent in tumour angiogenesis models, some authors demonstrated that low concentrations of NaBu may contribute to healing of tendon-bone injury in part at least through promotion of tissue remodelling. Here, we...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34649
更新日期：2016-10-03 00:00:00
abstract：:A two-dimensional electron gas (2DEG) with equal-strength Rashba and Dresselhaus spin-orbit coupling sustains persistent helical spin-wave states, which have remarkably long lifetimes. In the presence of an in-plane magnetic field, there exist single-particle excitations that have the character of propagating helical ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21818-8
更新日期：2018-02-22 00:00:00
abstract：:Transient ischemia produces postischemic tingling sensation. Ischemia also produces nerve conduction block that may modulate spinal neural circuits. In the present study, reduced mechanical thresholds for hindpaw-withdrawal reflex were found in mice after transient hindpaw ischemia, which was produced by a high pressu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11191
更新日期：2015-07-13 00:00:00
abstract：:Millions of individuals worldwide suffer from impaired vision, a condition with multiple origins that often impinge upon the light sensing cells of the retina, the photoreceptors, affecting their integrity. The molecular components contributing to this integrity are however not yet fully understood. Here we have asked...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61970-8
更新日期：2020-03-20 00:00:00
abstract：:In this study, we report on a new approach for remote temperature probing that provides accuracy as good as 0.017°C (0.0055% accuracy) by measuring the magnetisation curve of magnetic nanoparticles. We included here the theoretical model construction and the inverse calculation method, and explored the impact caused b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06338
更新日期：2014-10-15 00:00:00
abstract：:Human pluripotent stem cells (hPSCs) offer tremendous promise in tissue engineering and cell-based therapies due to their unique combination of two properties: pluripotency and unlimited proliferative capacity. However, directed differentiation of hPSCs to clinically relevant cell lineages is needed to achieve the goa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01684-6
更新日期：2017-05-08 00:00:00
abstract：:Cross-linked protein crystals (CLPCs) are very useful materials in applications such as biosensors, catalysis, and X-ray crystallography. Hence, preparation of CLPCs is an important research direction. During the preparation of CLPCs, an often encountered problem is that cracks may appear in the crystals, which may fi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34770
更新日期：2016-10-05 00:00:00
abstract：:We examined whether alterations in body perception in EDs extend to the integration of exteroceptive visual and tactile information. Moreover, we investigated the effect of self-focused attention on the ability to correctly detect tactile stimuli. Twenty-seven women reporting low ED symptoms, versus 26 women reporting...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68500-6
更新日期：2020-07-15 00:00:00
abstract：:There are no clinical guidelines for the timing of cholecystectomy (CCY) after performing therapeutic endoscopic retrograde cholangiopancreatography (ERCP) for choledocholithiasis. We tried to analyze the clinical practice patterns, medical expenses, and subsequent outcomes between the early CCY, delayed CCY, and no C...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-38428-z
更新日期：2019-02-18 00:00:00
abstract：:Unconventional superconductivity often emerges at the border of long-range magnetic orders. Understanding the low-energy charge dynamics may provide crucial information on the formation of superconductivity. Here we report the unpolarized/polarized optical conductivity study of high quality MnP single crystals at ambi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14648-7
更新日期：2017-10-27 00:00:00
abstract：:We analyze the ferroelectric domain-wall induced negative capacitance (NC) effect in Metal-FE-Insulator-Metal (MFIM) and Metal-FE-Insulator-Semiconductor (MFIS) stacks through phase-field simulations by self-consistently solving time-dependent Ginzburg Landau equation, Poisson's equation and semiconductor charge equat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66313-1
更新日期：2020-06-23 00:00:00
abstract：:The phytohormone auxin is a major determinant and regulatory component important for plant development. Auxin transport between cells is mediated by a complex system of transporters such as AUX1/LAX, PIN, and ABCB proteins, and their localization and activity is thought to be influenced by phosphatases and kinases. Fl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41906
更新日期：2017-02-06 00:00:00
abstract：:Daily life stress is an omnipresent phenomenon in modern society. Research has linked prolonged activation of the hypothalamic-pituitary-adrenal axis to psychiatric and somatic diseases. Everyday stressors substantially contribute to these health risks. Despite the notion that the physiological stress response is high...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33708-0
更新日期：2018-10-18 00:00:00
abstract：:A scheme is presented to realize a single-photon transistor based on cavity quantum electrodynamics (QED) with Rydberg atomic ensemble. By combining the advantages of the cavity-enhanced interaction and Rydberg blockade, we achieve a high gain single-photon transistor. The numerical calculation shows that by using one...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41185-2
更新日期：2019-03-18 00:00:00
abstract：:We investigated the validity of panoramic ultrasound (US) compared to magnetic resonance imaging (MRI) for the assessment of hamstrings cross-sectional area (CSA) and volume. Hamstrings CSA were acquired with US (by an expert operator) at four different sites of femur length (FL) in 85 youth competitive alpine skiers ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71123-6
更新日期：2020-08-24 00:00:00
abstract：:Spontaneous isopeptide bond formation, a stabilizing posttranslational modification that can be found in gram-positive bacterial cell surface proteins, has previously been used to develop a peptide-peptide ligation technology that enables the polymerization of tagged-proteins catalyzed by SpyLigase. Here we adapted th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39291
更新日期：2016-12-16 00:00:00
abstract：:Urban coach cabin is an important indoor environment for long journey, formaldehyde (HCHO) is a carcinogenic gas and damages indoor air quality of cabins. In order to control the HCHO pollution, the air samples inside cabins were analysed with a thermally desorbed gas chromatograph, and the HCHO diffusion was simulate...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-57263-4
更新日期：2020-01-15 00:00:00
abstract：:Arbuscular mycorrhizal fungi (AMF) and phosphate solubilizing bacteria (PSB) could interact synergistically because PSB solubilize sparingly available phosphorous compounds into orthophosphate that AMF can absorb and transport to the host plant. Little is known about the interactions between these two groups in terms ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61846-x
更新日期：2020-03-18 00:00:00
abstract：:We study the interaction between localized vibrational modes and propagating phonons in graphene nanoribbons with different types of localized internal and edge defects. We analyze discrete eigenmodes of the nanoribbons with defects and also employ direct numerical simulations of the ballistic phonon and heat transpor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04987-w
更新日期：2017-07-05 00:00:00
abstract：:Artificial tissues constructed from therapeutic cells offer a promising approach for improving the treatment of severe peripheral nerve injuries. In this study the effectiveness of using CTX0E03, a conditionally immortalised human neural stem cell line, as a source of allogeneic cells for constructing living artificia...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20927-8
更新日期：2018-02-13 00:00:00
abstract：:One of the most challenging issues in HIV-associated neurocognitive disorders (HAND) caused by HIV-1 virotoxins and drug abuse is the lack of understanding the underlying mechanisms that are commonly associated with disorders of the blood-brain barrier (BBB), which mainly consists of brain microvascular endothelial ce...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40467
更新日期：2017-01-11 00:00:00
abstract：:Plastic degradation rates in the marine environment are essential to understand. This study demonstrates that in plastic-microbial interaction experiments, residual monomeric and oligomeric content of PA6 significantly influences the development of dissolved organic carbon. While it is well recognized that additives i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38685-6
更新日期：2019-02-14 00:00:00
abstract：:O antigen (O-Ag) in many bacteria is synthesized via the Wzx/Wzy-dependent pathway in which Wzy polymerizes lipid-linked O-Ag subunits to modal lengths regulated by Wzz. Characterization of 83 site-directed mutants of Wzy from Pseudomonas aeruginosa PAO1 (WzyPa) in topologically-mapped periplasmic (PL) and cytoplasmic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03441
更新日期：2013-12-06 00:00:00
abstract：:Biopharming for the production of recombinant pharmaceutical proteins in the mammary gland of transgenic animals is an attractive but laborious alternative compared to mammalian cell fermentation. The disadvantage of the lengthy process of genetically modifying an entire animal could be circumvented with somatic trans...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15115
更新日期：2015-10-14 00:00:00
abstract：:Stem and progenitor cells are the critical units for tissue maintenance, regeneration, and repair. The activation of regenerative events in response to tissue injury has been correlated with mobilization of tissue-resident progenitor cells, which is functional to the wound healing process. However, until now there has...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16574
更新日期：2015-11-12 00:00:00
abstract：:Natural competence for genetic transformation refers to the natural ability of various bacteria to take up exogenous DNA from their surroundings and to incorporate internalized genetic information into their genomes. By promoting bacterial diversification and adaptability, this process represents a major driving force...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47423-x
更新日期：2019-07-30 00:00:00
abstract：:Randomizing the layer thickness of superlattices (SL) can lead to localization of coherent phonons and thereby reduces the lattice thermal conductivity κ l . In this work, we propose strategies that can suppress incoherent phonon transport in the above random multilayer (RML) structure to further reduce κ l . Molecula...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08359-2
更新日期：2017-08-15 00:00:00
abstract：:Perinatally HIV-infected patients face the consequences of both chronic infection effects per se and long-term combination antiretroviral therapy (cART) on immunosenescence. Aims of our study were to evaluate which factors independently contribute to immunosenescence in HIV-infected young adults with a very different ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67100-8
更新日期：2020-06-22 00:00:00
abstract：:Recently, there has been increasing interest in strategies to predict neurological recovery in cervical myelopathy (CM) based on clinical images of the cervical spine. In this study, we aimed to explore potential preoperative brain biomarkers that can predict postoperative neurological recovery in CM patients by using...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46859-5
更新日期：2019-07-18 00:00:00
