An all-in-one, Tet-On 3G inducible PiggyBac system for human pluripotent stem cells and derivatives.

abstract：:MicroRNAs (miRNAs) are important regulators involved in various cancers, including colorectal cancer (CRC). The functions and mechanisms of the miRNAs involved in CRC progress and metastasis are largely unknown. In this study, miRNA microarray analysis was performed to screen crucial miRNAs involved in CRC progress, a...

journal_title：Scientific reports

authors： Li Q,Liang X,Wang Y,Meng X,Xu Y,Cai S,Wang Z,Liu J,Cai G

更新日期：2016-05-31 00:00:00

abstract：:Self-assembly of a nucleoside on Au(111) was studied to ascertain whether polymerization on well-defined substrates constitutes a promising approach for making sequence-controlled polymers. Scanning tunneling microscopy and density functional theory were used to investigate the self-assembly on Au(111) of (RS)-N(9)-(2...

journal_title：Scientific reports

authors： Wang J,Bonnesen PV,Rangel E,Vallejo E,Sanchez-Castillo A,James Cleaves Ii H,Baddorf AP,Sumpter BG,Pan M,Maksymovych P,Fuentes-Cabrera M

更新日期：2016-01-04 00:00:00

abstract：:Figure-ground segregation is the process by which the visual system identifies image elements of figures and segregates them from the background. Previous studies examined figure-ground segregation in the visual cortex of monkeys where figures elicit stronger neuronal responses than backgrounds. It was demonstrated in...

journal_title：Scientific reports

authors： Schnabel UH,Bossens C,Lorteije JAM,Self MW,Op de Beeck H,Roelfsema PR

更新日期：2018-12-12 00:00:00

abstract：:In this study, we report on a new approach for remote temperature probing that provides accuracy as good as 0.017°C (0.0055% accuracy) by measuring the magnetisation curve of magnetic nanoparticles. We included here the theoretical model construction and the inverse calculation method, and explored the impact caused b...

journal_title：Scientific reports

authors： Zhong J,Liu W,Kong L,Morais PC

更新日期：2014-10-15 00:00:00

abstract：:Because of ubiquity of thioesters, thioesterases play a critical role in metabolism, membrane biosynthesis, signal transduction, and gene regulation. In many bacteria, YbgC is such an enzyme, whose coding gene mostly resides in the tol-pal cluster. Although all other proteins encoded in the tol-pal cluster are clearly...

journal_title：Scientific reports

authors： Gao T,Meng Q,Gao H

更新日期：2017-06-21 00:00:00

abstract：:There is an unmet need for treatments to reduce abdominal aortic aneurysm (AAA) progression. Vascular smooth muscle cell (VSMC) apoptosis precipitates AAA formation, whereas VSMC proliferation repairs the vessel wall. We previously demonstrated that over-expression of EC4-Fc (truncated N-cadherin), or deletion of matr...

journal_title：Scientific reports

authors： Lyon CA,Williams H,Bianco R,Simmonds SJ,Brown BA,Wadey KS,Smith FCT,Johnson JL,George SJ

更新日期：2017-12-11 00:00:00

abstract：:Ultra-fast synchrotron radiation emission can arise from the transverse betatron motion of an electron in a laser plasma wakefield, and the radiation spectral peak is limited to tens of keV. Here, we present a new method for achieving high-energy radiation via accelerated electrons wiggling in an additional laser fiel...

journal_title：Scientific reports

authors： Feng J,Li Y,Wang J,Li D,Li F,Yan W,Wang W,Chen L

更新日期：2019-02-21 00:00:00

abstract：:Greater levels of solar energy storage provide an effective solution to the inherent nature of intermittency, and can substantially improve reliability, availability, and quality of the renewable energy source. Here we demonstrated an all-vanadium (all-V) continuous-flow photoelectrochemical storage cell (PESC) to ach...

journal_title：Scientific reports

authors： Wei Z,Shen Y,Liu D,Liu F

更新日期：2017-04-04 00:00:00

abstract：:We compared the gut microbial populations in 100 women, from rural Ghana and urban US [50% lean (BMI < 25 kg/m2) and 50% obese (BMI ≥ 30 kg/m2)] to examine the ecological co-occurrence network topology of the gut microbiota as well as the relationship of short chain fatty acids (SCFAs) with obesity. Ghanaians consumed...

journal_title：Scientific reports

authors： Dugas LR,Bernabé BP,Priyadarshini M,Fei N,Park SJ,Brown L,Plange-Rhule J,Nelson D,Toh EC,Gao X,Dong Q,Sun J,Kliethermes S,Gottel N,Luke A,Gilbert JA,Layden BT

更新日期：2018-11-20 00:00:00

abstract：:This study aims to prepare, characterize and evaluate the pharmacokinetics of liposomal donepezil HCl (LDH) dispersed into thiolated chitosan hydrogel (TCH) in rabbits. Various hydrogels including TCH were prepared, and after characterization, TCH was selected for subsequent evaluations, due to the promising results. ...

journal_title：Scientific reports

authors： Al Harthi S,Alavi SE,Radwan MA,El Khatib MM,AlSarra IA

更新日期：2019-07-02 00:00:00

abstract：:Heavy metal pollution has been a problem since the advent of modern transportation, which despite efforts to curb emissions, continues to play a critical role in environmental pollution. Copper ions (Cu2+), in particular, are one of the more prevalent metals that have widespread detrimental ramifications. From this pe...

journal_title：Scientific reports

authors： Hwang J,Hwang MP,Choi M,Seo Y,Jo Y,Son J,Hong J,Choi J

更新日期：2016-10-18 00:00:00

abstract：:Sense of touch is a major part of man's communication with their environment. Artificial skins can help robots to have the same sense of touch, especially for their social interactions. This paper presents a pressure mapping sensing using piezo-resistive fabric to represent aspects of the sense of touch. In past few y...

journal_title：Scientific reports

authors： Duan X,Taurand S,Soleimani M

更新日期：2019-06-20 00:00:00

abstract：:Microvascular endothelial cell heterogeneity and its relationship to hemodynamics remains poorly understood due to a lack of sufficient methods to examine these parameters in vivo at high resolution throughout an angiogenic network. The availability of surrogate markers for functional vascular proteins, such as green ...

journal_title：Scientific reports

authors： Kelly-Goss MR,Ning B,Bruce AC,Tavakol DN,Yi D,Hu S,Yates PA,Peirce SM

更新日期：2017-08-22 00:00:00

abstract：:The transient silencing effects currently demonstrated by nonviral siRNA delivery systems limit the therapeutic utility of RNAi, but it remains a technical challenge to prolong duration of gene silencing. We have developed a T7 autogene-based hybrid mRNA/DNA system to enable long-term expression of shRNA in cytoplasm ...

journal_title：Scientific reports

authors： Kwak SY,Han HD,Ahn HJ

更新日期：2019-02-28 00:00:00

abstract：:The bacterial stringent response is a key regulator of bacterial virulence, biofilm formation and antibiotic tolerance, and is a promising target for the development of new antibacterial compounds. The intracellular nucleotide (p)ppGpp acts as a messenger orchestrating the stringent response. A synthetic peptide 1018 ...

journal_title：Scientific reports

authors： Andresen L,Tenson T,Hauryliuk V

更新日期：2016-11-07 00:00:00

abstract：:The human transcription elongation factor DSIF is highly conserved throughout all kingdoms of life and plays multiple roles during transcription. DSIF is a heterodimer, consisting of Spt4 and Spt5 that interacts with RNA polymerase II (RNAP II). DSIF binds to the elongation complex and induces promoter-proximal pausin...

journal_title：Scientific reports

authors： Zuber PK,Hahn L,Reinl A,Schweimer K,Knauer SH,Gottesman ME,Rösch P,Wöhrl BM

更新日期：2018-08-03 00:00:00

abstract：:Therapeutic application of newly developed oximes is limited due to their adverse effects on different tissues. Within this article, it has been investigated which morphological changes could be observed in Wistar rats after the treatment with increasing doses of selected acetyl cholinesterase reactivators - asoxime, ...

journal_title：Scientific reports

authors： Jaćević V,Nepovimova E,Kuča K

更新日期：2019-02-06 00:00:00

abstract：:This prospective study investigates whether measurement of plasma intestinal-fatty acid binding protein (I-FABP), a sensitive marker for small intestinal epithelial damage, improves non-invasive diagnosing of celiac disease (CD), and whether I-FABP levels are useful to evaluate mucosal healing in patients on a gluten-...

journal_title：Scientific reports

authors： Adriaanse MPM,Mubarak A,Riedl RG,Ten Kate FJW,Damoiseaux JGMC,Buurman WA,Houwen RHJ,Vreugdenhil ACE,Celiac Disease Study Group.

更新日期：2017-08-17 00:00:00

abstract：:Age and sleep both affect emotional functioning. Since sleep patterns change over the lifespan, we investigated the effects of short sleep and age on empathic responses. In a randomized cross-over experimental design, healthy young and older volunteers (n = 47 aged 20-30 years and n = 39 aged 65-75 years) underwent fu...

journal_title：Scientific reports

authors： Tamm S,Nilsonne G,Schwarz J,Lamm C,Kecklund G,Petrovic P,Fischer H,Åkerstedt T,Lekander M

更新日期：2017-09-25 00:00:00

abstract：:Osteochondral defects contain damage to both the articular cartilage and underlying subchon- dral bone, which remains a significant challenge in orthopedic surgery. Layered structure of bone, cartilage and the bone-cartilage interface must be taken into account in the case of biofabrication of the osteochondral (OC) i...

journal_title：Scientific reports

authors： Ayan B,Wu Y,Karuppagounder V,Kamal F,Ozbolat IT

更新日期：2020-08-04 00:00:00

abstract：:To gain the fundamental understanding of deformation mechanisms in an aluminum-containing austenitic high-Mn steel (Fe-32Mn-8.9Al-0.78 C (wt.%)), in-situ straining transmission electron microscopy (TEM) analysis is conducted. The in-situ observation during the deformation demonstrates that the plastic deformation is a...

journal_title：Scientific reports

authors： Kim SD,Park JY,Park SJ,Jang JH,Moon J,Ha HY,Lee CH,Kang JY,Shin JH,Lee TH

更新日期：2019-10-23 00:00:00

abstract：:Intracellular calcium ([Ca2+]i) signaling is an essential universal secondary messenger in articular chondrocytes. However, little is known about its spatiotemporal features in the context of osteoarthritis (OA). Herein, by examining the cartilage samples collected from patients undergoing knee arthroscopic surgery, w...

journal_title：Scientific reports

authors： Gong X,Xie W,Wang B,Gu L,Wang F,Ren X,Chen C,Yang L

更新日期：2017-12-06 00:00:00

abstract：:Hydrogen has therapeutic and preventive effects against various diseases. Although animal and clinical studies have reported promising results, hydrogen distribution in organs after administration remains unclear. Herein, the sequential changes in hydrogen concentration in tissues over time were monitored using a high...

journal_title：Scientific reports

authors： Yamamoto R,Homma K,Suzuki S,Sano M,Sasaki J

更新日期：2019-02-04 00:00:00

abstract：:The presence of well-vascularised, endosteal bone in the medullary region of long bones of nonavian dinosaurs has been invoked as being homologous to medullary bone, a specialised bone tissue formed during ovulation in birds. However, similar bone tissues can result as a pathological response in modern birds and in no...

journal_title：Scientific reports

authors： Chinsamy A,Cerda I,Powell J

更新日期：2016-04-26 00:00:00

abstract：:Ocular graft-versus-host disease (GVHD) is a common complication after hematopoietic stem cell transplantation (HSCT). Here we compared the diagnostic rates of ocular GVHD, including its severity, prognosis and the agreement, obtained using three grading scales: the National Institutes of Health (NIH) eye score, Japan...

journal_title：Scientific reports

authors： Tatematsu Y,Ogawa Y,Abe T,Kamoi M,Uchino M,Saijo-Ban Y,Yaguchi S,Mukai S,Mori T,Okamoto S,Tsubota K

更新日期：2014-10-22 00:00:00

abstract：:Cardiac output during cardiac catheterization is often estimated using the modified Fick method (COFick). In this proof-of-concept, prospective non-randomized study carried out in a single academic healthcare centre, we examined whether replacing COFick in the Gorlin formula with Cheetah-NICOM monitor cardiac output (...

journal_title：Scientific reports

authors： Mitrev L,van Helmond N,Kaddissi G,Awad A,Patel K,Aji J,Ogbara J,Rafeq Z,Nagubandi V,Orr D,Gaughan J,Rosenbloom M

更新日期：2020-05-12 00:00:00

abstract：:G-protein-coupled receptors (GPCRs) are important drug targets with diverse therapeutic applications. However, there are still more than a hundred orphan GPCRs, whose protein functions and biochemical features remain unidentified. Gpr176 encodes a class-A orphan GPCR that has a role in circadian clock regulation in mo...

journal_title：Scientific reports

authors： Wang T,Nakagawa S,Miyake T,Setsu G,Kunisue S,Goto K,Hirasawa A,Okamura H,Yamaguchi Y,Doi M

更新日期：2020-03-10 00:00:00

abstract：:Understanding mechanisms mediating tumor metastasis is crucial for diagnostic and therapeutic targeting. Here, we take advantage of a transparent embryonic zebrafish xenograft model (eZXM) to visualize and track metastatic cells in real time using selective plane illumination microscopy (SPIM) for up to 30 h. Injected...

journal_title：Scientific reports

authors： Asokan N,Daetwyler S,Bernas SN,Schmied C,Vogler S,Lambert K,Wobus M,Wermke M,Kempermann G,Huisken J,Brand M,Bornhäuser M

更新日期：2020-08-06 00:00:00

abstract：:Social information use has well-known fitness benefits. However, causes underlying the apparent inter-individual variability in the propensity to use social information are poorly studied. Melanins are pigments responsible for most of intra-specific color variation in vertebrates and their variation is often associate...

journal_title：Scientific reports

authors： Parejo D,Avilés JM

更新日期：2020-02-05 00:00:00

abstract：:More than 12 GW of offshore wind turbines are currently in operation in European waters. To optimise the use of the marine areas, wind farms are typically clustered in units of several hundred turbines. Understanding wakes of wind farms, which is the region of momentum and energy deficit downwind, is important for opt...

journal_title：Scientific reports

authors： Platis A,Siedersleben SK,Bange J,Lampert A,Bärfuss K,Hankers R,Cañadillas B,Foreman R,Schulz-Stellenfleth J,Djath B,Neumann T,Emeis S

更新日期：2018-02-01 00:00:00