Abstract:
:Millions of individuals worldwide suffer from impaired vision, a condition with multiple origins that often impinge upon the light sensing cells of the retina, the photoreceptors, affecting their integrity. The molecular components contributing to this integrity are however not yet fully understood. Here we have asked whether Secreted Frizzled Related Protein 1 (SFRP1) may be one of such factors. SFRP1 has a context-dependent function as modulator of Wnt signalling or of the proteolytic activity of A Disintegrin And Metalloproteases (ADAM) 10, a main regulator of neural cell-cell communication. We report that in Sfrp1-/- mice, the outer limiting membrane (OLM) is discontinuous and the photoreceptors disorganized and more prone to light-induced damage. Sfrp1 loss significantly enhances the effect of the Rpe65Leu450Leu genetic variant -present in the mouse genetic background- which confers sensitivity to light-induced stress. These alterations worsen with age, affect visual function and are associated to an increased proteolysis of Protocadherin 21 (PCDH21), localized at the photoreceptor outer segment, and N-cadherin, an OLM component. We thus propose that SFRP1 contributes to photoreceptor fitness with a mechanism that involves the maintenance of OLM integrity. These conclusions are discussed in view of the broader implication of SFRP1 in neurodegeneration and aging.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Cisneros E,di Marco F,Rueda-Carrasco J,Lillo C,Pereyra G,Martín-Bermejo MJ,Vargas A,Sanchez R,Sandonís Á,Esteve P,Bovolenta Pdoi
10.1038/s41598-020-61970-8subject
Has Abstractpub_date
2020-03-20 00:00:00pages
5115issue
1issn
2045-2322pii
10.1038/s41598-020-61970-8journal_volume
10pub_type
杂志文章abstract::An experimental method for fabrication of a nanocomposite metamaterial based on a self-assembly of titanium dioxide microtubes with encapsulated gold nanoparticles (NPs) is proposed. The formation of microtubes is induced by laser irradiation in the presence of an external magnetic field. It is shown that the variatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43588-7
更新日期:2019-05-07 00:00:00
abstract::Membrane fouling remains an obstacle to wide-spread applications of membrane bioreactors (MBRs) for wastewater treatment and reclamation. Herein, we report a simple method to prepare a composite conductive microfiltration (MF) membrane by introducing a stainless steel mesh into a polymeric MF membrane and to effective...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09268
更新日期:2015-03-18 00:00:00
abstract::Anthropogenic radionuclides contaminate a range of environments as a result of nuclear activities, for example, leakage from waste storage tanks/ponds (e.g. Hanford, USA or Sellafield sites, UK) or as a result of large scale nuclear accidents (e.g. Chernobyl, Ukraine or Fukushima, Japan). One of the most widely applie...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23361
更新日期:2016-03-18 00:00:00
abstract::Fibroblast growth factor 21 (FGF21) and cytokeratin 18 (CK18) were previously reported to be elevated in nonalcoholic fatty liver disease (NAFLD). We aim to analyze the differential roles of FGF21, cell apoptosis marker CK18 fragment M30 and total cell death marker CK18 M65ED in monitoring the different stages of NAFL...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05257-5
更新日期:2017-07-11 00:00:00
abstract::HMG domain transcription factor, Sox2, is a critical gene for the development of cochlear hair cells, the receptor cells for hearing, but this has been ascribed to expansion of the progenitors that become hair cells. Here, we show that Sox2 activated Atoh1, a transcription factor important for hair cell differentiatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23293
更新日期:2016-03-18 00:00:00
abstract::Diabetic nephropathy is characterised by the excessive amount of extracellular matrix in glomeruli and tubulointerstitial space. Lysyl oxidase-like 2 (LOXL2) is elevated in renal fibrosis and known to play key roles in ECM stabilisation by facilitating collagen cross-links, epithelial to mesenchymal transition and myo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27462-6
更新日期:2018-06-21 00:00:00
abstract::We report the development of complete structural AlGaN-based deep-ultraviolet light-emitting diodes with an aluminum thin layer for increasing light extraction efficiency. A 217% enhancement in peak photoluminescence intensity at 294 nm is observed. Cathodoluminescence measurement demonstrates that the internal quantu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00816
更新日期:2012-01-01 00:00:00
abstract::TBX21 recode T-bet which is an important transcription factor that drives the Th1 immune response primarily by promoting expression of the interferon-gamma (IFNG) gene. Recent studies have shown that genetic variants in TBX21 and IFNG are connected with risk of systemic lupus erythematosus (SLE). The aim of the presen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22081
更新日期:2016-02-26 00:00:00
abstract::One way of expediting materials development is to decrease the need for new experiments by making greater use of published literature. Here, we use data mining and automated image analysis to gather new insights on nanoporous gold (NPG) without conducting additional experiments or simulations. NPG is a three-dimension...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25122-3
更新日期:2018-04-30 00:00:00
abstract::Ample evidence indicates that obesity causes dysfunctions in the lung. Previous studies also show that cholinergic anti-inflammatory pathways play crucial roles in obesity-induced chronic inflammation via α7 nicotinic acetylcholine receptor (α7nAChR) signaling. However, it remains unclear whether and how obesity affec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75414-w
更新日期:2020-10-27 00:00:00
abstract::Corline Heparin Conjugate (CHC), a compound of multiple unfractionated heparin chains, coats cells with a glycocalyx-like layer and may inhibit (xeno)transplant-associated activation of the plasma cascade systems. Here, we investigated the use of CHC to protect WT and genetically modified (GTKO.hCD46.hTBM) pig aortic ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04898-w
更新日期:2017-06-30 00:00:00
abstract::In the modern era, diathermic oils have been gotten the great attention from researchers due to its notable and momentous applications in engineering, mechanics and in the industrial field. The aim of this paper is to model the problem to augment the heat transfer rate of diathermic oils, specifically, Engine-oil (EO)...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33547-z
更新日期:2018-10-16 00:00:00
abstract::During recent military operations, eye-related injuries have risen in frequency due to increased use of explosive weaponry which often result in corneal puncture injuries. These have one of the poorest visual outcomes for wounded soldiers, often resulting in blindness due to the large variations in injury shape, size,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61079-y
更新日期:2020-03-06 00:00:00
abstract::Tuberculosis (TB) is the leading cause of death due to an infectious agent, but only a small fraction of those infected develop the disease. Cytokines are involved in the mediation and regulation of immunity, and their secretion patterns may reflect the infection status. To increase our understanding of immune respons...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44294-0
更新日期:2019-06-03 00:00:00
abstract::Whole-slide imaging of histologic sections captures tissue microenvironments and cytologic details in expansive high-resolution images. These images can be mined to extract quantitative features that describe tissues, yielding measurements for hundreds of millions of histologic objects. A central challenge in utilizin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15092-3
更新日期:2017-11-06 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-62904-0
更新日期:2020-04-10 00:00:00
abstract::Antibiogram profile of 1590 clinical bacterial isolates based on thirteen different antimicrobial compounds showed that 1.6% of the bacterial isolates are multidrug resistant. Distribution pattern based on 16S rRNA sequence analysis showed that Pseudomonas aeruginosa constituted the largest group (83.6%) followed by B...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23156
更新日期:2016-03-18 00:00:00
abstract::Helicobacter pylori cagA-positive strains are critically involved in the development of gastric cancer. Upon delivery into gastric epithelial cells via type IV secretion, the cagA-encoded CagA interacts with and thereby perturbs the pro-oncogenic phosphatase SHP2 and the polarity-regulating kinase PAR1b via the tyrosi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34425-4
更新日期:2018-10-29 00:00:00
abstract::The bacterial translational GTPase EF4/LepA is structurally similar to the canonical elongation factor EF-G. While sharing core structural features with other translational GTPases, the function of EF4 remains unknown. Recent structural data locates the unique C-terminal domain (CTD) of EF4 in proximity to the ribosom...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08573
更新日期:2015-02-25 00:00:00
abstract::Melimine and Mel4 are chimeric cationic peptides with broad-spectrum antimicrobial activity. They have been shown to be highly biocompatible in animal models and human clinical trials. The current study examined the mechanism of action of these two antimicrobial peptides against P. aeruginosa. The effect of the peptid...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42440-2
更新日期:2019-05-08 00:00:00
abstract::microRNAs are an abundant class of small non-coding RNAs that control gene expression post-transcriptionally. Importantly, microRNA activity participates in the regulation of cellular processes and is a potentially valuable source of biomarkers in the diagnosis and prognosis of human diseases. Here we introduce miQPCR...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11590
更新日期:2015-06-25 00:00:00
abstract::The expanding distribution of African swine fever (ASF) is threatening the pig industry worldwide. Most outbreaks occur in backyard and small-scale herds, where poor farmers often attempt to limit the disease's economic consequences by the emergency sale of their pigs. The risk of African swine fever virus (ASFV) rele...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17074
更新日期:2015-11-27 00:00:00
abstract::Hepatocellular carcinoma (HCC) is one of the most common cause of malignancy-related mortality worldwide. It is urgently needed to develop potential drugs with good efficacy and low toxicity for HCC treatment. The anti-tumor effect of Traditional Chinese Medicine (TCM) has received increasing attention worldwide. Tram...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31298
更新日期:2016-08-09 00:00:00
abstract::Are you walking at me? Biological movement and the encoding of its motion and orientation. A person's motion conveys a wealth of information that ranges from the complex, such as intention or emotional state, to the simple, such as direction of locomotion. How we recognise and recover people's motion is addressed by m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22393
更新日期:2016-02-29 00:00:00
abstract::Vascular endothelial growth factor receptor-2 (VEGFR2) and its ligands (VEGFs) are crucial players in vasculogenesis and angiogenesis. General blocking of this signaling system with antibodies or small molecule inhibitors is an established strategy to treat cancer and age-related macular degeneration. Nevertheless, th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49646-4
更新日期:2019-09-16 00:00:00
abstract::The persistent public health threat of animal to human transmission of influenza A virus (IAV) has stimulated interest in rapid and accurate detection of all IAV subtypes in clinical specimens of animal origin. In this study, a new set of primers and probes was designed for one-step pan-IAV reverse-transcription fluor...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30015
更新日期:2016-07-22 00:00:00
abstract::The maternal environment can influence the intensity of seed dormancy and thus seasonal germination timing and post-germination life history traits. We tested the hypotheses that germination season influences phenotypic expression of post-germination life history traits in the cold desert annual Isatis violascens and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25076
更新日期:2016-04-27 00:00:00
abstract::Allocation of limited nutrients, such as nitrogen (N) and phosphorus (P), among plant organs reflects the influences of evolutionary and ecological processes on functional traits of plants, and thus is related to functional groups and environmental conditions. In this study, we tested this hypothesis by exploring the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20099
更新日期:2016-02-05 00:00:00
abstract::The combustion of hydrocarbon fuels within the automotive industry results in harmful and reactive incomplete combustion byproducts. Specifically, nitric oxide emissions (NO) lead to increased smog, acid rain, climate change, and respiratory inflammation within the population [Nitrogen Dioxide | American Lung Associat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75360-7
更新日期:2020-10-30 00:00:00
abstract::With millions of new dental and orthopedic implants inserted annually, periprosthetic osteolysis becomes a major concern. In dentistry, peri-implantitis management includes cleaning using ultrasonic scaling. We examined whether ultrasonic scaling releases titanium particles and induces inflammation and osteolysis. Tit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39612
更新日期:2017-01-06 00:00:00