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Sox2 in the differentiation of cochlear progenitor cells.

Abstract：

:HMG domain transcription factor, Sox2, is a critical gene for the development of cochlear hair cells, the receptor cells for hearing, but this has been ascribed to expansion of the progenitors that become hair cells. Here, we show that Sox2 activated Atoh1, a transcription factor important for hair cell differentiation, through an interaction with the 3' enhancer of Atoh1. Binding to consensus sequences in the Atoh1 enhancer was dependent on the level of Sox2, and the extent of enhancer binding correlated to the extent of activation. Atoh1 activation by Sox2 was required for embryonic hair cell development: deletion of Sox2 in an inducible mutant, even after progenitor cells were fully established, halted development of hair cells, and silencing also inhibited postnatal differentiation of hair cells induced by inhibition of γ-secretase. Sox2 is thus required in the cochlea to both expand the progenitor cells and initiate their differentiation to hair cells.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Kempfle JS,Turban JL,Edge AS

doi

10.1038/srep23293

subject

Has Abstract

pub_date

2016-03-18 00:00:00

pages

23293

issn

2045-2322

pii

srep23293

journal_volume

6

pub_type

杂志文章

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