Abstract:
:With millions of new dental and orthopedic implants inserted annually, periprosthetic osteolysis becomes a major concern. In dentistry, peri-implantitis management includes cleaning using ultrasonic scaling. We examined whether ultrasonic scaling releases titanium particles and induces inflammation and osteolysis. Titanium discs with machined, sandblasted/acid-etched and sandblasted surfaces were subjected to ultrasonic scaling and we physically and chemically characterized the released particles. These particles induced a severe inflammatory response in macrophages and stimulated osteoclastogenesis. The number of released particles and their chemical composition and nanotopography had a significant effect on the inflammatory response. Sandblasted surfaces released the highest number of particles with the greatest nanoroughness properties. Particles from sandblasted/acid-etched discs induced a milder inflammatory response than those from sandblasted discs but a stronger inflammatory response than those from machined discs. Titanium particles were then embedded in fibrin membranes placed on mouse calvariae for 5 weeks. Using micro-CT, we observed that particles from sandblasted discs induced more osteolysis than those from sandblasted/acid-etched discs. In summary, ultrasonic scaling of titanium implants releases particles in a surface type-dependent manner and may aggravate peri-implantitis. Future studies should assess whether surface roughening affects the extent of released wear particles and aseptic loosening of orthopedic implants.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Eger M,Sterer N,Liron T,Kohavi D,Gabet Ydoi
10.1038/srep39612subject
Has Abstractpub_date
2017-01-06 00:00:00pages
39612issn
2045-2322pii
srep39612journal_volume
7pub_type
杂志文章abstract::Sensitivity to sounds is one frequent symptom of a sport-related concussion, but its assessment rarely goes beyond a single question. Here we examined sensitivity to sounds using psychoacoustic and psychometric outcomes in athletes beyond the acute phase of injury. Fifty-eight college athletes with normal hearing who ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28312-1
更新日期:2018-07-02 00:00:00
abstract::L-arginine:glycine amidinotransferase (AGAT) and its metabolites creatine and homoarginine (HA) have been linked to cardiovascular pathologies in both human and murine studies, but the underlying molecular mechanisms are poorly understood. Here, we report the first analysis of heart transcriptome variation using micro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61638-3
更新日期:2020-03-16 00:00:00
abstract::Gelatin, derived from collagen, has both the mechanical properties required for tissue growth, as well the functional domains required for cell binding. In its natural state, gelatin derives its properties from a network of structured, intertwined, triple helical chains, which is stabilized by hydrogen bonds at temper...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25495
更新日期:2016-05-05 00:00:00
abstract::In this work, we introduce a novel and facile method of exfoliating large-area, single-layer graphene oxide using a shearing stress. The shearing stress reactor consists of two concentric cylinders, where the inner cylinder rotates at controlled speed while the outer cylinder is kept stationary. We found that the form...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16649-y
更新日期:2017-11-27 00:00:00
abstract::We evaluate the track segment yield G' of typical water radiolysis products (eaq-, ·OH and H2O2) under heavy ions (He, C and Fe ions) using a Monte Carlo simulation code in the Geant4-DNA. Furthermore, we reproduce experimental results of ·OH of He and C ions around the Bragg peak energies (< 6 MeV/u). In the relative...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81215-6
更新日期:2021-01-15 00:00:00
abstract::Fear is an adaptive emotion that elicits defensive behavioural responses against aversive threats in animals. In mammals, serotonin receptors (5-HTRs) have been shown to modulate fear-related neural circuits in the basolateral amygdala complex (BLA). To understand the phylogenetic continuity of the neural basis for fe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78247-9
更新日期:2020-12-03 00:00:00
abstract::Poor oral health is not only associated with diabetes and cardiovascular disease but adverse pregnancy outcomes. However the influence of dental caries on pregnancy is unknown. The aim of this study was to evaluate the association between dental caries and adverse pregnancy outcomes and the effect of treatment for den...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62306-2
更新日期:2020-03-24 00:00:00
abstract::Although recent studies focused on traditional Chinese medicine (TCM) for the treatment of refractory schizophrenia have reported that it may be beneficial, there is still lack of convincing evidence and critical meta-analytic work regarding its effectiveness as an adjunctive therapy. Therefore, we performed a meta-an...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-018-24547-0
更新日期:2018-04-18 00:00:00
abstract::Advanced age is associated with a decline in cognitive function, likely caused by a combination of modifiable and non-modifiable factors such as genetics and lifestyle choices. Mounting evidence suggests that humanin and other mitochondrial derived peptides play a role in several age-related conditions including neuro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32616-7
更新日期:2018-09-21 00:00:00
abstract::The production of male and female offspring is often determined by the presence of specific sex chromosomes which control sex-specific expression, and sex chromosomes evolve through reduced recombination and specialized gene content. Here we present the genomes of Chrysomya rufifacies, a monogenic blow fly (females pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72880-0
更新日期:2020-09-25 00:00:00
abstract::A tetrameric N-acetyl galactosaminyl (GalNAc) peptidomimetic was constructed by N-acetylation of repeating proline-based hydroxamic acid units, followed by a convergent 'click chemistry' coupling. This novel glycopeptidomimetic was determined to effectively antagonize the interaction between a transmembrane hepatic le...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05513
更新日期:2014-07-01 00:00:00
abstract::Sugarcane (Saccharum spp. hybrids) is a potential lignocellulosic feedstock for biofuel production due to its exceptional biomass accumulation ability, high convertible carbohydrate content and a favorable energy input/output ratio. Genetic modification of biofuel traits to improve biomass conversion requires an under...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30033-4
更新日期:2018-08-02 00:00:00
abstract::Disc degeneration (DD) is a multifaceted chronic process that alters the structure and function of intervertebral discs. The pathophysiology of degeneration is not completely understood, but the consensus is that changes in genes encoding extracellular matrix (ECM) proteins in the disc are the leading factors contribu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04384-3
更新日期:2017-06-23 00:00:00
abstract::Liver chips have been developed to recapitulate in vivo physiological conditions to enhance hepatocyte functions for assessing acute responses to drugs. To develop liver chips that can assess repeated dosing chronic hepatotoxicity, we need to ensure that hepatocyte functions be maintained at constant values over two w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13848-5
更新日期:2017-11-06 00:00:00
abstract::The mechanisms by which the airborne pathogen Mycobacterium tuberculosis spreads within the lung and leaves its primary niche to colonize other organs, thus inducing extrapulmonary forms of tuberculosis (TB) in humans, remains poorly understood. Herein, we used a transcriptomic approach to investigate the host cell ge...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33162
更新日期:2016-09-12 00:00:00
abstract::Three-dimensional (3D) bioprinting is driving major innovations in the area of cartilage tissue engineering. Extrusion-based 3D bioprinting necessitates a phase change from a liquid bioink to a semi-solid crosslinked network achieved by a photo-initiated free radical polymerization reaction that is known to be cytotox...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05699-x
更新日期:2017-07-19 00:00:00
abstract::The differential conductance of graphene is shown to exhibit a zero-bias anomaly at low temperatures, arising from a suppression of the quantum corrections due to weak localization and electron interactions. A simple rescaling of these data, free of any adjustable parameters, shows that this anomaly exhibits a univers...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62313-3
更新日期:2020-03-27 00:00:00
abstract::Mycoplasma pneumoniae infection is conventionally diagnosed using serum antibody testing, microbial culture, and genetic testing. Recently, immunochromatography-based rapid mycoplasma antigen test kits have been developed and commercialised for rapid diagnosis of M. pneumoniae infection. However, as these kits do not ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19734-y
更新日期:2018-01-23 00:00:00
abstract::Hepatocarcinoma (HCC) is one of the deadliest cancers in the world and represents a significant disease burden. Better biomarkers are needed for early detection of HCC. Metabolomics was applied to urine samples obtained from HCC patients to discover noninvasive and reliable biomarkers for rapid diagnosis of HCC. Metab...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19763
更新日期:2016-01-25 00:00:00
abstract::The highly polymorphic human leukocyte antigen (HLA) plays a crucial role in adaptive immunity and is associated with various complex diseases. Accurate analysis of HLA genes using ancient DNA (aDNA) data is crucial for understanding their role in human adaptation to pathogens. Here, we describe the TARGT pipeline for...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64312-w
更新日期:2020-04-30 00:00:00
abstract::Candida albicans biofilm formation is governed by a regulatory circuit comprising nine transcription factors which control a network of target genes. However, there are still unknown genes contributing to biofilm features. Thus, the GRACE library was screened to identify genes involved in mature biofilm development. T...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45624-y
更新日期:2019-06-24 00:00:00
abstract::Increased activity of brown adipose tissue (BAT) activity in adults is thought to prevent obesity. Therefore, regulators of BAT activity might serve as anti-obesity therapy in future, but are not investigated thoroughly up to now. In our study, we assessed retrospectively the association of BAT activity with several e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37924-6
更新日期:2019-02-13 00:00:00
abstract::Prostate-specific antigen (PSA) kinetics predicts survival in castration-resistant prostate cancer (CRPC); however, the influence of prior treatment on this relationship is unclear. Patients with CRPC were stratified according to time to PSA nadir and time to CRPC progression to investigate their prognostic significan...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48424-6
更新日期:2019-08-15 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-27850-y
更新日期:2018-06-22 00:00:00
abstract::Although aversive memory has been mainly addressed by analysing the changes occurring in average populations, the study of neuronal mechanisms of outliers allows understanding the involvement of individual differences in fear conditioning and extinction. We recently developed an innovative experimental model of indivi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21205
更新日期:2016-02-15 00:00:00
abstract::The clinical significance of STIM proteins and Orai Ca2+ channels in tumor progression has been demonstrated in different types of cancers. Podosomes are dynamic actin-rich cellular protrusions that facilitate cancer cell invasiveness by degrading extracellular matrix. Whether STIM1-dependent Ca2+ signaling facilitate...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11273-2
更新日期:2017-09-14 00:00:00
abstract::Trypanosoma cruzi is the etiological agent of Chagas disease, a neglected and emerging tropical disease, endemic to South America and present in non-endemic regions due to human migration. The MASP multigene family is specific to T. cruzi, accounting for 6% of the parasite's genome and plays a key role in immune evasi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27293
更新日期:2016-06-08 00:00:00
abstract::Rabies is still a public health threat in China. Evaluating the exposure history, clinical characteristics, and post-exposure prophylaxis (PEP) of the cases could help in identifying approaches to reducing the number of these preventable deaths. We analysed data collected from 10,971 case-investigations conducted in C...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35158-0
更新日期:2018-11-21 00:00:00
abstract::The associations of 18F-THK5351 tau positron emission tomography (PET) findings with core domains of progressive supranuclear palsy (PSP) and its diagnostic certainty have yet to be fully elucidated. The 18F-THK5351 PET patterns of 17 patients with PSP (68.9 ± 6.5 years; 8 women) were compared with those observed in 2...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76339-0
更新日期:2020-11-10 00:00:00
abstract::In chickens, the sensory organs for taste are the taste buds in the oral cavity, of which there are ~240-360 in total number as estimated by scanning electron microscopy (SEM). There is not an easy way to visualize all taste buds in chickens. Here, we report a highly efficient method for labeling chicken taste buds in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37247
更新日期:2016-11-17 00:00:00