18F-THK5351 PET imaging in patients with progressive supranuclear palsy: associations with core domains and diagnostic certainty.

abstract：:Recently, CuZr-based bulk metallic glass (BMG) composites reinforced by the TRIP (transformation-induced plasticity) effect have been explored in attempt to accomplish an optimal of trade-off between strength and ductility. However, the design of such BMG composites with advanced mechanical properties still remains a ...

journal_title：Scientific reports

authors： Qin YS,Han XL,Song KK,Tian YH,Peng CX,Wang L,Sun BA,Wang G,Kaban I,Eckert J

更新日期：2017-02-13 00:00:00

abstract：:The existing molecular cloning methods are often limited by the availability of suitable restriction sites. It is still a challenge for simultaneous cloning of multiple fragments into different sites of a single vector. Here we developed a novel method named improved overlap extension PCR (IOEP) for restriction enzyme...

journal_title：Scientific reports

authors： Guo W,Xie B,Jiang M,Zhu XJ,Qiu M,Dai ZM

更新日期：2019-10-30 00:00:00

abstract：:Temporomandibular disorders (TMD), when progress to a chronic state, might contribute to psychosocial or psychological distress. This study aimed to evaluate the effect of stabilization splint (SS) therapy on pain, pain-related disability and psychological traits of chronic TMD patients, as well as to assess selected ...

journal_title：Scientific reports

authors： Alajbeg IZ,Vrbanović E,Lapić I,Alajbeg I,Vuletić L

更新日期：2020-07-03 00:00:00

abstract：:Chronic myeloid leukemia (CML) is characterized in the majority of cases by a t(9;22)(q34;q11) translocation, also called the Philadelphia chromosome, giving rise to the BCR-ABL1 fusion protein. Current treatment with tyrosine kinase inhibitors is directed against the constitutively active ABL1 domain of the fusion pr...

journal_title：Scientific reports

authors： Löf L,Arngården L,Olsson-Strömberg U,Siart B,Jansson M,Dahlin JS,Thörn I,Christiansson L,Hermansson M,Larsson A,Ahlstrand E,Wålinder G,Söderberg O,Rosenquist R,Landegren U,Kamali-Moghaddam M

更新日期：2017-04-04 00:00:00

abstract：:Energetic ions have been widely used to evaluate the irradiation tolerance of structural materials for nuclear power applications and to modify material properties. It is important to understand the defect production, annihilation and migration mechanisms during and after collision cascades. In this study, single crys...

journal_title：Scientific reports

authors： Lu C,Jin K,Béland LK,Zhang F,Yang T,Qiao L,Zhang Y,Bei H,Christen HM,Stoller RE,Wang L

更新日期：2016-02-01 00:00:00

abstract：:As a noninvasive and "task-free" technique, resting-state functional magnetic resonance imaging (rs-fMRI) has been gradually applied to pre-surgical functional mapping. Independent component analysis (ICA)-based mapping has shown advantage, as no a priori information is required. We developed an automated method for i...

journal_title：Scientific reports

authors： Lu J,Zhang H,Hameed NUF,Zhang J,Yuan S,Qiu T,Shen D,Wu J

更新日期：2017-10-23 00:00:00

abstract：:The Schumann Resonances (ScR) are Extremely Low Frequency (ELF) electromagnetic resonances in the Earth-ionosphere cavity excited by global lightning discharges. This natural electromagnetic noise has likely existed on the Earth ever since the Earth had an atmosphere and an ionosphere, hence surrounding us throughout ...

journal_title：Scientific reports

authors： Elhalel G,Price C,Fixler D,Shainberg A

更新日期：2019-02-07 00:00:00

abstract：:DNA-directed RNA polymerase II (pol II) is composed of ten core and two dissociable subunits. The dissociable subcomplex is a heterodimer of Rpb4/Polr2d and Rpb7/Polr2g, which are encoded by RPB4/polr2d and RPB7/polr2g genes, respectively. Functional studies of Rpb4/Polr2d in yeast have revealed that Rpb4 plays a role...

journal_title：Scientific reports

authors： Maeta M,Kataoka M,Nishiya Y,Ogino K,Kashima M,Hirata H

更新日期：2020-08-06 00:00:00

abstract：:Efficient hematopoietic reconstitution of wild type mice requires preconditioning. Established experimental protocols exist to transplant hematopoietic stem cells into lethally irradiated or chemically myeloablated adult mice or unirradiated immunodeficient mice. We sought to develop a protocol to reconstitute immuno-...

journal_title：Scientific reports

authors： Laky K,Dugan P,Frischmeyer-Guerrerio PA

更新日期：2018-08-16 00:00:00

abstract：:Dolphin morbillivirus (DMV) has been responsible for several outbreaks of systemic infection and has resulted in cetacean strandings in the Mediterranean. In August-October 2016, seven striped dolphins (Stenella coeruleoalba) stranded on the Sicilian coastline (Italy) tested positive for DMV. Tissue samples from brain...

journal_title：Scientific reports

authors： Mira F,Rubio-Guerri C,Purpari G,Puleio R,Caracappa G,Gucciardi F,Russotto L,Loria GR,Guercio A

更新日期：2019-07-05 00:00:00

abstract：:Synthetic fertilizer production is associated with a high environmental footprint, as compounds typically dissolve rapidly leaching emissions to the atmosphere or surface waters. We tested two recovered nutrients with slower release patterns, as promising alternatives for synthetic fertilizers: struvite and a commerci...

journal_title：Scientific reports

authors： Grunert O,Robles-Aguilar AA,Hernandez-Sanabria E,Schrey SD,Reheul D,Van Labeke MC,Vlaeminck SE,Vandekerckhove TGL,Mysara M,Monsieurs P,Temperton VM,Boon N,Jablonowski ND

更新日期：2019-07-02 00:00:00

abstract：:Dravet syndrome is the prototype of SCN1A-mutation associated epilepsies. It is characterised by prolonged seizures, typically provoked by fever. We describe the evaluation of an SCN1A mutation in a child with early-onset temperature-sensitive seizures. The patient carries a heterozygous missense variant (c3818C > T; ...

journal_title：Scientific reports

authors： Peters C,Rosch RE,Hughes E,Ruben PC

更新日期：2016-09-01 00:00:00

abstract：:Although plants are essentially sessile in nature, these organisms are very much in tune with their environment and are capable of a variety of movements. This may come as a surprise to many non-botanists, but not to Charles Darwin, who reported that plants do produce movements. Following Darwin's specific interest on...

journal_title：Scientific reports

authors： Guerra S,Peressotti A,Peressotti F,Bulgheroni M,Baccinelli W,D'Amico E,Gómez A,Massaccesi S,Ceccarini F,Castiello U

更新日期：2019-11-12 00:00:00

abstract：:Odorant binding proteins (OBPs) play critical roles in chemical communication of insects, as they recognize and transport environmental chemical signals to receptors. The diving beetle Cybister japonicus Sharp shows a remarkable sexual dimorphism. The foreleg tarsi of males are equipped with large suction cups, believ...

journal_title：Scientific reports

authors： Song LM,Jiang X,Wang XM,Li JD,Zhu F,Tu XB,Zhang ZH,Ban LP

更新日期：2016-08-22 00:00:00

abstract：:Converging evidence from laboratory models pointed that the widely used antidiabetic drug metformin has direct effects on cancer cells. Thus far, relatively little attention has been addressed to the drug exposures used experimentally relative to those achievable clinically. Here, we demonstrated that metformin loaded...

journal_title：Scientific reports

authors： Yoo S,Hou J,Yi W,Li Y,Chen W,Meng L,Si J,Hou X

更新日期：2017-04-21 00:00:00

abstract：:Breast cancer is a serious problem causing the death of women across the world. At present, one of the major challenges is to design drugs to target breast cancer specific gene(s). RNA interference (RNAi) is an important technique for targeted gene silencing that may lead to promising novel therapeutic strategies for ...

journal_title：Scientific reports

authors： Tyagi A,Semwal M,Sharma A

更新日期：2017-08-18 00:00:00

abstract：:Free carriers, polarons (P), in conjugated polymers play a key role in the performance of optoelectronic devices. Here, we present solid evidence that P can be predominantly generated from polaron pairs (PP) in a poly(3-hexylthiophene) (P3HT) film under zero electric field. P formation from PP strongly depends on temp...

journal_title：Scientific reports

authors： Ogata Y,Kawaguchi D,Tanaka K

更新日期：2015-02-13 00:00:00

abstract：:This multi-institutional study sought to clarify the association between the preoperative serum albumin/globulin ratio (AGR) and the prognosis of renal cell carcinoma (RCC) in a large cohort. This study encompassed eight institutions and 2,970 non-metastatic RCC patients who underwent a radical or partial nephrectomy ...

journal_title：Scientific reports

authors： Chung JW,Park DJ,Chun SY,Choi SH,Lee JN,Kim BS,Kim HT,Kim TH,Yoo ES,Byun SS,Hwang EC,Kang SH,Hong SH,Chung J,Kwak C,Kim YJ,Ha YS,Kwon TG

更新日期：2020-07-20 00:00:00

abstract：:Global climate change has resulted in a warmer Arctic, with projections indicating accelerated modifications to permafrost in the near future. The thermal, hydrological, and mechanical physics of permafrost thaw have been hypothesized to couple in a complex fashion but data collection efforts to study these feedbacks ...

journal_title：Scientific reports

authors： Wagner AM,Lindsey NJ,Dou S,Gelvin A,Saari S,Williams C,Ekblaw I,Ulrich C,Borglin S,Morales A,Ajo-Franklin J

更新日期：2018-07-19 00:00:00

abstract：:Boolean multiplex (multilevel) networks (BMNs) are currently receiving considerable attention as theoretical arguments for modeling of biological systems and system level analysis. Studying control-related problems in BMNs may not only provide new views into the intrinsic control in complex biological systems, but als...

journal_title：Scientific reports

authors： Wu Y,Xu J,Sun XM,Wang W

更新日期：2017-04-28 00:00:00

abstract：:Although the initial formulation of modern concepts of adaptive radiation arose from consideration of the fossil data, rigorous attempts to identify this phenomenon in the fossil record are largely uncommon. Here I focus on direct evidence of the diet (through tooth-wear patterns) and ecologically-relevant traits of o...

journal_title：Scientific reports

authors： DeMiguel D

更新日期：2016-07-13 00:00:00

abstract：:Whole-slide imaging of histologic sections captures tissue microenvironments and cytologic details in expansive high-resolution images. These images can be mined to extract quantitative features that describe tissues, yielding measurements for hundreds of millions of histologic objects. A central challenge in utilizin...

journal_title：Scientific reports

authors： Nalisnik M,Amgad M,Lee S,Halani SH,Velazquez Vega JE,Brat DJ,Gutman DA,Cooper LAD

更新日期：2017-11-06 00:00:00

abstract：:Resistance to 157 different herbicides and 88% of known sites of action has been observed, with many weeds resistant to two or more modes. Coupled with tighter environmental regulation, this demonstrates the need to identify new modes of action and novel herbicides. The plant sphingolipid biosynthetic enzyme, inositol...

journal_title：Scientific reports

authors： Pinneh EC,Mina JG,Stark MJR,Lindell SD,Luemmen P,Knight MR,Steel PG,Denny PW

更新日期：2019-05-30 00:00:00

abstract：:Zika virus infection and dengue and chikungunya fevers are emerging viral diseases that have become public health threats. Their aetiologic agents are transmitted by the bite of genus Aedes mosquitoes. Without effective therapies or vaccines, vector control is the main strategy for preventing the spread of these disea...

journal_title：Scientific reports

authors： Lopez SBG,Guimarães-Ribeiro V,Rodriguez JVG,Dorand FAPS,Salles TS,Sá-Guimarães TE,Alvarenga ESL,Melo ACA,Almeida RV,Moreira MF

更新日期：2019-03-11 00:00:00

abstract：:Kalata B1 has been demonstrated to have bioactivity relating to membrane disruption. In this study, we conducted coarse-grained molecular dynamics simulations to gain further insight into kB1 bioactivity. The simulations were performed at various concentrations of kB1 to capture the overall progression of its activity...

journal_title：Scientific reports

authors： Nawae W,Hannongbua S,Ruengjitchatchawalya M

更新日期：2014-02-03 00:00:00

abstract：:In the present work, an attempt has been made to synthesize the 1,2,3-triazole derivatives resulting from the click reaction, in a mild and green environment using the new copper(II)-coated magnetic core-shell nanoparticles Fe3O4@SiO2 modified by isatoic anhydride. The structure of the catalyst has been determined by ...

journal_title：Scientific reports

authors： Rajabi-Moghaddam H,Naimi-Jamal MR,Tajbakhsh M

更新日期：2021-01-22 00:00:00

abstract：:In this study we investigated the biological role and mechanism of miR-198 in colorectal carcinoma (CRC). MiR-198 expression was shown to exhibit a strongly negative correlation with lymph node invasion, distant metastasis and patient survival in examinations of colorectal cancer tissues and paired normal colorectal m...

journal_title：Scientific reports

authors： Wang M,Wang J,Kong X,Chen H,Wang Y,Qin M,Lin Y,Chen H,Xu J,Hong J,Chen YX,Zou W,Fang JY

更新日期：2014-09-01 00:00:00

abstract：:The increasing incidence of obesity accentuates the importance of identifying mechanisms and optimal therapeutic strategies for patients with heart failure (HF) in relation to obesity status. Here, we investigated the association between plasma level of apelin, an adipocyte-derived factor, and clinicopathological feat...

journal_title：Scientific reports

authors： Boal F,Roumegoux J,Alfarano C,Timotin A,Calise D,Anesia R,Drougard A,Knauf C,Lagente C,Roncalli J,Desmoulin F,Tronchere H,Valet P,Parini A,Kunduzova O

更新日期：2015-11-06 00:00:00

abstract：:Viral hepatitis leads to immune-mediated liver injury. The rate of disease progression varies between individuals. We aimed to phenotype immune cells associated with preservation of normal liver function during hepatitis C virus (HCV) infection. Clinical data and specimens were obtained from 19 HCV-infected patients u...

journal_title：Scientific reports

authors： Doyle EH,Aloman C,El-Shamy A,Eng F,Rahman A,Klepper AL,Haydel B,Florman SS,Fiel MI,Schiano T,Branch AD

更新日期：2021-01-15 00:00:00

abstract：:Acclimation and adaptation, which are key to species survival in a changing climate, can be observed in terms of membrane lipid composition. Remodelling membrane lipids, via homeoviscous adaptation (HVA), counteracts membrane dysfunction due to temperature in poikilotherms. In order to assess the potential for acclima...

journal_title：Scientific reports

authors： Muir AP,Nunes FL,Dubois SF,Pernet F

更新日期：2016-10-20 00:00:00