Handheld Co-Axial Bioprinting: Application to in situ surgical cartilage repair.

abstract：:L-R (left and right) symmetry breaking during embryogenesis and the establishment of asymmetric body plan are key issues in developmental biology, but the onset including the handedness-determining gene locus still remains unknown. Using pure dextral (DD) and sinistral (dd) strains of the pond snail Lymnaea stagnalis ...

journal_title：Scientific reports

authors： Kuroda R,Fujikura K,Abe M,Hosoiri Y,Asakawa S,Shimizu M,Umeda S,Ichikawa F,Takahashi H

更新日期：2016-10-06 00:00:00

abstract：:Molecular imaging technique is an attractive tool to detect liver disease at early stage. This study aims to develop a simultaneous dual-isotope single photon emission computed tomography (SPECT)/CT imaging method to assist diagnosis of hepatic tumor and liver fibrosis. Animal models of liver fibrosis and orthotopic h...

journal_title：Scientific reports

authors： Guo Z,Gao M,Zhang D,Li Y,Song M,Zhuang R,Su X,Chen G,Liu T,Liu P,Wu H,Du J,Zhang X

更新日期：2016-07-05 00:00:00

abstract：:Significant technical and optical advances are required for intraoperative optical coherence tomography (OCT) to be utilized during otological surgeries. Integrating OCT with surgical microscopy makes it possible to evaluate soft tissue in real-time and at a high resolution. Herein, we describe an augmented-reality, i...

journal_title：Scientific reports

authors： Lee J,Wijesinghe RE,Jeon D,Kim P,Choung YH,Jang JH,Jeon M,Kim J

更新日期：2018-11-27 00:00:00

abstract：:To effectively manage a watershed and successfully restore a river system, it is very important to assess the toxicity of sediments and identify the substances causing the toxicity. Seventy-six sediments collected in the Haihe River Basin (HRB) in China were screened for acute toxicity using Chironomus dilutus. We fou...

journal_title：Scientific reports

authors： Zhu X,Shan B,Tang W,Zhang C

更新日期：2017-05-03 00:00:00

abstract：:Dibutyl phthalate (DBP) is recognized as an environmental endocrine disruptor that has been detected in fetal and postnatal samples. Recent evidence found that in utero DBP exposure was associated with an increase of adipose tissue weight and serum lipids in offspring, but the precise mechanism is unknown. Here we aim...

journal_title：Scientific reports

authors： Li H,Li J,Qu Z,Qian H,Zhang J,Wang H,Xu X,Liu S

更新日期：2020-10-01 00:00:00

abstract：:Taste receptors on enteroendocrine cells sense nutrients and transmit signals that control gut hormone release. This study aimed to investigate the amino acid (AA) sensing mechanisms of the ghrelin cell in a gastric ghrelinoma cell line, tissue segments and mice. Peptone and specific classes of amino acids stimulate g...

journal_title：Scientific reports

authors： Vancleef L,Van Den Broeck T,Thijs T,Steensels S,Briand L,Tack J,Depoortere I

更新日期：2015-10-29 00:00:00

abstract：:Mycobacterium marinum (M. marinum) is a slowly growing nontuberculous mycobacterium. The incidence of M. marinum infections in Denmark is unknown. We conducted a retrospective nationwide study including all culture confirmed cases of M. marinum from 2004 to 2017 in Denmark. All available medical records were reviewed....

journal_title：Scientific reports

authors： Holden IK,Kehrer M,Andersen AB,Wejse C,Svensson E,Johansen IS

更新日期：2018-04-30 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) play diverse roles in biological processes. Aedes aegypti (Ae. aegypti), a blood-sucking mosquito, is the principal vector responsible for replication and transmission of arboviruses including dengue, Zika, and Chikungunya virus. Systematic identification and developmental characterisatio...

journal_title：Scientific reports

authors： Azlan A,Obeidat SM,Yunus MA,Azzam G

更新日期：2019-08-21 00:00:00

abstract：:The anatomic and functional combinations of cusps and lophs (ridges) define the tooth shape of rodent molars, which distinguishes species. The species-specific cusp patterns result from the spatiotemporal induction of enamel knots (EKs), which require precisely controlled cellular behavior to control the epithelial in...

journal_title：Scientific reports

authors： Li L,Tang Q,Nakamura T,Suh JG,Ohshima H,Jung HS

更新日期：2016-11-28 00:00:00

abstract：:Towards exploring advanced applications of terahertz (THz) electromagnetic waves, great efforts are being applied to develop a compact and sensitive THz receiver. Here, we propose a simple coherent detection system using a single resonant tunnelling diode (RTD) oscillator through self-oscillating mixing with an RTD os...

journal_title：Scientific reports

authors： Nishida Y,Nishigami N,Diebold S,Kim J,Fujita M,Nagatsuma T

更新日期：2019-12-02 00:00:00

abstract：:Experimental evidence supports that signaling pathways can induce different dynamics of transcription factor (TF) activation, but how an input signal is encoded by such a dynamic, noisy TF and further decoded by downstream genes remains largely unclear. Here, using a system of stochastic transcription with signal regu...

journal_title：Scientific reports

authors： Liu P,Wang H,Huang L,Zhou T

更新日期：2017-02-08 00:00:00

abstract：:Oceanic physics at fine scale; e.g. eddies, fronts, filaments; are notoriously difficult to sample. However, an increasing number of theoretical approaches hypothesize that these processes affect phytoplankton diversity which have cascading effects on regional ecosystems. In 2015, we targeted the Iroise Sea (France) a...

journal_title：Scientific reports

authors： Ramond P,Siano R,Schmitt S,de Vargas C,Marié L,Memery L,Sourisseau M

更新日期：2021-01-29 00:00:00

abstract：:Cortical spreading depolarization (SD) involves activation of NMDA receptors and elicit neurovascular unit dysfunction. NMDA cannot trigger SD in newborns, thus its effect on neurovascular function is not confounded by other aspects of SD. The present study investigated if NMDA affected hypercapnia-induced microvascul...

journal_title：Scientific reports

authors： Remzső G,Németh J,Tóth-Szűki V,Varga V,Kovács V,Domoki F

更新日期：2019-12-11 00:00:00

abstract：:The recent development of a CRISPR-Cas9-based homing system for the suppression of Anopheles gambiae is encouraging; however, with current designs, the slow emergence of homing-resistant alleles is expected to result in suppressed populations rapidly rebounding, as homing-resistant alleles have a significant fitness a...

journal_title：Scientific reports

authors： Marshall JM,Buchman A,Sánchez C HM,Akbari OS

更新日期：2017-06-19 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) patients have poor prognosis and poor response to treatment. This is largely due to PDAC being associated with a dense and active stroma and tumor fibrosis (desmoplasia). Desmoplasia is characterized by excessive degradation and formation of the extracellular matrix (ECM) genera...

journal_title：Scientific reports

authors： Willumsen N,Ali SM,Leitzel K,Drabick JJ,Yee N,Polimera HV,Nagabhairu V,Krecko L,Ali A,Maddukuri A,Moku P,Ali A,Poulose J,Menon H,Pancholy N,Costa L,Karsdal MA,Lipton A

更新日期：2019-12-24 00:00:00

abstract：:Given that the biological processes governing the oncogenesis of pancreatic cancers could present useful therapeutic targets, there is a pressing need to molecularly distinguish between different clinically relevant pancreatic cancer subtypes. To address this challenge, we used targeted proteomics and other molecular ...

journal_title：Scientific reports

authors： Sinkala M,Mulder N,Martin D

更新日期：2020-01-27 00:00:00

abstract：:The antioxidant and multiple organ protection effects of acid- extracted mycelia polysaccharides (Ac-MPS) from Pleurotus eryngii var. tuoliensis on HFE-induced hypertriglyceridemic mice were investigated. The results showed that Ac-MPS have potential ability to relieve the hypertriglyceridemia and preventing oxidative...

journal_title：Scientific reports

authors： Gao Z,Lai Q,Yang Q,Xu N,Liu W,Zhao F,Liu X,Zhang C,Zhang J,Jia L

更新日期：2018-11-30 00:00:00

abstract：:An ongoing challenge in biomedical research is the search for simple, yet robust assays using 3D cell cultures for toxicity screening. This study addresses that challenge with a novel spheroid assay, wherein spheroids, formed by magnetic 3D bioprinting, contract immediately as cells rearrange and compact the spheroid ...

journal_title：Scientific reports

authors： Tseng H,Gage JA,Shen T,Haisler WL,Neeley SK,Shiao S,Chen J,Desai PK,Liao A,Hebel C,Raphael RM,Becker JL,Souza GR

更新日期：2015-09-14 00:00:00

abstract：:The aim of this study was to determine the association of residual feed intake (RFI) with growth performance, blood metabolic parameters, and body composition factors in growing lambs. Individual body weight (BW) and dry matter intake (DMI) were determined in 137 male Hu lambs that were given a pellet feed four times ...

journal_title：Scientific reports

authors： Zhang X,Wang W,Mo F,La Y,Li C,Li F

更新日期：2017-10-04 00:00:00

abstract：:Identification of low-abundance, low-molecular-weight native peptides using non-tryptic plasma has long remained an unmet challenge, leaving potential bioactive/biomarker peptides undiscovered. We have succeeded in efficiently removing high-abundance plasma proteins to enrich and comprehensively identify low-molecular...

journal_title：Scientific reports

authors： Taguchi T,Kodera Y,Oba K,Saito T,Nakagawa Y,Kawashima Y,Shichiri M

更新日期：2021-01-13 00:00:00

abstract：:Although previous findings identified an association between C-reactive protein (CRP) levels, and impaired cognitive functions in patients with schizophrenia (SZ), little is currently known about the relationship between inflammation, cognition, and sex in SZ. The current study aimed to explore the association between...

journal_title：Scientific reports

authors： Dal Santo F,González-Blanco L,García-Álvarez L,de la Fuente-Tomás L,Velasco Á,Álvarez-Vázquez CM,Martínez-Cao C,Sáiz PA,García-Portilla MP,Bobes J

更新日期：2020-09-29 00:00:00

abstract：:Hybrid cells of Nicotiana suaveolens x N. tabacum grow normally at 36 °C, but immediately express lethality due to probable autoimmune response when transferred from 36 to 28 °C. Our recent study showed that the temperature-sensitive lethality of these hybrid cells occurs through autolytic programmed cell death (PCD)....

journal_title：Scientific reports

authors： Ueno N,Kashiwagi M,Kanekatsu M,Marubashi W,Yamada T

更新日期：2019-07-15 00:00:00

abstract：:A p-i-n junction diode based on the selectively doped single-walled carbon nanotube (SWCNT) had been investigated, in which two opposite ends of individual SWCNT channel were doped into the p- and n-type SWCNT respectively while the middle segment of SWCNT was kept as the intrinsic. The symmetric and asymmetric contac...

journal_title：Scientific reports

authors： Chen C,Liao C,Wei L,Zhong H,He R,Liu Q,Liu X,Lai Y,Song C,Jin T,Zhang Y

更新日期：2016-02-26 00:00:00

abstract：:Linearly polarized microwave radiation is shown to have its plane of polarization converted to the orthogonal state upon reflection from an ultrathin (λ/25) cavity array. The structure benefits from an uncomplicated design consisting of a metallic grating closely separated from a ground plane by a dielectric spacer. A...

journal_title：Scientific reports

authors： Tremain B,Rance HJ,Hibbins AP,Sambles JR

更新日期：2015-03-23 00:00:00

abstract：:We present measurements of the outdoor stability of PCDTBT:PC71BM based bulk heterojunction organic solar cells for over the course of a year. We find that the devices undergo a burn-in process lasting 450 hours followed by a TS80 lifetime of up to 6200 hours. We conclude that in the most stable devices, the observed ...

journal_title：Scientific reports

authors： Zhang Y,Bovill E,Kingsley J,Buckley AR,Yi H,Iraqi A,Wang T,Lidzey DG

更新日期：2016-02-09 00:00:00

abstract：:Transcription activator-like effector (TALE) nuclease (TALEN) is a site-specific nuclease, which can be freely designed and easily constructed. Numerous methods of constructing TALENs harboring different TALE scaffolds and repeat variants have recently been reported. However, the functionalities of structurally differ...

journal_title：Scientific reports

authors： Sakuma T,Ochiai H,Kaneko T,Mashimo T,Tokumasu D,Sakane Y,Suzuki K,Miyamoto T,Sakamoto N,Matsuura S,Yamamoto T

更新日期：2013-11-29 00:00:00

abstract：:Survival analyses for malignancies, including renal cell carcinoma (RCC), have primarily been conducted using the Cox proportional hazards (CPH) model. We compared the random survival forest (RSF) and DeepSurv models with the CPH model to predict recurrence-free survival (RFS) and cancer-specific survival (CSS) in non...

journal_title：Scientific reports

authors： Byun SS,Heo TS,Choi JM,Jeong YS,Kim YS,Lee WK,Kim C

更新日期：2021-01-13 00:00:00

abstract：:Multiphoton microscopes are hampered by limited dynamic range, preventing weak sample features from being detected in the presence of strong features, or preventing the capture of unpredictable bursts in sample strength. We present a digital electronic add-on technique that vastly improves the dynamic range of a multi...

journal_title：Scientific reports

authors： Yang R,Weber TD,Witkowski ED,Davison IG,Mertz J

更新日期：2017-07-19 00:00:00

abstract：:Living organisms in drying environments build anisotropic structures and exhibit directionality through self-organization of biopolymers. However, the process of macro-scale assembly is still unknown. Here, we introduce a dissipative structure through a non-equilibrium process between hydration and deposition in the d...

journal_title：Scientific reports

authors： Okeyoshi K,Okajima MK,Kaneko T

更新日期：2017-07-21 00:00:00

abstract：:Land use, habitat, and forage quality have emerged as critical factors influencing the health, productivity, and survival of honey bee colonies. However, characterization of the mechanistic relationship between differential land-use conditions and ultimate outcomes for honey bee colonies has been elusive. We assessed ...

journal_title：Scientific reports

authors： Smart MD,Otto CRV,Lundgren JG

更新日期：2019-11-07 00:00:00