Abstract:
:Molecular imaging technique is an attractive tool to detect liver disease at early stage. This study aims to develop a simultaneous dual-isotope single photon emission computed tomography (SPECT)/CT imaging method to assist diagnosis of hepatic tumor and liver fibrosis. Animal models of liver fibrosis and orthotopic human hepatocellular carcinoma (HCC) were established. The tracers of (131)I-NGA and (99m)Tc-3P-RGD2 were selected to target asialoglycoprotein receptor (ASGPR) on the hepatocytes and integrin αvβ3 receptor in tumor or fibrotic liver, respectively. SPECT imaging and biodistribution study were carried out to verify the feasibility and superiority. As expected, (99m)Tc-3P-RGD2 had the ability to evaluate liver fibrosis and detect tumor lesions. (131)I-NGA showed that it was effective in assessing the anatomy and function of the liver. In synchronized dual-isotope SPECT/CT imaging, clear fusion images can be got within 30 minutes for diagnosing liver fibrosis and liver cancer. This new developed imaging approach enables the acquisition of different physiological information for diagnosing liver fibrosis, liver cancer and evaluating residual functional liver volume simultaneously. So synchronized dual-isotope SPECT/CT imaging with (99m)Tc-3P-RGD2 and (131)I-NGA is an effective approach to detect liver disease, especially liver fibrosis and liver cancer.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Guo Z,Gao M,Zhang D,Li Y,Song M,Zhuang R,Su X,Chen G,Liu T,Liu P,Wu H,Du J,Zhang Xdoi
10.1038/srep28812subject
Has Abstractpub_date
2016-07-05 00:00:00pages
28812issn
2045-2322pii
srep28812journal_volume
6pub_type
杂志文章abstract::Mapping the structure of the mammalian brain at cellular resolution is a challenging task and one that requires capturing key anatomical features at the appropriate level of analysis. Although neuroscientific methods have managed to provide significant insights at the micro and macro level, in order to obtain a whole-...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50137-9
更新日期:2019-09-25 00:00:00
abstract::Acute-on-chronic liver failure (ACLF) is a dynamic syndrome, and sequential assessments can reflect its prognosis more accurately. Our aim was to build and validate a new scoring system to predict short-term prognosis using baseline and dynamic data in ACLF. We conducted a retrospective cohort analysis of patients wit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81431-0
更新日期:2021-01-19 00:00:00
abstract::Animals are capable of using visual cues to find the correct route during navigation. These visual cues, which contain spatial information on the direction towards the goal point, are perceived either allocentrically or egocentrically. In this study, we examined how navigating with these two types of visual cues affec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42852-0
更新日期:2019-04-23 00:00:00
abstract::Both targeted therapy and immunotherapy have been used successfully to treat melanoma, but the development of resistance and poor response rates to the individual therapies has limited their success. Designing rational combinations of targeted therapy and immunotherapy may overcome these obstacles, but requires assess...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37883-y
更新日期:2019-02-04 00:00:00
abstract::Fat deposition of beef cattle varies between breeds. However, the regulation mechanism is still not elucidated completely at molecular level. In the present study, we comparatively analyzed transcriptome of subcutaneous adipose tissue between Wagyu and Holstein cattle with a significant difference in fat deposition to...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05702-5
更新日期:2017-07-13 00:00:00
abstract::We report a new family with autosomal dominant inheritance of a late onset rapidly progressive leukodystrophy in which exome sequencing has revealed a novel mutation p.R782G in the Colony-Stimulating Factor 1 Receptor gene (CSF1R). Neuropathology of two affected family members showed cerebral white matter degeneration...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10042
更新日期:2015-05-15 00:00:00
abstract::Experience is an important asset in almost any professional activity. In basketball, there is believed to be a positive association between coaching experience and effective use of team timeouts. Here, we analyze both the extent to which a team's change in scoring margin per possession after timeouts deviate from the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00676
更新日期:2012-01-01 00:00:00
abstract::There are still lot of controversies whether aberrant left hepatic artery (ALHA) originating from left gastric artery should be ligated or preserved during gastric cancer (GC) surgery. We aimed to investigate this issue. We reviewed ALHA cases who had laparoscopic gastrectomy for gastric cancer at Seoul National Unive...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62587-7
更新日期:2020-04-03 00:00:00
abstract::A novel imaging-driven technique with an integrated fluorescence signature to enable automated enumeration of two species of cyanobacteria and an alga of somewhat similar morphology to one of the cyanobacteria is presented to demonstrate proof-of-concept that high accuracy, imaging-based, rapid water quality analysis ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27406-0
更新日期:2018-06-13 00:00:00
abstract::Fungus-growing termites engage in an obligate mutualistic relationship with Termitomyces fungi, which they maintain in monocultures on specialised fungus comb structures, without apparent problems with infectious diseases. While other fungi have been reported in the symbiosis, detailed comb fungal community analyses h...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45364-z
更新日期:2019-06-19 00:00:00
abstract::Novel natural products 7R, 8R, 7'R, 9'S-verniciasin A (1a), 7S, 8S, 7'S, 9'R- verniciasin A (1b), 7R, 8R, 7'R, 9'S-7'-methoxylverniciasin A (2a) and 7S, 8S, 7'S, 9'R-7'-methoxylverniciasin A (2b) were characterized from the seed capsule of Vernicia fordii. And the unique 9-O-9'-7, 9'-cyclo-8, 1'-neolignan skeleton wit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14062-z
更新日期:2017-10-19 00:00:00
abstract::Limbal stem cell deficiency can be treated with transplantation of cultured human limbal epithelial cells (LEC). It can be advantageous to produce LEC in centralized labs and thereafter ship them to eye clinics. The present study used transport simulations of LEC to determine if vigorous shaking during transport alter...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28553-0
更新日期:2018-07-12 00:00:00
abstract::Geometric mean concentrations of fecal indicator bacteria E. coli and enterococci are commonly used to evaluate the microbial quality of irrigation, recreation, and other types of waters, as well in watershed-scale microbial water quality modeling. It is not known how the uncertainty of those geometric mean concentrat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58603-5
更新日期:2020-02-03 00:00:00
abstract::The synthetic cyclic hexapeptide cWFW (cyclo(RRRWFW)) has a rapid bactericidal activity against both Gram-positive and Gram-negative bacteria. Its detailed mode of action has, however, remained elusive. In contrast to most antimicrobial peptides, cWFW neither permeabilizes the membrane nor translocates to the cytoplas...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44332
更新日期:2017-03-09 00:00:00
abstract::We recently showed that spinal cord injury (SCI) leads to a decrease in mRNA editing of serotonin receptor 2C (5-HT2CR) contributing to post-SCI spasticity. Here we study post-SCI mRNA editing and global gene expression using massively parallel sequencing. Evidence is presented that the decrease in 5-HT2CR editing is ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12615
更新日期:2015-07-30 00:00:00
abstract::Finding strategies to preserve quantum resources in open systems is nowadays a main requirement for reliable quantum-enhanced technologies. We address this issue by considering structured cavities embedding qubits driven by a control technique known as frequency modulation. We first study a single qubit in a lossy cav...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32661-2
更新日期:2018-09-24 00:00:00
abstract::Guanylate binding proteins (GBPs) belongs to the interferons (IFNs) induced guanylate-binding protein family (Guanosine triphosphatases, GTPases) consisting of seven homologous members, termed GBP1 to GBP7. We used multidimensional survey ways to explore GBPs expression, regulation, mutations, immune infiltration and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63246-7
更新日期:2020-04-08 00:00:00
abstract::The self-organisation of void and gas bubbles in solids into superlattices is an intriguing nanoscale phenomenon. Despite the discovery of these lattices 45 years ago, the atomistics behind the ordering mechanisms responsible for the formation of these nanostructures are yet to be fully elucidated. Here we report on t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07711-w
更新日期:2017-08-10 00:00:00
abstract::Studies on the phenomenon of magnetoresistance (MR) have produced intriguing and application-oriented outcomes for decades-colossal MR, giant MR and recently discovered extremely large MR of millions of percents in semimetals can be taken as examples. We report here the discovery of novel multiple sign changes versus ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42789
更新日期:2017-02-17 00:00:00
abstract::Pulmonary alveolar proteinosis (PAP) is a rare pulmonary disease in which the abnormalities in alveolar surfactant accumulation are caused by impairments of GM-CSF pathway attributing to defects in a variety of genes. However, hereditary PAP is extremely uncommon and a detailed understanding in the genetic inheritance...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43469
更新日期:2017-02-24 00:00:00
abstract::Western wheatgrass (Pascopyrum smithii Rydb.) is an important cool-season forage and turfgrass. However, due to seed dormancy and poor seedling vigor, it is difficult to develop high seed yield production systems, and assessing these components in response to seed yield. Based on multifactor orthogonally designed fiel...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54586-0
更新日期:2019-11-29 00:00:00
abstract::Approximately 300,000 men around the globe self-identify as Ashkenazi Levites, of whom two thirds were previously shown to descend from a single male. The paucity of whole Y-chromosome sequences precluded conclusive identification of this ancestor's age, geographic origin and migration patterns. Here, we report the va...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14761-7
更新日期:2017-11-02 00:00:00
abstract::All-dielectric nanophotonics lies at a forefront of nanoscience and technology as it allows to control light at the nanoscale using its electric and magnetic components. Bulk silicon does not experience any magnetic response, nevertheless, we demonstrate that the metasurface made of silicon parallelepipeds allows to e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40226-0
更新日期:2019-03-05 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-71840-y
更新日期:2020-09-01 00:00:00
abstract::Microbial secondary metabolites are valuable resources for novel drug discovery. In particular, actinomycetes expressed a range of antibiotics against a spectrum of bacteria. In genus level, strain Allosalinactinospora lopnorensis CA15-2(T) is the first new actinomycete isolated from the Lop Nor region, China. Antimic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20667
更新日期:2016-02-11 00:00:00
abstract::Irreversible electroporation (IRE) is an emerging focal therapy which is demonstrating utility in the treatment of unresectable tumors where thermal ablation techniques are contraindicated. IRE uses ultra-short duration, high-intensity monopolar pulsed electric fields to permanently disrupt cell membranes within a wel...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14999
更新日期:2015-10-13 00:00:00
abstract::Influenza viruses are among the most common pathogens that threaten the health of humans and animals worldwide. Various anti-viral therapeutic agents are currently used for treatment and prophylaxis of influenza virus, but the targets of these drugs are easily mutated and result in resistance. Therefore, medications t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29684
更新日期:2016-07-11 00:00:00
abstract::Previous studies demonstrated independent contributions of plasma free amino acids (PFAAs) and high uric acid (UA) concentrations to increased risks of lifestyle-related diseases (LSRDs), but the important associations between these factors and LSRDs remain unknown. We quantified PFAAs and UA amongst Japanese subjects...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17710-6
更新日期:2017-12-15 00:00:00
abstract::Being one of the most common trees in forests, Pinus sylvestris L. is a frequently used raw material for wood products. Its specific odour is, however, mostly unresolved to date. Accordingly, we investigated Scots pine wood samples grown in Germany for their main odorant composition. We employed dedicated odorant anal...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26626-8
更新日期:2018-05-29 00:00:00
abstract::We consider an optimal quantum key distribution setup based on minimal number of measurement bases with binary yields used by parties against an eavesdropper limited only by the no-signaling principle. We note that in general, the maximal key rate can be achieved by determining the optimal tradeoff between measurement...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30959
更新日期:2016-08-03 00:00:00