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A novel immunogenic mouse model of melanoma for the preclinical assessment of combination targeted and immune-based therapy.

Abstract：

:Both targeted therapy and immunotherapy have been used successfully to treat melanoma, but the development of resistance and poor response rates to the individual therapies has limited their success. Designing rational combinations of targeted therapy and immunotherapy may overcome these obstacles, but requires assessment in preclinical models with the capacity to respond to both therapeutic classes. Herein, we describe the development and characterization of a novel, immunogenic variant of the BrafV600ECdkn2a-/-Pten-/- YUMM1.1 tumor model that expresses the immunogen, ovalbumin (YOVAL1.1). We demonstrate that, unlike parental tumors, YOVAL1.1 tumors are immunogenic in vivo and can be controlled by immunotherapy. Importantly, YOVAL1.1 tumors are sensitive to targeted inhibitors of BRAFV600E and MEK, responding in a manner consistent with human BRAFV600E melanoma. The YOVAL1.1 melanoma model is transplantable, immunogenic and sensitive to clinical therapies, making it a valuable platform to guide strategic development of combined targeted therapy and immunotherapy approaches in BRAFV600E melanoma.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Lelliott EJ,Cullinane C,Martin CA,Walker R,Ramsbottom KM,Souza-Fonseca-Guimaraes F,Abuhammad S,Michie J,Kirby L,Young RJ,Slater A,Lau P,Meeth K,Oliaro J,Haynes N,McArthur GA,Sheppard KE

doi

10.1038/s41598-018-37883-y

subject

Has Abstract

pub_date

2019-02-04 00:00:00

pages

1225

issue

1

issn

2045-2322

pii

10.1038/s41598-018-37883-y

journal_volume

9

pub_type

杂志文章

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