Whole-Genome Sequencing of a Family with Hereditary Pulmonary Alveolar Proteinosis Identifies a Rare Structural Variant Involving CSF2RA/CRLF2/IL3RA Gene Disruption.

abstract：:This study aimed to evaluate the effect of brain atrophy on the functional outcome of patients with moderate-volume basal ganglia hemorrhage. Of 1003 patients with spontaneous intracerebral hemorrhage, 124 with moderate-volume basal ganglia hemorrhage (hematoma volume of 20-50 mL) were enrolled. The intercaudate dista...

journal_title：Scientific reports

authors： Kwon SM,Choi KS,Yi HJ,Ko Y,Kim YS,Bak KH,Chun HJ,Lee YJ,Lee JY

更新日期：2018-03-19 00:00:00

abstract：:Nowadays Field Emission Gun-Scanning Electron Microscopes provide detailed crystallographic information with high spatial and angular resolutions, and allow direct observation of crystalline defects, such as dislocations, through an attractive technique called Electron Channeling Contrast Imaging (ECCI). Dislocations ...

journal_title：Scientific reports

authors： Kriaa H,Guitton A,Maloufi N

更新日期：2017-08-29 00:00:00

abstract：:Helicobacter pylori (H. pylori) is one of the most important factors that affect the development of gastric cancer, and its mechanism remains un-elucidated. Our present study found that, miR-30a is crucial for regulating the growth and migration of H. pylori infected gastric cancer in vitro by targeting COX-2 and BCL9...

journal_title：Scientific reports

authors： Liu X,Ji Q,Zhang C,Liu X,Liu Y,Liu N,Sui H,Zhou L,Wang S,Li Q

更新日期：2017-08-02 00:00:00

abstract：:Chronic alcohol feeding causes lipid accumulation and apoptosis in the liver. This study investigated the role of bioactive lipid metabolites in alcohol-induced liver damage and tested the potential of targeting arachidonate 15-lipoxygenase (ALOX15) in treating alcoholic liver disease (ALD). Results showed that chroni...

journal_title：Scientific reports

authors： Zhang W,Zhong W,Sun Q,Sun X,Zhou Z

更新日期：2017-08-21 00:00:00

abstract：:In mouse embryonic stem (mES) cells, ubiquitylation of histone H2A lysine 119 represses a large number of developmental genes and maintains mES cell pluripotency. It has been suggested that a number of H2A ubiquitin ligases as well as deubiquitylases and related peptide fragments contribute to a delicate balance betwe...

journal_title：Scientific reports

authors： Inoue D,Aihara H,Sato T,Mizusaki H,Doiguchi M,Higashi M,Imamura Y,Yoneda M,Miyanishi T,Fujii S,Okuda A,Nakagawa T,Ito T

更新日期：2015-11-16 00:00:00

abstract：:Spores of pathogenic fungi are virtually ubiquitous and cause human disease and severe losses in crops. The endophytic fungi Alternaria species produce host-selective phytotoxins. Alt a 1 is a strongly allergenic protein found in A. alternata that causes severe asthma. Despite the well-established pathogenicity of Alt...

journal_title：Scientific reports

authors： Garrido-Arandia M,Silva-Navas J,Ramírez-Castillejo C,Cubells-Baeza N,Gómez-Casado C,Barber D,Pozo JC,Melendi PG,Pacios LF,Díaz-Perales A

更新日期：2016-09-16 00:00:00

abstract：:The presenilin 1 (PSEN1) L271V mutation causes early-onset familial Alzheimer's disease by disrupting the alternative splicing of the PSEN1 gene, producing some transcripts harboring the L271V point mutation and other transcripts lacking exon 8 (PS1(∆exon8)). We previously reported that PS1 L271V increased amyloid bet...

journal_title：Scientific reports

authors： Brautigam H,Moreno CL,Steele JW,Bogush A,Dickstein DL,Kwok JB,Schofield PR,Thinakaran G,Mathews PM,Hof PR,Gandy S,Ehrlich ME

更新日期：2015-11-26 00:00:00

abstract：:Keratin 15 (K15), a type I keratin, which pairs with K5 in epidermis, has been used extensively as a biomarker for stem cells. Two commercial antibodies, LHK15, a mouse monoclonal and EPR1614Y, a rabbit monoclonal, have been widely employed to study K15 expression. Here we report differential reactivity of these antib...

journal_title：Scientific reports

authors： Aldehlawi H,Niemiec KA,Avisetti DR,Lalli A,Teh MT,Waseem A

更新日期：2019-02-13 00:00:00

abstract：:The future Internet is very likely the mixture of all-optical Internet with low power consumption and quantum Internet with absolute security guaranteed by the laws of quantum mechanics. Photons would be used for processing, routing and com-munication of data, and photonic transistor using a weak light to control a st...

journal_title：Scientific reports

authors： Hu CY

更新日期：2017-03-28 00:00:00

abstract：:During viral infections, some viruses subvert the host proteins to promote the translation or RNA replication with their protease-mediated cleavage. Poly (A)-binding protein (PABP) is a target for several RNA viruses; however, the impact of duck hepatitis A virus (DHAV) on PABP remains unknown. In this study, we demon...

journal_title：Scientific reports

authors： Sun D,Wang M,Wen X,Cheng A,Jia R,Sun K,Yang Q,Wu Y,Zhu D,Chen S,Liu M,Zhao X,Chen X

更新日期：2017-11-24 00:00:00

abstract：:Whale shark (Rhincodon typus) tourism is increasingly popular at predictable aggregations around the world, but only a few use provisioning to ensure close interactions. Understanding the effects of provisioning on the behaviour of this endangered species is critical to manage this growing industry. We recorded the di...

journal_title：Scientific reports

authors： Araujo G,Labaja J,Snow S,Huveneers C,Ponzo A

更新日期：2020-10-12 00:00:00

abstract：:Hydrostatic pressure is an important environmental factor affecting the vertical distribution of marine organisms. Laboratory-based studies have shown that many extant shallow-water marine benthic invertebrates can tolerate hydrostatic pressure outside their known natural distributions. However, only a few studies hav...

journal_title：Scientific reports

authors： Chen J,Liu H,Cai S,Zhang H

更新日期：2019-03-05 00:00:00

abstract：:Uncovering complex oil-water flow structure represents a challenge in diverse scientific disciplines. This challenge stimulates us to develop a new distributed conductance sensor for measuring local flow signals at different positions and then propose a novel approach based on multi-frequency complex network to uncove...

journal_title：Scientific reports

authors： Gao ZK,Yang YX,Fang PC,Jin ND,Xia CY,Hu LD

更新日期：2015-02-04 00:00:00

abstract：:The striatum plays important motor, associative and cognitive roles in brain functions. However, the rodent dorsolateral (the primate putamen) and dorsomedial (the primate caudate nucleus) striatum are not anatomically separated, making it difficult to distinguish their functions. By contrast, anatomical separation ex...

journal_title：Scientific reports

authors： Takaji M,Takemoto A,Yokoyama C,Watakabe A,Mizukami H,Ozawa K,Onoe H,Nakamura K,Yamamori T

更新日期：2016-11-02 00:00:00

abstract：:Exendin-4 is a long acting glucagon-like peptide 1 (GLP-1) analogue that is an agonist for the GLP-1 receptor, a G-protein coupled receptor (GPCR). Exendin-4 is used to clinically improve glucose tolerance in diabetic patients due to its ability to enhance insulin secretion. In rodents, and possibly in humans, exendin...

journal_title：Scientific reports

authors： Fusco J,Xiao X,Prasadan K,Sheng Q,Chen C,Ming YC,Gittes G

更新日期：2017-08-22 00:00:00

abstract：:Muscle specific receptor tyrosine kinase (MuSK) is an essential postsynaptic transmembrane molecule that mediates clustering of acetylcholine receptors (AChR). MUSK exon 10 is alternatively skipped in human, but not in mouse. Skipping of this exon disrupts a cysteine-rich region (Fz-CRD), which is essential for Wnt-me...

journal_title：Scientific reports

authors： Nasrin F,Rahman MA,Masuda A,Ohe K,Takeda J,Ohno K

更新日期：2014-10-30 00:00:00

abstract：:Amine quantification is an important strategy in patient stratification and personalised medicine. This is because amines, including amino acids and methylarginines impact on many homeostatic processes. One important pathway regulated by amine levels is nitric oxide synthase (NOS). NOS is regulated by levels of (i) th...

journal_title：Scientific reports

authors： Ahmetaj-Shala B,Olanipekun M,Tesfai A,MacCallum N,Kirkby NS,Quinlan GJ,Shih CC,Kawai R,Mumby S,Paul-Clark M,Want EJ,Mitchell JA

更新日期：2018-09-18 00:00:00

abstract：:Metasurfaces, owing to their attractive features, provide a wide range of potential applications. Electromagnetic absorbers based on metasurfaces have significantly improved responses compared to the earlier absorbers made from composite materials. Active metasurfaces, in contrast to the passive designs, can exhibit m...

journal_title：Scientific reports

authors： Ghosh S,Lim S

更新日期：2018-07-05 00:00:00

abstract：:Multi-atlas-based segmentation (MAS) methods have demonstrated superior performance in the field of automatic image segmentation, and label fusion is an important part of MAS methods. In this paper, we propose a label fusion method that incorporates pixel greyscale probability information. The proposed method combines...

journal_title：Scientific reports

authors： Wang M,Li P

更新日期：2019-11-29 00:00:00

abstract：:Exploiting new, low-cost and efficient electrocatalysts for hydrogen evolution reaction (HER) is important to resolve the energy crisis and environment pollution. In this work, graphene decorated with Ni nanoparticles (NPs) were synthesized via one-pot reduction using graphene oxide (GO, the obtained composite was den...

journal_title：Scientific reports

authors： Zhang W,Li Y,Zeng X,Peng S

更新日期：2015-06-12 00:00:00

abstract：:Hydroxyapatite (HA) is the principal inorganic component of bones and teeth and has been widely used as a bone repair material because of its good biocompatibility and bioactivity. Understanding the interactions between proteins and HA is crucial for designing biomaterials for bone regeneration. In this study, we eval...

journal_title：Scientific reports

authors： Wang Q,Wang M,Lu X,Wang K,Fang L,Ren F,Lu G

更新日期：2017-11-09 00:00:00

abstract：:Langerhans cells (LCs) are able to orchestrate adaptive immune responses in the skin by interpreting the microenvironmental context in which they encounter foreign substances, but the regulatory basis for this has not been established. Utilising systems immunology approaches combining in silico modelling of a reconstr...

journal_title：Scientific reports

authors： Polak ME,Ung CY,Masapust J,Freeman TC,Ardern-Jones MR

更新日期：2017-04-06 00:00:00

abstract：:In this study, we propose a novel sensitive solid-based immunosensor developed on a plasmonic nanopaper platform for the detection of Escherichia coli (E. coli) bacteria. This plasmonic nanopaper that comprises of carboxylated bacterial cellulose (CBC) impregnated with gold nanoparticles (AuNP-CBC), employed as a quen...

journal_title：Scientific reports

authors： Heli B,Ajji A

更新日期：2020-09-01 00:00:00

abstract：:Tench (Tinca tinca L.) is one of the most valued species of the Cyprinidae. This species is commercially important and has been intensively domesticated in recent years. To avoid excessive production losses, the health of farm fish must be maintained. Characterization of the tench gut microbiome can help achieve this ...

journal_title：Scientific reports

authors： Dulski T,Kozłowski K,Ciesielski S

更新日期：2020-03-10 00:00:00

abstract：:Ocean warming (OW) and acidification (OA) are key features of global change and are predicted to have negative consequences for marine species and ecosystems. At a smaller scale increasing oil and gas activities at northern high latitudes could lead to greater risk of petroleum pollution, potentially exacerbating the ...

journal_title：Scientific reports

authors： Arnberg M,Calosi P,Spicer JI,Taban IC,Bamber SD,Westerlund S,Vingen S,Baussant T,Bechmann RK,Dupont S

更新日期：2018-11-26 00:00:00

abstract：:Tropical Pacific stalagmites are commonly affected by dating uncertainties because of their low U concentration and/or elevated initial 230Th content. This poses problems in establishing reliable trends and periodicities for droughts and pluvial episodes in a region vulnerable to climate change. Here we constrain the ...

journal_title：Scientific reports

authors： Faraji M,Borsato A,Frisia S,Hellstrom JC,Lorrey A,Hartland A,Greig A,Mattey DP

更新日期：2021-01-26 00:00:00

abstract：:Brain µ-opioid receptors (MOR) mediate reward and help coping with pain, social rejection, anxiety and depression. The dorsal midline thalamus (dMT) integrates visceral/emotional signals and biases behavior towards aversive or defensive states through projections to the amygdala. While a dense MOR expression in the dM...

journal_title：Scientific reports

authors： Goedecke L,Bengoetxea X,Blaesse P,Pape HC,Jüngling K

更新日期：2019-11-28 00:00:00

abstract：:In music, the perception of pitch is governed largely by its tonal function given the preceding harmonic structure of the music. While behavioral research has advanced our understanding of the perceptual representation of musical pitch, relatively little is known about its representational structure in the brain. Usin...

journal_title：Scientific reports

authors： Sankaran N,Thompson WF,Carlile S,Carlson TA

更新日期：2018-01-16 00:00:00

abstract：:Early diagnosis of dementia including Alzheimer's disease (AD) is an urgent medical and welfare issue. However, to date, no simple biometrics have been available. We reported that blood DNA methylation levels of the COASY gene, which encodes coenzyme A synthase, were increased in individuals with AD and amnestic mild ...

journal_title：Scientific reports

authors： Kobayashi N,Shinagawa S,Niimura H,Kida H,Nagata T,Tagai K,Shimada K,Oka N,Shikimoto R,Noda Y,Nakajima S,Mimura M,Shigeta M,Kondo K

更新日期：2020-07-22 00:00:00

abstract：:We report on an angle resolved photoemission (ARPES) study of bulk electron-doped perovskite iridate, (Sr(1-x)La(x))3Ir2O7. Fermi surface pockets are observed with a total electron count in keeping with that expected from La substitution. Depending on the energy and polarization of the incident photons, these pockets ...

journal_title：Scientific reports

authors： He J,Hafiz H,Mion TR,Hogan T,Dhital C,Chen X,Lin Q,Hashimoto M,Lu DH,Zhang Y,Markiewicz RS,Bansil A,Wilson SD,He RH

更新日期：2015-02-23 00:00:00