Distinct roles for primate caudate dopamine D1 and D2 receptors in visual discrimination learning revealed using shRNA knockdown.

abstract：:Transcriptome expression reflects genetic response in diverse conditions. In this study, RNA sequencing was utilized to profile multiple tissues such as liver, breast, caecum, and gizzard of Korean commercial chicken raised in Korea and Kyrgyzstan. We analyzed ten samples per tissue from each location to identify cand...

journal_title：Scientific reports

authors： Kumar H,Choo H,Iskender AU,Srikanth K,Kim H,Zhunushov AT,Jang GW,Lim Y,Song KD,Park JE

更新日期：2020-11-06 00:00:00

abstract：:Oil spills represent an overwhelming carbon input to the marine environment that immediately impacts the sea surface ecosystem. Microbial communities degrading the oil fraction that eventually sinks to the seafloor must also deal with hydrostatic pressure, which linearly increases with depth. Piezosensitive hydrocarbo...

journal_title：Scientific reports

authors： Scoma A,Barbato M,Hernandez-Sanabria E,Mapelli F,Daffonchio D,Borin S,Boon N

更新日期：2016-03-29 00:00:00

abstract：:The physiological roles of the protease inhibitor SERPINB3 (SB3) are still largely unknown. The study was addressed to assess the biological effects of this serpin in vivo using a SB3 transgenic mouse model. Two colonies of mice (123 transgenic for SB3 and 148 C57BL/6J controls) have been studied. Transgenic (TG) mice...

journal_title：Scientific reports

authors： Villano G,Ruvoletto M,Ceolotto G,Quarta S,Calabrese F,Turato C,Tono N,Crescenzi M,Biasiolo A,Cattelan A,Merkel C,Avogaro A,Gatta A,Pontisso P

更新日期：2013-10-28 00:00:00

abstract：:Genomic selection (GS) by selecting lines prior to field phenotyping using genotyping data has the potential to enhance the rate of genetic gains. Genotype × environment (G × E) interaction inclusion in GS models can improve prediction accuracy hence aid in selection of lines across target environments. Phenotypic dat...

journal_title：Scientific reports

authors： Roorkiwal M,Jarquin D,Singh MK,Gaur PM,Bharadwaj C,Rathore A,Howard R,Srinivasan S,Jain A,Garg V,Kale S,Chitikineni A,Tripathi S,Jones E,Robbins KR,Crossa J,Varshney RK

更新日期：2018-08-03 00:00:00

abstract：:Metabonomics/metabolomics is a rapid technology for comprehensive profiling of small molecule metabolites in cells, tissues, or whole organisms, the application of which has led to understanding pathophysiologic mechanisms of cardiometabolic diseases, defining predictive biomarkers for those diseases, and also assessi...

journal_title：Scientific reports

authors： Jiang M,Wang Q,Chen J,Wang Y,Fan G,Zhu Y

更新日期：2017-08-18 00:00:00

abstract：:Cytochrome P450 monooxygenases (P450s) are heme-thiolate proteins whose role as drug targets against pathogens, as well as in valuable chemical production and bioremediation, has been explored. In this study we performed comprehensive comparative analysis of P450s in 13 newly explored oomycete pathogens. Three hundred...

journal_title：Scientific reports

authors： Sello MM,Jafta N,Nelson DR,Chen W,Yu JH,Parvez M,Kgosiemang IKR,Monyaki R,Raselemane SC,Qhanya LB,Mthakathi NT,Sitheni Mashele S,Syed K

更新日期：2015-07-01 00:00:00

abstract：:Nuclear proteins are primarily regulatory factors governing gene expression. Multiple factors determine the localization of a protein in the nucleus. An upright identification of nuclear proteins is way far from accuracy. We have attempted to combine information from subcellular prediction tools, experimental evidence...

journal_title：Scientific reports

authors： Deveshwar P,Sharma S,Prusty A,Sinha N,Zargar SM,Karwal D,Parashar V,Singh S,Tyagi AK

更新日期：2020-09-15 00:00:00

abstract：:A microfluidic laminar flow cell (LFC) forms an indispensable component in single-molecule experiments, enabling different substances to be delivered directly to the point under observation and thereby tightly controlling the biochemical environment immediately surrounding single molecules. Despite substantial progres...

journal_title：Scientific reports

authors： Ahmadi A,Till K,Hafting Y,Schüttpelz M,Bjørås M,Glette K,Tørresen J,Rowe AD,Dalhus B

更新日期：2019-11-14 00:00:00

abstract：:The dispersion of organic N-benzyl-2-methyl-4-nitroaniline (BNA) in nematic liquid crystals (LCs) is studied. BNA doping decreases the threshold voltage of cell because of the reduced splay elastic constant and increased dielectric anisotropy of the LC mixture. When operated in the high voltage difference condition, t...

journal_title：Scientific reports

authors： Selvaraj P,Subramani K,Srinivasan B,Hsu CJ,Huang CY

更新日期：2020-08-31 00:00:00

abstract：:We report here the design and multiple functions of a new hierarchical nanotheronostic platform consisting of an upconversion nanoparticle (UCNP) core: shell with an additional mesoporous silica (mSiO2) matrix load shell containing sealed, high concentration of ICG molecules. We demonstrate that this UCNP@mSiO2-ICG na...

journal_title：Scientific reports

authors： Lv R,Wang D,Xiao L,Chen G,Xia J,Prasad PN

更新日期：2017-11-16 00:00:00

abstract：:Breast cancer (BC) has a higher incidence in young Lebanese woman as compared to the West. We assessed the microRNA (miRNA) microarray profile of tissues derived from Lebanese patients with early BC and performed mRNA-miRNA integration analysis. 173 miRNAs were significantly dysregulated in 45 BC versus 17 normal adja...

journal_title：Scientific reports

authors： Nassar FJ,Talhouk R,Zgheib NK,Tfayli A,El Sabban M,El Saghir NS,Boulos F,Jabbour MN,Chalala C,Boustany RM,Kadara H,Zhang Z,Zheng Y,Joyce B,Hou L,Bazarbachi A,Calin G,Nasr R

更新日期：2017-12-04 00:00:00

abstract：:Meromictic lakes are useful biogeochemical models because of their stratified chemical gradients and separation of redox reactions down the water column. Perennially ice-covered meromictic lakes are particularly stable, with long term constancy in their density profiles. Here we sampled Lake A, a deep meromictic lake ...

journal_title：Scientific reports

authors： Comeau AM,Harding T,Galand PE,Vincent WF,Lovejoy C

更新日期：2012-01-01 00:00:00

abstract：:The recently described site of Kalinga in the Philippines adds to our understanding of Early-Middle Pleistocene hominin behaviour. Yet, disentangling the natural from the anthropogenic modifications that have taken place in such an old archaeological site is challenging. In this paper we use a set of taphonomic tools ...

journal_title：Scientific reports

authors： Ingicco T,Reyes MC,de Vos J,Belarmino M,Albers PCH,Lipardo I,Gallet X,Amano N,van den Bergh GD,Cosalan AD,Bautista A

更新日期：2020-07-06 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease for which the pathophysiological mechanisms of motor neuron loss are not precisely clarified. Environmental and epigenetic mechanisms such as microRNAs (miRNAs) could have a role in disease progression. We studied the expression pattern of miRNAs in AL...

journal_title：Scientific reports

authors： De Luna N,Turon-Sans J,Cortes-Vicente E,Carrasco-Rozas A,Illán-Gala I,Dols-Icardo O,Clarimón J,Lleó A,Gallardo E,Illa I,Rojas-García R

更新日期：2020-03-09 00:00:00

abstract：:Complex regulatory networks control epithelial-to-mesenchymal transition (EMT) but the underlying epigenetic control is poorly understood. Lysine-specific demethylase 1 (LSD1) is a key histone demethylase that alters the epigenetic landscape. Here we explored the role of LSD1 in global epigenetic regulation of EMT, ca...

journal_title：Scientific reports

authors： Boulding T,McCuaig RD,Tan A,Hardy K,Wu F,Dunn J,Kalimutho M,Sutton CR,Forwood JK,Bert AG,Goodall GJ,Malik L,Yip D,Dahlstrom JE,Zafar A,Khanna KK,Rao S

更新日期：2018-01-08 00:00:00

abstract：:To compare the soil water balance, yield and water use efficiency (WUE) of spring maize under different mulching types in the Loess Plateau, a 7-year field experiment was conducted in the Changwu region of the Loess Plateau. Three treatments were used in this experiment: straw mulch (SM), plastic film mulch (PM) and c...

journal_title：Scientific reports

authors： Lin W,Liu W,Xue Q

更新日期：2016-12-15 00:00:00

abstract：:Accumulating of evidence suggests that activation of nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinases (MAPKs) exacerbates early brain injury (EBI) following subarachnoid hemorrhage (SAH) by provoking pro-inflammatory and pro-apoptotic signaling. Myeloid differentiation primary response protein 88 (...

journal_title：Scientific reports

authors： Yan H,Zhang D,Wei Y,Ni H,Liang W,Zhang H,Hao S,Jin W,Li K,Hang CH

更新日期：2017-11-17 00:00:00

abstract：:Cell division during the reproductive phase of the Streptomyces life-cycle requires tight coordination between synchronous formation of multiple septa and DNA segregation. One remarkable difference with most other bacterial systems is that cell division in Streptomyces is positively controlled by the recruitment of Ft...

journal_title：Scientific reports

authors： Zhang L,Willemse J,Hoskisson PA,van Wezel GP

更新日期：2018-05-09 00:00:00

abstract：:The goal of this work was to develop a mathematical model to predict Kaplan-Meier survival curves for chemotherapy combined with radiation in Non-Small Cell Lung Cancer patients for use in clinical trial design. The Gompertz model was used to describe tumor growth, radiation effect was simulated by the linear-quadrati...

journal_title：Scientific reports

authors： Geng C,Paganetti H,Grassberger C

更新日期：2017-10-19 00:00:00

abstract：:The exovesicles (EVs) are involved in pathologic host-parasite immune associations and have been recently used as biomarkers for diagnosis of infectious diseases. The release of EVs by Trypanosoma cruzi, the causative agent of Chagas disease, has recently been described, with different protein cargoes including the MA...

journal_title：Scientific reports

authors： Díaz Lozano IM,De Pablos LM,Longhi SA,Zago MP,Schijman AG,Osuna A

更新日期：2017-03-15 00:00:00

abstract：:The association between cervical lymph node metastasis (LNM) and ultrasonographic features as well as BRAFV600E mutations in patients with papillary thyroid carcinoma (PTC) remained controversial. This study investigated the association between LNM and ultrasonographic features as well as BRAFV600E mutation in Chinese...

journal_title：Scientific reports

authors： Guo L,Ma YQ,Yao Y,Wu M,Deng ZH,Zhu FW,Luo YK,Tang J

更新日期：2019-01-11 00:00:00

abstract：:Over the years, electrophysiological recordings in macaque monkeys performing visuomotor tasks brought about accumulating evidence for the expression of neuronal properties (e.g., selectivity in the visuospatial and somatosensory domains, encoding of visual affordances and motor cues) in the posterior parietal area V6...

journal_title：Scientific reports

authors： Santandrea E,Breveglieri R,Bosco A,Galletti C,Fattori P

更新日期：2018-05-02 00:00:00

abstract：:Acute kidney injury (AKI) in patients with septic shock is associated with high mortality, but the appropriate timing for initiating continuous renal replacement therapy (CRRT) is controversial. We retrospectively enrolled 158 septic shock patients with AKI in the medical intensive care unit (ICU) from July 2016 to Ap...

journal_title：Scientific reports

authors： Yoon BR,Leem AY,Park MS,Kim YS,Chung KS

更新日期：2019-08-19 00:00:00

abstract：:Cross-talk between exogenous salicylic acid (SA) and endogenous phytohormone pathways affects the antioxidant defense system and its response to salt stress. The study presented here investigated the effects of SA treatment before and during salt stress on the levels of endogenous plant growth regulators in three barl...

journal_title：Scientific reports

authors： Torun H,Novák O,Mikulík J,Pěnčík A,Strnad M,Ayaz FA

更新日期：2020-08-17 00:00:00

abstract：:The therapeutic effects of C16, which is an inhibitor of RNA-dependent protein kinase (PKR), on growth of hepatocellular carcinoma (HCC) cells and tumor progression in vitro and in vivo were evaluated. Huh7 cells, a human HCC cell line, were used. The effects of C16 on cell viability were evaluated with the MTT assay,...

journal_title：Scientific reports

authors： Watanabe T,Ninomiya H,Saitou T,Takanezawa S,Yamamoto S,Imai Y,Yoshida O,Kawakami R,Hirooka M,Abe M,Imamura T,Hiasa Y

更新日期：2020-03-20 00:00:00

abstract：:We extend an agent-based multiscale model of vascular tumour growth and angiogenesis to describe transarterial chemoembolisation (TACE) therapies. The model accounts for tumour and normal cells that are both nested in a vascular system that changes its structure according to tumour-related growth factors. Oxygen promo...

journal_title：Scientific reports

authors： Perfahl H,Jain HV,Joshi T,Horger M,Malek N,Bitzer M,Reuss M

更新日期：2020-06-29 00:00:00

abstract：:We investigated retinal structure and function in eyes with optic nerve hypoplasia (ONH). Twenty-nine eyes of 18 patients with ONH and 21 eyes of 21 control patients were analyzed. Spectral-domain optical coherence tomography (SD-OCT), full-field electroretinography (FF-ERG), and focal macular ERG (FM-ERG) were perfor...

journal_title：Scientific reports

authors： Katagiri S,Nishina S,Yokoi T,Mikami M,Nakayama Y,Tanaka M,Azuma N

更新日期：2017-02-16 00:00:00

abstract：:A major limitation hindering the widespread use of synthetic phages in medical and industrial settings is the lack of an efficient phage-engineering platform. Classical T4 phage engineering and several newly proposed methods are often inefficient and time consuming and consequently, only able to produce an inconsisten...

journal_title：Scientific reports

authors： Duong MM,Carmody CM,Ma Q,Peters JE,Nugen SR

更新日期：2020-10-26 00:00:00

abstract：:CDK5 Regulatory Subunit-Associated Protein 1-like 1 (CDKAL1) was identified as a susceptibility gene for type 2 diabetes and body mass index in genome-wide association studies. Although it was reported that CDKAL1 is a methylthiotransferase essential for tRNALys(UUU) and faithful translation of proinsulin generated in...

journal_title：Scientific reports

authors： Take K,Waki H,Sun W,Wada T,Yu J,Nakamura M,Aoyama T,Yamauchi T,Kadowaki T

更新日期：2017-08-04 00:00:00

abstract：:Ophidian accidents are considered an important neglected tropical disease by the World Health Organization. Particularly in Latin America, Bothrops snakes are responsible for the majority of the snakebite envenomings that are not efficiently treated by conventional serum therapy. Thus, the search for simple and effici...

journal_title：Scientific reports

authors： Salvador GHM,Cardoso FF,Gomes AA,Cavalcante WLG,Gallacci M,Fontes MRM

更新日期：2019-01-24 00:00:00