Immune complexes in chronic Chagas disease patients are formed by exovesicles from Trypanosoma cruzi carrying the conserved MASP N-terminal region.

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Stringer BW,Day BW,D'Souza RCJ,Jamieson PR,Ensbey KS,Bruce ZC,Lim YC,Goasdoué K,Offenhäuser C,Akgül S,Allan S,Robertson T,Lucas P,Tollesson G,Campbell S,Winter C,Do H,Dobrovic A,Inglis PL,Jeffree RL,Johns TG,Boy

更新日期：2020-01-21 00:00:00

abstract：:Wolfram syndrome (WS) is a rare neurodegenerative disorder that is mainly characterized by diabetes mellitus, optic nerve atrophy, deafness, and progressive brainstem degeneration. Treatment with GLP-1 receptor agonists has shown a promising anti-diabetic effect in WS treatment in both animal models and in human patie...

journal_title：Scientific reports

authors： Seppa K,Toots M,Reimets R,Jagomäe T,Koppel T,Pallase M,Hasselholt S,Krogsbæk Mikkelsen M,Randel Nyengaard J,Vasar E,Terasmaa A,Plaas M

更新日期：2019-10-31 00:00:00

abstract：:Iron is an essential mineral required for most forms of life. However, very little is known in relation to the different forms of dietary iron on the development of NAFLD. The aims of this study were to investigate the effects of iron intake from different food types on risk of NAFLD and whether this effect may be mod...

journal_title：Scientific reports

authors： Peng XE,Xu SH,Liu W,Hu Z,Lin Z,Lin X

更新日期：2019-03-11 00:00:00

abstract：:Studies investigating association of depression with overall survival (OS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) yielded conflicting results. A nationwide cohort study, which included all adult patients [n = 7,170; depression group, 13.3% (N = 956); non-depression group, 86.7% (N = 6,214...

journal_title：Scientific reports

authors： Wang SM,Park SS,Park SH,Kim NY,Kang DW,Na HR,Lee JW,Han S,Lim HK

更新日期：2020-09-17 00:00:00

abstract：:Zebrafish (Danio rerio), largely used as a model for studying developmental processes, has also emerged as a valuable system for modelling human inflammatory diseases. However, in a context where even mice have been questioned as a valid model for these analysis, a systematic study evaluating the reproducibility of hu...

journal_title：Scientific reports

authors： Forn-Cuní G,Varela M,Pereiro P,Novoa B,Figueras A

更新日期：2017-02-03 00:00:00

abstract：:Heparan sulfate (HS) is a polysaccharide known to modulate many important biological processes, including Wnt signaling. However, the biochemical interaction between HS and Wnt molecules is not well characterized largely due to the lack of suitable methods. To determine the Wnt binding domain in HS, we used a Wnt sign...

journal_title：Scientific reports

authors： Gao W,Xu Y,Liu J,Ho M

更新日期：2016-05-17 00:00:00

abstract：:Accurately representing the Indian Ocean Dipole (IOD) is crucial for reliable climate predictions and future projections. However, El Niño-Southern Oscillation (ENSO) and IOD interact, making it necessary to evaluate ENSO and IOD simultaneously. Using the historical simulation from 32 fifth phase of Coupled Model Inte...

journal_title：Scientific reports

authors： McKenna S,Santoso A,Gupta AS,Taschetto AS,Cai W

更新日期：2020-07-13 00:00:00

abstract：:Intervertebral disc (IVD) degeneration is a leading cause of chronic low back pain that affects millions of people every year. Yet identification of the specific IVD causing this pain is based on qualitative visual interpretation rather than objective findings. One possible approach to diagnosing pain-associated IVD c...

journal_title：Scientific reports

authors： Bez M,Zhou Z,Sheyn D,Tawackoli W,Giaconi JC,Shapiro G,Ben David S,Gazit Z,Pelled G,Li D,Gazit D

更新日期：2018-11-26 00:00:00

abstract：:The PDZ domain-containing scaffold protein, syntenin-1, binds to the transmembrane proteoglycan, syndecan-4, but the molecular mechanism/function of this interaction are unknown. Crystal structure analysis of syntenin-1/syndecan-4 cytoplasmic domains revealed that syntenin-1 forms a symmetrical pair of dimers anchored...

journal_title：Scientific reports

authors： Choi Y,Yun JH,Yoo J,Lee I,Kim H,Son HN,Kim IS,Yoon HS,Zimmermann P,Couchman JR,Cho HS,Oh ES,Lee W

更新日期：2016-11-10 00:00:00

abstract：:Urate transporter 1 (URAT1/SLC22A12), a urate transporter gene, is a causative gene for renal hypouricemia type 1. Among several reported nonsynonymous URAT1 variants, R90H (rs121907896) and W258X (rs121907892) are frequent causative mutations for renal hypouricemia. However, no case-control study has evaluated the re...

journal_title：Scientific reports

authors： Sakiyama M,Matsuo H,Shimizu S,Nakashima H,Nakamura T,Nakayama A,Higashino T,Naito M,Suma S,Hishida A,Satoh T,Sakurai Y,Takada T,Ichida K,Ooyama H,Shimizu T,Shinomiya N

更新日期：2016-01-29 00:00:00

abstract：:To realize the economical production of ethanol and other bio-based chemicals from lignocellulosic biomass by consolidated bioprocessing (CBP), various cellulases from different sources were tested to improve the level of cellulase secretion in the yeast Saccharomyces cerevisiae by screening an optimal translational f...

journal_title：Scientific reports

authors： Lee CR,Sung BH,Lim KM,Kim MJ,Sohn MJ,Bae JH,Sohn JH

更新日期：2017-06-30 00:00:00

abstract：:Nutrient resorption processes in the plants infected by pathogen remain poorly understood. Huanglongbing (HLB) is a destructive disease of citrus. HLB-pathogen 'Candidatus Liberibacter asiaticus' grows specifically in the phloem of hosts and may cause problems in the plant vascular system after infection. Therefore, i...

journal_title：Scientific reports

authors： Cao J,Cheng C,Yang J,Wang Q

更新日期：2015-09-30 00:00:00

abstract：:West Nile virus (WNV) is a neurotropic pathogen which causes zoonotic disease in humans. Recently, there have been an increasing number of infected cases and there are no clinically approved vaccines or effective drugs to treat WNV infections in humans. The purpose of this study was to facilitate vaccine and antiviral...

journal_title：Scientific reports

authors： Li W,Ma L,Guo LP,Wang XL,Zhang JW,Bu ZG,Hua RH

更新日期：2017-06-12 00:00:00

abstract：:The primary objective of this study was to evaluate how schizophrenia (SCH) spectrum disorders and applied antipsychotic (AP) treatment affect serum level of amino acids (AAs) and biogenic amines (BAs) in the early course of the disorder. We measured 21 different AAs and 10 BAs in a sample of antipsychotic (AP)-naïve ...

journal_title：Scientific reports

authors： Parksepp M,Leppik L,Koch K,Uppin K,Kangro R,Haring L,Vasar E,Zilmer M

更新日期：2020-08-19 00:00:00

abstract：:Ascertaining the existence of hidden objects in a complex system, objects that cannot be observed from the external world, not only is curiosity-driven but also has significant practical applications. Generally, uncovering a hidden node in a complex network requires successful identification of its neighboring nodes, ...

journal_title：Scientific reports

authors： Su RQ,Lai YC,Wang X,Do Y

更新日期：2014-02-03 00:00:00

abstract：:HIV-infected subjects under virological control still exhibit a persistent proinflammatory state. Thus, chronic HIV infection changes the host homeostasis towards an adapted immune response that may affect the outcome of coinfections. However, little is known about the impact of HIV infection on inflammatory amplifica...

journal_title：Scientific reports

authors： Hottz ED,Quirino-Teixeira AC,Valls-de-Souza R,Zimmerman GA,Bozza FA,Bozza PT

更新日期：2019-05-08 00:00:00

abstract：:We have quantitatively evaluated the macular and peripapillary microvascular changes in eyes with chiasmal compression caused by brain tumors compared with healthy control eyes using optical coherence tomography angiography (OCT-A) and correlated them with other ocular parameters. This cross-sectional study involved t...

journal_title：Scientific reports

authors： Lee GI,Park KA,Oh SY,Kong DS

更新日期：2020-02-07 00:00:00

abstract：:Long-term skills training is known to induce neuroplastic alterations, but it is still debated whether these changes are always modality-specific or can be supramodal components. To address this issue, we compared finger-targeted somatosensory-evoked and auditory-evoked potentials under both Go (response) and Nogo (re...

journal_title：Scientific reports

authors： Yamashiro K,Yamazaki Y,Siiya K,Ikarashi K,Baba Y,Otsuru N,Onishi H,Sato D

更新日期：2021-01-26 00:00:00

abstract：:Recent genome-wide association studies (GWAS) of Parkinson's disease (PD) revealed at least 26 risk loci, with associated single nucleotide polymorphisms (SNPs) located in non-coding DNA having unknown functions in risk. In order to explore in which cell types these SNPs (and their correlated surrogates at r(2) ≥ 0.8)...

journal_title：Scientific reports

authors： Coetzee SG,Pierce S,Brundin P,Brundin L,Hazelett DJ,Coetzee GA

更新日期：2016-07-27 00:00:00

abstract：:Diabetes mellitus accelerates vascular calcification (VC) and increases the risk of end-stage renal disease (ESRD). Nevertheless, the impact of VC in renal disease progression in type 2 diabetes mellitus (T2DM) is poorly understood. We addressed the effect of VC and mechanisms involved in renal dysfunction in a murine...

journal_title：Scientific reports

authors： Almeida YE,Fessel MR,do Carmo LS,Jorgetti V,Farias-Silva E,Pescatore LA,Gamarra LF,Andrade MC,Simplicio-Filho A,Mangueira CLP,Rangel ÉB,Liberman M

更新日期：2020-01-09 00:00:00

abstract：:Pancreatic adenocarcinoma upregulated factor (PAUF) is a ligand of toll-like receptors (TLRs) and has been reported to be involved in pancreatic tumor development. However, the significance of PAUF expression in epithelial ovarian cancer remains unclear. We aimed to investigate the possible clinical significance of PA...

journal_title：Scientific reports

authors： Choi CH,Kang TH,Song JS,Kim YS,Chung EJ,Ylaya K,Kim S,Koh SS,Chung JY,Kim JH,Hewitt SM

更新日期：2018-08-15 00:00:00

abstract：:Decoders optimized offline to reconstruct intended movements from neural recordings sometimes fail to achieve optimal performance online when they are used in closed-loop as part of an intracortical brain-computer interface (iBCI). This is because typical decoder calibration routines do not model the emergent interact...

journal_title：Scientific reports

authors： Willett FR,Young DR,Murphy BA,Memberg WD,Blabe CH,Pandarinath C,Stavisky SD,Rezaii P,Saab J,Walter BL,Sweet JA,Miller JP,Henderson JM,Shenoy KV,Simeral JD,Jarosiewicz B,Hochberg LR,Kirsch RF,Bolu Ajiboye A

更新日期：2019-06-20 00:00:00

abstract：:Silver nanorod arrays prepared by oblique angle deposition (AgOADs) represent versatile, simple and inexpensive substrates for high sensitivity surface enhanced Raman scattering (SERS) applications. Their anisotropic nature suggests that their optical responses such as the SERS signal, the depolarization ratio, reflec...

journal_title：Scientific reports

authors： Šubr M,Petr M,Kylián O,Štěpánek J,Veis M,Procházka M

更新日期：2017-06-27 00:00:00

abstract：:In swine the upper reproductive tract undergoes early postnatal development, however little is known about the lower reproductive tract. Our objective was to measure cytology and proteome of vaginal swab samples taken on postnatal day (PND) 2 and 16 in gilts to determine if temporal changes occurred in cell and protei...

journal_title：Scientific reports

authors： Harlow K,Suarez-Trujillo A,Hedrick V,Sobreira T,Aryal UK,Stewart K,Casey T

更新日期：2019-09-13 00:00:00

abstract：:The Notch signaling network determines stemness in various tissues and targeting signaling activity in malignant brain cancers by gamma-secretase inhibitors (GSI) has shown promising preclinical success. However, the clinical translation remains challenging due to severe toxicity side effects and emergence of therapy ...

journal_title：Scientific reports

authors： Herrera-Rios D,Li G,Khan D,Tsiampali J,Nickel AC,Aretz P,Hewera M,Suwala AK,Jiang T,Steiger HJ,Kamp MA,Muhammad S,Hänggi D,Maciaczyk J,Zhang W,Kahlert UD

更新日期：2020-10-01 00:00:00

abstract：:The hitherto difficult task of reliably estimating populations of wide-ranging megafauna has been enabled by advances in capture-recapture methodology. Here we combine photographic sampling with a Bayesian spatially-explicit capture-recapture (SCR) model to estimate population parameters for the endangered Asian eleph...

journal_title：Scientific reports

authors： Goswami VR,Yadava MK,Vasudev D,Prasad PK,Sharma P,Jathanna D

更新日期：2019-06-12 00:00:00

abstract：:Calibration of quantum computers is essential to the effective utilisation of their quantum resources. Specifically, the performance of quantum annealers is likely to be significantly impaired by noise in their programmable parameters, effectively misspecification of the computational problem to be solved, often resul...

journal_title：Scientific reports

authors： Perdomo-Ortiz A,O'Gorman B,Fluegemann J,Biswas R,Smelyanskiy VN

更新日期：2016-01-19 00:00:00

abstract：:This study measured the effects of vitamin D (VD) supplementation on the underlying molecular pathways involved in renal and testicular damage induced by lead (Pb) toxicity. Thirty two adult male Wistar rats were divided equally into four groups that were treated individually or simultaneously, except the negative con...

journal_title：Scientific reports

authors： BaSalamah MA,Abdelghany AH,El-Boshy M,Ahmad J,Idris S,Refaat B

更新日期：2018-03-19 00:00:00

abstract：:Pectins, the major components of cell walls in plants, are synthesized and secreted to cell walls as highly methyl-esterified polymers and then demethyl-esterified by pectin methylesterases (PMEs). The PMEs are spatially regulated by pectin methylesterase inhibitors (PMEIs). In this study, 43 and 49 putative PME and P...

journal_title：Scientific reports

authors： Zhang P,Wang H,Qin X,Chen K,Zhao J,Zhao Y,Yue B

更新日期：2019-12-27 00:00:00

abstract：:Tuberous sclerosis complex (TSC) is a rare autosomal dominant disorder causing benign tumors in the brain and other vital organs. The genes implicated in disease development are TSC1 and TSC2. Here, we have performed mutational analysis followed by a genotype-phenotype correlation study based on the clinical character...

journal_title：Scientific reports

authors： Avgeris S,Fostira F,Vagena A,Ninios Y,Delimitsou A,Vodicka R,Vrtel R,Youroukos S,Stravopodis DJ,Vlassi M,Astrinidis A,Yannoukakos D,Voutsinas GE

更新日期：2017-12-01 00:00:00