Abstract:
:Intervertebral disc (IVD) degeneration is a leading cause of chronic low back pain that affects millions of people every year. Yet identification of the specific IVD causing this pain is based on qualitative visual interpretation rather than objective findings. One possible approach to diagnosing pain-associated IVD could be to identify acidic IVDs, as decreased pH within an IVD has been postulated to mediate discogenic pain. We hypothesized that quantitative chemical exchange saturation transfer (qCEST) MRI could detect pH changes in IVDs, and thence be used to diagnose pathologically painful IVDs objectively and noninvasively. To test this hypothesis, a surgical model of IVD degeneration in Yucatan minipigs was used. Direct measurement of pH inside the degenerated IVDs revealed a significant drop in pH after degeneration, which correlated with a significant increase in the qCEST signal. Gene analysis of harvested degenerated IVDs revealed significant upregulation of pain-, nerve- and inflammatory-related markers after IVD degeneration. A strong positive correlation was observed between the expression of pain markers and the increase in the qCEST signal. Collectively, these findings suggest that this approach might be used to identify which IVD is causing low back pain, thereby providing valuable guidance for pain and surgical management.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Bez M,Zhou Z,Sheyn D,Tawackoli W,Giaconi JC,Shapiro G,Ben David S,Gazit Z,Pelled G,Li D,Gazit Ddoi
10.1038/s41598-018-34582-6subject
Has Abstractpub_date
2018-11-26 00:00:00pages
17363issue
1issn
2045-2322pii
10.1038/s41598-018-34582-6journal_volume
8pub_type
杂志文章abstract::Objectum-sexuality (OS) is a sexual orientation which has received little attention in the academic literature. Individuals who identify as OS experience emotional, romantic and/or sexual feelings towards inanimate objects (e.g. a bridge, a statue). We tested 34 OS individuals and 88 controls, and provide the first em...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56449-0
更新日期:2019-12-27 00:00:00
abstract::Medicinal herbs belonging to the same genus are always easily confused due to their extremely similar morphology and metabolites. Previously, to differentiate them, inherently specific biomarkers were screened out via intuitive comparison of their metabolite profiles. Unfortunately, the selected biomarkers have worked...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04712-7
更新日期:2017-07-04 00:00:00
abstract::Analysing the link between terrestrial ecosystem productivity (i.e., Net Primary Productivity: NPP) and extreme climate conditions is vital in the context of increasing threats due to climate change. To reveal the impact of changing extreme conditions on NPP, a copula-based probabilistic model was developed, and the s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55067-0
更新日期:2019-12-12 00:00:00
abstract::In optics, when polychromatic light is filtered by an optical filter, the monochromaticity of the light can be improved. In this work, we reported that Ag dopant atoms could be used as an optical filter for nanosized Mn:ZnSe quantum dots (QDs). If no Ag doping, aqueous Mn:ZnSe QDs have low monochromaticity due to coex...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14817
更新日期:2015-10-08 00:00:00
abstract::Protein colocalisation is often studied using pixel intensity-based coefficients such as Pearson, Manders, Li or Costes. However, these methods cannot be used to study object-based colocalisations in biological systems. Therefore, a novel method is required to automatically identify regions of fluorescent signal in tw...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08786-1
更新日期:2017-08-21 00:00:00
abstract::Multiple parasitic arthropods of medical importance depend on symbiotic bacteria. While the link between scabies and secondary bacterial infections causing post infective complications of Group A streptococcal and staphylococcal pyoderma is increasingly recognized, very little is known about the microbiota of Sarcopte...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47892-0
更新日期:2019-08-13 00:00:00
abstract::Monolayer germanene, a novel graphene-like germanium allotrope akin to silicene has been recently grown on metallic substrates. Lying directly on the metal surfaces the reconstructed atom-thin sheets are prone to lose the massless Dirac fermion character and unique associated physical properties of free standing germa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20714
更新日期:2016-02-10 00:00:00
abstract::This work reports a facile method for preparing the new photoactive In(2)O(3) films as well as their implementation in photoelectrochemical (PEC) application. We firstly investigated the relationship between oxygen vacancies (V(O)) and PEC performance and revealed a rule between them. We found that the optimized In(2)...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01021
更新日期:2013-01-01 00:00:00
abstract::In the epoch of the Anthropocene change, complexity, and uncertainty create a demand for new systems of water management and governance. One such management model that is rapidly gaining traction amongst both scholars and practitioners is the concept of water resilience. Although increasing attention has been paid to ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62896-x
更新日期:2020-04-06 00:00:00
abstract::Autonomic modulation and cardiorespiratory variables are influenced by numerous factors, including anthropometric variables. We investigated autonomic recovery following aerobic exercise in healthy men with different waist-stature ratio (WSR) values. The study was conducted with 52 healthy men aged 18 to 30 years, div...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-018-34246-5
更新日期:2018-10-31 00:00:00
abstract::SNPs, abundant in human genome with lower mutation rate, are attractive to genetic application like forensic, anthropological and evolutionary studies. Universal SNPs showing little allelic frequency variation among populations while remaining highly informative for human identification were obtained from previous stu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18683
更新日期:2015-12-22 00:00:00
abstract::The non-enzymatic browning, namely Maillard reaction is commonly invoked to account for abiotic chemical transformations of organic matter. Here we report a new reaction pathway via the Maillard reaction to systematically synthesize a series of nitrogen-doped carbon dots (C-dots) with superhigh quantum yield (QY) and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03564
更新日期:2014-01-06 00:00:00
abstract::In this study we characterise three tandem promoters (PR1-1, PR1-2 and PR1-3) within the PR1 regulatory region of the Escherichia coli kps capsule gene cluster. Transcription from promoter PR1-2 was dependent on the activity of the upstream promoter PR1-1, which activated PR1-2 via transcription coupled DNA supercoili...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17891-0
更新日期:2017-12-20 00:00:00
abstract::Anion exchange membrane fuel cells (AEMFCs) have captivated vast interest due to non-platinum group metal catalysts and fuel flexibility. One of the major shortcomings of AEMFCs, however, is the lack of a stable and high anion conducting membrane. This study introduces a new strategy for fabrication of high conducting...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45947-w
更新日期:2019-07-02 00:00:00
abstract::Decarboxylation of fatty acids over non-noble metal catalysts without added hydrogen was studied. Ni/C catalysts were prepared and exhibited excellent activity and maintenance for decarboxylation. Thereafter, the effects of nickel loading, catalyst loading, temperature, and carbon number on the decarboxylation of fatt...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27820
更新日期:2016-06-13 00:00:00
abstract::The association of fasting glucose with the risk of death according to sex and age remains unclear, and insufficient information is available on sex- and age-specific glucose concentrations within ethnic groups. This study analyzed a sample of 12,455,361 Korean adults who participated in health examinations during 200...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08498-6
更新日期:2017-08-15 00:00:00
abstract::Although most models suggest continental Antarctica was covered by ice during the Last Glacial Maximum (LGM) it has been speculated that endemic species of soil invertebrates could have survived the Pleistocene at high elevation habitats protruding above the ice sheets. We analyzed a series of soil samples from differ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26189
更新日期:2016-05-18 00:00:00
abstract::Natural infection with measles virus (MV) establishes lifelong immunity. Persistent infection with MV is likely involved in this phenomenon, as non-replicating protein antigens never induce such long-term immunity. Although MV establishes stable persistent infection in vitro and possibly in vivo, the mechanism by whic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37163
更新日期:2016-11-24 00:00:00
abstract::A high prevalence of obstructive sleep apnea (OSA) has been reported in Down syndrome (DS) owing to the coexistence of multiple predisposing factors related to its genetic abnormality, posing a challenge for the management of OSA. We hypothesized that DS mice recapitulate craniofacial abnormalities and upper airway ob...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78278-2
更新日期:2020-12-07 00:00:00
abstract::We propose a simple quantum voting scenario with a set of pairs of particles in a multi-particle entangled state. This scenario is suitable for large scale general votings. We also provide a proof of security of our scheme against the most general type of attack by generalizing Shor and Preskill's proof of security of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07976-1
更新日期:2017-08-08 00:00:00
abstract::We aimed to investigate whether the newborns of mothers with maternal depression (MD) had lower vitamin D levels than newborns of non-MD (NMD) mothers and identify the potential mechanism underlying this association. Maternal depressive symptoms in late pregnancy and concentrations of cord blood 25 hydroxyvitamin D (2...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01778-1
更新日期:2017-05-08 00:00:00
abstract::In the last decades, AC powered atmospheric dielectric barrier discharges (DBDs) in air with a liquid electrode have been proposed as a promising plasma technology with versatile applicability in medicine, agriculture and water treatment. The fundamental features of the micro-discharge filaments that make up this type...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29189-w
更新日期:2018-07-19 00:00:00
abstract::Carbon nanomaterials' reactivity towards oxygen is very poor, limiting their potential applications. However, nitrogen doping is an established way to introduce active sites that facilitate interaction with gases. This boosts the materials' reactivity for bio-/gas sensing and enhances their catalytic performance for t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08651-1
更新日期:2017-08-11 00:00:00
abstract::Fluorescence lifetime imaging microscopy (FLIM) is a key technology that provides direct insight into cell metabolism, cell dynamics and protein activity. However, determining the lifetimes of different fluorescent proteins requires the detection of a relatively large number of photons, hence slowing down total acquis...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77737-0
更新日期:2020-12-02 00:00:00
abstract::Prostate-specific antigen (PSA) kinetics predicts survival in castration-resistant prostate cancer (CRPC); however, the influence of prior treatment on this relationship is unclear. Patients with CRPC were stratified according to time to PSA nadir and time to CRPC progression to investigate their prognostic significan...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48424-6
更新日期:2019-08-15 00:00:00
abstract::Controlling the angular momentum of spins with very short external perturbations is a key issue in modern magnetism. For example it allows manipulating the magnetization for recording purposes or for inducing high frequency spin torque oscillations. Towards that purpose it is essential to modify and control the angula...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08511
更新日期:2015-02-17 00:00:00
abstract::Electrostatic gates are of paramount importance for the physics of devices based on high-mobility two-dimensional electron gas (2DEG) since they allow depletion of electrons in selected areas. This field-effect gating enables the fabrication of a wide range of devices such as, for example, quantum point contacts (QPC)...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13494
更新日期:2015-09-22 00:00:00
abstract::This study aimed to explore the risk of dementia in a middle- and older-aged population with severe or profound hearing impairments. Data were collected for the Korean National Health Insurance Service-National Sample Cohort from 2002 to 2013. Participants aged 40 or older were selected. The 4,432 severely hearing-imp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33325-x
更新日期:2018-10-15 00:00:00
abstract::In Duchenne muscular dystrophy, progressive loss of muscle tissue is accompanied by fibrosis, chronic inflammation and reduced muscle regenerative capacity. Although much is known about the development of fibrosis and chronic inflammation in muscular dystrophy, less is known about how they are mechanistically linked t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24708
更新日期:2016-05-31 00:00:00
abstract::The sensitivity of many ion channels to phosphatidylinositol-4,5-bisphosphate (PIP2) levels in the cell membrane suggests that PIP2 fluctuations are important and general signals modulating neuronal excitability. Yet the PIP2 dynamics of central neurons in their native environment remained largely unexplored. Here, we...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31322-8
更新日期:2018-08-28 00:00:00